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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gamma-hexachlorocyclohexane
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Accession:CHEBI:32888 term browser browse the term
Definition:A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Synonyms:exact_synonym: (1r,2R,3S,4r,5R,6S)-1,2,3,4,5,6-hexachlorocyclohexane
 related_synonym: (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-1,2,3,4,5,6-hexachlorocyclohexane;   (1r,2c,3t,4c,5c,6t)-1,2,3,4,5,6-hexachlorocyclohexane;   1,2,3,4,5,6-Hexachlorocyclohexane;   Benzene hexachloride;   Formula=C6H6Cl6;   InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+;   InChIKey=JLYXXMFPNIAWKQ-GNIYUCBRSA-N;   Kwell;   Lindan;   Lindane;   SMILES=Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl;   gamma-1,2,3,4,5,6-hexachlorocyclohexane;   gamma-BHC;   gamma-HCH;   gamma-Hexachlorzyklohexan;   gamma-benzene hexachloride;   gamma-lindane
 alt_id: CHEBI:10567;   CHEBI:24184;   CHEBI:6473
 xref: Beilstein:1907337;   CAS:55963-79-6;   CAS:58-89-9;   DrugBank:DB00431;   Drug_Central:1583;   Gmelin:2179629;   KEGG:C06595;   KEGG:C07075;   KEGG:D00360
 xref_mesh: MESH:D001556
 xref: PPDB:370;   UM-BBD_compID:c0141;   VSDB:370;   Wikipedia:Lindane


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gamma-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Hexachlorocyclohexane results in increased expression of ABCA1 mRNA CTD PMID:24356939 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Hexachlorocyclohexane results in increased expression of ABCB1 mRNA CTD PMID:24464585 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Hexachlorocyclohexane results in increased expression of ABCC3 mRNA CTD PMID:17785943 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Hexachlorocyclohexane results in increased expression of ABCG1 mRNA CTD PMID:24356939 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Hexachlorocyclohexane results in increased expression of ABCG2 mRNA CTD PMID:24464585 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
increases activity
affects activity
ISO
EXP
Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
Hexachlorocyclohexane results in decreased activity of ACHE protein
Hexachlorocyclohexane results in increased activity of ACHE protein
Hexachlorocyclohexane affects the activity of ACHE protein
CTD PMID:6186625, PMID:19893075, PMID:20663516 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase decreases expression
affects activity
EXP Hexachlorocyclohexane results in decreased expression of ACLY mRNA
Hexachlorocyclohexane affects the activity of ACLY protein
CTD PMID:7535533, PMID:17785943 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aco2 aconitase 2 increases expression EXP Hexachlorocyclohexane results in increased expression of ACO2 mRNA CTD PMID:17785943 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP Hexachlorocyclohexane results in decreased expression of ACSL5 mRNA CTD PMID:17785943 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Actb actin, beta affects expression EXP Hexachlorocyclohexane affects the expression of ACTB mRNA CTD PMID:22001173 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Acvr1 activin A receptor type 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of ACVR1 mRNA CTD PMID:17785943 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G Acvr1c activin A receptor type 1C increases expression EXP Hexachlorocyclohexane results in increased expression of ACVR1C mRNA CTD PMID:17785943 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
JBrowse link
G Add3 adducin 3 affects expression EXP Hexachlorocyclohexane affects the expression of ADD3 mRNA CTD PMID:17785943 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Hexachlorocyclohexane results in increased expression of AHR mRNA CTD PMID:17785943, PMID:25572523 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ak4 adenylate kinase 4 decreases expression ISO Hexachlorocyclohexane results in decreased expression of AK4 mRNA CTD PMID:24356939 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Hexachlorocyclohexane results in increased expression of AKR7A3 mRNA CTD PMID:17785943 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Hexachlorocyclohexane results in decreased phosphorylation of AKT1 protein CTD PMID:30248393 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 increases expression ISO Hexachlorocyclohexane results in increased expression of ALDH8A1 mRNA CTD PMID:24356939 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
JBrowse link
G Alk ALK receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 NCBI chr 6:22,696,415...23,203,791
Ensembl chr 6:22,696,397...23,203,775
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression
increases activity
EXP [Hexachlorocyclohexane co-treated with isoproturon] results in decreased activity of ALPL protein; [Hexachlorocyclohexane co-treated with isoproturon] results in increased expression of ALPL protein
Hexachlorocyclohexane results in increased expression of ALPL protein
Hexachlorocyclohexane results in increased activity of ALPL protein
CTD PMID:11180283 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Apob apolipoprotein B affects expression EXP Hexachlorocyclohexane affects the expression of APOB mRNA CTD PMID:17785943 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Hexachlorocyclohexane binds to AR protein
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD PMID:14565775, PMID:21295777, PMID:26022396 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Armc6 armadillo repeat containing 6 decreases expression EXP Hexachlorocyclohexane results in decreased expression of ARMC6 mRNA CTD PMID:17785943 NCBI chr16:20,939,311...20,949,732
Ensembl chr16:20,939,655...20,954,246
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression EXP Hexachlorocyclohexane results in increased expression of ARNT mRNA CTD PMID:25572523 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Arsa arylsulfatase A decreases activity ISO Hexachlorocyclohexane results in decreased activity of ARSA protein CTD PMID:16818664 NCBI chr 7:130,446,644...130,452,632
Ensembl chr 7:130,446,668...130,451,283
JBrowse link
G Asip agouti signaling protein increases response to substance ISO A mutant form results in increased susceptibility to Hexachlorocyclohexane CTD PMID:2445499 NCBI chr 3:150,492,010...150,579,870
Ensembl chr 3:150,574,473...150,579,870
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Hexachlorocyclohexane results in increased expression of ASNS mRNA CTD PMID:24356939 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta decreases expression EXP Hexachlorocyclohexane results in decreased expression of ATP5F1D mRNA CTD PMID:17785943 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of ATPIF1 mRNA CTD PMID:17785943 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
decreases expression
multiple interactions
ISO
EXP
Hexachlorocyclohexane results in increased expression of BAX mRNA; Hexachlorocyclohexane results in increased expression of BAX protein
Hexachlorocyclohexane results in decreased expression of BAX protein
Estradiol inhibits the reaction [Hexachlorocyclohexane results in decreased expression of BAX protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in decreased expression of BAX protein]; Hexachlorocyclohexane promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein]
CTD PMID:14688026, PMID:18174961, PMID:19041923 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Hexachlorocyclohexane results in decreased activity of BCHE protein
CTD PMID:20455324, PMID:20663516 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO
EXP
Hexachlorocyclohexane results in decreased expression of BCL2 protein
Hexachlorocyclohexane results in increased expression of BCL2 mRNA; Hexachlorocyclohexane results in increased expression of BCL2 protein
[Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of BCL2 protein
Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]
CTD PMID:14688026, PMID:18174961, PMID:19041923 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions
EXP Hexachlorocyclohexane results in increased expression of BCL2L1 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]
CTD PMID:19041923, PMID:22001173 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO Hexachlorocyclohexane results in increased expression of BCL6 mRNA CTD PMID:24356939 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Hexachlorocyclohexane results in increased expression of BDNF protein CTD PMID:11279263 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 affects expression
