CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tertiary amine
Accession: CHEBI:32876
browse the term
Definition: A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.
Synonyms: exact_synonym: tertiary amines
related_synonym: Formula=NR3; R3N; SMILES=[*]N([*])[*]; tertiaeres Amin
alt_id: CHEBI:26879; CHEBI:9458
xref: KEGG:C02196
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Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
multiple interactions
ISO
[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658 PMID:18448488
NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
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Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
affects response to substance multiple interactions
ISO
CHRNA7 protein mutant form affects the susceptibility to Lobeline Lobeline binds to and results in decreased activity of CHRNA7 protein; Lobeline binds to and results in increased activity of CHRNA7 protein mutant form
CTD
PMID:10082212
NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14645658 PMID:18448488
NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
Lobeline results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]
CTD
PMID:18448488 PMID:20106947
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk3
mitogen-activated protein kinase 3
multiple interactions
ISO
[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]
CTD
PMID:18448488 PMID:20106947
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
CTD
PMID:18448488 PMID:20106947
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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Acta2
actin alpha 2, smooth muscle, aorta
multiple interactions
EXP
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]
CTD
PMID:34609854
NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
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Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
multiple interactions
ISO
Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Oxidopamine affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Rotenone affects the localization of AIFM1 protein]
CTD
PMID:12880480
NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440
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Akt1
thymoma viral proto-oncogene 1
multiple interactions increases phosphorylation
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein Selegiline results in increased phosphorylation of AKT1 protein
CTD
PMID:22019741
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Bach1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
multiple interactions
ISO
Selegiline inhibits the reaction [Smoke analog affects the localization of BACH1 protein]
CTD
PMID:28108387
NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
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Bax
BCL2-associated X protein
multiple interactions
EXP
Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein]
CTD
PMID:12880480
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bcl2
B cell leukemia/lymphoma 2
multiple interactions
EXP
Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein]
CTD
PMID:12880480
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Casp3
caspase 3
multiple interactions
ISO EXP
Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein] Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]
CTD
PMID:12880480 PMID:14724376 PMID:23696560
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Cat
catalase
multiple interactions
ISO
Selegiline promotes the reaction [Rotenone results in increased activity of CAT protein] Selegiline inhibits the reaction [Smoke analog results in decreased activity of CAT protein]
CTD
PMID:16490285 PMID:28108387
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Col1a1
collagen, type I, alpha 1
multiple interactions
EXP
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]
CTD
PMID:34609854
NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
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Col3a1
collagen, type III, alpha 1
multiple interactions
EXP
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]
CTD
PMID:34609854
NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
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Cxcl15
C-X-C motif chemokine ligand 15
multiple interactions
ISO
Selegiline inhibits the reaction [Smoke analog results in increased secretion of CXCL8 protein]
CTD
PMID:28108387
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Cycs
cytochrome c, somatic
multiple interactions
EXP
Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein]
CTD
PMID:12880480
NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects metabolic processing
ISO
CYP1A2 protein affects the metabolism of Selegiline
CTD
PMID:16198659
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
multiple interactions decreases activity
ISO
Selegiline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion] Selegiline results in decreased activity of CYP2B6 protein
CTD
PMID:25656918
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Fos
FBJ osteosarcoma oncogene
multiple interactions
ISO
Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of FOS mRNA]
CTD
PMID:14724376
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Gapdh
glyceraldehyde-3-phosphate dehydrogenase
multiple interactions
ISO EXP
Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GAPDH mRNA] Selegiline inhibits the reaction [Paraquat affects the localization of GAPDH protein] Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]
CTD
PMID:14724376 PMID:20478973 PMID:23696560
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
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Hmox1
heme oxygenase 1
multiple interactions
ISO
Selegiline inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein]
CTD
PMID:28108387
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Jun
jun proto-oncogene
multiple interactions increases expression
ISO
Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of JUN mRNA] Selegiline results in increased expression of JUN protein
CTD
PMID:14724376 PMID:16099847
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Maoa
monoamine oxidase A
decreases activity
ISO
Selegiline results in decreased activity of MAOA protein
CTD
PMID:31323226
NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057
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Maob
monoamine oxidase B
affects binding decreases activity multiple interactions
ISO EXP
Selegiline binds to MAOB protein Selegiline results in decreased activity of MAOB protein [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid; [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid; [Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopamine [Selegiline results in decreased activity of MAOB protein] which results in increased susceptibility to Methamphetamine; zonisamide inhibits the reaction [Selegiline binds to MAOB protein] Selegiline inhibits the reaction [MAOB protein results in decreased amination of Dopamine]; Selegiline inhibits the reaction [MAOB protein results in increased degradation of Dopamine]; Selegiline inhibits the reaction [Smoke analog results in increased activity of MAOB protein]
CTD
PMID:1905457 PMID:15178694 PMID:15545290 PMID:16012872 PMID:16252076 PMID:19948168 PMID:21405131 PMID:21696156 PMID:21923181 PMID:21923198 PMID:26721607 PMID:28108387 PMID:28302559 PMID:30036687 PMID:31323226 More...
NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605
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Mapk1
mitogen-activated protein kinase 1
multiple interactions increases phosphorylation
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK1 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein
CTD
PMID:16099847 PMID:22019741
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk3
mitogen-activated protein kinase 3
multiple interactions increases phosphorylation
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein
CTD
PMID:16099847 PMID:22019741
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Mt1
metallothionein 1
multiple interactions
EXP
Selegiline inhibits the reaction [linsidomine results in increased expression of MT1 protein]
CTD
PMID:12880480
NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
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Myc
myelocytomatosis oncogene
increases phosphorylation multiple interactions
ISO
Selegiline results in increased phosphorylation of MYC protein MYC protein affects the reaction [Selegiline results in increased expression of TXN]
CTD
PMID:16099847
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
multiple interactions increases localization
ISO
NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased localization of NFE2L2 protein] Selegiline inhibits the reaction [Smoke analog affects the localization of NFE2L2 protein] Selegiline results in increased localization of NFE2L2 protein
CTD
PMID:22019741 PMID:28108387
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Nqo1
NAD(P)H dehydrogenase, quinone 1
multiple interactions increases activity
ISO
NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein] Selegiline inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]
CTD
PMID:22019741 PMID:28108387
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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Parp1
poly (ADP-ribose) polymerase family, member 1
multiple interactions
EXP
Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein]
CTD
PMID:12880480
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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Prkn
parkin RBR E3 ubiquitin protein ligase
multiple interactions
ISO
Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein]
CTD
PMID:12880480
NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
Selegiline inhibits the reaction [Smoke analog affects the localization of RELA protein]
CTD
PMID:28108387
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Siah1a
siah E3 ubiquitin protein ligase 1A
multiple interactions
ISO
Selegiline inhibits the reaction [Paraquat affects the localization of SIAH1A protein]
CTD
PMID:20478973
NCBI chr 8:87,442,450...87,472,634
Ensembl chr 8:87,450,635...87,472,562
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Selegiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Snca
synuclein, alpha
multiple interactions
ISO
Selegiline inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]; Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein]
CTD
PMID:12880480 PMID:15114628
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
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Stat3
signal transducer and activator of transcription 3
multiple interactions
EXP
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein]
CTD
PMID:34609854
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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Th
tyrosine hydroxylase
multiple interactions decreases expression
ISO
Selegiline inhibits the reaction [Rotenone results in decreased expression of TH protein] Selegiline results in decreased expression of TH mRNA
CTD
PMID:11862330 PMID:16490285
NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
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Txn1
thioredoxin 1
multiple interactions increases expression affects response to substance
ISO EXP
Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN]; Dinitrochlorobenzene inhibits the reaction [TXN protein affects the susceptibility to Selegiline]; MYC protein affects the reaction [Selegiline results in increased expression of TXN] Selegiline results in increased expression of TXN protein
CTD
PMID:16099847
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases methylation increases metabolic processing increases hydroxylation
ISO
CYP1A1 protein results in decreased methylation of almotriptan CYP1A1 protein results in increased metabolism of almotriptan CYP1A1 protein results in increased hydroxylation of almotriptan
CTD
PMID:12642466
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases methylation
ISO
CYP1A2 protein results in decreased methylation of almotriptan
CTD
PMID:12642466
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
decreases methylation
ISO
CYP2C8 protein results in decreased methylation of almotriptan
CTD
PMID:12642466
NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
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Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
decreases methylation
ISO
CYP2C19 protein results in decreased methylation of almotriptan
CTD
PMID:12642466
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
decreases methylation increases hydroxylation
ISO
CYP2D6 protein results in decreased methylation of almotriptan CYP2D6 protein results in increased hydroxylation of almotriptan
CTD
PMID:12642466
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
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Fmo3
flavin containing monooxygenase 3
increases oxidation
ISO
FMO3 protein results in increased oxidation of almotriptan
CTD
PMID:12642466
NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097
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Htr1b
5-hydroxytryptamine (serotonin) receptor 1B
multiple interactions
ISO
HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]
CTD
PMID:11134654
NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881
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Maoa
monoamine oxidase A
increases metabolic processing
ISO
MAOA protein results in increased metabolism of almotriptan
CTD
PMID:12642466
NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057
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Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
affects binding
ISO
alverine binds to HTR1A protein
CTD
PMID:11697552
NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
alverine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Aadat
aminoadipate aminotransferase
affects expression
ISO
Amitriptyline affects the expression of AADAT mRNA
CTD
PMID:18355885
NCBI chr 8:60,958,877...60,998,711
Ensembl chr 8:60,958,966...60,998,711
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Abat
4-aminobutyrate aminotransferase
decreases expression
ISO
Amitriptyline results in decreased expression of ABAT mRNA
CTD
PMID:21820738
NCBI chr16:8,331,293...8,439,432
Ensembl chr16:8,331,293...8,439,432
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Abcb11
ATP-binding cassette, sub-family B member 11
decreases expression
ISO
Amitriptyline results in decreased expression of ABCB11 mRNA
CTD
PMID:27765674
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcb1a
ATP-binding cassette, sub-family B member 1A
affects transport affects expression increases transport
EXP ISO
ABCB1A protein affects the transport of Amitriptyline Amitriptyline affects the expression of ABCB1 mRNA ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite
CTD
PMID:10700657 PMID:12082591 PMID:18355885
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcd2
ATP-binding cassette, sub-family D member 2
decreases expression
ISO
Amitriptyline results in decreased expression of ABCD2 mRNA
CTD
PMID:22341215
NCBI chr15:91,029,874...91,076,013
Ensembl chr15:91,030,074...91,076,002
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Abcg5
ATP binding cassette subfamily G member 5
decreases expression
ISO
Amitriptyline results in decreased expression of ABCG5 mRNA
CTD
PMID:27765674
NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439
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Abcg8
ATP binding cassette subfamily G member 8
decreases expression
ISO
Amitriptyline results in decreased expression of ABCG8 mRNA
CTD
PMID:27765674
NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761
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Ace2
angiotensin converting enzyme 2
increases expression
ISO
Amitriptyline results in increased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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Ache
acetylcholinesterase
decreases expression increases activity
ISO EXP
Amitriptyline results in decreased expression of ACHE mRNA Amitriptyline results in increased activity of ACHE protein
CTD
PMID:21820738 PMID:29614332
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
affects expression
ISO
Amitriptyline affects the expression of ALDH1A1 mRNA
CTD
PMID:18355885
NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
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Ankrd1
ankyrin repeat domain 1
increases expression
ISO
Amitriptyline results in increased expression of ANKRD1 mRNA
CTD
PMID:22341215
NCBI chr19:36,089,365...36,097,244
Ensembl chr19:36,089,361...36,097,499
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Ano3
anoctamin 3
decreases expression
ISO
Amitriptyline results in decreased expression of ANO3 mRNA
CTD
PMID:22341215
NCBI chr 2:110,485,546...110,780,854
Ensembl chr 2:110,485,546...110,781,268
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Ap1s1
adaptor protein complex AP-1, sigma 1
decreases expression
ISO
Amitriptyline results in decreased expression of AP1S1 mRNA
CTD
PMID:17175557 PMID:17567588
NCBI chr 5:137,063,852...137,074,917
Ensembl chr 5:137,063,847...137,074,989
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Apoa4
apolipoprotein A-IV
affects expression
ISO
Amitriptyline affects the expression of APOA4 mRNA
CTD
PMID:18355885
NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
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Arg1
arginase, liver
increases expression
ISO
Amitriptyline results in increased expression of ARG1 mRNA
CTD
PMID:22341215
NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Amitriptyline results in increased expression of ASAH1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810
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Asns
asparagine synthetase
increases expression
ISO
Amitriptyline results in increased expression of ASNS mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
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Atf3
activating transcription factor 3
increases expression
ISO
Amitriptyline results in increased expression of ATF3 mRNA
CTD
PMID:22341215
NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
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Bax
BCL2-associated X protein
multiple interactions
ISO
Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
CTD
PMID:19135049
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bcl2
B cell leukemia/lymphoma 2
multiple interactions
ISO
Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
CTD
PMID:19135049
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Bhmt
betaine-homocysteine methyltransferase
affects expression
ISO
Amitriptyline affects the expression of BHMT mRNA
CTD
PMID:18355885
NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
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C1qa
complement component 1, q subcomponent, alpha polypeptide
increases expression
ISO
Amitriptyline results in increased expression of C1QA mRNA
CTD
PMID:22341215
NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114
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C1qc
complement component 1, q subcomponent, C chain
increases expression
ISO
Amitriptyline results in increased expression of C1QC mRNA
CTD
PMID:22341215
NCBI chr 4:136,617,115...136,620,225
Ensembl chr 4:136,617,115...136,620,376
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Cacna2d1
calcium channel, voltage-dependent, alpha2/delta subunit 1
increases expression
ISO
Amitriptyline results in increased expression of CACNA2D1 mRNA
CTD
PMID:22341215
NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502
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Casp1
caspase 1
multiple interactions
EXP
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]
CTD
PMID:28633109
NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
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Casp3
caspase 3
multiple interactions increases expression increases activity
ISO
Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] Amitriptyline results in increased expression of CASP3 mRNA Amitriptyline results in increased activity of CASP3 protein
CTD
PMID:16717317 PMID:19135049 PMID:19815060
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casr
calcium-sensing receptor
decreases expression
ISO
Amitriptyline results in decreased expression of CASR mRNA
CTD
PMID:22341215
NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503
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Cat
catalase
decreases expression
ISO
Amitriptyline results in decreased expression of CAT protein
CTD
PMID:1937386
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
increases expression
ISO
Amitriptyline results in increased expression of CD74 mRNA
CTD
PMID:22341215
NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
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Cdkn2c
cyclin dependent kinase inhibitor 2C
affects expression
ISO
Amitriptyline affects the expression of CDKN2C mRNA
CTD
PMID:18355885
NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
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Ces2h
carboxylesterase 2H
affects expression
ISO
Amitriptyline affects the expression of CES2 mRNA
CTD
PMID:18355885
NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
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Chat
choline acetyltransferase
increases expression
ISO
Amitriptyline results in increased expression of CHAT mRNA
CTD
PMID:21820738
NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
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Chrna3
cholinergic receptor, nicotinic, alpha polypeptide 3
decreases expression
ISO
Amitriptyline results in decreased expression of CHRNA3 mRNA
CTD
PMID:22341215
NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
decreases expression increases response to substance
ISO EXP
Amitriptyline results in decreased expression of CHRNB2 mRNA CHRNB2 protein results in increased susceptibility to Amitriptyline
CTD
PMID:21820738 PMID:21905669
NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
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Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
affects expression
ISO
Amitriptyline affects the expression of CMTM6 mRNA
CTD
PMID:18355885
NCBI chr 9:114,560,184...114,578,412
Ensembl chr 9:114,560,184...114,578,412
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Cpne4
copine IV
decreases expression
ISO
Amitriptyline results in decreased expression of CPNE4 mRNA
CTD
PMID:22341215
NCBI chr 9:104,443,900...104,911,747
Ensembl chr 9:104,424,485...104,911,743
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Cpped1
calcineurin-like phosphoesterase domain containing 1
affects expression
ISO
Amitriptyline affects the expression of CPPED1 mRNA
CTD
PMID:18355885
NCBI chr16:11,621,546...11,727,377
Ensembl chr16:11,621,585...11,727,309
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Crem
cAMP responsive element modulator
affects expression
ISO
Amitriptyline affects the expression of CREM mRNA
CTD
PMID:18355885
NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748
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Csrp3
cysteine and glycine-rich protein 3
increases expression
ISO
Amitriptyline results in increased expression of CSRP3 mRNA
CTD
PMID:22341215
NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781
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Cybb
cytochrome b-245, beta polypeptide
multiple interactions
EXP
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein]
CTD
PMID:28633109
NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing multiple interactions
ISO
Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD
PMID:18359012 PMID:23397584 PMID:27320963
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp2a22
cytochrome P450, family 2, subfamily a, polypeptide 22
affects expression
ISO
Amitriptyline affects the expression of CYP2A1 mRNA
CTD
PMID:18355885
NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
increases metabolic processing
ISO
CYP2B6 protein results in increased metabolism of Amitriptyline
CTD
PMID:27320963
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
increases expression
ISO
Amitriptyline results in increased expression of CYP2B2 mRNA
CTD
PMID:10945841
NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
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Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
multiple interactions increases metabolic processing
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CYP2C19 protein results in increased metabolism of Amitriptyline
CTD
PMID:23397584 PMID:27320963
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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Cyp2c65
cytochrome P450, family 2, subfamily c, polypeptide 65
multiple interactions
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD
PMID:23397584
NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
multiple interactions increases metabolic processing decreases activity
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline Amitriptyline results in decreased activity of CYP2D6 protein
CTD
PMID:16044105 PMID:18359012 PMID:18359183 PMID:23397584 PMID:27320963
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
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Cyp3a13
cytochrome P450, family 3, subfamily a, polypeptide 13
increases metabolic processing
ISO
Amitriptyline results in increased metabolism of CYP3A5 protein
CTD
PMID:18359012
NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
G
Dcaf8
DDB1 and CUL4 associated factor 8
affects expression
ISO
Amitriptyline affects the expression of DCAF8 mRNA
CTD
PMID:18355885
NCBI chr 1:171,975,574...172,023,959
Ensembl chr 1:171,975,651...172,024,572
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Depp1
DEPP1 autophagy regulator
increases expression
ISO
Amitriptyline results in increased expression of DEPP1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755
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Des
desmin
multiple interactions
EXP
Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein]
CTD
PMID:23024785
NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223
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Dnmt1
DNA methyltransferase 1
decreases activity
ISO
Amitriptyline results in decreased activity of DNMT1 protein Amitriptyline decreases activity of Dnmt1 protein in astrocyte nucleus
