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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:octadecane
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Accession:CHEBI:32926 term browser browse the term
Definition:A straight-chain alkane carrying 18 carbon atoms.
Synonyms:related_synonym: CH3-[CH2]16-CH3;   Formula=C18H38;   InChI=1S/C18H38/c1-3-5-7-9-11-13-15-17-18-16-14-12-10-8-6-4-2/h3-18H2,1-2H3;   InChIKey=RZJRJXONCZWCBN-UHFFFAOYSA-N;   Oktadekan;   SMILES=CCCCCCCCCCCCCCCCCC;   n-octadecane
 xref: Beilstein:1740138;   CAS:593-45-3;   Gmelin:263389;   KNApSAcK:C00030879;   PMID:9842728;   Reaxys:1740138


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1-octadecanoyl-2-[(9Z)-octadecenoyl]-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions
decreases abundance
ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol
LIPC gene mutant form results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol
CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lipg lipase G, endothelial type decreases abundance
multiple interactions
ISO LIPG gene mutant form results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol
CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
1-stearoyl-2-arachidonoyl-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dagla diacylglycerol lipase, alpha increases metabolic processing ISO DAGLA protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol CTD PMID:18657971 NCBI chr 1:226,297,013...226,353,712
Ensembl chr 1:226,297,016...226,353,611
JBrowse link
G Daglb diacylglycerol lipase, beta increases metabolic processing ISO DAGLB protein results in increased metabolism of 1-stearoyl-2-arachidonoylglycerol CTD PMID:18657971 NCBI chr12:13,113,073...13,157,748
Ensembl chr12:13,113,237...13,157,666
JBrowse link
G Dgke diacylglycerol kinase epsilon increases phosphorylation ISO DGKE protein results in increased phosphorylation of 1-stearoyl-2-arachidonoylglycerol CTD PMID:17455907 NCBI chr10:76,375,981...76,408,224
Ensembl chr10:76,386,471...76,407,989
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO 1-stearoyl-2-arachidonoylglycerol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 multiple interactions ISO TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Barium]; TRPM6 protein affects the reaction [1-stearoyl-2-arachidonoylglycerol results in increased transport of Calcium] CTD PMID:11988098 NCBI chr 1:234,478,908...234,631,264
Ensembl chr 1:234,479,289...234,596,971
JBrowse link
1-stearoyl-2-linoleoyl-sn-glycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type decreases abundance ISO LIPC gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lipg lipase G, endothelial type decreases abundance ISO LIPG gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
1-stearoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
9-hydroxyoctadecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adtrp androgen-dependent TFPI-regulating protein affects chemical synthesis ISO ADTRP protein affects the chemical synthesis of 9-hydroxystearic acid CTD PMID:32152231 NCBI chr17:22,619,913...22,688,296
Ensembl chr17:22,619,891...22,688,307
JBrowse link
G Aig1 androgen-induced 1 affects chemical synthesis ISO AIG1 protein affects the chemical synthesis of 9-hydroxystearic acid CTD PMID:32152231 NCBI chr 1:7,816,841...8,038,805
Ensembl chr 1:7,816,838...8,038,665
JBrowse link
cholesteryl stearate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipg lipase G, endothelial type decreases abundance ISO LIPG gene mutant form results in decreased abundance of cholesterol stearate CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
octadecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO stearic acid results in increased expression of ABCG1 mRNA CTD PMID:16730733 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
ISO stearic acid results in decreased expression of ADIPOQ mRNA
resveratrol inhibits the reaction [stearic acid results in decreased expression of ADIPOQ mRNA]
CTD PMID:17374693 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; epigallocatechin gallate inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; resveratrol inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein] CTD PMID:23880231 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO ALB protein binds to stearic acid; stearic acid binds to ALB protein
[[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [ALB protein binds to stearic acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to stearic acid] promotes the reaction [Pyruvaldehyde results in increased oxidation of ALB protein]; [ALB protein modified form binds to stearic acid] which results in decreased reduction of Dithionitrobenzoic Acid; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein]; stearic acid inhibits the reaction [ziprasidone binds to ALB protein]
CTD PMID:25451573, PMID:31400341 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO stearic acid results in decreased expression of ALDH1A1 protein CTD PMID:26739624 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Apoa4 apolipoprotein A4 increases expression ISO stearic acid results in increased expression of APOA4 mRNA CTD PMID:26739624 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Ar androgen receptor multiple interactions ISO stearic acid binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Casp3 caspase 3 multiple interactions EXP SCD1 protein inhibits the reaction [stearic acid results in increased activity of CASP3 protein]; stearic acid results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:22413010 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity EXP stearic acid results in increased activity of CASP7 protein CTD PMID:22413010 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase increases activity EXP stearic acid results in increased activity of CAT protein CTD PMID:17302992 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [stearic acid results in increased expression of CCL2 mRNA] CTD PMID:17374693 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO stearic acid results in increased expression of CCL3 mRNA CTD PMID:21745629 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity ISO stearic acid results in increased activity of CYP2E1 protein CTD PMID:26739624 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Edn1 endothelin 1 increases expression ISO stearic acid results in increased expression of EDN1 mRNA; stearic acid results in increased expression of EDN1 protein CTD PMID:16895544 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO stearic acid binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [stearic acid results in decreased expression of FOXO1 protein] CTD PMID:17374693 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [stearic acid results in decreased expression of GPX1 mRNA] CTD PMID:17374693 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO stearic acid results in increased expression of HMOX1 mRNA CTD PMID:26739624 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Curcumin inhibits the reaction [stearic acid results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [stearic acid results in increased expression of IL1B protein]; epigallocatechin gallate inhibits the reaction [stearic acid results in increased expression of IL1B mRNA]; epigallocatechin gallate inhibits the reaction [stearic acid results in increased expression of IL1B protein]; resveratrol inhibits the reaction [stearic acid results in increased expression of IL1B mRNA]; resveratrol inhibits the reaction [stearic acid results in increased expression of IL1B protein]; Zyflamend inhibits the reaction [stearic acid results in increased expression of IL1B mRNA]; Zyflamend inhibits the reaction [stearic acid results in increased expression of IL1B protein]