multiple interactions
EXP Hexachlorocyclohexane affects the expression of BECN1 protein
Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]
CTD PMID:19041923 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA CTD PMID:28263720 NCBI chr12:12,403,385...12,409,103
Ensembl chr12:12,403,385...12,407,561
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 decreases expression EXP Hexachlorocyclohexane results in decreased expression of BHLHE40 mRNA CTD PMID:17785943 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Hexachlorocyclohexane results in increased expression of BIRC3 mRNA CTD PMID:24356939 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Calr calreticulin decreases expression EXP Hexachlorocyclohexane results in decreased expression of CALR mRNA CTD PMID:17785943 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression ISO Hexachlorocyclohexane results in increased expression of CARS1 mRNA CTD PMID:24356939 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
decreases activity
EXP
ISO
Hexachlorocyclohexane results in increased expression of CASP3 mRNA; Hexachlorocyclohexane results in increased expression of CASP3 protein
Hexachlorocyclohexane results in increased activity of CASP3 protein
[Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP3 protein; Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]
Hexachlorocyclohexane results in decreased activity of CASP3 protein
CTD PMID:19038305, PMID:19041923, PMID:19221147, PMID:19815060, PMID:20036686, PMID:22001173 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions EXP [Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP7 protein CTD PMID:20036686 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
increases activity
decreases activity
EXP Hexachlorocyclohexane results in increased expression of CASP9 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]
Hexachlorocyclohexane results in decreased activity of CASP9 protein
CTD PMID:19038305, PMID:19041923, PMID:22001173 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cast calpastatin increases expression EXP Hexachlorocyclohexane results in increased expression of CAST mRNA CTD PMID:17785943 NCBI chr 2:1,452,111...1,561,669
Ensembl chr 2:1,452,116...1,561,464
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
ISO
EXP
Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]
Hexachlorocyclohexane results in increased activity of CAT protein
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of CAT protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]
CTD PMID:1708174, PMID:2429406, PMID:2469257, PMID:9057899, PMID:9467884, PMID:9704597, PMID:10097797, PMID:10817630, PMID:11349524, PMID:11404799, PMID:11561191, PMID:12364975, PMID:12516873, PMID:16046044, PMID:16127354, PMID:16432761, PMID:17884035, PMID:17997001, PMID:20182699, PMID:20455324, PMID:21976817, PMID:22224058, PMID:22302394 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Hexachlorocyclohexane results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd47 Cd47 molecule decreases expression EXP Hexachlorocyclohexane results in decreased expression of CD47 mRNA CTD PMID:17785943 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cd69 Cd69 molecule increases expression ISO Hexachlorocyclohexane results in increased expression of CD69 mRNA CTD PMID:24356939 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cd84 CD84 molecule increases expression ISO Hexachlorocyclohexane results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr13:90,241,369...90,283,625
Ensembl chr13:90,244,681...90,277,865
JBrowse link
G Cdc42 cell division cycle 42 decreases expression EXP Hexachlorocyclohexane results in decreased expression of CDC42 mRNA CTD PMID:17785943 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase affects activity ISO Hexachlorocyclohexane affects the activity of CDIPT protein CTD PMID:2579070 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
multiple interactions
ISO
EXP
Hexachlorocyclohexane results in increased expression of CDKN1A mRNA; Hexachlorocyclohexane results in increased expression of CDKN1A protein
Hexachlorocyclohexane results in decreased expression of CDKN1A protein
Hexachlorocyclohexane affects the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased expression of CDKN1A protein]
CTD PMID:14688026, PMID:17785943, PMID:18174961 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Hexachlorocyclohexane results in increased expression of CEBPB mRNA CTD PMID:24356939 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Hexachlorocyclohexane results in increased expression of CES2 mRNA CTD PMID:17785943 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Hexachlorocyclohexane results in increased expression of CHAC1 mRNA CTD PMID:23824090, PMID:24356939 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Hexachlorocyclohexane results in decreased expression of CIDEA mRNA CTD PMID:17785943 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression EXP Hexachlorocyclohexane results in decreased expression of CISH mRNA CTD PMID:17785943 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression EXP Hexachlorocyclohexane results in increased expression of CITED2 mRNA CTD PMID:17785943 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Clcn5 chloride voltage-gated channel 5 decreases expression EXP Hexachlorocyclohexane results in decreased expression of CLCN5 mRNA CTD PMID:17785943 NCBI chr  X:16,170,585...16,196,691
Ensembl chr  X:16,050,780...16,196,789
JBrowse link
G Clu clusterin increases expression EXP Hexachlorocyclohexane results in increased expression of CLU protein CTD PMID:17997001 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of CNGA1 mRNA CTD PMID:17785943 NCBI chr14:38,155,771...38,171,107
Ensembl chr14:38,155,759...38,171,010
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases activity EXP Hexachlorocyclohexane results in decreased activity of CNP protein CTD PMID:1701514 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Cpd carboxypeptidase D increases expression EXP Hexachlorocyclohexane results in increased expression of CPD mRNA CTD PMID:17785943 NCBI chr10:63,325,764...63,389,811
Ensembl chr10:63,325,199...63,389,817
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 increases expression ISO Hexachlorocyclohexane results in increased expression of CRIM1 mRNA CTD PMID:24356939 NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
JBrowse link
G Cst8 cystatin 8 affects expression EXP Hexachlorocyclohexane affects the expression of CST8 mRNA CTD PMID:17785943 NCBI chr 3:143,129,240...143,141,000
Ensembl chr 3:143,129,248...143,156,177
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO Hexachlorocyclohexane results in decreased expression of CX3CR1 mRNA CTD PMID:24356939 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Cycs cytochrome c, somatic affects expression EXP Hexachlorocyclohexane affects the expression of CYCS mRNA CTD PMID:17785943 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO
EXP
Hexachlorocyclohexane results in decreased expression of CYP11A1 mRNA
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]
CTD PMID:15749814, PMID:17080404 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA] CTD PMID:17080404 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA] CTD PMID:17080404 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:17080404 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
decreases activity
ISO Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]
Hexachlorocyclohexane results in increased expression of CYP19A1 mRNA
Hexachlorocyclohexane results in increased activity of CYP19A1 protein
Hexachlorocyclohexane results in decreased activity of CYP19A1 protein
CTD PMID:12849724, PMID:17080404 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions
ISO
EXP
Hexachlorocyclohexane results in increased activity of CYP1A1 protein
Hexachlorocyclohexane results in increased expression of CYP1A1 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A1 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]
Hexachlorocyclohexane inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD PMID:11684361, PMID:12842176, PMID:15620088, PMID:16641539, PMID:17919674, PMID:17984293, PMID:18174961, PMID:18486174, PMID:23927878, PMID:25572523 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
multiple interactions
EXP Hexachlorocyclohexane results in increased activity of CYP1A2 protein