CTD RGD
PMID:19924110 PMID:22880885
RGD:9588218
NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
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Drd1
dopamine receptor D1
increases expression
ISO
Amitriptyline results in increased expression of DRD1 mRNA
CTD
PMID:16499906
NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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Drd3
dopamine receptor D3
increases expression
ISO
Amitriptyline results in increased expression of DRD3 mRNA
CTD
PMID:21820738
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
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Ecel1
endothelin converting enzyme-like 1
increases expression
ISO
Amitriptyline results in increased expression of ECEL1 mRNA
CTD
PMID:22341215
NCBI chr 1:87,070,596...87,084,867
Ensembl chr 1:87,075,377...87,084,243
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Eif4b
eukaryotic translation initiation factor 4B
affects expression
ISO
Amitriptyline affects the expression of EIF4B mRNA
CTD
PMID:18355885
NCBI chr15:101,982,208...102,005,608
Ensembl chr15:101,982,208...102,005,608
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Ephx1
epoxide hydrolase 1, microsomal
affects expression
ISO
Amitriptyline affects the expression of EPHX1 mRNA
CTD
PMID:18355885
NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
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Erp29
endoplasmic reticulum protein 29
affects expression
ISO
Amitriptyline affects the expression of ERP29 mRNA
CTD
PMID:18355885
NCBI chr 5:121,582,816...121,590,537
Ensembl chr 5:121,566,653...121,590,569
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Fabp1
fatty acid binding protein 1, liver
increases expression
ISO
Amitriptyline results in increased expression of FABP1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
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Flrt3
fibronectin leucine rich transmembrane protein 3
increases expression
ISO
Amitriptyline results in increased expression of FLRT3 mRNA
CTD
PMID:22341215
NCBI chr 2:140,500,118...140,513,396
Ensembl chr 2:140,492,834...140,513,389
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Fmo3
flavin containing monooxygenase 3
increases metabolic processing
ISO
FMO3 protein results in increased metabolism of Amitriptyline
CTD
PMID:27320963
NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097
G
Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Amitriptyline results in increased expression of FNDC4 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 5:31,449,589...31,453,279
Ensembl chr 5:31,449,586...31,453,424
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
increases expression decreases expression
ISO
Amitriptyline results in increased expression of GABRA1 mRNA Amitriptyline results in decreased expression of GABRA1 mRNA
CTD
PMID:21820738 PMID:22341215
NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
increases expression
ISO
Amitriptyline results in increased expression of GABRA2 mRNA
CTD
PMID:21820738
NCBI chr 5:71,115,735...71,253,192
Ensembl chr 5:71,114,940...71,253,192
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Gabra4
gamma-aminobutyric acid type A receptor subunit alpha 4
increases expression
ISO
Amitriptyline results in increased expression of GABRA4 mRNA
CTD
PMID:21820738
NCBI chr 5:71,727,077...71,815,651
Ensembl chr 5:71,727,092...71,815,651
G
Gabrb3
GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3
increases expression
ISO
Amitriptyline results in increased expression of GABRB3 mRNA
CTD
PMID:21820738
NCBI chr 7:57,240,266...57,478,550
Ensembl chr 7:57,069,440...57,478,550
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Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
increases expression
ISO
Amitriptyline results in increased expression of GADD45A mRNA
CTD
PMID:22341215
NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
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Gal
galanin and GMAP prepropeptide
increases expression
ISO
Amitriptyline results in increased expression of GAL mRNA
CTD
PMID:22341215
NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544
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Gckr
glucokinase regulatory protein
affects expression
ISO
Amitriptyline affects the expression of GCKR mRNA
CTD
PMID:18355885
NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Amitriptyline results in increased expression of GDPD3 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 7:126,365,586...126,374,817
Ensembl chr 7:126,365,506...126,374,821
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Gfap
glial fibrillary acidic protein
increases expression
ISO
Amitriptyline results in increased expression of GFAP mRNA
CTD
PMID:22954530
NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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Gls2
glutaminase 2 (liver, mitochondrial)
affects expression
ISO
Amitriptyline affects the expression of GLS2 mRNA
CTD
PMID:18355885
NCBI chr10:128,030,504...128,045,873
Ensembl chr10:128,030,326...128,045,873
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Got2
glutamatic-oxaloacetic transaminase 2, mitochondrial
affects expression
ISO
Amitriptyline affects the expression of GOT2 mRNA
CTD
PMID:18355885
NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
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Grb14
growth factor receptor bound protein 14
affects expression
ISO
Amitriptyline affects the expression of GRB14 mRNA
CTD
PMID:18355885
NCBI chr 2:64,742,820...64,853,143
Ensembl chr 2:64,742,820...64,855,331
G
Grik1
glutamate receptor, ionotropic, kainate 1
decreases expression
ISO
Amitriptyline results in decreased expression of GRIK1 mRNA
CTD
PMID:22341215
NCBI chr16:87,692,789...88,087,751
Ensembl chr16:87,692,788...88,087,153
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Gstp1
glutathione S-transferase, pi 1
decreases activity
ISO
Amitriptyline results in decreased activity of GSTP1 protein
CTD
PMID:15094841
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
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H2-Ea
histocompatibility 2, class II antigen E alpha
increases expression
ISO
Amitriptyline results in increased expression of RT1-DA mRNA
CTD
PMID:22341215
NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618
G
H2-Eb1
histocompatibility 2, class II antigen E beta
increases expression
ISO
Amitriptyline results in increased expression of RT1-DB1 mRNA
CTD
PMID:22341215
NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
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Hal
histidine ammonia lyase
affects expression
ISO
Amitriptyline affects the expression of HAL mRNA
CTD
PMID:18355885
NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166
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Hmgb2
high mobility group box 2
affects expression
ISO
Amitriptyline affects the expression of HMGB2 mRNA
CTD
PMID:18355885
NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033
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Hmgcs1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
increases expression
ISO
Amitriptyline results in increased expression of HMGCS1 mRNA
CTD
PMID:16324787
NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
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Hoxd1
homeobox D1
decreases expression
ISO
Amitriptyline results in decreased expression of HOXD1 mRNA
CTD
PMID:22341215
NCBI chr 2:74,593,324...74,595,486
Ensembl chr 2:74,593,324...74,595,486
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Hpn
hepsin
increases expression
ISO
Amitriptyline results in increased expression of HPN mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 7:30,798,150...30,814,751
Ensembl chr 7:30,798,150...30,814,715
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Hpse
heparanase
decreases expression
ISO
Amitriptyline results in decreased expression of HPSE mRNA
CTD
PMID:22341215
NCBI chr 5:100,827,350...100,867,582
Ensembl chr 5:100,827,350...100,867,582
G
Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
decreases expression
ISO
Amitriptyline results in decreased expression of HS3ST2 mRNA
CTD
PMID:22341215
NCBI chr 7:120,990,785...121,196,555
Ensembl chr 7:120,991,082...121,100,993
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Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
increases expression
ISO
Amitriptyline results in increased expression of HTR1A protein
CTD
PMID:1589591
NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630
G
Htr1d
5-hydroxytryptamine (serotonin) receptor 1D
decreases expression
ISO
Amitriptyline results in decreased expression of HTR1D mRNA
CTD
PMID:22341215
NCBI chr 4:136,150,835...136,171,716
Ensembl chr 4:136,150,835...136,171,709
G
Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
affects binding
ISO
Amitriptyline binds to HTR2C protein
CTD
PMID:18083778
NCBI chr X:145,745,509...145,980,273
Ensembl chr X:145,745,509...145,980,273
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Il1b
interleukin 1 beta
multiple interactions
EXP
Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein]
CTD
PMID:28633109
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Il33
interleukin 33
affects expression
ISO
Amitriptyline affects the expression of IL33 mRNA
CTD
PMID:18355885
NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
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Inhbe
inhibin beta-E
increases expression
ISO
Amitriptyline results in increased expression of INHBE mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280
G
Itgb6
integrin beta 6
decreases expression
ISO
Amitriptyline results in decreased expression of ITGB6 mRNA
CTD
PMID:22341215
NCBI chr 2:60,428,636...60,553,005
Ensembl chr 2:60,428,636...60,552,987
G
Kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
decreases expression
ISO
Amitriptyline results in decreased expression of KCNA4 mRNA
CTD
PMID:22341215
NCBI chr 2:107,120,934...107,157,149
Ensembl chr 2:107,120,984...107,128,847
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
multiple interactions
ISO
Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:19583963 PMID:21158687
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
decreases activity
ISO
Amitriptyline results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950
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Kcns1
K+ voltage-gated channel, subfamily S, 1
decreases expression
ISO
Amitriptyline results in decreased expression of KCNS1 mRNA
CTD
PMID:22341215
NCBI chr 2:164,005,539...164,013,865
Ensembl chr 2:164,005,539...164,013,033
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Kcns3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
decreases expression
ISO
Amitriptyline results in decreased expression of KCNS3 mRNA
CTD
PMID:22341215
NCBI chr12:11,140,738...11,201,186
Ensembl chr12:11,140,203...11,201,057
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Lox
lysyl oxidase
affects expression
ISO
Amitriptyline affects the expression of LOX mRNA
CTD
PMID:18355885
NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
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Lss
lanosterol synthase
increases expression
ISO
Amitriptyline results in increased expression of LSS mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972
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Macroh2a1
macroH2A.1 histone
affects expression
ISO
Amitriptyline affects the expression of MACROH2A1 mRNA
CTD
PMID:18355885
NCBI chr13:56,221,435...56,283,439
Ensembl chr13:56,221,432...56,284,174
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Manba
mannosidase, beta A, lysosomal
affects expression
ISO
Amitriptyline affects the expression of MANBA mRNA
CTD
PMID:18355885
NCBI chr 3:135,191,367...135,277,165
Ensembl chr 3:135,191,372...135,277,165
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Maoa
monoamine oxidase A
affects expression
ISO
Amitriptyline affects the expression of MAOA mRNA
CTD
PMID:21820738
NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057
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Mlx
MAX-like protein X
affects expression
ISO
Amitriptyline affects the expression of MLX mRNA
CTD
PMID:18355885
NCBI chr11:100,978,116...100,983,033
Ensembl chr11:100,978,103...100,983,033
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Mmp16
matrix metallopeptidase 16
increases expression
ISO
Amitriptyline results in increased expression of MMP16 mRNA
CTD
PMID:22341215
NCBI chr 4:17,853,072...18,117,479
Ensembl chr 4:17,852,893...18,119,145
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Mrps18b
mitochondrial ribosomal protein S18B
affects expression
ISO
Amitriptyline affects the expression of MRPS18B mRNA
CTD
PMID:18355885
NCBI chr17:36,221,272...36,227,332
Ensembl chr17:36,221,271...36,227,281
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Msmo1
methylsterol monoxygenase 1
affects expression
ISO
Amitriptyline affects the expression of MSMO1 mRNA
CTD
PMID:18355885
NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein]
CTD
PMID:28633109
NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
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Nmb
neuromedin B
decreases expression
ISO
Amitriptyline results in decreased expression of NMB mRNA
CTD
PMID:22341215
NCBI chr 7:80,551,975...80,554,810
Ensembl chr 7:80,551,975...80,554,824
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Nmur1
neuromedin U receptor 1
decreases expression
ISO
Amitriptyline results in decreased expression of NMUR1 mRNA
CTD
PMID:21820738
NCBI chr 1:86,313,964...86,317,083
Ensembl chr 1:86,314,025...86,353,950
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Nog
noggin
decreases expression
ISO
Amitriptyline results in decreased expression of NOG mRNA
CTD
PMID:22341215
NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158
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Nphs2
nephrosis 2, podocin
multiple interactions
EXP
Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]
CTD
PMID:23024785
NCBI chr 1:156,138,105...156,155,605
Ensembl chr 1:156,138,297...156,155,605
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Npy
neuropeptide Y
increases expression
ISO
Amitriptyline results in increased expression of NPY mRNA
CTD
PMID:22341215
NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
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Npy5r
neuropeptide Y receptor Y5
increases expression
ISO
Amitriptyline results in increased expression of NPY5R mRNA
CTD
PMID:21820738
NCBI chr 8:67,132,617...67,140,746
Ensembl chr 8:67,132,617...67,140,780
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Amitriptyline results in increased expression of NR0B2 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects response to substance
EXP
NR3C1 protein affects the susceptibility to Amitriptyline
CTD
PMID:11226678
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
increases expression
ISO
Amitriptyline results in increased expression of NR3C2 mRNA
CTD
PMID:12393271
NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641
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Nrep
neuronal regeneration related protein
affects expression
ISO
Amitriptyline affects the expression of NREP mRNA
CTD
PMID:18355885
NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
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Ntng1
netrin G1
decreases expression
ISO
Amitriptyline results in decreased expression of NTNG1 mRNA
CTD
PMID:22341215
NCBI chr 3:109,687,366...110,057,291
Ensembl chr 3:109,687,356...110,051,327
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Nupr1
nuclear protein transcription regulator 1
increases expression
ISO
Amitriptyline results in increased expression of NUPR1 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
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Oaf
out at first homolog
affects expression
ISO
Amitriptyline affects the expression of OAF mRNA
CTD
PMID:18355885
NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208
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Patj
PATJ, crumbs cell polarity complex component
decreases expression
ISO
Amitriptyline results in decreased expression of PATJ mRNA
CTD
PMID:22341215
NCBI chr 4:98,283,803...98,607,840
Ensembl chr 4:98,284,022...98,607,840
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Pcx
pyruvate carboxylase
affects expression
ISO
Amitriptyline affects the expression of PC mRNA
CTD
PMID:18355885
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
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Pecr
peroxisomal trans-2-enoyl-CoA reductase
affects expression
ISO
Amitriptyline affects the expression of PECR mRNA
CTD
PMID:18355885
NCBI chr 1:72,298,331...72,323,480
Ensembl chr 1:72,298,326...72,323,473
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Phyh
phytanoyl-CoA hydroxylase
increases expression
ISO
Amitriptyline results in increased expression of PHYH mRNA
CTD
PMID:15342952
NCBI chr 2:4,923,807...4,943,554
Ensembl chr 2:4,923,830...4,943,541
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Plcd4
phospholipase C, delta 4
decreases expression
ISO
Amitriptyline results in decreased expression of PLCD4 mRNA
CTD
PMID:22341215
NCBI chr 1:74,581,175...74,605,137
Ensembl chr 1:74,582,047...74,606,953
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Plpp4
phospholipid phosphatase 4
decreases expression
ISO
Amitriptyline results in decreased expression of PLPP4 mRNA
CTD
PMID:22341215
NCBI chr 7:128,858,114...128,993,138
Ensembl chr 7:128,858,755...128,993,136
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Por
cytochrome p450 oxidoreductase
affects expression
ISO
Amitriptyline affects the expression of POR mRNA
CTD
PMID:18355885
NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
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Prokr1
prokineticin receptor 1
decreases expression
ISO
Amitriptyline results in decreased expression of PROKR1 mRNA
CTD
PMID:21820738
NCBI chr 6:87,555,568...87,567,741
Ensembl chr 6:87,555,573...87,567,725
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Pycard
PYD and CARD domain containing
multiple interactions
EXP
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein]
CTD
PMID:28633109
NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
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Rasd1
RAS, dexamethasone-induced 1
increases expression
ISO
Amitriptyline results in increased expression of RASD1 mRNA
CTD
PMID:22341215
NCBI chr11:59,854,007...59,855,770
Ensembl chr11:59,854,007...59,855,770
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Rbl2
RB transcriptional corepressor like 2
affects expression
ISO
Amitriptyline affects the expression of RBL2 mRNA
CTD
PMID:18355885
NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472
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Reg3b
regenerating islet-derived 3 beta
increases expression
ISO
Amitriptyline results in increased expression of REG3B mRNA
CTD
PMID:22341215
NCBI chr 6:78,347,868...78,350,449
Ensembl chr 6:78,347,640...78,350,449
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Rnf112
ring finger protein 112
decreases expression
ISO
Amitriptyline results in decreased expression of RNF112 mRNA
CTD
PMID:22341215
NCBI chr11:61,339,243...61,345,014
Ensembl chr11:61,339,268...61,344,957
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Scd2
stearoyl-Coenzyme A desaturase 2
increases expression
ISO
Amitriptyline results in increased expression of SCD mRNA
CTD
PMID:16324787
NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
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Scn11a
sodium channel, voltage-gated, type XI, alpha
decreases expression
ISO
Amitriptyline results in decreased expression of SCN11A mRNA
CTD
PMID:22341215
NCBI chr 9:119,582,829...119,654,522
Ensembl chr 9:119,582,825...119,654,522
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Sema6a
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
increases expression
ISO
Amitriptyline results in increased expression of SEMA6A mRNA
CTD
PMID:22341215
NCBI chr18:47,378,321...47,504,267
Ensembl chr18:47,368,665...47,501,937
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Serpina3b
serine (or cysteine) peptidase inhibitor, clade A, member 3B
increases expression
ISO
Amitriptyline results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804
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Sh3gl3
SH3-domain GRB2-like 3
affects expression
ISO
Amitriptyline affects the expression of SH3GL3 mRNA
CTD
PMID:18355885
NCBI chr 7:81,824,581...81,956,618
Ensembl chr 7:81,823,588...81,956,627
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Slc22a1
solute carrier family 22 (organic cation transporter), member 1
multiple interactions decreases activity
ISO
Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide] Amitriptyline results in decreased activity of SLC22A1 protein
CTD
PMID:30189235 PMID:31364238
NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions decreases activity
ISO
Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] Amitriptyline results in decreased activity of SLC22A2 protein
CTD
PMID:21599003 PMID:23770354 PMID:28629854 PMID:30189235 PMID:31364238
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc22a6
solute carrier family 22 (organic anion transporter), member 6
multiple interactions
ISO
Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:21561794
NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663
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Slc2a3
solute carrier family 2 (facilitated glucose transporter), member 3
decreases expression
ISO
Amitriptyline results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599
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Slc47a2
solute carrier family 47, member 2
multiple interactions
ISO
Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium]
CTD
PMID:28629854
NCBI chr11:61,192,453...61,233,686
Ensembl chr11:61,192,457...61,233,686
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Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
affects expression
ISO
Amitriptyline affects the expression of SLC6A6 mRNA
CTD
PMID:18355885
NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047
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Slco1a4
solute carrier organic anion transporter family, member 1a4
affects expression
ISO
Amitriptyline affects the expression of SLCO1A4 mRNA
CTD
PMID:18355885
NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
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Smagp
small cell adhesion glycoprotein
increases expression
ISO
Amitriptyline results in increased expression of SMAGP mRNA
CTD
PMID:22341215
NCBI chr15:100,519,220...100,534,821
Ensembl chr15:100,519,220...100,534,821
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Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
increases response to substance multiple interactions decreases activity
EXP ISO
SMPD1 protein results in increased susceptibility to Amitriptyline [Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein Amitriptyline results in decreased activity of SMPD1 protein
CTD
PMID:23770692
NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596
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Sod1
superoxide dismutase 1, soluble
increases expression
ISO
Amitriptyline results in increased expression of SOD1 mRNA
CTD
PMID:10721683
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Sorl1
sortilin-related receptor, LDLR class A repeats-containing
decreases expression
ISO
Amitriptyline results in decreased expression of SORL1 mRNA
CTD
PMID:22341215
NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593
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Sox11
SRY (sex determining region Y)-box 11
increases expression
ISO
Amitriptyline results in increased expression of SOX11 mRNA
CTD
PMID:22341215
NCBI chr12:27,384,267...27,392,717
Ensembl chr12:27,384,263...27,392,573
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Sprr1a
small proline-rich protein 1A
increases expression
ISO
Amitriptyline results in increased expression of SPRR1A mRNA
CTD
PMID:22341215
NCBI chr 3:92,391,261...92,393,188
Ensembl chr 3:92,391,259...92,393,202
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Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein
CTD
PMID:16324787
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
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Srebf2
sterol regulatory element binding factor 2
multiple interactions
ISO
Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein
CTD
PMID:16324787
NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
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Sstr1
somatostatin receptor 1
decreases expression
ISO
Amitriptyline results in decreased expression of SSTR1 mRNA
CTD
PMID:21820738
NCBI chr12:58,258,524...58,262,822
Ensembl chr12:58,258,558...58,260,673
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St13
suppression of tumorigenicity 13
affects expression
ISO
Amitriptyline affects the expression of ST13 mRNA
CTD
PMID:18355885
NCBI chr15:81,247,869...81,284,278
Ensembl chr15:81,247,870...81,284,278
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Stac2
SH3 and cysteine rich domain 2
increases expression
ISO
Amitriptyline results in increased expression of STAC2 mRNA
CTD
PMID:22341215
NCBI chr11:97,927,449...97,944,288
Ensembl chr11:97,927,449...97,944,288
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Stbd1
starch binding domain 1
affects expression
ISO
Amitriptyline affects the expression of STBD1 mRNA
CTD
PMID:18355885
NCBI chr 5:92,750,910...92,754,438
Ensembl chr 5:92,750,900...92,754,438
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Stmn1
stathmin 1
affects expression
ISO
Amitriptyline affects the expression of STMN1 mRNA
CTD
PMID:18355885
NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154
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Stmn4
stathmin-like 4
increases expression
ISO
Amitriptyline results in increased expression of STMN4 mRNA
CTD
PMID:22341215
NCBI chr14:66,581,806...66,599,129
Ensembl chr14:66,581,745...66,599,129
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Tagln
transgelin
decreases expression
ISO
Amitriptyline results in decreased expression of TAGLN mRNA
CTD
PMID:15342952 PMID:17175557 PMID:17567588
NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