stearic acid results in increased expression of IL1B mRNA; stearic acid results in increased expression of IL1B protein
CTD PMID:23880231 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [stearic acid results in increased expression of IL6 mRNA] CTD PMID:17374693 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO INS protein inhibits the reaction [stearic acid results in decreased expression of CYP3A4 mRNA]; INS protein inhibits the reaction [stearic acid results in increased chemical synthesis of 6-hydroxychlorzoxazone]; INS protein inhibits the reaction [stearic acid results in increased hydroxylation of Chlorzoxazone]
[1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of stearic acid analog; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased abundance of stearic acid analog
CTD PMID:26739624, PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein] CTD PMID:32006539 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO stearic acid results in increased expression of NFE2L2 mRNA; stearic acid results in increased expression of NFE2L2 protein CTD PMID:28555106 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO stearic acid results in decreased expression of PKLR protein CTD PMID:26739624 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Plin1 perilipin 1 increases expression ISO stearic acid results in increased expression of PLIN1 mRNA CTD PMID:26739624 NCBI chr 1:141,458,907...141,470,927
Ensembl chr 1:141,458,181...141,471,010
JBrowse link
G Plin2 perilipin 2 increases expression ISO stearic acid results in increased expression of PLIN2 mRNA CTD PMID:26739624 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO stearic acid binds to and results in increased activity of PPARA protein CTD PMID:10403814 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP stearic acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARG protein] CTD PMID:17302992 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO stearic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [stearic acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [stearic acid results in increased expression of PTGS2 protein]; epigallocatechin gallate inhibits the reaction [stearic acid results in increased expression of PTGS2 mRNA]; epigallocatechin gallate inhibits the reaction [stearic acid results in increased expression of PTGS2 protein]; resveratrol inhibits the reaction [stearic acid results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [stearic acid results in increased expression of PTGS2 protein]; Zyflamend inhibits the reaction [stearic acid results in increased expression of PTGS2 mRNA]; Zyflamend inhibits the reaction [stearic acid results in increased expression of PTGS2 protein]
stearic acid results in increased expression of PTGS2 mRNA; stearic acid results in increased expression of PTGS2 protein
CTD PMID:23880231 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [stearic acid results in increased phosphorylation of RELA protein] CTD PMID:23880231 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases response to substance
increases expression
EXP SCD1 protein inhibits the reaction [stearic acid results in increased abundance of Ceramides]; SCD1 protein inhibits the reaction [stearic acid results in increased abundance of Reactive Oxygen Species]; SCD1 protein inhibits the reaction [stearic acid results in increased activity of CASP3 protein]
SCD1 protein results in decreased susceptibility to stearic acid
stearic acid results in increased expression of SCD1 mRNA
CTD PMID:22413010 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [stearic acid results in increased expression of SERPINE1 mRNA] CTD PMID:17374693 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sod1 superoxide dismutase 1 increases activity EXP stearic acid results in increased activity of SOD1 protein CTD PMID:17302992 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [stearic acid results in decreased expression of SOD2 mRNA] CTD PMID:17374693 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Curcumin inhibits the reaction [stearic acid results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [stearic acid results in increased expression of TNF protein]; epigallocatechin gallate inhibits the reaction [stearic acid results in increased expression of TNF mRNA]; epigallocatechin gallate inhibits the reaction [stearic acid results in increased expression of TNF protein]; resveratrol inhibits the reaction [stearic acid results in increased expression of TNF mRNA]; resveratrol inhibits the reaction [stearic acid results in increased expression of TNF protein]; Zyflamend inhibits the reaction [stearic acid results in increased expression of TNF mRNA]; Zyflamend inhibits the reaction [stearic acid results in increased expression of TNF protein]
stearic acid results in increased expression of TNF mRNA; stearic acid results in increased expression of TNF protein
CTD PMID:23880231 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO stearic acid results in increased expression of TRIB3 mRNA CTD PMID:26739624 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO [perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein
CTD PMID:15781658, PMID:21267448, PMID:30265530, PMID:31445927 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein
CTD PMID:15781658, PMID:25416439 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP8 protein CTD PMID:15781658 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Egf epidermal growth factor multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA CTD PMID:30265530 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions
decreases response to substance
decreases expression
ISO ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]
LAT2 protein results in decreased susceptibility to perifosine
CTD PMID:23001822 NCBI chr12:25,114,099...25,128,381
Ensembl chr12:25,119,355...25,125,749
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:15781658 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
stearoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO stearoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO stearoyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO stearoyl-coenzyme A binds to and results in increased activity of PPARG protein CTD PMID:11139385 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            eukaryotic metabolite 18908
              plant metabolite 17360
                octadecane 60
                  1,2-octadecanediol 0
                  octadecan-1-ol + 18
                  octadecanedioic acid 0
                  octadecanoic acid + 46
                  stearyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  alkane 13684
                                    long-chain alkane 415
                                      octadecane 60
                                        1,2-octadecanediol 0
                                        octadecan-1-ol + 18
                                        octadecanedioic acid 0
                                        octadecanoic acid + 46
                                        stearyl group 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.