Hexachlorocyclohexane results in increased expression of CYP1A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A2 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]
CTD PMID:12842176, PMID:16641539, PMID:17919674, PMID:17984293, PMID:18486174, PMID:23927878, PMID:25572523 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of CYP1B1 mRNA CTD PMID:17785943 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases activity EXP Hexachlorocyclohexane results in increased activity of CYP2A1 protein CTD PMID:3569844 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
increases activity
EXP Hexachlorocyclohexane results in increased expression of CYP2B1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B1 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]
Hexachlorocyclohexane results in increased activity of CYP2B1 protein
CTD PMID:11684361, PMID:12842176, PMID:17919674, PMID:17984293, PMID:18486174, PMID:23927878, PMID:25572523 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions
increases activity
EXP Hexachlorocyclohexane results in increased expression of CYP2B2 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B2 protein
Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]
Hexachlorocyclohexane results in increased activity of CYP2B2 protein
CTD PMID:11684361, PMID:12842176, PMID:17785943, PMID:17919674, PMID:17984293, PMID:18486174, PMID:23927878, PMID:25572523 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Hexachlorocyclohexane results in increased expression of CYP2B6 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B6 protein CTD PMID:15548381, PMID:20035023 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP Hexachlorocyclohexane results in increased expression of CYP2C11 mRNA; Hexachlorocyclohexane results in increased expression of CYP2C11 protein CTD PMID:11684361, PMID:16837770 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP Hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA CTD PMID:17785943 NCBI chr 1:258,709,726...258,766,873
Ensembl chr 1:258,709,721...258,766,881
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 increases expression EXP Hexachlorocyclohexane results in increased expression of CYP2D1 mRNA CTD PMID:25572523 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases expression ISO Hexachlorocyclohexane results in decreased expression of CYP2D6 mRNA CTD PMID:20035023 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
increases expression
decreases response to substance
decreases expression
EXP
ISO
Hexachlorocyclohexane results in increased activity of CYP2E1 protein
Hexachlorocyclohexane results in increased expression of CYP2E1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2E1 protein
CYP2E1 protein results in decreased susceptibility to Hexachlorocyclohexane
Hexachlorocyclohexane results in decreased expression of CYP2E1 mRNA
CTD PMID:12842176, PMID:14631868, PMID:17919674, PMID:17984293, PMID:20035023, PMID:21458603, PMID:23927878, PMID:25572523 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases activity
EXP Hexachlorocyclohexane results in increased expression of CYP3A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP3A2 protein
Hexachlorocyclohexane results in increased activity of CYP3A2 protein
CTD PMID:3569844, PMID:11684361, PMID:16837770 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
affects expression
EXP Hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA
Hexachlorocyclohexane affects the expression of CYP3A23-3A1 mRNA
CTD PMID:14613717, PMID:22001173, PMID:25572523 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Hexachlorocyclohexane results in increased expression of CYP51 mRNA CTD PMID:17785943 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Dap3 death associated protein 3 increases expression ISO Hexachlorocyclohexane results in increased expression of DAP3 mRNA CTD PMID:23777605 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Dcn decorin decreases expression EXP Hexachlorocyclohexane results in decreased expression of DCN mRNA CTD PMID:17785943 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Hexachlorocyclohexane results in increased expression of DNAJB4 mRNA CTD PMID:24356939 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 decreases expression EXP Hexachlorocyclohexane results in decreased expression of DNAJC5 mRNA CTD PMID:17785943 NCBI chr 3:177,012,714...177,047,787
Ensembl chr 3:177,013,604...177,043,902
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Hexachlorocyclohexane results in increased expression of DRD2 mRNA CTD PMID:25572523 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of DUSP1 mRNA CTD PMID:17785943 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Hexachlorocyclohexane results in increased expression of DUSP10 mRNA CTD PMID:24356939 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects expression EXP Hexachlorocyclohexane affects the expression of EEF1A1 mRNA CTD PMID:22001173 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Egr1 early growth response 1 increases expression EXP Hexachlorocyclohexane results in increased expression of EGR1 mRNA CTD PMID:17785943 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma affects expression EXP Hexachlorocyclohexane affects the expression of EIF2B3 mRNA CTD PMID:22001173 NCBI chr 5:135,882,946...135,949,276
Ensembl chr 5:135,882,967...135,949,818
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta affects expression EXP Hexachlorocyclohexane affects the expression of EIF2B4 mRNA CTD PMID:22001173 NCBI chr 6:26,546,917...26,552,474
Ensembl chr 6:26,546,924...26,552,430
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 increases expression EXP Hexachlorocyclohexane results in increased expression of EIF5 mRNA CTD PMID:17785943 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
JBrowse link
G Epha3 Eph receptor A3 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA CTD PMID:28263720 NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
JBrowse link
G Epha8 Eph receptor A8 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA CTD PMID:28263720 NCBI chr 5:155,293,731...155,321,016
Ensembl chr 5:155,295,314...155,316,495
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
affects binding
decreases expression
ISO [DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; Hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
Hexachlorocyclohexane results in increased activity of ESR1 protein
Hexachlorocyclohexane binds to ESR1 protein
Hexachlorocyclohexane results in decreased expression of ESR1 protein
Hexachlorocyclohexane binds to and results in increased activity of ESR1 protein
CTD PMID:14579009, PMID:15253041, PMID:16329587, PMID:20209442, PMID:21278053, PMID:21295777, PMID:26022396, PMID:26139245 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Hexachlorocyclohexane results in increased activity of ESR2 protein CTD PMID:15064155, PMID:26139245 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Hexachlorocyclohexane results in increased expression of ESRRA mRNA CTD PMID:23777605 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Hexachlorocyclohexane results in increased expression of EVI2A mRNA CTD PMID:24356939 NCBI chr10:66,870,048...66,873,948
Ensembl chr10:66,870,067...66,873,948
JBrowse link
G Fam107b family with sequence similarity 107, member B increases expression ISO Hexachlorocyclohexane results in increased expression of FAM107B mRNA CTD PMID:24356939 NCBI chr17:78,489,667...78,689,933
Ensembl chr17:78,489,668...78,561,613
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Hexachlorocyclohexane results in increased expression of FAS protein CTD PMID:19038305 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression EXP Hexachlorocyclohexane results in increased expression of FASLG protein CTD PMID:19038305 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase affects activity EXP Hexachlorocyclohexane affects the activity of FASN protein CTD PMID:7535533 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO Hexachlorocyclohexane results in increased expression of FBXO32 mRNA CTD PMID:24356939 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 affects expression EXP Hexachlorocyclohexane affects the expression of FKBP3 mRNA CTD PMID:17785943 NCBI chr 6:86,810,865...86,822,115
Ensembl chr 6:86,810,809...86,822,094
JBrowse link
G Fn1 fibronectin 1 affects expression EXP Hexachlorocyclohexane affects the expression of FN1 mRNA CTD PMID:17785943 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
Hexachlorocyclohexane results in increased expression of FOS mRNA
alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]
Hexachlorocyclohexane results in increased expression of FOS mRNA; Hexachlorocyclohexane results in increased expression of FOS protein
W 7 inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]
CTD PMID:1380685, PMID:1710164, PMID:7531829, PMID:7534335, PMID:10072926 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxa1 forkhead box A1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of FOXA1 mRNA CTD PMID:17785943 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Frat1 FRAT regulator of WNT signaling pathway 1 increases expression ISO Hexachlorocyclohexane results in increased expression of FRAT1 mRNA CTD PMID:24356939 NCBI chr 1:261,071,965...261,075,244 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein] CTD PMID:15749814 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase affects activity
increases activity
EXP Hexachlorocyclohexane affects the activity of G6PD protein
Hexachlorocyclohexane results in increased activity of G6PD protein
CTD PMID:2461408, PMID:7535533, PMID:8519523 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of GABARAPL2 mRNA CTD PMID:17785943 NCBI chr19:44,164,935...44,175,771
Ensembl chr19:44,164,935...44,175,770
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
increases expression
ISO
EXP
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Hexachlorocyclohexane results in increased expression of GABRA1 mRNA
CTD PMID:9316872, PMID:11156579, PMID:14637376, PMID:25572523 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 affects binding
multiple interactions
ISO Hexachlorocyclohexane binds to GABRB1 protein
Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]
CTD PMID:11156579, PMID:11489356 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions
ISO Hexachlorocyclohexane binds to GABRB3 protein
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:9316872, PMID:11312652, PMID:11489356, PMID:16537435 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872, PMID:11156579, PMID:14637376 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gabrr1 gamma-aminobutyric acid type A receptor subunit rho 1 affects binding ISO Hexachlorocyclohexane binds to GABRR1 protein CTD PMID:11879973 NCBI chr 5:48,374,048...48,411,170
Ensembl chr 5:48,374,096...48,411,170
JBrowse link
G Gata3 GATA binding protein 3 increases expression ISO Hexachlorocyclohexane results in increased expression of GATA3 mRNA CTD PMID:24356939 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gck glucokinase increases expression EXP Hexachlorocyclohexane results in increased expression of GCK mRNA CTD PMID:17785943 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Hexachlorocyclohexane results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Hexachlorocyclohexane results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA CTD PMID:28263720 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
affects activity
decreases activity
increases activity
ISO
EXP
Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in increased activity of GGT1 protein]
Hexachlorocyclohexane affects the activity of GGT1 protein
Hexachlorocyclohexane results in decreased activity of GGT1 protein
CTD PMID:8519523, PMID:9475050, PMID:11349524 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gja1 gap junction protein, alpha 1 affects localization
decreases phosphorylation
decreases expression
increases degradation
increases phosphorylation
multiple interactions
ISO
EXP
Hexachlorocyclohexane affects the localization of GJA1 protein
Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein
Hexachlorocyclohexane results in decreased expression of GJA1 mRNA; Hexachlorocyclohexane results in decreased expression of GJA1 protein
Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form
Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]; Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane affects the localization of GJA1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]
CTD PMID:7530866, PMID:8824497, PMID:11532877, PMID:12807735, PMID:15194225, PMID:15749814, PMID:18040759 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glra1 glycine receptor, alpha 1 decreases activity ISO Hexachlorocyclohexane results in decreased activity of GLRA1 protein CTD PMID:22035056 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Glra2 glycine receptor, alpha 2 decreases activity ISO Hexachlorocyclohexane results in decreased activity of GLRA2 protein CTD PMID:22035056 NCBI chr  X:30,612,894...30,832,078
Ensembl chr  X:30,612,903...30,831,483
JBrowse link
G Glra3 glycine receptor, alpha 3 decreases activity ISO Hexachlorocyclohexane results in decreased activity of GLRA3 protein CTD PMID:22035056 NCBI chr16:37,676,959...37,908,221
Ensembl chr16:37,676,962...38,063,821
JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP Hexachlorocyclohexane results in decreased expression of GLUL mRNA CTD PMID:17785943 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Glyat glycine-N-acyltransferase affects expression EXP Hexachlorocyclohexane affects the expression of GLYAT mRNA CTD PMID:17785943 NCBI chr 1:229,060,125...229,081,113
Ensembl chr 1:229,063,714...229,080,410
JBrowse link
G Gna12 G protein subunit alpha 12 affects expression EXP Hexachlorocyclohexane affects the expression of GNA12 mRNA CTD PMID:17785943 NCBI chr12:15,890,202...15,971,212
Ensembl chr12:15,890,170...15,971,212
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with DDT] results in increased expression of GNRH1 CTD PMID:16329587 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression EXP Hexachlorocyclohexane results in increased expression of GOT1 mRNA CTD PMID:17785943 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Hexachlorocyclohexane results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Gpr18 G protein-coupled receptor 18 increases expression ISO Hexachlorocyclohexane results in increased expression of GPR18 mRNA CTD PMID:23824090, PMID:24356939 NCBI chr15:108,323,157...108,326,907
Ensembl chr15:108,323,179...108,326,907
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP [Hexachlorocyclohexane co-treated with isoproturon] results in increased activity of GPT protein
Hexachlorocyclohexane results in increased activity of GPT protein
CTD PMID:11180283 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO Hexachlorocyclohexane results in increased expression of GPT2 mRNA CTD PMID:24356939 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
decreases activity
increases activity
ISO
EXP
[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Permethrin] results in decreased activity of GSR protein; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]
Hexachlorocyclohexane results in increased expression of GSR mRNA
Hexachlorocyclohexane results in increased activity of GSR protein
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of GSR protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in increased activity of GSR protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]
CTD PMID:1716606, PMID:9704597, PMID:10817630, PMID:11349524, PMID:11404799, PMID:11561191, PMID:16046044, PMID:16718366, PMID:21976817, PMID:22224058, PMID:26198647 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects expression EXP Hexachlorocyclohexane affects the expression of GSTA2 mRNA CTD PMID:22001173 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Hexachlorocyclohexane results in increased expression of GSTA5 mRNA CTD PMID:17785943 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gusb glucuronidase, beta affects activity EXP Hexachlorocyclohexane affects the activity of GUSB protein CTD PMID:8519523 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hbe2 hemoglobin, epsilon 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of HBG2 protein CTD PMID:7512143 NCBI chr 1:169,000,133...169,001,761
Ensembl chr 1:169,000,133...169,001,761
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Hexachlorocyclohexane results in decreased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha affects expression EXP Hexachlorocyclohexane affects the expression of HNF4A mRNA CTD PMID:17785943 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase increases expression EXP Hexachlorocyclohexane results in increased expression of HPD mRNA CTD PMID:17785943 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of HPRT1 mRNA CTD PMID:17785943 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases activity EXP Hexachlorocyclohexane results in decreased activity of HSD17B1 protein CTD PMID:11404799 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity EXP Hexachlorocyclohexane results in decreased activity of HSD3B1 protein CTD PMID:11404799