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Tex261
testis expressed gene 261
affects expression
ISO
Amitriptyline affects the expression of TEX261 mRNA
CTD
PMID:18355885
NCBI chr 6:83,745,863...83,752,804
Ensembl chr 6:83,745,867...83,752,795
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Tgm1
transglutaminase 1, K polypeptide
increases expression
ISO
Amitriptyline results in increased expression of TGM1 mRNA
CTD
PMID:22341215
NCBI chr14:55,937,466...55,951,378
Ensembl chr14:55,937,466...55,951,383
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Timm10b
translocase of inner mitochondrial membrane 10B
affects expression
ISO
Amitriptyline affects the expression of TIMM10B mRNA
CTD
PMID:18355885
NCBI chr 7:105,289,652...105,304,955
Ensembl chr 7:105,289,263...105,292,844 Ensembl chr 7:105,289,263...105,292,844
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Trh
thyrotropin releasing hormone
multiple interactions
ISO
Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein]
CTD
PMID:6455462
NCBI chr 6:92,219,042...92,221,631
Ensembl chr 6:92,219,042...92,221,631
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Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
ISO
Amitriptyline inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]
CTD
PMID:23264033
NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
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Tshb
thyroid stimulating hormone, beta subunit
multiple interactions
ISO
Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein]
CTD
PMID:6455462
NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
affects expression
ISO
Amitriptyline affects the expression of UBA52 mRNA
CTD
PMID:18355885
NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451
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Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
affects expression
ISO
Amitriptyline affects the expression of UGT1A1 mRNA
CTD
PMID:18355885
NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
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Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
affects expression
ISO
Amitriptyline affects the expression of UGT2A1 mRNA
CTD
PMID:18355885
NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
affects expression
ISO
Amitriptyline affects the expression of UGT2B1 mRNA
CTD
PMID:18355885
NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389
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Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]
CTD
PMID:23024785
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Amitriptyline results in increased expression of WIPI1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793
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Hrh1
histamine receptor H1
multiple interactions
ISO
azatadine binds to and results in decreased activity of HRH1 protein
CTD
PMID:2864258
NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
increases metabolic processing
ISO
CYP2B6 protein results in increased metabolism of Benzphetamine
CTD
PMID:12464242 PMID:15769884
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Abcb1a
ATP-binding cassette, sub-family B member 1A
multiple interactions
ISO
Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
CTD
PMID:11895100
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Atf4
activating transcription factor 4
increases expression
ISO
Bepridil results in increased expression of ATF4 protein
CTD
PMID:21292685
NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Bepridil results in increased expression of DDIT3 protein
CTD
PMID:21292685
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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Eif2a
eukaryotic translation initiation factor 2A
increases phosphorylation
ISO
Bepridil results in increased phosphorylation of EIF2A protein
CTD
PMID:21292685
NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922
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Kcna5
potassium voltage-gated channel, shaker-related subfamily, member 5
decreases activity
ISO
Bepridil results in decreased activity of KCNA5 protein
CTD
PMID:11711026
NCBI chr 6:126,509,514...126,512,518
Ensembl chr 6:126,509,514...126,512,375
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
multiple interactions decreases activity
ISO
Bepridil binds to and results in decreased activity of KCNH2 protein; Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Bepridil results in decreased activity of KCNH2 protein
CTD
PMID:15272206 PMID:15671647 PMID:21158687 PMID:24052561
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Slc8a1
solute carrier family 8 (sodium/calcium exchanger), member 1
multiple interactions
ISO
Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]
CTD
PMID:16009740
NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806
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Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
increases response to substance
ISO
Bepridil results in increased susceptibility to TNFSF10 protein
CTD
PMID:21292685
NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]
CTD
PMID:23688403
NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
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Cxcl10
C-X-C motif chemokine ligand 10
multiple interactions
ISO
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]
CTD
PMID:24471457
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
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Cxcl15
C-X-C motif chemokine ligand 15
multiple interactions
ISO
butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]
CTD
PMID:23688403
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Il4
interleukin 4
multiple interactions
ISO
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]
CTD
PMID:23688403
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
multiple interactions
ISO
butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]
CTD
PMID:23688403
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
butenafine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased activity of STAT1 protein]]; butenafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]
CTD
PMID:24471457
NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
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Tslp
thymic stromal lymphopoietin
multiple interactions
ISO
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]
CTD
PMID:23688403
NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
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Abcb11
ATP-binding cassette, sub-family B member 11
multiple interactions decreases expression
ISO EXP
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB11 mRNA Chlorpromazine results in decreased expression of ABCB11 mRNA; Chlorpromazine results in decreased expression of ABCB11 protein
CTD
PMID:27344345 PMID:27765674 PMID:28391356 PMID:35708773
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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Abcb1a
ATP-binding cassette, sub-family B member 1A
increases expression decreases activity
ISO
Chlorpromazine analog results in increased expression of ABCB1 mRNA Chlorpromazine results in decreased activity of ABCB1 protein
CTD
PMID:15924885 PMID:16810505
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcb1b
ATP-binding cassette, sub-family B member 1B
affects activity
ISO
Chlorpromazine affects the activity of ABCB1B protein
CTD
PMID:12626638
NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
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Abcb4
ATP-binding cassette, sub-family B member 4
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB4 mRNA
CTD
PMID:27344345
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Abcb6
ATP-binding cassette, sub-family B member 6
decreases expression
ISO
Chlorpromazine results in decreased expression of ABCB6 mRNA
CTD
PMID:25596134
NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036
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Abcb9
ATP-binding cassette, sub-family B member 9
increases expression
ISO
Chlorpromazine results in increased expression of ABCB9 mRNA
CTD
PMID:25596134
NCBI chr 5:124,199,920...124,234,009
Ensembl chr 5:124,199,593...124,233,861
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Abcc2
ATP-binding cassette, sub-family member 2
increases expression multiple interactions
ISO EXP
Chlorpromazine results in increased expression of ABCC2 mRNA [Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC2 mRNA
CTD
PMID:27765674 PMID:35708773
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc3
ATP-binding cassette, sub-family C member 3
increases expression multiple interactions decreases expression
ISO EXP
Chlorpromazine analog results in increased expression of ABCC3 mRNA [Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC3 mRNA Chlorpromazine results in decreased expression of ABCC3 mRNA
CTD
PMID:15924885 PMID:25596134 PMID:35708773
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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Abcc4
ATP-binding cassette, sub-family C member 4
increases expression
EXP
Chlorpromazine results in increased expression of ABCC4 mRNA
CTD
PMID:35708773
NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
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Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
multiple interactions
ISO
Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]
CTD
PMID:18834354
NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
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Abcg8
ATP binding cassette subfamily G member 8
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA
CTD
PMID:27344345
NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761
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Acaca
acetyl-Coenzyme A carboxylase alpha
decreases phosphorylation
ISO
Chlorpromazine results in decreased phosphorylation of ACACA protein
CTD
PMID:17512020
NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Chlorpromazine results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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Ache
acetylcholinesterase
decreases activity increases activity multiple interactions
ISO EXP
Chlorpromazine results in decreased activity of ACHE protein Chlorpromazine results in increased activity of ACHE protein Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]
CTD
PMID:4859365 PMID:29614332
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Acp5
acid phosphatase 5, tartrate resistant
multiple interactions
EXP
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
CTD
PMID:21869564
NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007
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Adra1a
adrenergic receptor, alpha 1a
decreases activity
ISO
Chlorpromazine results in decreased activity of ADRA1A protein
CTD
PMID:23611293
NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
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Adra1b
adrenergic receptor, alpha 1b
decreases activity
ISO
Chlorpromazine results in decreased activity of ADRA1B protein
CTD
PMID:23611293
NCBI chr11:43,665,432...43,792,076
Ensembl chr11:43,665,433...43,792,037
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Afp
alpha fetoprotein
decreases expression
ISO
Chlorpromazine analog results in decreased expression of AFP mRNA
CTD
PMID:15924885
NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
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Agrn
agrin
decreases expression
ISO
Chlorpromazine results in decreased expression of AGRN mRNA
CTD
PMID:25596134
NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945
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Ahr
aryl-hydrocarbon receptor
affects activity
ISO
Chlorpromazine affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
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Ak3
adenylate kinase 3
decreases expression
ISO
Chlorpromazine results in decreased expression of AK3 mRNA
CTD
PMID:25596134
NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361
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Akp3
alkaline phosphatase 3, intestine, not Mn requiring
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA]
CTD
PMID:16036225
NCBI chr 1:87,052,676...87,056,450
Ensembl chr 1:87,052,695...87,055,634
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Akt1
thymoma viral proto-oncogene 1
decreases phosphorylation
ISO
Chlorpromazine results in decreased phosphorylation of AKT1 protein
CTD
PMID:17512020
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA
CTD
PMID:27344345
NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
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Ap1s1
adaptor protein complex AP-1, sigma 1
decreases expression
ISO
Chlorpromazine results in decreased expression of AP1S1 mRNA
CTD
PMID:17175557
NCBI chr 5:137,063,852...137,074,917
Ensembl chr 5:137,063,847...137,074,989
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Apoc4
apolipoprotein C-IV
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA
CTD
PMID:27344345
NCBI chr 7:19,412,009...19,415,385
Ensembl chr 7:19,412,008...19,415,404
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Apof
apolipoprotein F
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOF mRNA
CTD
PMID:27344345
NCBI chr10:128,104,568...128,107,119
Ensembl chr10:128,103,866...128,106,022
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Areg
amphiregulin
decreases expression
ISO
Chlorpromazine results in decreased expression of AREG mRNA
CTD
PMID:15924885 PMID:30703373
NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291
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Arfgef2
ADP ribosylation factor guanine nucleotide exchange factor 2
increases expression
ISO
Chlorpromazine results in increased expression of ARFGEF2 mRNA
CTD
PMID:25596134
NCBI chr 2:166,647,371...166,739,972
Ensembl chr 2:166,647,508...166,739,972
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Arhgef10
Rho guanine nucleotide exchange factor 10
decreases expression
ISO
Chlorpromazine results in decreased expression of ARHGEF10 mRNA
CTD
PMID:25596134
NCBI chr 8:14,956,405...15,051,085
Ensembl chr 8:14,961,663...15,051,085
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
Chlorpromazine results in increased expression of ASAH1 mRNA
CTD
PMID:17175557
NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810
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Asns
asparagine synthetase
increases expression
ISO
Chlorpromazine results in increased expression of ASNS mRNA
CTD
PMID:17175557
NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
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Atf4
activating transcription factor 4
affects activity multiple interactions
ISO
Chlorpromazine affects the activity of ATF4 protein [Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA
CTD
PMID:25596134 PMID:27344345
NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
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Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
decreases expression
ISO
Chlorpromazine results in decreased expression of ATP6V1B2 protein
CTD
PMID:19441803
NCBI chr 8:69,541,388...69,566,370
Ensembl chr 8:69,541,298...69,566,363
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Avp
arginine vasopressin
increases expression multiple interactions
ISO
Chlorpromazine results in increased expression of AVP protein Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]
CTD
PMID:3567260 PMID:3976404
NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474
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Bag4
BCL2-associated athanogene 4
decreases expression
ISO
Chlorpromazine analog results in decreased expression of BAG4 mRNA
CTD
PMID:15924885
NCBI chr 8:26,254,566...26,275,237
Ensembl chr 8:26,254,566...26,275,315
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Bcl2l1
BCL2-like 1
increases expression
EXP
Chlorpromazine results in increased expression of BCL2L1 mRNA
CTD
PMID:21683644
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
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Bdnf
brain derived neurotrophic factor
affects response to substance affects expression
ISO
BDNF affects the susceptibility to Chlorpromazine Chlorpromazine affects the expression of BDNF mRNA
CTD
PMID:18408624 PMID:31324950
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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Bhlhe40
basic helix-loop-helix family, member e40
increases expression
ISO
Chlorpromazine analog results in increased expression of BHLHE40 mRNA
CTD
PMID:15924885
NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886
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Birc2
baculoviral IAP repeat-containing 2
decreases expression
ISO
Chlorpromazine results in decreased expression of BIRC2 mRNA
CTD
PMID:30703373
NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of BIRC5 mRNA; Chlorpromazine results in decreased expression of BIRC5 mRNA
CTD
PMID:15924885 PMID:30703373
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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Bnip3
BCL2/adenovirus E1B interacting protein 3
increases expression
ISO
Chlorpromazine results in increased expression of BNIP3 mRNA
CTD
PMID:25596134
NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
Chlorpromazine analog results in increased expression of BTG2 mRNA
CTD
PMID:15924885
NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
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Btg3
BTG anti-proliferation factor 3
increases expression
ISO
Chlorpromazine analog results in increased expression of BTG3 mRNA
CTD
PMID:15924885
NCBI chr16:78,156,748...78,174,069
Ensembl chr16:78,129,525...78,174,080
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C3
complement component 3
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA
CTD
PMID:27344345
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
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C6
complement component 6
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of C6 mRNA
CTD
PMID:27344345
NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449
G
Calcr
calcitonin receptor
multiple interactions
EXP
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]
CTD
PMID:21869564
NCBI chr 6:3,685,678...3,764,713
Ensembl chr 6:3,685,680...3,764,714
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Calr
calreticulin
decreases expression
ISO
Chlorpromazine results in decreased expression of CALR mRNA
CTD
PMID:18246545
NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
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Car2
carbonic anhydrase 2
multiple interactions
EXP
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]
CTD
PMID:21869564
NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
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Cat
catalase
multiple interactions decreases expression decreases activity
ISO
carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; zolpidem inhibits the reaction [Chlorpromazine results in decreased activity of CAT]
CTD
PMID:12010767 PMID:17513028 PMID:25449126
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
G
Ccn2
cellular communication network factor 2
decreases expression
ISO
Chlorpromazine results in decreased expression of CCN2 mRNA; Chlorpromazine results in decreased expression of CCN2 protein
CTD
PMID:30703373
NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
G
Ccn3
cellular communication network factor 3
affects expression
ISO
Chlorpromazine affects the expression of CCN3 mRNA
CTD
PMID:31324950
NCBI chr15:54,609,306...54,617,158
Ensembl chr15:54,609,098...54,617,435
G
Ccnb2
cyclin B2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCNB2 mRNA; Chlorpromazine results in decreased expression of CCNB2 mRNA
CTD
PMID:15924885
NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
G
Ccnd1
cyclin D1
decreases expression
ISO
Chlorpromazine results in decreased expression of CCND1 mRNA
CTD
PMID:17202759
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
G
Ccnd3
cyclin D3
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCND3 mRNA
CTD
PMID:15924885
NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616
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Ccnf
cyclin F
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CCNF mRNA
CTD
PMID:15924885
NCBI chr17:24,441,518...24,470,333
Ensembl chr17:24,441,172...24,470,458
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Cd274
CD274 antigen
multiple interactions
ISO
Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein]
CTD
PMID:31150782
NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495
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Cd44
CD44 antigen
multiple interactions decreases expression
EXP ISO
Chlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein] Chlorpromazine results in decreased expression of CD44 protein
CTD
PMID:9929743 PMID:30703373
NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
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Cd86
CD86 antigen
increases expression
ISO
Chlorpromazine results in increased expression of CD86 protein
CTD
PMID:19665512
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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Cdk5
cyclin dependent kinase 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CDK5 mRNA
CTD
PMID:15924885
NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
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Cdk7
cyclin dependent kinase 7
increases expression
ISO
Chlorpromazine analog results in increased expression of CDK7 mRNA
CTD
PMID:15924885
NCBI chr13:100,833,532...100,867,454
Ensembl chr13:100,839,139...100,867,447
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Cdkn1a
cyclin dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]
CTD
PMID:20368687
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cdkn2c
cyclin dependent kinase inhibitor 2C
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CDKN2C mRNA
CTD
PMID:15924885
NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
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Ces2h
carboxylesterase 2H
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CES2 mRNA
CTD
PMID:27344345
NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
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Cfh
complement component factor h
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA
CTD
PMID:27344345
NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502
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Cgref1
cell growth regulator with EF hand domain 1
decreases expression
ISO
Chlorpromazine results in decreased expression of CGREF1 mRNA
CTD
PMID:17202759
NCBI chr 5:31,090,487...31,102,771
Ensembl chr 5:31,090,487...31,102,935
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Chtf18
CTF18, chromosome transmission fidelity factor 18
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CHTF18 mRNA
CTD
PMID:15924885
NCBI chr17:25,938,004...25,946,409
Ensembl chr17:25,937,900...25,946,393
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Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
decreases expression
ISO
Chlorpromazine results in decreased expression of CITED2 mRNA
CTD
PMID:18246545
NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422
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Cks2
CDC28 protein kinase regulatory subunit 2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of CKS2 mRNA
CTD
PMID:15924885
NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
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Clcf1
cardiotrophin-like cytokine factor 1
increases expression
EXP
Chlorpromazine results in increased expression of CLCF1 mRNA
CTD
PMID:21683644
NCBI chr19:4,264,479...4,273,548
Ensembl chr19:4,264,292...4,273,544
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Col18a1
collagen, type XVIII, alpha 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA
CTD
PMID:27344345
NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382
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Col1a1
collagen, type I, alpha 1
increases expression
EXP
Chlorpromazine results in increased expression of COL1A1 mRNA
CTD
PMID:35708773
NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
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Col4a1
collagen, type IV, alpha 1
decreases expression
ISO
Chlorpromazine results in decreased expression of COL4A1 mRNA
CTD
PMID:25596134
NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826
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Cort
cortistatin
affects expression
ISO
Chlorpromazine affects the expression of CORT mRNA
CTD
PMID:31324950
NCBI chr 4:149,209,491...149,211,132
Ensembl chr 4:149,209,491...149,211,220
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Cox8a
cytochrome c oxidase subunit 8A
affects expression increases expression
ISO
Chlorpromazine affects the expression of COX8A mRNA Chlorpromazine results in increased expression of COX8A mRNA
CTD
PMID:18246545
NCBI chr19:7,192,523...7,194,981
Ensembl chr19:7,192,518...7,194,981
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Crh
corticotropin releasing hormone
decreases expression
ISO
Chlorpromazine results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
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Cth
cystathionine gamma lyase
decreases expression
ISO
Chlorpromazine results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714
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Ctsk
cathepsin K
multiple interactions
EXP
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]
CTD
PMID:21869564
NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673
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Cxcl15
C-X-C motif chemokine ligand 15
increases expression multiple interactions
ISO
Chlorpromazine results in increased expression of CXCL8 mRNA [Chlorpromazine co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA
CTD
PMID:29594315
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity decreases response to substance increases expression
ISO
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Chlorpromazine results in decreased activity of CYP1A1 protein CYP1A1 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in increased expression of CYP1A1 mRNA
CTD
PMID:17202759 PMID:18246545 PMID:18493746 PMID:25596134 PMID:26477383 PMID:29724254 PMID:33814510 More...