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases expression
multiple interactions
ISO Hexachlorocyclohexane results in decreased expression of HSD3B2 mRNA
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]
CTD PMID:17080404 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects localization ISO Hexachlorocyclohexane affects the localization of HSPA1A protein CTD PMID:12919956 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression EXP Hexachlorocyclohexane results in increased expression of HSPA4 protein CTD PMID:30248393 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases expression EXP Hexachlorocyclohexane results in increased expression of HTR2A mRNA CTD PMID:25572523 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Hyls1 HYLS1, centriolar and ciliogenesis associated decreases expression ISO Hexachlorocyclohexane results in decreased expression of HYLS1 mRNA CTD PMID:24356939 NCBI chr 8:36,763,470...36,772,199
Ensembl chr 8:36,763,481...36,764,422
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO Hexachlorocyclohexane results in decreased expression of ID1 mRNA CTD PMID:24356939 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 affects expression EXP Hexachlorocyclohexane affects the expression of IDH1 mRNA CTD PMID:17785943 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Hexachlorocyclohexane results in increased expression of IER3 mRNA CTD PMID:24356939 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifng interferon gamma decreases expression ISO Hexachlorocyclohexane results in decreased expression of IFNG protein CTD PMID:15319175 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of IGF1 mRNA CTD PMID:17785943 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
EXP alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]
Hexachlorocyclohexane results in increased expression of IL1A mRNA; Hexachlorocyclohexane results in increased expression of IL1A protein
CTD PMID:15025948 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il5 interleukin 5 decreases expression ISO Hexachlorocyclohexane results in decreased expression of IL5 protein CTD PMID:15319175 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation EXP Hexachlorocyclohexane results in decreased phosphorylation of IRS1 protein CTD PMID:30248393 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Isl2 ISL LIM homeobox 2 increases expression ISO Hexachlorocyclohexane results in increased expression of ISL2 mRNA CTD PMID:24356939 NCBI chr 8:60,117,565...60,122,716
Ensembl chr 8:60,117,729...60,122,211
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
ISO
EXP
Hexachlorocyclohexane results in increased phosphorylation of JUN protein
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of JUN protein
CTD PMID:15888667, PMID:23927878 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif21b kinesin family member 21B increases expression ISO Hexachlorocyclohexane results in increased expression of KIF21B mRNA CTD PMID:24356939 NCBI chr13:52,976,505...53,026,750
Ensembl chr13:52,976,507...53,023,103
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA CTD PMID:28263720 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression EXP Hexachlorocyclohexane results in increased expression of KLF9 mRNA CTD PMID:17785943 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Hexachlorocyclohexane results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Hexachlorocyclohexane results in decreased expression of LDHA protein CTD PMID:6164129 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B decreases expression ISO Hexachlorocyclohexane results in decreased expression of LDHB protein CTD PMID:6164129 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Lep leptin affects expression EXP Hexachlorocyclohexane affects the expression of LEP mRNA CTD PMID:17785943 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP Hexachlorocyclohexane results in decreased expression of LHCGR protein CTD PMID:11250058 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Hexachlorocyclohexane results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Lrrc2 leucine rich repeat containing 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA CTD PMID:28263720 NCBI chr 8:119,226,651...119,259,649
Ensembl chr 8:119,228,612...119,259,645
JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 increases expression EXP Hexachlorocyclohexane results in increased expression of XLKD1 mRNA CTD PMID:17785943 NCBI chr 1:175,663,266...175,676,699
Ensembl chr 1:175,663,266...175,676,699
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression EXP Hexachlorocyclohexane results in increased expression of MAP1LC3B mRNA CTD PMID:17785943 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K2 protein CTD PMID:15888667 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 decreases expression EXP Hexachlorocyclohexane results in decreased expression of MAP4K4 mRNA CTD PMID:17785943 NCBI chr 9:46,657,444...46,782,545
Ensembl chr 9:46,657,575...46,782,545
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD PMID:12807735, PMID:15888667, PMID:16818664, PMID:18040759, PMID:21278053 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD PMID:12807735, PMID:15888667, PMID:16818664, PMID:18040759, PMID:21278053, PMID:23927878 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:23927878 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK9 protein CTD PMID:23927878 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mbp myelin basic protein decreases expression
affects expression
EXP Hexachlorocyclohexane results in decreased expression of MBP protein
Hexachlorocyclohexane affects the expression of MBP mRNA
CTD PMID:1701514, PMID:22954530 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 increases expression EXP Hexachlorocyclohexane results in increased expression of MBTPS2 mRNA CTD PMID:17785943 NCBI chr  X:40,258,933...40,309,047
Ensembl chr  X:40,258,493...40,310,563
JBrowse link
G Meox2 mesenchyme homeobox 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of MEOX2 mRNA CTD PMID:17785943 NCBI chr 6:56,625,768...56,689,195
Ensembl chr 6:56,625,650...56,689,238
JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA CTD PMID:28263720 NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP [Hexachlorocyclohexane co-treated with Iron] results in increased activity of MPO protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased activity of MPO protein
Hexachlorocyclohexane results in increased activity of MPO protein
CTD PMID:7503757, PMID:11141352 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of MSH2 mRNA CTD PMID:17785943 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Hexachlorocyclohexane results in increased expression of MT1A mRNA CTD PMID:17785943 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtch2 mitochondrial carrier 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of MTCH2 mRNA CTD PMID:17785943 NCBI chr 3:79,678,141...79,695,356
Ensembl chr 3:79,678,201...79,694,006
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO Hexachlorocyclohexane results in increased expression of MTHFD2 mRNA CTD PMID:24356939 NCBI chr 4:115,004,433...115,015,965
Ensembl chr 4:115,004,448...115,015,965
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Hexachlorocyclohexane results in decreased expression of MYC mRNA CTD PMID:17785943 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh3 myosin heavy chain 3 affects expression EXP Hexachlorocyclohexane affects the expression of MYH3 mRNA CTD PMID:17785943 NCBI chr10:53,621,375...53,645,194
Ensembl chr10:53,621,375...53,645,194
JBrowse link
G Nanos1 nanos C2HC-type zinc finger 1 decreases expression ISO Hexachlorocyclohexane results in decreased expression of NANOS1 mRNA CTD PMID:24356939 NCBI chr 1:282,134,676...282,140,370
Ensembl chr 1:282,134,981...282,135,772
JBrowse link
G Ncoa7 nuclear receptor coactivator 7 increases expression ISO Hexachlorocyclohexane results in increased expression of NCOA7 mRNA CTD PMID:24356939 NCBI chr 1:29,225,727...29,386,642
Ensembl chr 1:29,225,707...29,385,199
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of NFE2L2 mRNA CTD PMID:17785943 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfe2l3 nuclear factor, erythroid 2-like 3 decreases expression ISO Hexachlorocyclohexane results in decreased expression of NFE2L3 mRNA CTD PMID:24356939 NCBI chr 4:81,205,214...81,233,068
Ensembl chr 4:81,205,404...81,232,813
JBrowse link
G Nfia nuclear factor I/A decreases expression EXP Hexachlorocyclohexane results in decreased expression of NFIA mRNA CTD PMID:17785943 NCBI chr 5:116,421,895...116,750,381
Ensembl chr 5:116,420,690...116,751,416
JBrowse link
G Nfib nuclear factor I/B decreases expression EXP Hexachlorocyclohexane results in decreased expression of NFIB mRNA CTD PMID:17785943 NCBI chr 5:100,436,343...100,647,962
Ensembl chr 5:100,439,082...100,647,727
JBrowse link
G Nfix nuclear factor I X increases expression EXP Hexachlorocyclohexane results in increased expression of NFIX mRNA CTD PMID:17785943 NCBI chr19:25,818,640...25,914,777
Ensembl chr19:25,821,780...25,914,696
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases phosphorylation
increases activity
EXP alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of NFKB1 protein]
Hexachlorocyclohexane results in increased phosphorylation of NFKB1 protein
CTD PMID:15019085, PMID:15025948 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation EXP Hexachlorocyclohexane results in increased phosphorylation of NFKBIA protein CTD PMID:30248393 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nipbl NIPBL, cohesin loading factor increases expression EXP Hexachlorocyclohexane results in increased expression of NIPBL mRNA CTD PMID:17785943 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
G Nop58 NOP58 ribonucleoprotein increases expression EXP Hexachlorocyclohexane results in increased expression of NOL5 mRNA CTD PMID:17785943 NCBI chr 9:66,495,881...66,520,521
Ensembl chr 9:66,495,832...66,519,788
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Hexachlorocyclohexane results in increased expression of NOS2 protein CTD PMID:23777605 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP [Hexachlorocyclohexane co-treated with Dieldrin] results in decreased expression of NOX1 protein CTD PMID:30240590 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP Hexachlorocyclohexane results in increased expression of NR0B2 mRNA CTD PMID:17785943 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
increases activity
EXP
ISO
Hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
Hexachlorocyclohexane results in increased expression of NR1I2 mRNA
Hexachlorocyclohexane results in increased activity of NR1I2 protein
CTD PMID:14613717, PMID:15548381, PMID:16054614, PMID:25572523, PMID:25680588 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
EXP
ISO
Hexachlorocyclohexane results in increased expression of NR1I3 mRNA
Hexachlorocyclohexane results in increased activity of NR1I3 protein
CTD PMID:25572523, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 affects expression EXP Hexachlorocyclohexane affects the expression of NR2F6 mRNA CTD PMID:17785943 NCBI chr16:19,769,968...19,777,414
Ensembl chr16:19,769,968...19,777,414
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Hexachlorocyclohexane results in increased expression of NR3C1 mRNA CTD PMID:17785943 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression EXP Hexachlorocyclohexane results in increased expression of NR4A2 mRNA CTD PMID:8737662 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Hexachlorocyclohexane results in increased expression of NRF1 mRNA CTD PMID:23777605 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA CTD PMID:28263720 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity
increases expression
EXP Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased activity of ODC1 protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of ODC1 mRNA] CTD PMID:1710164 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases expression EXP Hexachlorocyclohexane results in increased expression of OGT mRNA CTD PMID:17785943 NCBI chr  X:71,540,870...71,585,906
Ensembl chr  X:71,528,988...71,585,908
JBrowse link
G Onecut1 one cut homeobox 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of ONECUT1 mRNA CTD PMID:17785943 NCBI chr 8:81,765,779...81,799,894
Ensembl chr 8:81,766,041...81,793,577
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of P4HA1 mRNA CTD PMID:17785943 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Hexachlorocyclohexane results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA CTD PMID:28263720 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of PDLIM1 mRNA CTD PMID:17785943 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 increases expression ISO Hexachlorocyclohexane results in increased expression of PELI1 mRNA CTD PMID:24356939 NCBI chr14:106,008,086...106,062,566
Ensembl chr14:106,008,086...106,061,641
JBrowse link
G Per2 period circadian regulator 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of PER2 mRNA CTD PMID:17785943 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pgd phosphogluconate dehydrogenase affects activity EXP Hexachlorocyclohexane affects the activity of PGD protein CTD PMID:7535533 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pgr progesterone receptor affects binding
multiple interactions
ISO Hexachlorocyclohexane binds to PGR protein
[Progesterone co-treated with Hexachlorocyclohexane] results in decreased expression of PGR mRNA; Hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Hexachlorocyclohexane inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:9144411, PMID:14579009, PMID:26022396 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pigr polymeric immunoglobulin receptor increases expression EXP Hexachlorocyclohexane results in increased expression of PIGR mRNA CTD PMID:17785943 NCBI chr13:47,564,176...47,592,093
Ensembl chr13:47,572,219...47,591,699
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 increases expression EXP Hexachlorocyclohexane results in increased expression of PJA2 mRNA CTD PMID:17785943 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240
JBrowse link
G Plaat5 phospholipase A and acyltransferase 5 decreases expression EXP Hexachlorocyclohexane results in decreased expression of PLAAT5 mRNA CTD PMID:17785943 NCBI chr 1:222,907,159...222,937,643
Ensembl chr 1:222,907,159...222,937,633
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Hexachlorocyclohexane results in increased expression of PLCL1 mRNA CTD PMID:24356939 NCBI chr 9:62,016,112...62,349,244
Ensembl chr 9:62,291,405...62,349,309
JBrowse link
G Plpp3 phospholipid phosphatase 3 increases expression EXP Hexachlorocyclohexane results in increased expression of PLPP3 mRNA CTD PMID:17785943 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Plxnd1 plexin D1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA CTD PMID:28263720 NCBI chr 4:147,854,309...147,894,170
Ensembl chr 4:147,854,309...147,893,992
JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 increases expression ISO Hexachlorocyclohexane results in increased expression of PNRC1 mRNA CTD PMID:24356939 NCBI chr 5:48,501,472...48,504,511
Ensembl chr 5:48,501,472...48,504,511
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit increases expression EXP Hexachlorocyclohexane results in increased expression of POLG2 mRNA CTD PMID:17785943 NCBI chr10:94,968,836...94,979,259
Ensembl chr10:94,968,836...94,979,259
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC CTD PMID:16329587 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP Hexachlorocyclohexane results in increased expression of POR mRNA CTD PMID:17785943 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Hexachlorocyclohexane results in increased expression of PPARGC1A mRNA CTD PMID:23777605 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression EXP Hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA CTD PMID:17785943 NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809
JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Hexachlorocyclohexane results in increased expression of PPRC1 mRNA CTD PMID:23777605 NCBI chr 1:265,809,892...265,826,319
Ensembl chr 1:265,809,754...265,826,306
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta affects expression EXP Hexachlorocyclohexane affects the expression of PRKACB mRNA CTD PMID:17785943 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Prkch protein kinase C, eta affects expression EXP Hexachlorocyclohexane affects the expression of PRKCH mRNA CTD PMID:22001173 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prxl2b peroxiredoxin like 2B decreases expression ISO Hexachlorocyclohexane results in decreased expression of PRXL2B mRNA CTD PMID:24356939 NCBI chr 5:172,304,799...172,307,402
Ensembl chr 5:172,304,758...172,307,431
JBrowse link