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases response to substance increases expression increases oxidation affects expression decreases methylation
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine CYP1A2 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in increased expression of CYP1A2 mRNA CYP1A2 protein results in increased oxidation of Chlorpromazine Chlorpromazine affects the expression of CYP1A2 mRNA CYP1A2 protein results in decreased methylation of Chlorpromazine
CTD
PMID:18246545 PMID:18493746 PMID:19482014 PMID:20615392 PMID:23397584 PMID:25596134 PMID:26477383 PMID:27344345 More...
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases response to substance decreases activity multiple interactions
ISO
CYP1B1 protein results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of CYP1B1 protein [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
CTD
PMID:26477383 PMID:29724254 PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
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Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
decreases activity decreases response to substance
ISO
Chlorpromazine results in decreased activity of CYP2A6 protein CYP2A6 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:15135088 PMID:26477383
NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
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Cyp2b10
cytochrome P450, family 2, subfamily b, polypeptide 10
multiple interactions decreases response to substance
EXP ISO
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA] CYP2B6 protein results in decreased susceptibility to Chlorpromazine [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
CTD
PMID:10037683 PMID:12049174 PMID:17041008 PMID:26477383
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
decreases response to substance
ISO
CYP2C8 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:26477383
NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
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Cyp2c38
cytochrome P450, family 2, subfamily c, polypeptide 38
decreases activity decreases response to substance affects methylation multiple interactions
ISO
Chlorpromazine results in decreased activity of CYP2C19 protein CYP2C19 protein results in decreased susceptibility to Chlorpromazine CYP2C19 protein affects the methylation of Chlorpromazine [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CTD
PMID:15135088 PMID:20615392 PMID:23397584 PMID:26477383
NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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Cyp2c52-ps
cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene
decreases expression decreases response to substance
ISO
Chlorpromazine results in decreased expression of CYP2C mRNA; Chlorpromazine results in decreased expression of CYP2C11 mRNA CYP2C18 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:18246545 PMID:26477383
NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
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Cyp2c65
cytochrome P450, family 2, subfamily c, polypeptide 65
decreases activity multiple interactions decreases response to substance
ISO
Chlorpromazine results in decreased activity of CYP2C9 protein [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine CYP2C9 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:15135088 PMID:23397584 PMID:26477383
NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
multiple interactions decreases response to substance
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine CYP2D6 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:19482014 PMID:23397584 PMID:26477383
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity decreases response to substance
ISO
Chlorpromazine results in decreased activity of CYP2E1 protein CYP2E1 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:15135088 PMID:26477383
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
multiple interactions
EXP
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]
CTD
PMID:12049174
NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
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Cyp3a13
cytochrome P450, family 3, subfamily a, polypeptide 13
decreases response to substance
ISO
CYP3A7 protein results in decreased susceptibility to Chlorpromazine CYP3A5 protein results in decreased susceptibility to Chlorpromazine
CTD
PMID:26477383
NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
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Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA
CTD
PMID:27344345
NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371
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Dao
D-amino acid oxidase
decreases activity
ISO
Chlorpromazine results in decreased activity of DAO protein
CTD
PMID:18615285
NCBI chr 5:114,137,696...114,163,736
Ensembl chr 5:114,141,764...114,163,743
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Dcstamp
dendrocyte expressed seven transmembrane protein
multiple interactions
EXP
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]
CTD
PMID:21869564
NCBI chr15:39,609,326...39,624,334
Ensembl chr15:39,609,326...39,624,334
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Chlorpromazine results in increased expression of DDIT3 mRNA
CTD
PMID:25596134
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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Depp1
DEPP1 autophagy regulator
increases expression
ISO
Chlorpromazine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755
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Drd1
dopamine receptor D1
decreases activity
ISO
Chlorpromazine results in decreased activity of DRD1 protein
CTD
PMID:23611293
NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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Drd2
dopamine receptor D2
decreases response to substance decreases activity
ISO
DRD2 polymorphism results in decreased susceptibility to Chlorpromazine Chlorpromazine results in decreased activity of DRD2 protein
CTD
PMID:15694263 PMID:23611293
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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Dusp1
dual specificity phosphatase 1
increases expression affects expression
ISO EXP
Chlorpromazine analog results in increased expression of DUSP1 mRNA Chlorpromazine affects the expression of DUSP1 mRNA
CTD
PMID:15924885 PMID:20843724
NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
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Dusp9
dual specificity phosphatase 9
decreases expression
ISO
Chlorpromazine analog results in decreased expression of DUSP9 mRNA
CTD
PMID:15924885
NCBI chr X:72,682,995...72,687,120
Ensembl chr X:72,683,025...72,687,120
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E2f1
E2F transcription factor 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of E2F1 mRNA
CTD
PMID:15924885
NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
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Egr1
early growth response 1
increases expression multiple interactions
ISO
Chlorpromazine results in increased expression of EGR1 [EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]; MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD
PMID:20368687
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
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Eif1
eukaryotic translation initiation factor 1
increases expression
ISO
Chlorpromazine results in increased expression of EIF1 mRNA
CTD
PMID:25596134
NCBI chr11:100,210,775...100,212,925
Ensembl chr11:100,210,711...100,212,922
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Eno2
enolase 2, gamma neuronal
increases expression
ISO
Chlorpromazine results in increased expression of ENO2 mRNA
CTD
PMID:25596134
NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
Chlorpromazine results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228
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F2
coagulation factor II
decreases expression
ISO
Chlorpromazine analog results in decreased expression of F2 mRNA
CTD
PMID:15924885
NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
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Fabp1
fatty acid binding protein 1, liver
increases expression
ISO
Chlorpromazine results in increased expression of FABP1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
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Fas
Fas cell surface death receptor
increases expression
ISO
Chlorpromazine analog results in increased expression of FAS mRNA
CTD
PMID:15924885
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Fbp1
fructose bisphosphatase 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FBP1 mRNA
CTD
PMID:27344345
NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096
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Fbxo22
F-box protein 22
decreases expression
ISO
Chlorpromazine results in decreased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 9:55,116,219...55,131,717
Ensembl chr 9:55,116,209...55,131,717
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Fech
ferrochelatase
decreases expression
ISO
Chlorpromazine results in decreased expression of FECH mRNA
CTD
PMID:25596134
NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322
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Fetub
fetuin beta
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FETUB mRNA
CTD
PMID:27344345
NCBI chr16:22,737,132...22,758,518
Ensembl chr16:22,737,084...22,758,528
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Fga
fibrinogen alpha chain
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA
CTD
PMID:27344345
NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934
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Fgf2
fibroblast growth factor 2
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FGF2 mRNA
CTD
PMID:27344345
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
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Fgfr1
fibroblast growth factor receptor 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of FGFR1 mRNA
CTD
PMID:15924885
NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
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Fgr
FGR proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
Chlorpromazine results in decreased expression of FGR mRNA
CTD
PMID:25596134
NCBI chr 4:132,701,406...132,729,204
Ensembl chr 4:132,701,406...132,729,221
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Fkbp5
FK506 binding protein 5
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein]
CTD
PMID:21034739
NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
Chlorpromazine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 5:31,449,589...31,453,279
Ensembl chr 5:31,449,586...31,453,424
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Fos
FBJ osteosarcoma oncogene
affects expression
EXP
Chlorpromazine affects the expression of FOS mRNA
CTD
PMID:20843724
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Fosb
FBJ osteosarcoma oncogene B
affects expression
EXP
Chlorpromazine affects the expression of FOSB mRNA
CTD
PMID:20843724
NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
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Fosl1
fos-like antigen 1
increases expression affects expression
ISO EXP
Chlorpromazine analog results in increased expression of FOSL1 mRNA Chlorpromazine affects the expression of FOSL1 mRNA
CTD
PMID:15924885 PMID:20843724
NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
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Fosl2
fos-like antigen 2
affects expression
EXP
Chlorpromazine affects the expression of FOSL2 mRNA
CTD
PMID:20843724
NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186
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Fth1
ferritin heavy polypeptide 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of FTH1 mRNA
CTD
PMID:27344345
NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
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G6pdx
glucose-6-phosphate dehydrogenase X-linked
decreases expression multiple interactions decreases activity
ISO
Chlorpromazine analog results in decreased expression of G6PD mRNA [Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]
CTD
PMID:15924885 PMID:33548410
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
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Gad1
glutamate decarboxylase 1
decreases methylation multiple interactions
EXP
Chlorpromazine results in decreased methylation of GAD1 promoter Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]
CTD
PMID:19110320
NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
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Gcgr
glucagon receptor
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of GCGR mRNA
CTD
PMID:27344345
NCBI chr11:120,420,011...120,429,815
Ensembl chr11:120,421,525...120,429,812
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Gclc
glutamate-cysteine ligase, catalytic subunit
decreases expression
ISO
Chlorpromazine results in decreased expression of GCLC mRNA
CTD
PMID:25596134
NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
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Gdf15
growth differentiation factor 15
increases expression
ISO
Chlorpromazine results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
Chlorpromazine results in increased expression of GDPD3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 7:126,365,586...126,374,817
Ensembl chr 7:126,365,506...126,374,821
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Gfap
glial fibrillary acidic protein
affects expression
ISO
Chlorpromazine affects the expression of GFAP mRNA
CTD
PMID:31324950
NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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Gpnmb
glycoprotein (transmembrane) nmb
increases expression
ISO
Chlorpromazine results in increased expression of GPNMB mRNA
CTD
PMID:25596134
NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863
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Gpt
glutamic pyruvic transaminase, soluble
increases expression
ISO
Chlorpromazine results in increased expression of GPT protein
CTD
PMID:35722787
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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Gsr
glutathione reductase
decreases activity
ISO
Chlorpromazine results in decreased activity of GSR protein
CTD
PMID:6693892
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
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Hif1a
hypoxia inducible factor 1, alpha subunit
affects activity
ISO
Chlorpromazine affects the activity of HIF1A protein
CTD
PMID:25596134
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
increases expression
ISO
Chlorpromazine results in increased expression of HMGCR mRNA
CTD
PMID:17052361
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
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Hmgcs1
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
increases expression
ISO
Chlorpromazine results in increased expression of HMGCS1 mRNA
CTD
PMID:17052361
NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
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Hmox1
heme oxygenase 1
increases expression affects expression
ISO
Chlorpromazine results in increased expression of HMOX1 mRNA Chlorpromazine affects the expression of HMOX1 mRNA
CTD
PMID:15924885 PMID:25596134 PMID:31324950
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Hpn
hepsin
increases expression
ISO
Chlorpromazine results in increased expression of HPN mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 7:30,798,150...30,814,751
Ensembl chr 7:30,798,150...30,814,715
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Hspa2
heat shock protein 2
decreases expression increases expression
ISO
Chlorpromazine results in decreased expression of HSPA2 mRNA; Chlorpromazine results in decreased expression of HSPA2 protein Chlorpromazine results in increased expression of HSPA2 mRNA
CTD
PMID:36751017
NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712
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Hspb1
heat shock protein 1
decreases expression increases expression
ISO
Chlorpromazine results in decreased expression of HSPB1 mRNA Chlorpromazine results in increased expression of HSPB1 mRNA
CTD
PMID:36751017
NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417
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Hspd1
heat shock protein 1 (chaperonin)
increases expression
ISO
Chlorpromazine results in increased expression of HSPD1 mRNA
CTD
PMID:36751017
NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
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Hspe1
heat shock protein 1 (chaperonin 10)
increases expression
ISO
Chlorpromazine results in increased expression of HSPE1 mRNA
CTD
PMID:36751017
NCBI chr 1:55,127,307...55,130,476
Ensembl chr 1:55,127,291...55,130,466
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Ibsp
integrin binding sialoprotein
decreases expression multiple interactions
ISO
Chlorpromazine results in decreased expression of IBSP mRNA herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]; U 0126 inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]
CTD
PMID:16294319
NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335
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Ifnb1
interferon beta 1, fibroblast
multiple interactions
ISO
Chlorpromazine promotes the reaction [PAM2-CSK4 results in increased expression of IFNB1 mRNA]
CTD
PMID:32796029
NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
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Ifng
interferon gamma
multiple interactions
ISO
[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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Ifnlr1
interferon lambda receptor 1
increases expression
EXP
Chlorpromazine results in increased expression of IFNLR1 mRNA
CTD
PMID:21683644
NCBI chr 4:135,413,513...135,435,492
Ensembl chr 4:135,413,598...135,435,492
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Igfbp1
insulin-like growth factor binding protein 1
increases expression
ISO
Chlorpromazine results in increased expression of IGFBP1 mRNA
CTD
PMID:15924885
NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546
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Ikbkg
inhibitor of kappaB kinase gamma
increases expression
ISO
Chlorpromazine analog results in increased expression of IKBKG mRNA
CTD
PMID:15924885
NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine
CTD
PMID:19362101
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Il1b
interleukin 1 beta
decreases expression
ISO
Chlorpromazine results in decreased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Il2
interleukin 2
multiple interactions
ISO
[Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11014349 PMID:29594315
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
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Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine
CTD
PMID:19362101
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Inhbe
inhibin beta-E
increases expression
ISO
Chlorpromazine results in increased expression of INHBE mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280
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Ins1
insulin I
decreases secretion
ISO
Chlorpromazine results in decreased secretion of INS1 protein
CTD
PMID:18308779
NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
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Insig2
insulin induced gene 2
decreases expression
ISO
Chlorpromazine results in decreased expression of INSIG2 mRNA
CTD
PMID:25596134
NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318
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Irs2
insulin receptor substrate 2
multiple interactions
ISO
Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein; Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein
CTD
PMID:17512020 PMID:18308779
NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
multiple interactions decreases activity
ISO
Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Chlorpromazine results in decreased activity of KCNH2 protein
CTD
PMID:15071359 PMID:21158687 PMID:24052561
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
decreases activity
ISO
Chlorpromazine results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950
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Klf4
Kruppel-like transcription factor 4 (gut)
multiple interactions decreases expression
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA Chlorpromazine results in decreased expression of KLF4 mRNA
CTD
PMID:27344345 PMID:30703373
NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466
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Klkb1
kallikrein B, plasma 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA
CTD
PMID:27344345
NCBI chr 8:45,719,725...45,747,872
Ensembl chr 8:45,719,726...45,747,896
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Kng1
kininogen 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of KNG1 mRNA
CTD
PMID:27344345
NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
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Lats1
large tumor suppressor
increases phosphorylation
ISO
Chlorpromazine results in increased phosphorylation of LATS1 protein
CTD
PMID:30703373
NCBI chr10:7,556,964...7,592,225
Ensembl chr10:7,556,978...7,592,224
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Ldhc
lactate dehydrogenase C
multiple interactions decreases activity
ISO
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]
CTD
PMID:33548410
NCBI chr 7:46,510,687...46,527,571
Ensembl chr 7:46,510,627...46,527,566
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Ldlr
low density lipoprotein receptor
increases expression
ISO
Chlorpromazine results in increased expression of LDLR mRNA
CTD
PMID:17052361
NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
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Lep
leptin
increases expression
ISO
Chlorpromazine results in increased expression of LEP protein
CTD
PMID:17512020
NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
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Lss
lanosterol synthase
increases expression
ISO
Chlorpromazine results in increased expression of LSS mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972
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Map2
microtubule-associated protein 2
increases expression
ISO
Chlorpromazine results in increased expression of MAP2 mRNA
CTD
PMID:15079866
NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
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Mapk1
mitogen-activated protein kinase 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein] MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD
PMID:11014349 PMID:20368687
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk14
mitogen-activated protein kinase 14
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MAPK14 mRNA
CTD
PMID:15924885
NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
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Mapk3
mitogen-activated protein kinase 3
decreases expression multiple interactions
ISO
Chlorpromazine analog results in decreased expression of MAPK3 mRNA MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1] Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11014349 PMID:15924885 PMID:20368687
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]
CTD
PMID:23238562
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mapkapk2
MAP kinase-activated protein kinase 2
increases expression
ISO
Chlorpromazine results in increased expression of MAPKAPK2 mRNA
CTD
PMID:19441803
NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563
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Mcm3
minichromosome maintenance complex component 3
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MCM3 mRNA
CTD
PMID:15924885
NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536
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Mcm5
minichromosome maintenance complex component 5
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MCM5 mRNA
CTD
PMID:15924885
NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067
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Mdm2
transformed mouse 3T3 cell double minute 2
increases expression
ISO
Chlorpromazine results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
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Mitf
melanogenesis associated transcription factor
increases expression
ISO
Chlorpromazine results in increased expression of MITF protein
CTD
PMID:25449126
NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310
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Mki67
antigen identified by monoclonal antibody Ki 67
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MKI67 mRNA
CTD
PMID:15924885
NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]
CTD
PMID:25200491
NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
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Msc
musculin
decreases expression
ISO
Chlorpromazine results in decreased expression of MSC mRNA
CTD
PMID:25596134
NCBI chr 1:14,823,570...14,826,216
Ensembl chr 1:14,823,570...14,826,216
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Msh2
mutS homolog 2
decreases expression
ISO
Chlorpromazine results in decreased expression of MSH2 mRNA
CTD
PMID:15924885
NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
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Mst1
macrophage stimulating 1 (hepatocyte growth factor-like)
increases phosphorylation
ISO
Chlorpromazine results in increased phosphorylation of MST1 protein
CTD
PMID:30703373
NCBI chr 9:107,957,607...107,962,226
Ensembl chr 9:107,957,635...107,962,202
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Mybl2
myeloblastosis oncogene-like 2
decreases expression
ISO
Chlorpromazine analog results in decreased expression of MYBL2 mRNA
CTD
PMID:15924885
NCBI chr 2:162,896,246...162,926,608
Ensembl chr 2:162,896,607...162,926,608
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Myc
myelocytomatosis oncogene
decreases expression
ISO
Chlorpromazine results in decreased expression of MYC mRNA
CTD
PMID:30703373
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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Nampt
nicotinamide phosphoribosyltransferase
increases expression
ISO
Chlorpromazine results in increased expression of NAMPT mRNA
CTD
PMID:25596134
NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348
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Nanog
Nanog homeobox
decreases expression
ISO
Chlorpromazine results in decreased expression of NANOG mRNA
CTD
PMID:30703373
NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592
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Ndufs3
NADH:ubiquinone oxidoreductase core subunit S3
decreases expression
ISO
Chlorpromazine results in decreased expression of NDUFS3 protein
CTD
PMID:19441803
NCBI chr 2:90,724,971...90,735,065
Ensembl chr 2:90,724,978...90,735,171
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Nectin2
nectin cell adhesion molecule 2
multiple interactions
EXP
Chlorpromazine inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein]
CTD
PMID:25046863
NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408
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Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
decreases expression
ISO
Chlorpromazine results in decreased expression of NEDD9 mRNA
CTD
PMID:25596134
NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838
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Nefh
neurofilament, heavy polypeptide
affects expression
ISO
Chlorpromazine affects the expression of NEFH mRNA
CTD
PMID:31324950
NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
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Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
multiple interactions
EXP
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:21869564
NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
decreases expression affects activity
ISO
Chlorpromazine results in decreased expression of NFE2L2 mRNA Chlorpromazine affects the activity of NFE2L2 protein
CTD
PMID:25596134
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Ninj1
ninjurin 1
increases expression
ISO
Chlorpromazine results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720
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Nppb
natriuretic peptide type B
increases expression
ISO
Chlorpromazine results in increased expression of NPPB protein
CTD
PMID:36751017
NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Chlorpromazine results in increased expression of NR0B2 mRNA
CTD
PMID:17175557
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
decreases expression
ISO
Chlorpromazine results in decreased expression of NR1H4 mRNA
CTD
PMID:27765674 PMID:28391356
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases expression multiple interactions
ISO
Chlorpromazine analog results in increased expression of NR1I2 mRNA [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD
PMID:15924885 PMID:17041008
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity increases expression multiple interactions
EXP ISO
Chlorpromazine results in increased activity of NR1I3 protein Chlorpromazine results in increased expression of NR1I3 mRNA [Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]] NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]
CTD
PMID:10037683 PMID:12049174 PMID:12948398 PMID:17041008 PMID:22310298 PMID:27344345 More...
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
EXP
Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]
CTD
PMID:16581232
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Nupr1
nuclear protein transcription regulator 1
increases expression
ISO
Chlorpromazine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
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Orc1
origin recognition complex, subunit 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of ORC1 mRNA
CTD
PMID:15924885
NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
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Orm1
orosomucoid 1
affects binding multiple interactions
ISO
Chlorpromazine binds to ORM1 protein alternative form Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
CTD
PMID:8946472
NCBI chr 4:63,262,793...63,266,400
Ensembl chr 4:63,262,797...63,266,400
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Orm2
orosomucoid 2
affects binding multiple interactions
ISO
Chlorpromazine binds to ORM2 protein alternative form Chlorpromazine inhibits the reaction [Imipramine binds to ORM2 protein alternative form]
CTD
PMID:8946472
NCBI chr 4:63,280,543...63,284,114
Ensembl chr 4:63,280,686...63,284,115
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Pdia2
protein disulfide isomerase associated 2
increases expression
ISO
Chlorpromazine analog results in increased expression of PDIA2 mRNA
CTD
PMID:15924885
NCBI chr17:26,414,973...26,418,108
Ensembl chr17:26,414,973...26,418,061
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Pdia5
protein disulfide isomerase associated 5
decreases expression
ISO
Chlorpromazine results in decreased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr16:35,217,678...35,311,289
Ensembl chr16:35,217,682...35,311,243
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Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
increases expression
ISO
Chlorpromazine results in increased expression of PDK1 mRNA
CTD
PMID:25596134
NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
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Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
increases expression
ISO
Chlorpromazine results in increased expression of PDK4 mRNA
CTD
PMID:25596134
NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
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Phyh
phytanoyl-CoA hydroxylase
increases expression
ISO
Chlorpromazine results in increased expression of PHYH mRNA
CTD
PMID:15342952
NCBI chr 2:4,923,807...4,943,554
Ensembl chr 2:4,923,830...4,943,541
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Pias1
protein inhibitor of activated STAT 1
increases expression
EXP
Chlorpromazine results in increased expression of PIAS1 mRNA
CTD
PMID:21683644
NCBI chr 9:62,785,648...62,888,161
Ensembl chr 9:62,785,650...62,895,206
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Pim1
proviral integration site 1
increases expression
ISO
Chlorpromazine analog results in increased expression of PIM1 mRNA
CTD
PMID:15924885
NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086
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Pir
pirin
decreases expression
ISO
Chlorpromazine results in decreased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007
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Plin2
perilipin 2
increases expression
ISO
Chlorpromazine results in increased expression of PLIN2 mRNA
CTD
PMID:25596134
NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
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Pmepa1
prostate transmembrane protein, androgen induced 1
decreases expression
ISO
Chlorpromazine results in decreased expression of PMEPA1 mRNA
CTD
PMID:25596134
NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326
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Pola1
polymerase (DNA directed), alpha 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of POLA1 mRNA
CTD
PMID:15924885
NCBI chr X:92,348,372...92,675,993
Ensembl chr X:92,348,373...92,675,761
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Pold4
polymerase (DNA-directed), delta 4
increases expression
ISO
Chlorpromazine analog results in increased expression of POLD4 mRNA
CTD
PMID:15924885
NCBI chr19:4,281,947...4,283,688
Ensembl chr19:4,281,953...4,283,688
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Pou5f1
POU domain, class 5, transcription factor 1
decreases expression
ISO
Chlorpromazine results in decreased expression of POU5F1 mRNA
CTD
PMID:30703373
NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
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Pparg
peroxisome proliferator activated receptor gamma
affects activity
ISO
Chlorpromazine affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
Chlorpromazine results in increased expression of PPP1R15A mRNA
CTD
PMID:25596134
NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692
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Prkaa1
protein kinase, AMP-activated, alpha 1 catalytic subunit
decreases phosphorylation
ISO
Chlorpromazine results in decreased phosphorylation of PRKAA1 protein
CTD
PMID:17512020
NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
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Prl
prolactin
increases expression
ISO
Chlorpromazine results in increased expression of PRL protein
CTD
PMID:718334 PMID:996201
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Rara
retinoic acid receptor, alpha
decreases expression
ISO
Chlorpromazine results in decreased expression of RARA mRNA
CTD
PMID:18246545
NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768
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Rnd1
Rho family GTPase 1
decreases expression
ISO
Chlorpromazine results in decreased expression of RND1 mRNA
CTD
PMID:25596134
NCBI chr15:98,567,086...98,575,342
Ensembl chr15:98,561,302...98,575,342
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Rnd3
Rho family GTPase 3
decreases expression
ISO
Chlorpromazine results in decreased expression of RND3 mRNA
CTD
PMID:25596134
NCBI chr 2:51,020,451...51,039,123
Ensembl chr 2:51,020,450...51,039,123
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Rnf121
ring finger protein 121
decreases expression
ISO
Chlorpromazine results in decreased expression of RNF121 mRNA
CTD
PMID:25596134
NCBI chr 7:101,668,344...101,721,712
Ensembl chr 7:101,668,344...101,714,676
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Runx1
runt related transcription factor 1
increases expression
ISO
Chlorpromazine results in increased expression of RUNX1 mRNA
CTD
PMID:25596134
NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037
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Rxrg
retinoid X receptor gamma
affects response to substance
EXP
RXRG protein affects the susceptibility to Chlorpromazine
CTD
PMID:10336693
NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192
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Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
ISO
Chlorpromazine results in increased expression of SAT1 mRNA
CTD
PMID:25596134
NCBI chr X:153,996,128...153,999,345
Ensembl chr X:153,996,128...153,999,445
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Chlorpromazine results in increased expression of SC5D mRNA
CTD
PMID:17052361
NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552
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Serpina3b
serine (or cysteine) peptidase inhibitor, clade A, member 3B
increases expression
ISO
Chlorpromazine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804
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Serpinh1
serine (or cysteine) peptidase inhibitor, clade H, member 1
increases expression
EXP
Chlorpromazine results in increased expression of SERPINH1 mRNA
CTD
PMID:35708773
NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446
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Sesn1
sestrin 1
decreases expression
ISO
Chlorpromazine results in decreased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420
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Sik1
salt inducible kinase 1
decreases expression
ISO
Chlorpromazine results in decreased expression of SIK1 mRNA
CTD
PMID:25596134
NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778
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Slc10a1
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
decreases expression increases expression
ISO EXP
Chlorpromazine results in decreased expression of SLC10A1 mRNA Chlorpromazine results in increased expression of SLC10A1 mRNA
CTD
PMID:27765674 PMID:28391356 PMID:35708773
NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
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Slc12a8
solute carrier family 12 (potassium/chloride transporters), member 8
increases expression
ISO
Chlorpromazine results in increased expression of SLC12A8 mRNA
CTD
PMID:25596134
NCBI chr16:33,337,440...33,484,508
Ensembl chr16:33,337,698...33,484,505
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Slc19a1
solute carrier family 19 (folate transporter), member 1
multiple interactions decreases activity
ISO
Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate] Chlorpromazine results in decreased activity of SLC19A1 protein
CTD
PMID:17482559
NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836
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Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
increases expression
ISO
Chlorpromazine results in increased expression of SLC1A5 mRNA
CTD
PMID:25596134
NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Chlorpromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc22a7
solute carrier family 22 (organic anion transporter), member 7
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA
CTD
PMID:27344345
NCBI chr17:46,743,111...46,749,403
Ensembl chr17:46,743,109...46,749,383
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Slc2a3
solute carrier family 2 (facilitated glucose transporter), member 3
decreases expression
ISO
Chlorpromazine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599
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Slc31a1
solute carrier family 31, member 1
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]
CTD
PMID:12501239
NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006
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Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
increases expression
ISO
Chlorpromazine results in increased expression of SLC3A2 mRNA
CTD
PMID:25596134
NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
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Slc51b
solute carrier family 51, beta subunit
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC51B mRNA
CTD
PMID:27344345
NCBI chr 9:65,320,035...65,330,055
Ensembl chr 9:65,319,996...65,330,237
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Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
increases expression
ISO
Chlorpromazine results in increased expression of SLC6A6 mRNA
CTD
PMID:25596134
NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047
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Slco2b1
solute carrier organic anion transporter family, member 2b1
decreases expression
ISO
Chlorpromazine results in decreased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547
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Sod1
superoxide dismutase 1, soluble
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]
CTD
PMID:22362149
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Sox2
SRY (sex determining region Y)-box 2
decreases expression
ISO
Chlorpromazine results in decreased expression of SOX2 mRNA
CTD
PMID:30703373
NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610
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Spp1
secreted phosphoprotein 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA
CTD
PMID:27344345
NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
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Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
ISO
Chlorpromazine results in increased expression of SPSB1 mRNA
CTD
PMID:25596134
NCBI chr 4:149,980,740...150,039,494
Ensembl chr 4:149,980,740...150,039,500
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Src
Rous sarcoma oncogene
multiple interactions
ISO
Chlorpromazine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of SRC protein]
CTD
PMID:29702141
NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
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Srebf2
sterol regulatory element binding factor 2
multiple interactions
ISO
Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein
CTD
PMID:17052361
NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
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Strbp
spermatid perinuclear RNA binding protein
increases expression
ISO
Chlorpromazine results in increased expression of STRBP mRNA
CTD
PMID:25596134
NCBI chr 2:37,459,880...37,593,890
Ensembl chr 2:37,373,240...37,593,871
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Sts
steroid sulfatase
multiple interactions
ISO
Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein]
CTD
PMID:16178010
NCBI chr X:168,856,332...169,015,037
Ensembl chr X:168,909,030...169,014,924
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Tagln
transgelin
decreases expression
ISO
Chlorpromazine results in decreased expression of TAGLN mRNA
CTD
PMID:17175557
NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
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Tfdp1
transcription factor Dp 1
decreases expression
ISO
Chlorpromazine analog results in decreased expression of TFDP1 mRNA
CTD
PMID:15924885
NCBI chr 8:13,388,273...13,428,448
Ensembl chr 8:13,388,751...13,428,448
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
Chlorpromazine results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939
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Tirap
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
multiple interactions
EXP
TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid]
CTD
PMID:23238562
NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587
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Tnf
tumor necrosis factor
decreases expression increases response to substance multiple interactions
ISO EXP
Chlorpromazine analog results in decreased expression of TNF protein; Chlorpromazine results in decreased expression of TNF mRNA TNF protein results in increased susceptibility to Chlorpromazine [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Chlorpromazine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein] [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine; Chlorpromazine results in decreased expression of and results in decreased activity of TNF protein
CTD
PMID:8550079 PMID:15052360 PMID:19362101 PMID:20371967 PMID:22414385 PMID:23238562 More...
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tnfaip8
tumor necrosis factor, alpha-induced protein 8
increases expression
ISO
Chlorpromazine results in increased expression of TNFAIP8 mRNA
CTD
PMID:25596134
NCBI chr18:50,112,494...50,226,296
Ensembl chr18:50,112,494...50,240,240
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Tnfrsf14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
increases expression
ISO
Chlorpromazine analog results in increased expression of TNFRSF14 mRNA
CTD
PMID:15924885
NCBI chr 4:155,002,944...155,013,077
Ensembl chr 4:155,006,390...155,013,020
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Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
decreases activity multiple interactions
EXP
Chlorpromazine results in decreased activity of TNFSF11; Chlorpromazine results in decreased activity of TNFSF11 protein Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:21869564
NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
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Trafd1
TRAF type zinc finger domain containing 1
decreases expression
ISO
Chlorpromazine results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr 5:121,509,788...121,524,543
Ensembl chr 5:121,509,788...121,523,695
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Trf
transferrin
affects localization
ISO
Chlorpromazine affects the localization of TF protein
CTD
PMID:12501239
NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
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Trp53
transformation related protein 53
affects activity
ISO
Chlorpromazine affects the activity of TP53 protein
CTD
PMID:25596134
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Tuba1a
tubulin, alpha 1A
decreases expression
EXP
Chlorpromazine results in decreased expression of TUBA1A mRNA
CTD
PMID:27015953
NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584
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Txn1
thioredoxin 1
decreases expression
ISO
Chlorpromazine results in decreased expression of TXN1 mRNA
CTD
PMID:25596134
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
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Txnrd1
thioredoxin reductase 1
multiple interactions
ISO
[Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA
CTD
PMID:27344345
NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
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Tyr
tyrosinase
increases expression
ISO
Chlorpromazine results in increased expression of TYR protein
CTD
PMID:25449126
NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720
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Ung
uracil DNA glycosylase
decreases expression
ISO
Chlorpromazine analog results in decreased expression of UNG mRNA
CTD
PMID:15924885
NCBI chr 5:114,268,427...114,277,382
Ensembl chr 5:114,268,447...114,277,384
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Unkl
unkempt family like zinc finger
decreases expression
ISO
Chlorpromazine results in decreased expression of UNKL mRNA
CTD
PMID:25596134
NCBI chr17:25,407,336...25,453,417
Ensembl chr17:25,407,371...25,453,417
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
Chlorpromazine analog results in increased expression of VEGFA mRNA
CTD
PMID:15924885
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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Vegfb
vascular endothelial growth factor B
increases expression
ISO
Chlorpromazine results in increased expression of VEGFB mRNA
CTD
PMID:25596134
NCBI chr19:6,959,840...6,965,019
Ensembl chr19:6,959,841...6,965,019
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Wars1
tryptophanyl-tRNA synthetase1
increases expression
ISO
Chlorpromazine results in increased expression of WARS1 mRNA
CTD
PMID:25596134
NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
Chlorpromazine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952 PMID:17175557
NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793
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Xbp1
X-box binding protein 1
affects activity decreases expression
ISO
Chlorpromazine affects the activity of XBP1 protein Chlorpromazine results in decreased expression of XBP1 mRNA
CTD
PMID:25596134
NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
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Xpc
xeroderma pigmentosum, complementation group C
decreases expression
ISO
Chlorpromazine results in decreased expression of XPC mRNA
CTD
PMID:25596134
NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870
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Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
decreases expression
ISO
Chlorpromazine results in decreased expression of XRCC4 mRNA
CTD
PMID:15924885
NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727
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Yap1
yes-associated protein 1
multiple interactions
ISO
Chlorpromazine results in decreased expression of and results in increased phosphorylation of and affects the localization of YAP1 protein
CTD
PMID:30703373
NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
clidinium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Abhd2
abhydrolase domain containing 2
decreases expression
ISO
Clomiphene results in decreased expression of ABHD2 mRNA
CTD
PMID:26865669
NCBI chr 7:78,923,002...79,015,257
Ensembl chr 7:78,922,947...79,015,256
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Ar
androgen receptor
affects binding multiple interactions
ISO
Clomiphene binds to AR protein Clomiphene binds to and results in decreased activity of AR protein; Clomiphene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:14565775 PMID:25752796 PMID:33049310
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
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Car12
carbonic anhydrase 12
decreases expression
ISO
Clomiphene results in decreased expression of CA12 mRNA
CTD
PMID:26865669
NCBI chr 9:66,619,026...66,674,127
Ensembl chr 9:66,620,968...66,674,127
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Ccnd1
cyclin D1
decreases expression
ISO
Clomiphene results in decreased expression of CCND1 mRNA
CTD
PMID:26865669
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccng2
cyclin G2
increases expression
ISO
Clomiphene results in increased expression of CCNG2 mRNA
CTD
PMID:26865669
NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090
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Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
Clomiphene results in decreased expression of CXCL12 mRNA
CTD
PMID:26865669
NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Clomiphene results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Clomiphene results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
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Dkk1
dickkopf WNT signaling pathway inhibitor 1
decreases expression
ISO
Clomiphene results in decreased expression of DKK1 protein
CTD
PMID:21851939
NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065
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Efna1
ephrin A1
increases expression
ISO
Clomiphene results in increased expression of EFNA1 mRNA
CTD
PMID:26865669
NCBI chr 3:89,179,037...89,188,258
Ensembl chr 3:89,179,040...89,188,449
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Egr3
early growth response 3
decreases expression
ISO
Clomiphene results in decreased expression of EGR3 mRNA
CTD
PMID:26865669
NCBI chr14:70,314,766...70,320,062
Ensembl chr14:70,314,652...70,320,063
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Esr1
estrogen receptor 1 (alpha)
multiple interactions affects binding
ISO
Clomiphene binds to and results in decreased activity of ESR1 protein; Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Clomiphene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form] Clomiphene binds to ESR1 protein
CTD
PMID:9048584 PMID:15521089 PMID:19233257 PMID:25012808 PMID:25752796 PMID:26865669 PMID:33049310 More...