G Psmb3 proteasome 20S subunit beta 3 decreases expression EXP Hexachlorocyclohexane results in decreased expression of PSMB3 mRNA CTD PMID:17785943 NCBI chr10:85,646,646...85,653,729
Ensembl chr10:85,646,633...85,653,729
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP Hexachlorocyclohexane results in increased expression of and results in increased activity of PTGS2 protein
Hexachlorocyclohexane results in increased expression of PTGS2 mRNA; Hexachlorocyclohexane results in increased expression of PTGS2 protein
CTD PMID:10426785 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression EXP Hexachlorocyclohexane results in increased expression of PTP4A1 mRNA CTD PMID:17785943 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression EXP Hexachlorocyclohexane results in increased expression of RAB14 mRNA CTD PMID:17785943 NCBI chr 3:14,373,270...14,395,357
Ensembl chr 3:14,373,275...14,395,362
JBrowse link
G Rab34 RAB34, member RAS oncogene family affects expression EXP Hexachlorocyclohexane affects the expression of RAB34 mRNA CTD PMID:17785943 NCBI chr10:65,448,111...65,452,178
Ensembl chr10:65,448,950...65,452,177
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression EXP Hexachlorocyclohexane results in decreased expression of RAD23A mRNA CTD PMID:17785943 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of RAF1 protein CTD PMID:15888667 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rala RAS like proto-oncogene A increases expression EXP Hexachlorocyclohexane results in increased expression of RALA mRNA CTD PMID:17785943 NCBI chr17:49,676,073...49,729,133
Ensembl chr17:49,714,294...49,727,664
JBrowse link
G Ralgapa1 Ral GTPase activating protein catalytic subunit alpha 1 increases expression EXP Hexachlorocyclohexane results in increased expression of RALGAPA1 mRNA CTD PMID:17785943 NCBI chr 6:76,386,971...76,661,530
Ensembl chr 6:76,396,784...76,608,864
JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Hexachlorocyclohexane results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of RB1 mRNA CTD PMID:17785943 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbm10 RNA binding motif protein 10 decreases expression EXP Hexachlorocyclohexane results in decreased expression of RBM10 mRNA CTD PMID:17785943 NCBI chr  X:1,754,869...1,786,973
Ensembl chr  X:1,754,861...1,786,978
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
increases phosphorylation
affects localization
EXP alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of RELA protein]
Hexachlorocyclohexane results in increased phosphorylation of RELA protein
Hexachlorocyclohexane affects the localization of RELA protein
CTD PMID:15019085, PMID:15025948, PMID:19038305 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ret ret proto-oncogene multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA CTD PMID:28263720 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G RGD1305464 similar to human chromosome 15 open reading frame 39 decreases expression ISO Hexachlorocyclohexane results in decreased expression of C15ORF39 mRNA CTD PMID:24356939 NCBI chr 8:61,913,588...61,923,149
Ensembl chr 8:61,913,589...61,919,874
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Hexachlorocyclohexane results in decreased expression of RGS2 mRNA CTD PMID:24356939 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rnpep arginyl aminopeptidase decreases expression EXP Hexachlorocyclohexane results in decreased expression of RNPEP mRNA CTD PMID:17785943 NCBI chr13:52,092,863...52,124,006
Ensembl chr13:52,092,859...52,111,363
JBrowse link
G Rps15 ribosomal protein S15 decreases expression EXP Hexachlorocyclohexane results in decreased expression of RPS15 mRNA CTD PMID:17785943 NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of RSAD2 mRNA CTD PMID:17785943 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Rxra retinoid X receptor alpha affects expression EXP Hexachlorocyclohexane affects the expression of RXRA mRNA CTD PMID:17785943 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO Hexachlorocyclohexane results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma decreases expression EXP Hexachlorocyclohexane results in decreased expression of RXRG mRNA CTD PMID:17785943 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Hexachlorocyclohexane results in decreased expression of SCD1 mRNA CTD PMID:17785943 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Hexachlorocyclohexane results in increased expression of SDC4 mRNA CTD PMID:17785943 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sec22a SEC22 homolog A, vesicle trafficking protein decreases expression EXP Hexachlorocyclohexane results in decreased expression of SEC22A mRNA CTD PMID:17785943 NCBI chr11:68,633,080...68,686,553
Ensembl chr11:68,633,160...68,686,548
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component increases expression EXP Hexachlorocyclohexane results in increased expression of SEC31A mRNA CTD PMID:17785943 NCBI chr14:10,854,713...10,909,579
Ensembl chr14:10,854,682...10,909,612
JBrowse link
G Sema3g semaphorin 3G decreases expression ISO Hexachlorocyclohexane results in decreased expression of SEMA3G mRNA CTD PMID:24356939 NCBI chr16:7,303,582...7,315,214
Ensembl chr16:7,303,578...7,315,390
JBrowse link
G Serinc3 serine incorporator 3 affects expression EXP Hexachlorocyclohexane affects the expression of SERINC3 mRNA CTD PMID:17785943 NCBI chr 3:160,018,643...160,038,078
Ensembl chr 3:160,018,646...160,038,078
JBrowse link
G Serpine2 serpin family E member 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of SERPINE2 mRNA CTD PMID:17785943 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Hexachlorocyclohexane results in increased expression of SESN2 mRNA CTD PMID:24356939 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression
increases expression
EXP
ISO
Hexachlorocyclohexane results in decreased expression of SGK1 mRNA
Hexachlorocyclohexane results in increased expression of SGK1 mRNA
CTD PMID:17785943, PMID:24356939 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Shbg sex hormone binding globulin multiple interactions
decreases expression
ISO
EXP
Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
Hexachlorocyclohexane results in decreased expression of SHBG protein
CTD PMID:9171990, PMID:18248869 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Si sucrase-isomaltase decreases activity EXP Hexachlorocyclohexane results in decreased activity of SI protein CTD PMID:92405 NCBI chr 2:170,220,794...170,301,348
Ensembl chr 2:170,221,245...170,301,348
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Hexachlorocyclohexane results in decreased expression of SLC10A1 mRNA CTD PMID:24464585 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression EXP Hexachlorocyclohexane results in increased expression of SLC11A2 mRNA CTD PMID:17785943 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Hexachlorocyclohexane results in decreased activity of SLC22A1 protein CTD PMID:24464585 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a25 solute carrier family 22, member 25 affects expression EXP Hexachlorocyclohexane affects the expression of SLC22A9 mRNA CTD PMID:17785943 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP Hexachlorocyclohexane results in decreased expression of SLC25A30 mRNA CTD PMID:17785943 NCBI chr15:57,811,612...57,834,173
Ensembl chr15:57,813,356...57,834,173
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Hexachlorocyclohexane results in increased expression of SLC3A2 mRNA CTD PMID:24356939 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression EXP Hexachlorocyclohexane results in increased expression of SLC4A4 mRNA CTD PMID:17785943 NCBI chr14:20,476,258...20,817,042
Ensembl chr14:20,479,323...20,920,286
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Hexachlorocyclohexane results in increased expression of SLC7A11 mRNA CTD PMID:24356939, PMID:26198647 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc7a2 solute carrier family 7 member 2 increases expression EXP Hexachlorocyclohexane results in increased expression of SLC7A2 mRNA CTD PMID:17785943 NCBI chr16:54,459,409...54,513,349
Ensembl chr16:54,460,067...54,513,349
JBrowse link
G Snai2 snail family transcriptional repressor 2 affects expression EXP Hexachlorocyclohexane affects the expression of SNAI2 mRNA CTD PMID:17785943 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Snrnp70 small nuclear ribonucleoprotein U1 subunit 70 increases expression EXP Hexachlorocyclohexane results in increased expression of SNRNP70 mRNA CTD PMID:17785943 NCBI chr 1:101,367,470...101,388,153