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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Esr2
estrogen receptor 2 (beta)
increases activity affects binding multiple interactions
ISO
Clomiphene results in increased activity of ESR2 protein Clomiphene binds to Esr2 protein Clomiphene binds to and results in decreased activity of ESR2 protein Clomiphene binds to ESR2 protein Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
CTD RGD
PMID:9048584 PMID:12224631 PMID:19211805 PMID:25752796 PMID:9048584
RGD:8694130
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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F3
coagulation factor III
increases expression
ISO
Clomiphene results in increased expression of F3 protein
CTD
PMID:25569083
NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
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F5
coagulation factor V
affects response to substance
ISO
F5 gene polymorphism affects the susceptibility to Clomiphene
CTD
PMID:19371211
NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846
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Foxc1
forkhead box C1
decreases expression
ISO
Clomiphene results in decreased expression of FOXC1 mRNA
CTD
PMID:26865669
NCBI chr13:31,990,629...31,994,618
Ensembl chr13:31,990,616...31,996,459
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Fshb
follicle stimulating hormone beta
multiple interactions increases expression
ISO
Clomiphene promotes the reaction [Alcohols results in increased expression of FSHB protein] Clomiphene results in increased expression of FSHB protein
CTD
PMID:1915937 PMID:8590623
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
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Gnrh1
gonadotropin releasing hormone 1
multiple interactions
ISO
Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]
CTD
PMID:17054466
NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
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Hoxa10
homeobox A10
decreases expression
EXP
Clomiphene results in decreased expression of HOXA10 mRNA; Clomiphene results in decreased expression of HOXA10 protein
CTD
PMID:26603317
NCBI chr 6:52,208,177...52,217,658
Ensembl chr 6:52,208,177...52,217,834
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Id3
inhibitor of DNA binding 3
increases expression
ISO
Clomiphene results in increased expression of ID3 mRNA
CTD
PMID:26865669
NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066
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Itgb3
integrin beta 3
decreases expression
ISO EXP
Clomiphene results in decreased expression of ITGB3 protein Clomiphene results in decreased expression of ITGB3 mRNA; Clomiphene results in decreased expression of ITGB3 protein
CTD
PMID:15749485 PMID:26603317
NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
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Iyd
iodotyrosine deiodinase
multiple interactions
ISO
Clomiphene inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877
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Jak2
Janus kinase 2
decreases expression
ISO
Clomiphene results in decreased expression of JAK2 mRNA
CTD
PMID:26865669
NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
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Kynu
kynureninase
increases expression
ISO
Clomiphene results in increased expression of KYNU mRNA
CTD
PMID:26865669
NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734
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Lhb
luteinizing hormone beta
increases secretion multiple interactions
ISO
Clomiphene results in increased secretion of LHB protein Clomiphene promotes the reaction [Alcohols results in increased expression of LHB protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein]
CTD
PMID:3891423 PMID:8590623
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
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Lif
leukemia inhibitory factor
increases expression decreases expression
ISO EXP
Clomiphene results in increased expression of LIF mRNA Clomiphene results in decreased expression of LIF mRNA; Clomiphene results in decreased expression of LIF protein
CTD
PMID:21851939 PMID:26603317
NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
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Myb
myeloblastosis oncogene
decreases expression
ISO
Clomiphene results in decreased expression of MYB mRNA
CTD
PMID:26865669
NCBI chr10:21,000,829...21,036,883
Ensembl chr10:21,000,834...21,036,883
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Mybl1
myeloblastosis oncogene-like 1
decreases expression
ISO
Clomiphene results in decreased expression of MYBL1 mRNA
CTD
PMID:26865669
NCBI chr 1:9,737,632...9,770,664
Ensembl chr 1:9,737,640...9,770,434
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Nmrk1
nicotinamide riboside kinase 1
decreases expression
ISO
Clomiphene results in decreased expression of NMRK1 mRNA
CTD
PMID:26865669
NCBI chr19:18,609,380...18,629,555
Ensembl chr19:18,609,314...18,629,792
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity multiple interactions
ISO EXP
Clomiphene results in increased activity of NR1I2 protein Clomiphene binds to and results in increased activity of NR1I2 protein [Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Clomiphene binds to and results in increased activity of NR1I2 protein
CTD
PMID:25455453 PMID:33049310
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Olfm1
olfactomedin 1
decreases expression
ISO
Clomiphene results in decreased expression of OLFM1 mRNA
CTD
PMID:26865669
NCBI chr 2:28,083,105...28,120,748
Ensembl chr 2:28,083,004...28,120,748
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Pdzk1
PDZ domain containing 1
decreases expression
ISO
Clomiphene results in decreased expression of PDZK1 mRNA
CTD
PMID:26865669
NCBI chr 3:96,736,772...96,778,242
Ensembl chr 3:96,736,600...96,778,242
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Pgr
progesterone receptor
increases expression multiple interactions
ISO
Clomiphene results in increased expression of PGR protein Clomiphene binds to and results in decreased activity of PGR protein
CTD
PMID:15749485 PMID:25752796
NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
increases expression
ISO
Clomiphene results in increased expression of PIK3R3 mRNA
CTD
PMID:26865669
NCBI chr 4:116,078,593...116,160,253
Ensembl chr 4:116,078,815...116,160,253 Ensembl chr 4:116,078,815...116,160,253
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Prkce
protein kinase C, epsilon
affects localization
ISO
Clomiphene affects the localization of PRKCE protein
CTD
PMID:9714066
NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
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Prl
prolactin
multiple interactions
ISO
Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]; Clomiphene inhibits the reaction [Estradiol results in increased secretion of PRL protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein]
CTD
PMID:3891423 PMID:17054466
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Prss23
serine protease 23
decreases expression
ISO
Clomiphene results in decreased expression of PRSS23 mRNA
CTD
PMID:26865669
NCBI chr 7:89,156,988...89,176,399
Ensembl chr 7:89,156,991...89,176,395
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Ptges
prostaglandin E synthase
decreases expression
ISO
Clomiphene results in decreased expression of PTGES mRNA
CTD
PMID:26865669
NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875
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Rbbp8
retinoblastoma binding protein 8, endonuclease
decreases expression
ISO
Clomiphene results in decreased expression of RBBP8 mRNA
CTD
PMID:26865669
NCBI chr18:11,766,333...11,876,264
Ensembl chr18:11,766,333...11,878,278
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Rcl1
RNA terminal phosphate cyclase-like 1
decreases expression
ISO
Clomiphene results in decreased expression of RCL1 mRNA
CTD
PMID:26865669
NCBI chr19:29,078,761...29,121,251
Ensembl chr19:29,078,775...29,121,329
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Ret
ret proto-oncogene
decreases expression
ISO
Clomiphene results in decreased expression of RET mRNA
CTD
PMID:26865669
NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679
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Sgk1
serum/glucocorticoid regulated kinase 1
decreases expression
ISO
Clomiphene results in decreased expression of SGK1 mRNA
CTD
PMID:26865669
NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802
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Sgk3
serum/glucocorticoid regulated kinase 3
decreases expression
ISO
Clomiphene results in decreased expression of SGK3 mRNA
CTD
PMID:26865669
NCBI chr 1:9,868,355...9,972,795
Ensembl chr 1:9,868,332...9,971,070
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Shbg
sex hormone binding globulin
affects binding
ISO
Clomiphene binds to SHBG protein
CTD
PMID:25349334
NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731
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Siah2
siah E3 ubiquitin protein ligase 2
decreases expression
ISO
Clomiphene results in decreased expression of SIAH2 mRNA
CTD
PMID:26865669
NCBI chr 3:58,582,370...58,599,857
Ensembl chr 3:58,582,359...58,599,821
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Smox
spermine oxidase
decreases expression
ISO
Clomiphene results in decreased expression of SMOX mRNA
CTD
PMID:26865669
NCBI chr 2:131,333,624...131,367,103
Ensembl chr 2:131,333,416...131,367,842
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Ssbp2
single-stranded DNA binding protein 2
increases expression
ISO
Clomiphene results in increased expression of SSBP2 mRNA
CTD
PMID:26865669
NCBI chr13:91,608,449...91,854,299
Ensembl chr13:91,608,402...91,851,548
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Svil
supervillin
decreases expression
ISO
Clomiphene results in decreased expression of SVIL mRNA
CTD
PMID:26865669
NCBI chr18:4,920,497...5,119,290
Ensembl chr18:4,920,540...5,119,299
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Tfap2a
transcription factor AP-2, alpha
increases expression
ISO
Clomiphene results in increased expression of TFAP2A mRNA
CTD
PMID:26865669
NCBI chr13:40,867,278...40,891,715
Ensembl chr13:40,868,778...40,891,852
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Tfap2c
transcription factor AP-2, gamma
decreases expression
ISO
Clomiphene results in decreased expression of TFAP2C mRNA
CTD
PMID:26865669
NCBI chr 2:172,387,599...172,400,542
Ensembl chr 2:172,391,513...172,400,542
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Tfpi
tissue factor pathway inhibitor
increases expression
ISO
Clomiphene results in increased expression of TFPI mRNA
CTD
PMID:26865669
NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Clomiphene binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Clomiphene binds to and results in increased activity of THRB protein
CTD
PMID:33049310
NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435
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Casp3
caspase 3
increases expression
ISO
Cyproheptadine results in increased expression of CASP3 protein
CTD
PMID:33675893
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Cyproheptadine results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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Gh
growth hormone
increases expression
ISO
Cyproheptadine results in increased expression of GH1 protein
CTD
PMID:642945
NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
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Hsf1
heat shock factor 1
increases activity
ISO
Cyproheptadine results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
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Htr2a
5-hydroxytryptamine (serotonin) receptor 2A
multiple interactions
ISO
Cyproheptadine binds to and results in decreased activity of HTR2A protein
CTD
PMID:17031071
NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934
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Htr7
5-hydroxytryptamine (serotonin) receptor 7
affects binding multiple interactions
ISO
Cyproheptadine binds to HTR7 protein Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD
PMID:20827463
NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907
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Il6
interleukin 6
decreases expression
ISO
Cyproheptadine results in decreased expression of IL6 protein
CTD
PMID:33675893
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Kcnn2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
decreases activity
ISO
Cyproheptadine results in decreased activity of KCNN2 protein
CTD
PMID:10915830
NCBI chr18:45,401,754...45,818,954
Ensembl chr18:45,401,927...45,818,950
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Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
decreases expression
ISO
Cyproheptadine results in decreased expression of NFKB1 protein
CTD
PMID:33675893
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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Pomc
pro-opiomelanocortin-alpha
decreases secretion
ISO
Cyproheptadine results in decreased secretion of POMC protein
CTD
PMID:642945
NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
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Prl
prolactin
decreases secretion
ISO
Cyproheptadine results in decreased secretion of PRL protein
CTD
PMID:642945
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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Sirt1
sirtuin 1
increases expression
ISO
Cyproheptadine results in increased expression of SIRT1 protein
CTD
PMID:33675893
NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Cyproheptadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc22a5
solute carrier family 22 (organic cation transporter), member 5
multiple interactions
EXP
Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]
CTD
PMID:19821448
NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
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Abcb1a
ATP-binding cassette, sub-family B member 1A
affects response to substance
EXP
ABCB1A protein affects the susceptibility to Dextropropoxyphene
CTD
PMID:15502009
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcb1b
ATP-binding cassette, sub-family B member 1B
affects response to substance
EXP
ABCB1B protein affects the susceptibility to Dextropropoxyphene
CTD
PMID:15502009
NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
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Ces1d
carboxylesterase 1D
affects binding
ISO
Dextropropoxyphene binds to CES1 protein
CTD
PMID:10381793
NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
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Ces2h
carboxylesterase 2H
affects binding
ISO
Dextropropoxyphene binds to CES2 protein
CTD
PMID:10381793
NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
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Oprd1
opioid receptor, delta 1
multiple interactions affects binding
ISO
[Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD
PMID:7562497
NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797
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Oprk1
opioid receptor, kappa 1
multiple interactions affects binding
ISO
[Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD
PMID:7562497
NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354
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Oprm1
opioid receptor, mu 1
multiple interactions affects binding
ISO
[Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin
CTD
PMID:7562497
NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Trp53
transformation related protein 53
affects activity
ISO
Diphenoxylate affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Hrh1
histamine receptor H1
multiple interactions
ISO
diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein]
CTD
PMID:1912125
NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
diphenylpyraline results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases activity
ISO
Doxylamine results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions
ISO
Doxylamine binds to and results in increased activity of NR1I3 protein alternative form
CTD
PMID:20869355
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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Ache
acetylcholinesterase
decreases activity
ISO
EPTC results in decreased activity of ACHE protein
CTD
PMID:14644616
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Aldh2
aldehyde dehydrogenase 2, mitochondrial
decreases activity
EXP
EPTC metabolite results in decreased activity of ALDH2 protein
CTD
PMID:10513990
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
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Alox15
arachidonate 15-lipoxygenase
affects response to substance
ISO
ALOX15 gene SNP affects the susceptibility to EPTC
CTD
PMID:22919386
NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857
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Chrna3
cholinergic receptor, nicotinic, alpha polypeptide 3
multiple interactions
ISO
EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD
PMID:14644616
NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846
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Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
multiple interactions
ISO
EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
CTD
PMID:14644616
NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD
PMID:14644616
NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
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Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
multiple interactions
ISO
EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
CTD
PMID:14644616
NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063
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Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
increases expression
EXP
fenpropidine results in increased expression of ALDH1A2 mRNA
CTD
PMID:34737147
NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525
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Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
increases expression
EXP
fenpropidine results in increased expression of CYP26A1 mRNA
CTD
PMID:34737147
NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984
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Msmo1
methylsterol monoxygenase 1
increases expression
EXP
fenpropidine results in increased expression of MSMO1 mRNA
CTD
PMID:34737147
NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826
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Myh14
myosin, heavy polypeptide 14
decreases expression
EXP
fenpropidine results in decreased expression of MYH14 protein
CTD
PMID:34737147
NCBI chr 7:44,255,227...44,320,296
Ensembl chr 7:44,255,227...44,320,267
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Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
decreases expression
EXP
fenpropidine results in decreased expression of MYH6 mRNA
CTD
PMID:34737147
NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384
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Nes
nestin
increases expression
EXP
fenpropidine results in increased expression of NES mRNA
CTD
PMID:34737147
NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758
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Nkx2-5
NK2 homeobox 5
decreases expression
EXP
fenpropidine results in decreased expression of NKX2-5 mRNA
CTD
PMID:34737147
NCBI chr17:27,057,638...27,063,962
Ensembl chr17:27,057,638...27,063,983
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Tfap2a
transcription factor AP-2, alpha
increases expression
EXP
fenpropidine results in increased expression of TFAP2A protein
CTD
PMID:34737147
NCBI chr13:40,867,278...40,891,715
Ensembl chr13:40,868,778...40,891,852
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Tubb3
tubulin, beta 3 class III
increases expression
EXP
fenpropidine results in increased expression of TUBB3 mRNA
CTD
PMID:34737147
NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754
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Abcb1a
ATP-binding cassette, sub-family B member 1A
multiple interactions
ISO
ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein]
CTD
PMID:18385176
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcc1
ATP-binding cassette, sub-family C member 1
increases expression
EXP
ferric nitrilotriacetate results in increased expression of ABCC1 mRNA
CTD
PMID:18617210
NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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Abcc2
ATP-binding cassette, sub-family member 2
increases expression
EXP
ferric nitrilotriacetate results in increased expression of ABCC2 mRNA
CTD
PMID:18617210
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc4
ATP-binding cassette, sub-family C member 4
increases expression
EXP
ferric nitrilotriacetate results in increased expression of ABCC4 mRNA
CTD
PMID:18617210
NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
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Anxa2
annexin A2
increases expression
ISO
ferric nitrilotriacetate results in increased expression of ANXA2 mRNA
CTD
PMID:10854235
NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077
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Bax
BCL2-associated X protein
increases expression
ISO
ferric nitrilotriacetate results in increased expression of BAX mRNA
CTD
PMID:23208426
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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Bbc3
BCL2 binding component 3
increases expression
ISO
ferric nitrilotriacetate results in increased expression of BBC3 mRNA
CTD
PMID:23208426
NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
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Bik
BCL2-interacting killer
increases expression
ISO
ferric nitrilotriacetate results in increased expression of BIK mRNA
CTD
PMID:23208426
NCBI chr15:83,410,992...83,428,836
Ensembl chr15:83,411,063...83,428,835
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Cald1
caldesmon 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of CALD1 mRNA
CTD
PMID:10854235
NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
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Canx
calnexin
increases expression
ISO
ferric nitrilotriacetate results in increased expression of CANX protein
CTD
PMID:16908007
NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500
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Casp12
caspase 12
increases expression
ISO
ferric nitrilotriacetate results in increased expression of CASP12 mRNA
CTD
PMID:23208426
NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
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Casp3
caspase 3
multiple interactions
ISO
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA]
CTD
PMID:21907755
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp8
caspase 8
multiple interactions
ISO
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA]
CTD
PMID:21907755
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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Casp9
caspase 9
multiple interactions
ISO
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA]
CTD
PMID:21907755
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Cat
catalase
multiple interactions decreases activity
ISO
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]
CTD
PMID:9667754 PMID:15198074 PMID:18684806 PMID:21907755 PMID:23194824 PMID:30098279 More...