Ensembl chr 1:101,367,471...101,388,129
JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of SOCS2 mRNA CTD PMID:17785943 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Sord sorbitol dehydrogenase affects activity EXP Hexachlorocyclohexane affects the activity of SORD protein CTD PMID:8519523 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of SPRY1 mRNA CTD PMID:17785943 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331
JBrowse link
G Sqle squalene epoxidase increases expression EXP Hexachlorocyclohexane results in increased expression of SQLE mRNA CTD PMID:17785943 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Hexachlorocyclohexane results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of SREBF1 mRNA CTD PMID:17785943 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 increases expression EXP Hexachlorocyclohexane results in increased expression of SRSF2 mRNA CTD PMID:17785943 NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Hexachlorocyclohexane results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stam2 signal transducing adaptor molecule 2 increases expression ISO Hexachlorocyclohexane results in increased expression of STAM2 mRNA CTD PMID:24356939 NCBI chr 3:38,230,676...38,277,433
Ensembl chr 3:38,230,618...38,277,440
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
increases expression
ISO
EXP
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of STAR mRNA]
Hexachlorocyclohexane results in decreased expression of STAR protein
Hexachlorocyclohexane results in increased expression of STAR protein
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]
Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein]
Hexachlorocyclohexane results in increased expression of STAR mRNA
CTD PMID:10993823, PMID:15749814, PMID:17080404, PMID:18248869 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Hexachlorocyclohexane results in decreased expression of SULT1A1 mRNA CTD PMID:9566755 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
decreases expression
ISO
EXP
Hexachlorocyclohexane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA]
Hexachlorocyclohexane results in decreased expression of SULT2A1 mRNA
CTD PMID:9566755, PMID:17080404 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Hexachlorocyclohexane results in increased expression of TFAM mRNA CTD PMID:23777605 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tfb2m transcription factor B2, mitochondrial increases expression ISO Hexachlorocyclohexane results in increased expression of TFB2M mRNA CTD PMID:23777605 NCBI chr13:97,820,493...97,838,275
Ensembl chr13:97,820,493...97,838,228
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein] CTD PMID:15749814 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tjp1 tight junction protein 1 affects localization
multiple interactions
decreases expression
ISO
EXP
Hexachlorocyclohexane affects the localization of TJP1 protein
Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein]
Hexachlorocyclohexane results in decreased expression of TJP1 protein
CTD PMID:11532877, PMID:15194225 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tm6sf1 transmembrane 6 superfamily member 1 increases expression ISO Hexachlorocyclohexane results in increased expression of TM6SF1 mRNA CTD PMID:24356939 NCBI chr 1:143,657,607...143,703,829
Ensembl chr 1:143,661,521...143,703,759
JBrowse link
G Tmco6 transmembrane and coiled-coil domains 6 decreases expression ISO Hexachlorocyclohexane results in decreased expression of TMCO6 mRNA CTD PMID:24356939 NCBI chr18:29,579,145...29,585,740
Ensembl chr18:29,579,145...29,585,740
JBrowse link
G Tmem177 transmembrane protein 177 decreases expression ISO Hexachlorocyclohexane results in decreased expression of TMEM177 mRNA CTD PMID:24356939 NCBI chr13:35,929,783...35,933,271
Ensembl chr13:35,929,819...35,933,243
JBrowse link
G Tmem267 transmembrane protein 267 increases expression ISO Hexachlorocyclohexane results in increased expression of TMEM267 mRNA CTD PMID:24356939 NCBI chr 2:52,356,449...52,366,075
Ensembl chr 2:52,358,097...52,366,667
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
EXP
ISO
[Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]
Lindane increases expression of Tnf protein in serum
Hexachlorocyclohexane results in increased expression of TNF mRNA; Hexachlorocyclohexane results in increased expression of TNF protein
Hexachlorocyclohexane results in decreased expression of TNF protein
CTD PMID:15019085, PMID:15025948, PMID:15135310, PMID:15319175, PMID:15019085 RGD:14995431 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnxa-ps1 tenascin XA, pseudogene 1 affects expression EXP Hexachlorocyclohexane affects the expression of TNXA mRNA CTD PMID:17785943 NCBI chr20:4,485,316...4,486,671 JBrowse link
G Tor1aip1 torsin 1A interacting protein 1 increases expression EXP Hexachlorocyclohexane results in increased expression of TOR1AIP1 mRNA CTD PMID:17785943 NCBI chr13:73,670,649...73,704,668
Ensembl chr13:73,670,141...73,704,678
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of TP53 protein CTD PMID:18174961 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpm3 tropomyosin 3 affects expression EXP Hexachlorocyclohexane affects the expression of TPM3 mRNA CTD PMID:17785943 NCBI chr 2:189,423,534...189,451,340
Ensembl chr 2:189,423,559...189,451,029
JBrowse link
G Tra2b transformer 2 beta homolog affects expression EXP Hexachlorocyclohexane affects the expression of TRA2B mRNA CTD PMID:17785943 NCBI chr11:82,373,828...82,392,208
Ensembl chr11:82,373,870...82,392,083
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Hexachlorocyclohexane results in increased expression of TRIB3 mRNA CTD PMID:24356939 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression EXP Hexachlorocyclohexane results in decreased expression of TUBA4A mRNA CTD PMID:17785943 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
JBrowse link
G Txn2 thioredoxin 2 decreases expression EXP Hexachlorocyclohexane results in decreased expression of TXN2 mRNA CTD PMID:17785943 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase affects expression EXP Hexachlorocyclohexane affects the expression of TYRO3 mRNA CTD PMID:17785943 NCBI chr 3:111,597,102...111,616,142
Ensembl chr 3:111,597,102...111,616,142
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity EXP Hexachlorocyclohexane results in increased activity of UGT1A1 protein CTD PMID:16641539 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP Hexachlorocyclohexane results in increased expression of UGT1A6 mRNA CTD PMID:17785943 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Hexachlorocyclohexane results in increased expression of VEGFA mRNA CTD PMID:24356939 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vip vasoactive intestinal peptide decreases response to substance
multiple interactions
EXP Hexachlorocyclohexane results in decreased susceptibility to VIP protein
Hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP]
CTD PMID:2467674, PMID:4120787, PMID:20732086 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO Hexachlorocyclohexane results in increased expression of VLDLR mRNA CTD PMID:24356939 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Wasl WASP like actin nucleation promoting factor increases expression EXP Hexachlorocyclohexane results in increased expression of WASL mRNA CTD PMID:17785943 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
G Zfp354a zinc finger protein 354A increases expression EXP Hexachlorocyclohexane results in increased expression of ZFP354A mRNA CTD PMID:17785943 NCBI chr10:36,586,495...36,600,172
Ensembl chr10:36,589,181...36,600,469
JBrowse link
G Zfp628 zinc finger protein 628 decreases expression ISO Hexachlorocyclohexane results in decreased expression of ZNF628 mRNA CTD PMID:24356939 NCBI chr 1:72,465,403...72,474,442
Ensembl chr 1:72,465,341...72,468,738
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        agrochemical 14435
          gamma-hexachlorocyclohexane 333
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    monocyclic hydrocarbon 5766
                                      cycloalkane 504
                                        cyclohexane 504
                                          chlorocyclohexane 504
                                            hexachlorocyclohexane 504
                                              gamma-hexachlorocyclohexane 333
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.