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Ccnd1
cyclin D1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of CCND1 mRNA; ferric nitrilotriacetate results in increased expression of CCND1 protein
CTD
PMID:18055543
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Cd44
CD44 antigen
increases expression
ISO
ferric nitrilotriacetate results in increased expression of CD44 mRNA; ferric nitrilotriacetate results in increased expression of CD44 protein
CTD
PMID:18055543
NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
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Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
increases expression
ISO
ferric nitrilotriacetate results in increased expression of CD47 mRNA
CTD
PMID:9119739
NCBI chr16:49,671,691...49,732,799
Ensembl chr16:49,620,896...49,735,373
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Cdkn1a
cyclin dependent kinase inhibitor 1A
increases expression
ISO
ferric nitrilotriacetate results in increased expression of CDKN1A mRNA
CTD
PMID:23208426
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Chrm1
cholinergic receptor, muscarinic 1, CNS
decreases expression
ISO
ferric nitrilotriacetate results in decreased expression of CHRM1 mRNA
CTD
PMID:19490752
NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
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Chrm2
cholinergic receptor, muscarinic 2, cardiac
decreases expression
ISO
ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA
CTD
PMID:19490752
NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
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Col1a1
collagen, type I, alpha 1
increases expression multiple interactions
ISO
ferric nitrilotriacetate results in increased expression of COL1A1 protein ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]
CTD
PMID:11159895
NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
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Cygb
cytoglobin
multiple interactions
ISO
CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]
CTD
PMID:16581302
NCBI chr11:116,536,421...116,544,887
Ensembl chr11:116,536,421...116,545,139
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]
CTD
PMID:12086689 PMID:17034788 PMID:21352821
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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Fos
FBJ osteosarcoma oncogene
increases expression
ISO
ferric nitrilotriacetate results in increased expression of FOS mRNA
CTD
PMID:10381381
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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Fosl1
fos-like antigen 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of FOSL1 mRNA; ferric nitrilotriacetate results in increased expression of FOSL1 protein
CTD
PMID:18055543
NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
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G6pdx
glucose-6-phosphate dehydrogenase X-linked
decreases activity
ISO
ferric nitrilotriacetate results in decreased activity of G6PD protein
CTD
PMID:9667754
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
EXP
ferric nitrilotriacetate results in increased expression of GCLC mRNA
CTD
PMID:18617210
NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
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Gsr
glutathione reductase
decreases activity multiple interactions
ISO
ferric nitrilotriacetate results in decreased activity of GSR protein [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of GSR protein]
CTD
PMID:9667754 PMID:15198074 PMID:30098279
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
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Gtse1
G two S phase expressed protein 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of GTSE1 mRNA
CTD
PMID:23208426
NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
ISO
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]
CTD
PMID:21907755 PMID:30098279
NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
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Hif1a
hypoxia inducible factor 1, alpha subunit
multiple interactions
ISO
ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein]
CTD
PMID:18385176
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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Hmox1
heme oxygenase 1
increases expression
ISO EXP
ferric nitrilotriacetate results in increased expression of HMOX1 mRNA
CTD
PMID:18617210 PMID:19490752
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA
CTD
PMID:10854235
NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
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Il24
interleukin 24
increases expression
ISO
ferric nitrilotriacetate results in increased expression of IL24 mRNA
CTD
PMID:23208426
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
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Il6
interleukin 6
increases expression multiple interactions
EXP ISO
ferric nitrilotriacetate results in increased expression of IL6 protein ferric nitrilotriacetate results in increased expression of IL6 mRNA [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]
CTD
PMID:15781289 PMID:19490752 PMID:23194824
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Jun
jun proto-oncogene
increases expression
ISO
ferric nitrilotriacetate results in increased expression of JUN mRNA; ferric nitrilotriacetate results in increased expression of JUN protein
CTD
PMID:18055543
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Krt18
keratin 18
multiple interactions
ISO
[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein
CTD
PMID:17034788
NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
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Krt8
keratin 8
multiple interactions
ISO
[[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein
CTD
PMID:17034788
NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917
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Mcm3
minichromosome maintenance complex component 3
increases expression
ISO
ferric nitrilotriacetate results in increased expression of MCM3 mRNA
CTD
PMID:23208426
NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536
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Mt1
metallothionein 1
multiple interactions
EXP
[ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Cadmium]; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc]
CTD
PMID:22001350
NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
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Mt2
metallothionein 2
multiple interactions
EXP
[ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium]
CTD
PMID:22001350
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
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Mt3
metallothionein 3
decreases response to substance
ISO
MT3 protein results in decreased susceptibility to ferric nitrilotriacetate
CTD
PMID:12383939
NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
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Myc
myelocytomatosis oncogene
increases expression
ISO
ferric nitrilotriacetate results in increased expression of MYC mRNA; ferric nitrilotriacetate results in increased expression of MYC protein
CTD
PMID:18055543
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
affects localization
EXP
ferric nitrilotriacetate affects the localization of NFE2L2 protein
CTD
PMID:18617210
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
multiple interactions
ISO
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA]
CTD
PMID:21907755
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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Nos2
nitric oxide synthase 2, inducible
multiple interactions increases expression
EXP ISO
ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] ferric nitrilotriacetate results in increased expression of NOS2 protein [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; ferric nitrilotriacetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD
PMID:11461780 PMID:11746204 PMID:12490132 PMID:23194824
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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Nqo1
NAD(P)H dehydrogenase, quinone 1
increases expression
EXP
ferric nitrilotriacetate results in increased expression of NQO1 mRNA; ferric nitrilotriacetate results in increased expression of NQO1 protein
CTD
PMID:18617210
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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Odc1
ornithine decarboxylase, structural 1
multiple interactions increases activity
ISO
[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [ferric nitrilotriacetate results in increased activity of ODC1 protein]
CTD
PMID:9667754 PMID:14623030 PMID:15949125
NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
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Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
increases expression
ISO
ferric nitrilotriacetate results in increased expression of PCK1 mRNA
CTD
PMID:16960379
NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein]
CTD
PMID:21907755 PMID:23194824
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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Phlda3
pleckstrin homology like domain, family A, member 3
increases expression
ISO
ferric nitrilotriacetate results in increased expression of PHLDA3 mRNA
CTD
PMID:23208426
NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874
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Plau
plasminogen activator, urokinase
multiple interactions increases expression increases activity
ISO
Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]; Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA]
CTD
PMID:17571974
NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453
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Plk2
polo like kinase 2
increases expression
ISO
ferric nitrilotriacetate results in increased expression of PLK2 mRNA
CTD
PMID:23208426
NCBI chr13:110,531,578...110,537,378
Ensembl chr13:110,531,580...110,537,378
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Pola1
polymerase (DNA directed), alpha 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of POLA1 mRNA
CTD
PMID:10854235
NCBI chr X:92,348,372...92,675,993
Ensembl chr X:92,348,373...92,675,761
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Ppia
peptidylprolyl isomerase A
increases expression
ISO
ferric nitrilotriacetate results in increased expression of PPIA protein
CTD
PMID:16908007
NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
ISO
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]
CTD
PMID:23194824 PMID:30098279
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Ptprb
protein tyrosine phosphatase receptor type B
decreases expression
ISO
ferric nitrilotriacetate results in decreased expression of PTPRB mRNA
CTD
PMID:10854235
NCBI chr10:116,111,407...116,225,443
Ensembl chr10:116,111,428...116,225,440
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Ptprz1
protein tyrosine phosphatase receptor type Z, polypeptide 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of PTPRZ1 mRNA; ferric nitrilotriacetate results in increased expression of PTPRZ1 protein
CTD
PMID:18055543
NCBI chr 6:22,875,302...23,052,915
Ensembl chr 6:22,875,501...23,052,915
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein]
CTD
PMID:23194824
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Rpl19
ribosomal protein L19
increases expression
ISO
ferric nitrilotriacetate results in increased expression of RPL19 mRNA
CTD
PMID:10854235
NCBI chr11:97,912,829...97,921,319
Ensembl chr11:97,917,536...97,921,318
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Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
increases expression
ISO
ferric nitrilotriacetate results in increased expression of RPRM mRNA
CTD
PMID:23208426
NCBI chr 2:53,974,105...53,975,564
Ensembl chr 2:53,974,105...53,975,564
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Rps13
ribosomal protein S13
increases expression
ISO
ferric nitrilotriacetate results in increased expression of RPS13 mRNA
CTD
PMID:10854235
NCBI chr 7:115,930,742...115,933,425
Ensembl chr 7:115,930,740...115,933,430
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Rps15
ribosomal protein S15
increases expression
ISO
ferric nitrilotriacetate results in increased expression of RPS15 mRNA
CTD
PMID:10854235
NCBI chr10:80,128,265...80,129,948
Ensembl chr10:80,128,287...80,129,948
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Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
decreases expression
ISO
ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA
CTD
PMID:11925462
NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953
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Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
decreases expression
ISO
ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA
CTD
PMID:11925462
NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
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Sod1
superoxide dismutase 1, soluble
multiple interactions
ISO
ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein]
CTD
PMID:15842777
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Ssrp1
structure specific recognition protein 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of SSRP1 mRNA
CTD
PMID:8844983
NCBI chr 2:84,867,519...84,877,453
Ensembl chr 2:84,867,578...84,877,453
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Tgfa
transforming growth factor alpha
increases expression
ISO
ferric nitrilotriacetate results in increased expression of TGFA mRNA; ferric nitrilotriacetate results in increased expression of TGFA protein
CTD
PMID:8340253
NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]
CTD
PMID:16581302
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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Tgfb2
transforming growth factor, beta 2
increases expression
ISO
ferric nitrilotriacetate results in increased expression of TGFB2 mRNA
CTD
PMID:23208426
NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
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Timp1
tissue inhibitor of metalloproteinase 1
multiple interactions
ISO
[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]
CTD
PMID:16581302
NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974
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Tnf
tumor necrosis factor
increases expression multiple interactions
EXP ISO
ferric nitrilotriacetate results in increased expression of TNF protein [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]
CTD
PMID:15781289 PMID:23194824
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Trp53
transformation related protein 53
multiple interactions
ISO
[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein]
CTD
PMID:21907755
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Txn1
thioredoxin 1
increases expression
ISO
ferric nitrilotriacetate results in increased expression of TXN protein
CTD
PMID:15834431
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
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Txnip
thioredoxin interacting protein
decreases expression increases methylation
ISO
ferric nitrilotriacetate results in decreased expression of TXNIP protein ferric nitrilotriacetate results in increased methylation of TXNIP promoter
CTD
PMID:15834431
NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
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Ubd
ubiquitin D
increases expression
ISO
ferric nitrilotriacetate results in increased expression of UBD mRNA
CTD
PMID:23208426
NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
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Fshb
follicle stimulating hormone beta
decreases secretion
ISO
Lumefantrine results in decreased secretion of FSHB protein
CTD
PMID:26811345
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
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Prl
prolactin
increases secretion
ISO
Lumefantrine results in increased secretion of PRL protein
CTD
PMID:26811345
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
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A2m
alpha-2-macroglobulin
multiple interactions
ISO
N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein]
CTD
PMID:15618353
NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
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Cdh1
cadherin 1
multiple interactions
ISO
N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]
CTD
PMID:15618353
NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
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Cdh2
cadherin 2
multiple interactions
ISO
N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH2 protein]
CTD
PMID:15618353
NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
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Ctnnb1
catenin beta 1
multiple interactions
ISO
N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CTNNB1 protein]
CTD
PMID:15618353
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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Lig1
ligase I, DNA, ATP-dependent
multiple interactions
ISO
N(6),N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]
CTD
PMID:16700562
NCBI chr 7:13,011,101...13,045,351
Ensembl chr 7:13,011,239...13,045,350
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK8 protein]
CTD
PMID:15618353
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO
N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK9 protein]
CTD
PMID:15618353
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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Ocln
occludin
multiple interactions
ISO
N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of OCLN protein]
CTD
PMID:15618353
NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
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Tjp1
tight junction protein 1
multiple interactions
ISO
N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of TJP1 protein]
CTD
PMID:15618353
NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
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Axin2
axin 2
decreases expression
ISO
N,N-dimethylaniline analog results in decreased expression of AXIN2 protein
CTD
PMID:21291235
NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
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Myc
myelocytomatosis oncogene
decreases expression
ISO
N,N-dimethylaniline analog results in decreased expression of MYC protein
CTD
PMID:21291235
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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Pygo2
pygopus 2
decreases expression
ISO
N,N-dimethylaniline analog results in decreased expression of PYGO2 protein
CTD
PMID:21291235
NCBI chr 3:89,337,521...89,342,438
Ensembl chr 3:89,337,521...89,342,435
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Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
decreases expression
ISO
N,N-dimethylaniline analog results in decreased expression of TCF7L2 mRNA; N,N-dimethylaniline analog results in decreased expression of TCF7L2 protein
CTD
PMID:21291235
NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086
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Ar
androgen receptor
multiple interactions
ISO
Deanol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:18324785
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
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Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
naftifine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Abcb1a
ATP-binding cassette, sub-family B member 1A
affects response to substance increases transport
ISO EXP
ABCB1 exon SNP affects the susceptibility to Nortriptyline ABCB1A protein results in increased transport of Nortriptyline; ABCB1A protein results in increased transport of Nortriptyline metabolite
CTD
PMID:10700657 PMID:12082591
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases activity
ISO
Nortriptyline results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Casp3
caspase 3
decreases activity increases activity multiple interactions
EXP ISO
Nortriptyline results in decreased activity of CASP3 protein Nortriptyline results in increased activity of CASP3 protein Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein]
CTD
PMID:17686041 PMID:18174477 PMID:22700542
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp7
caspase 7
multiple interactions increases activity
ISO
Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein]
CTD
PMID:22700542
NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
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Cycs
cytochrome c, somatic
decreases secretion
EXP
Nortriptyline results in decreased secretion of CYCS protein
CTD
PMID:17686041
NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing
ISO
Nortriptyline results in increased metabolism of CYP1A2 protein
CTD
PMID:18359012
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
decreases activity multiple interactions
ISO
Nortriptyline results in decreased activity of CYP2C8 protein torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]
CTD
PMID:15304522
NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
decreases response to substance multiple interactions increases metabolic processing increases hydroxylation
ISO
CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline] Nortriptyline results in increased metabolism of CYP2D6 protein CYP2D6 protein results in increased hydroxylation of Nortriptyline
CTD
PMID:11673748 PMID:17470523 PMID:18359012
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
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Cyp3a13
cytochrome P450, family 3, subfamily a, polypeptide 13
increases metabolic processing
ISO
Nortriptyline results in increased metabolism of CYP3A5 protein
CTD
PMID:18359012
NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
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Gnb3
guanine nucleotide binding protein (G protein), beta 3
decreases response to substance increases response to substance
ISO
GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline GNB3 protein results in increased susceptibility to Nortriptyline
CTD
PMID:14604448
NCBI chr 6:124,811,203...124,817,238
Ensembl chr 6:124,811,203...124,817,238
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Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
decreases expression
ISO
Nortriptyline results in decreased expression of HTR2C protein
CTD
PMID:8131152
NCBI chr X:145,745,509...145,980,273
Ensembl chr X:145,745,509...145,980,273
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Il1a
interleukin 1 alpha
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline
CTD
PMID:19362101
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Il6
interleukin 6
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline
CTD
PMID:19362101
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
multiple interactions
ISO
Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD
PMID:21158687
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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Pf4
platelet factor 4
affects expression
ISO
Nortriptyline affects the expression of PF4 protein
CTD
PMID:10770450
NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242
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Ppbp
pro-platelet basic protein
affects expression
ISO
Nortriptyline affects the expression of PPBP protein
CTD
PMID:10770450
NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Nortriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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Slc6a2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
affects response to substance
ISO
SLC6A2 gene polymorphism affects the susceptibility to Nortriptyline
CTD
PMID:17018806
NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295
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Slc6a4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
affects response to substance increases response to substance decreases response to substance
ISO
SLC6A4 polymorphism affects the susceptibility to Nortriptyline; SLC6A4 promoter polymorphism affects the susceptibility to Nortriptyline SLC6A4 protein results in increased susceptibility to Nortriptyline SLC6A4 gene polymorphism results in decreased susceptibility to Nortriptyline
CTD
PMID:14604448 PMID:17018806 PMID:21658141
NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
G
Tnf
tumor necrosis factor
multiple interactions
ISO
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline
CTD
PMID:19362101
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
increases expression
ISO
benoxinate results in increased expression of AIFM1 protein
CTD
PMID:27590991
NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440
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Bax
BCL2-associated X protein
increases expression
ISO
benoxinate results in increased expression of BAX protein
CTD
PMID:27590991
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
G
Bcl2l1
BCL2-like 1
decreases expression
ISO
benoxinate results in decreased expression of BCL2L1 protein
CTD
PMID:27590991
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
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Casp2
caspase 2
increases activity
ISO
benoxinate results in increased activity of CASP2 protein
CTD
PMID:27590991
NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
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Casp3
caspase 3
increases activity
ISO
benoxinate results in increased activity of CASP3 protein
CTD
PMID:27590991
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Casp9
caspase 9
increases activity
ISO
benoxinate results in increased activity of CASP9 protein
CTD
PMID:27590991
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
benoxinate results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
benoxinate results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
G
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
benoxinate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
G
Akt1
thymoma viral proto-oncogene 1
multiple interactions increases phosphorylation
ISO
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]
CTD
PMID:32061592
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
G
Alpl
alkaline phosphatase, liver/bone/kidney
increases expression
ISO
Procaine results in increased expression of ALPL mRNA
CTD
PMID:22083529
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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Calca
calcitonin/calcitonin-related polypeptide, alpha
increases secretion
EXP
Procaine results in increased secretion of CALCA protein
CTD
PMID:18172555
NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
G
Capn1
calpain 1
multiple interactions
EXP
Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein]
CTD
PMID:26998625
NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927
G
Capn2
calpain 2
multiple interactions
EXP
Procaine inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein]
CTD
PMID:26998625
NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173
G
Casp12
caspase 12
multiple interactions
EXP
Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]
CTD
PMID:20079824 PMID:26998625
NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
G
Casp3
caspase 3
multiple interactions
EXP
Procaine inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]
CTD
PMID:26998625
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Cdh5
cadherin 5
decreases expression multiple interactions
ISO
Procaine results in decreased expression of CDH5 protein HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]
CTD
PMID:32061592
NCBI chr 8:104,828,247...104,871,136
Ensembl chr 8:104,828,257...104,871,143
G
Ces2h
carboxylesterase 2H
increases hydrolysis
ISO
CES2 protein results in increased hydrolysis of Procaine
CTD
PMID:9300133 PMID:15475733
NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
G
Esr1
estrogen receptor 1 (alpha)
increases expression
ISO
Procaine results in increased expression of ESR1 mRNA
CTD
PMID:22083529
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
G
Hrh1
histamine receptor H1
affects binding multiple interactions
ISO
HRH1 protein binds to Procaine [HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin]
CTD
PMID:32061592
NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
G
Hspa5
heat shock protein 5
multiple interactions
EXP
[Procaine co-treated with Paraoxon] results in increased expression of HSPA5 protein
CTD
PMID:26998625
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
G
Itpr1
inositol 1,4,5-trisphosphate receptor 1
multiple interactions increases phosphorylation
ISO
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]
CTD
PMID:32061592
NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
G
Mapk1
mitogen-activated protein kinase 1
multiple interactions increases phosphorylation
ISO
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]
CTD
PMID:32061592
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk3
mitogen-activated protein kinase 3
increases phosphorylation multiple interactions
ISO
Procaine results in increased phosphorylation of MAPK3 protein HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]
CTD
PMID:32061592
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Procaine results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Plcg1
phospholipase C, gamma 1
increases phosphorylation multiple interactions
ISO
Procaine results in increased phosphorylation of PLCG1 protein HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]
CTD
PMID:32061592
NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
increases activity
ISO
Procaine results in increased activity of TRPV1 protein
CTD
PMID:18172555
NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
G
Bche
butyrylcholinesterase
decreases activity
ISO
Promazine results in decreased activity of BCHE protein
CTD
PMID:236606
NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
G
Crh
corticotropin releasing hormone
decreases expression
ISO
Promazine results in decreased expression of CRH mRNA
CTD
PMID:16205782
NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
Promazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Promazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
G
Ambra1
autophagy/beclin 1 regulator 1
decreases expression
ISO
Promethazine results in decreased expression of AMBRA1 protein
CTD
PMID:31682805
NCBI chr 2:91,560,464...91,749,194
Ensembl chr 2:91,560,479...91,749,194
G
Atg5
autophagy related 5
decreases expression
ISO
Promethazine results in decreased expression of ATG5 protein
CTD
PMID:31682805
NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
G
Atg7
autophagy related 7
decreases expression
ISO
Promethazine results in decreased expression of ATG7 protein
CTD
PMID:31682805
NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
G
Atm
ataxia telangiectasia mutated
decreases expression
ISO
Promethazine results in decreased expression of ATM mRNA
CTD
PMID:26011634
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
G
Atp5f1b
ATP synthase F1 subunit beta
decreases expression
ISO
Promethazine results in decreased expression of ATP5F1B mRNA
CTD
PMID:28903497
NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
G
Aurka
aurora kinase A
decreases expression
ISO
Promethazine results in decreased expression of AURKA mRNA
CTD
PMID:26011634
NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
G
Aurkb
aurora kinase B
decreases expression
ISO
Promethazine results in decreased expression of AURKB mRNA
CTD
PMID:26011634
NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Promethazine results in increased expression of BAK1 protein
CTD
PMID:31682805
NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
G
Bche
butyrylcholinesterase
decreases activity
ISO
Promethazine results in decreased activity of BCHE protein
CTD
PMID:236606
NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
G
Bcl2
B cell leukemia/lymphoma 2
decreases expression
ISO
Promethazine results in decreased expression of BCL2 protein
CTD
PMID:31682805
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
G
Bcl2l1
BCL2-like 1
decreases expression
ISO
Promethazine results in decreased expression of BCL2L1 protein
CTD
PMID:31682805
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
G
Becn1
beclin 1, autophagy related
multiple interactions
ISO
Promethazine affects the expression of and results in increased phosphorylation of BECN1 protein
CTD
PMID:31682805
NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
G
Brca1
breast cancer 1, early onset
decreases expression
ISO
Promethazine results in decreased expression of BRCA1 mRNA
CTD
PMID:26011634
NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
G
Brca2
breast cancer 2, early onset
decreases expression
ISO
Promethazine results in decreased expression of BRCA2 mRNA
CTD
PMID:26011634
NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794
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Brcc3
BRCA1/BRCA2-containing complex, subunit 3
decreases expression
ISO
Promethazine results in decreased expression of BRCC3 mRNA
CTD
PMID:26011634
NCBI chr X:74,460,234...74,499,307
Ensembl chr X:74,460,234...74,497,607
G
Bub1
BUB1, mitotic checkpoint serine/threonine kinase
decreases expression
ISO
Promethazine results in decreased expression of BUB1 mRNA
CTD
PMID:26011634
NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
G
Casp3
caspase 3
decreases cleavage
ISO
Promethazine results in decreased cleavage of CASP3 protein
CTD
PMID:26011634
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Cdkn1a
cyclin dependent kinase inhibitor 1A
increases expression increases phosphorylation decreases expression
ISO
Promethazine results in increased expression of CDKN1A protein Promethazine results in increased phosphorylation of CDKN1A protein Promethazine results in decreased expression of CDKN1A mRNA
CTD
PMID:26011634 PMID:26558467
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
G
Cdkn2a
cyclin dependent kinase inhibitor 2A
decreases expression
ISO
Promethazine results in decreased expression of CDKN2A mRNA
CTD
PMID:26011634
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
G
Chek1
checkpoint kinase 1
increases expression decreases expression
ISO
Promethazine results in increased expression of CHEK1 mRNA Promethazine results in decreased expression of CHEK1 mRNA
CTD
PMID:26011634 PMID:26558467
NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
G
Chek2
checkpoint kinase 2
decreases expression
ISO
Promethazine results in decreased expression of CHEK2 mRNA
CTD
PMID:26011634
NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
G
Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
decreases metabolic processing
ISO
CYP2D6 gene polymorphism results in decreased metabolism of Promethazine
CTD
PMID:19814645
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
G
Esco1
establishment of sister chromatid cohesion N-acetyltransferase 1
decreases expression
ISO
Promethazine results in decreased expression of ESCO1 mRNA
CTD
PMID:26011634
NCBI chr18:10,566,507...10,610,863
Ensembl chr18:10,566,507...10,610,352
G
G6pdx
glucose-6-phosphate dehydrogenase X-linked
increases expression
ISO
Promethazine results in increased expression of G6PD mRNA
CTD
PMID:28903497
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
G
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
affects expression
ISO
Promethazine affects the expression of GADD45A mRNA
CTD
PMID:26011634
NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
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Gapdh
glyceraldehyde-3-phosphate dehydrogenase
decreases expression
ISO
Promethazine results in decreased expression of GAPDH mRNA
CTD
PMID:28903497
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
G
H2ax
H2A.X variant histone
decreases expression
ISO
Promethazine results in decreased expression of H2AX protein
CTD
PMID:26011634
NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
G
Hif1a
hypoxia inducible factor 1, alpha subunit
decreases expression
ISO
Promethazine results in decreased expression of HIF1A mRNA
CTD
PMID:28903497
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
G
Hk2
hexokinase 2
decreases expression
ISO
Promethazine results in decreased expression of HK2 mRNA
CTD
PMID:28903497
NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435
G
Hrh1
histamine receptor H1
multiple interactions
ISO
Promethazine binds to and results in decreased activity of HRH1 protein; Promethazine binds to and results in increased activity of HRH1 protein; Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]
CTD
PMID:1377455 PMID:1912125
NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
G
Hrh2
histamine receptor H2
multiple interactions
ISO
Promethazine binds to and results in decreased activity of HRH2 protein
CTD
PMID:1377455
NCBI chr13:54,345,990...54,390,201
Ensembl chr13:54,346,148...54,390,199
G
Hsf1
heat shock factor 1
decreases activity
ISO
Promethazine results in decreased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
G
Il1a
interleukin 1 alpha
increases expression
ISO
Promethazine results in increased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
G
Il1b
interleukin 1 beta
increases expression
ISO
Promethazine results in increased expression of IL1B protein
CTD
PMID:15265675
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Il6
interleukin 6
increases expression
ISO
Promethazine results in increased expression of IL6 protein
CTD
PMID:15265675
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Mad1l1
MAD1 mitotic arrest deficient 1-like 1
decreases expression
ISO
Promethazine results in decreased expression of MAD1L1 mRNA
CTD
PMID:26011634
NCBI chr 5:139,994,444...140,307,346
Ensembl chr 5:139,994,444...140,307,307
G
Mad2l1
MAD2 mitotic arrest deficient-like 1
increases expression decreases expression
ISO
Promethazine results in increased expression of MAD2L1 mRNA Promethazine results in decreased expression of MAD2L1 mRNA
CTD
PMID:26011634 PMID:26558467
NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204
G
Mcl1
myeloid cell leukemia sequence 1
decreases expression
ISO
Promethazine results in decreased expression of MCL1 protein
CTD
PMID:31682805
NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
G
Mdm2
transformed mouse 3T3 cell double minute 2
increases phosphorylation
ISO
Promethazine results in increased phosphorylation of MDM2 protein
CTD
PMID:26558467
NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
G
Mki67
antigen identified by monoclonal antibody Ki 67
increases expression affects expression
ISO
Promethazine results in increased expression of MKI67 protein Promethazine affects the expression of MKI67 protein
CTD
PMID:26011634 PMID:26558467
NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
Promethazine results in decreased expression of and results in decreased phosphorylation of MTOR protein
CTD
PMID:31682805
NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
G
Myc
myelocytomatosis oncogene
decreases expression
ISO
Promethazine results in decreased expression of MYC mRNA
CTD
PMID:28903497
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
G
Ngf
nerve growth factor
multiple interactions
ISO
Promethazine inhibits the reaction [Capsaicin results in increased expression of NGF protein]
CTD
PMID:15265675
NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
G
Pgam1
phosphoglycerate mutase 1
increases expression
ISO
Promethazine results in increased expression of PGAM1 mRNA
CTD
PMID:28903497
NCBI chr19:41,900,310...41,907,104
Ensembl chr19:41,900,362...41,907,099
G
Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Promethazine results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
G
Pkm
pyruvate kinase, muscle
decreases expression
ISO
Promethazine results in decreased expression of PKM mRNA
CTD
PMID:28903497
NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
G
Plk1
polo like kinase 1
decreases expression
ISO
Promethazine results in decreased expression of PLK1 mRNA
CTD
PMID:26011634
NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096
G
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
Promethazine results in increased expression of PMAIP1 protein
CTD
PMID:31682805
NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636
G
Rad17
RAD17 checkpoint clamp loader component
decreases expression
ISO
Promethazine results in decreased expression of RAD17 mRNA
CTD
PMID:26011634
NCBI chr13:100,753,672...100,787,569
Ensembl chr13:100,753,672...100,787,559
G
Rb1
RB transcriptional corepressor 1
decreases expression
ISO
Promethazine results in decreased expression of RB1 mRNA
CTD
PMID:26011634
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
G
Rbl2
RB transcriptional corepressor like 2
decreases expression
ISO
Promethazine results in decreased expression of RBL2 mRNA
CTD
PMID:26011634 PMID:26558467
NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472
G
Slc22a5
solute carrier family 22 (organic cation transporter), member 5
multiple interactions
EXP
Promethazine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]; Promethazine inhibits the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine]
CTD
PMID:19821448
NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
G
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
decreases expression
ISO
Promethazine results in decreased expression of SLC2A1 mRNA
CTD
PMID:28903497
NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
G
Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
decreases expression
ISO
Promethazine results in decreased expression of SLC2A2 mRNA
CTD
PMID:28903497
NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
G
Sqstm1
sequestosome 1
increases expression
ISO
Promethazine results in increased expression of SQSTM1 protein
CTD
PMID:31682805
NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
G
Tnf
tumor necrosis factor
increases expression
ISO
Promethazine results in increased expression of TNF protein
CTD
PMID:15265675
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
decreases activity
EXP
Promethazine results in decreased activity of TNFSF11
CTD
PMID:21869564
NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
G
Top2a
topoisomerase (DNA) II alpha
affects expression
ISO
Promethazine affects the expression of TOP2A protein
CTD
PMID:26011634
NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015
G
Trp53
transformation related protein 53
decreases expression
ISO
Promethazine results in decreased expression of TP53 mRNA
CTD
PMID:26011634
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
G
Ubd
ubiquitin D
decreases expression
ISO
Promethazine results in decreased expression of UBD protein
CTD
PMID:26011634
NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
G
Ulk1
unc-51 like kinase 1
increases expression
ISO
Promethazine results in increased expression of ULK1 protein
CTD
PMID:31682805
NCBI chr 5:110,932,355...110,957,991
Ensembl chr 5:110,932,354...110,957,963
G
Bcl2
B cell leukemia/lymphoma 2
increases expression
ISO
ropinirole results in increased expression of BCL2 protein
CTD
PMID:18242171
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
G
Casp3
caspase 3
multiple interactions
ISO
ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]
CTD
PMID:18242171
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Casp9
caspase 9
multiple interactions
ISO
ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]
CTD
PMID:18242171
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
G
Cat
catalase
multiple interactions
ISO
ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]
CTD
PMID:25053526
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
G
Drd2
dopamine receptor D2
multiple interactions
ISO
ropinirole binds to and results in increased activity of DRD2 protein
CTD
PMID:18393062
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
G
Drd3
dopamine receptor D3
multiple interactions
ISO
ropinirole binds to and results in increased activity of DRD3 protein
CTD
PMID:18242171 PMID:18393062
NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
G
Drd4
dopamine receptor D4
multiple interactions
ISO
ropinirole binds to and results in increased activity of DRD4 protein
CTD
PMID:18393062
NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377
G
Egr1
early growth response 1
decreases expression
ISO
ropinirole results in decreased expression of EGR1 mRNA
CTD
PMID:20452347
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
G
Il1b
interleukin 1 beta
multiple interactions
ISO
ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]]
CTD
PMID:25053526
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Jun
jun proto-oncogene
multiple interactions
ISO
ropinirole inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]
CTD
PMID:18242171
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
G
Mapk1
mitogen-activated protein kinase 1
increases phosphorylation
ISO
ropinirole results in increased phosphorylation of MAPK1 protein
CTD
PMID:18242171
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk3
mitogen-activated protein kinase 3
increases phosphorylation
ISO
ropinirole results in increased phosphorylation of MAPK3 protein
CTD
PMID:18242171
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Tnf
tumor necrosis factor
multiple interactions
ISO
ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]]
CTD
PMID:25053526
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
CTD
PMID:16784723
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Ccl27a
C-C motif chemokine ligand 27A
multiple interactions
ISO
Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]
CTD
PMID:16784723
NCBI chr 4:41,769,467...41,774,251
Ensembl chr 4:41,769,467...41,774,247
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]
CTD
PMID:16784723 PMID:23688403
NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
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Cxcl10
C-X-C motif chemokine ligand 10
multiple interactions
ISO
terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]
CTD
PMID:24471457
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
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Cxcl15
C-X-C motif chemokine ligand 15
multiple interactions increases expression
ISO
terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; U 0126 inhibits the reaction [terbinafine results in increased expression of CXCL8 protein]
CTD
PMID:20816994 PMID:23688403
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases activity
ISO
Terbinafine results in decreased activity of CYP1A1 protein
CTD
PMID:33814510
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Terbinafine results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
G
Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
multiple interactions decreases activity
ISO
[terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]
CTD
PMID:24894748
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
G
Gstp1
glutathione S-transferase, pi 1
multiple interactions
ISO
terbinafine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
G
H2-Q1
histocompatibility 2, Q region locus 1
affects response to substance
ISO
HLA-A gene polymorphism affects the susceptibility to terbinafine
CTD
PMID:28043905
NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075
G
Il4
interleukin 4
multiple interactions decreases secretion decreases expression
ISO
1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]
CTD
PMID:11886533 PMID:15284827 PMID:23688403
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
G
Il5
interleukin 5
multiple interactions decreases expression decreases secretion
ISO
1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]
CTD
PMID:11886533 PMID:15284827
NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
terbinafine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Mapk1
mitogen-activated protein kinase 1
increases phosphorylation
ISO
terbinafine results in increased phosphorylation of MAPK1 protein
CTD
PMID:20816994
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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Mapk3
mitogen-activated protein kinase 3
increases phosphorylation
ISO
terbinafine results in increased phosphorylation of MAPK3 protein
CTD
PMID:20816994
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
terbinafine results in decreased expression of MMP2 mRNA
CTD
PMID:17172416
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
terbinafine results in decreased expression of MMP9 mRNA
CTD
PMID:17172416
NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
affects response to substance
ISO
NFE2L2 protein affects the susceptibility to terbinafine
CTD
PMID:21540358
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
G
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
multiple interactions
ISO
terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]
CTD
PMID:23688403
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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Ptger2
prostaglandin E receptor 2 (subtype EP2)
multiple interactions increases response to substance
ISO
PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER2 protein results in increased susceptibility to terbinafine
CTD
PMID:16784723
NCBI chr14:45,225,568...45,241,277
Ensembl chr14:45,225,652...45,241,277
G
Ptger3
prostaglandin E receptor 3 (subtype EP3)
multiple interactions increases response to substance
ISO
PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER3 protein results in increased susceptibility to terbinafine
CTD
PMID:16784723
NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
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Ptk2
PTK2 protein tyrosine kinase 2
decreases phosphorylation
ISO
terbinafine results in decreased phosphorylation of PTK2 protein
CTD
PMID:17172416
NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129
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Pxn
paxillin
decreases phosphorylation
ISO
terbinafine results in decreased phosphorylation of PXN protein
CTD
PMID:17172416
NCBI chr 5:115,630,035...115,694,046
Ensembl chr 5:115,644,735...115,694,046
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Rhoa
ras homolog family member A
increases localization
ISO
terbinafine results in increased localization of RHOA protein
CTD
PMID:17172416
NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
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Rhob
ras homolog family member B
decreases expression
ISO
terbinafine results in decreased expression of RHOB protein
CTD
PMID:17172416
NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009
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Rhoc
ras homolog family member C
increases localization
ISO
terbinafine results in increased localization of RHOC protein
CTD
PMID:17172416
NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
terbinafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]
CTD
PMID:24471457
NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
G
Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; terbinafine inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; terbinafine promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; U 0126 inhibits the reaction [terbinafine results in increased expression of TNF protein]
CTD
PMID:16784723 PMID:20816994
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Tslp
thymic stromal lymphopoietin
multiple interactions
ISO
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]
CTD
PMID:23688403
NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
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Abcb4
ATP-binding cassette, sub-family B member 4
decreases activity
ISO
Tolterodine Tartrate results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
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Ahr
aryl-hydrocarbon receptor
decreases expression
ISO
Tolterodine Tartrate results in decreased expression of AHR mRNA
CTD
PMID:24316275
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
G
Chrm2
cholinergic receptor, muscarinic 2, cardiac
multiple interactions
ISO
Tolterodine Tartrate binds to and results in decreased activity of CHRM2 protein
CTD
PMID:15140916
NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349
G
Chrm3
cholinergic receptor, muscarinic 3, cardiac
multiple interactions
ISO
Tolterodine Tartrate binds to and results in decreased activity of CHRM3 protein
CTD
PMID:15140916
NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
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Cyp2d22
cytochrome P450, family 2, subfamily d, polypeptide 22
increases metabolic processing affects metabolic processing multiple interactions
ISO
CYP2D6 protein results in increased metabolism of Tolterodine Tartrate CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate]
CTD
PMID:10583026 PMID:28087463
NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
G
Il1b
interleukin 1 beta
decreases expression
ISO
Tolterodine Tartrate results in decreased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions decreases expression
ISO
Tolterodine Tartrate inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA] Tolterodine Tartrate results in decreased expression of NR3C1 mRNA
CTD
PMID:24316275
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Slc22a2
solute carrier family 22 (organic cation transporter), member 2
multiple interactions
ISO
Tolterodine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
G
Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Tolterodine Tartrate results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
G
Ar
androgen receptor
decreases activity
ISO
Toremifene results in decreased activity of AR protein
CTD
PMID:15316697
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
G
Esr1
estrogen receptor 1 (alpha)
multiple interactions
EXP ISO
Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of ESR1 protein] Toremifene binds to and results in decreased activity of ESR1 protein
CTD
PMID:12079510 PMID:25752796
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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Esr2
estrogen receptor 2 (beta)
increases expression multiple interactions
EXP ISO
Toremifene results in increased expression of ESR2 mRNA Toremifene binds to and results in decreased activity of ESR2 protein
CTD
PMID:12079510 PMID:25752796
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
G
Fos
FBJ osteosarcoma oncogene
multiple interactions
EXP
Toremifene inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of FOS protein]
CTD
PMID:12079510
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
G
Il1a
interleukin 1 alpha
multiple interactions
EXP
Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A mRNA]; Toremifene inhibits the reaction [Estradiol results in increased expression of IL1A protein]
CTD
PMID:12079510
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
Toremifene results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
decreases expression
ISO
Toremifene results in decreased expression of SERPINC1 protein
CTD
PMID:14692654
NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433
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Shbg
sex hormone binding globulin
increases expression affects binding
ISO
Toremifene results in increased expression of SHBG protein Toremifene binds to SHBG protein
CTD
PMID:14692654 PMID:25349334
NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731
G
Park7
Parkinson disease (autosomal recessive, early onset) 7
decreases activity
ISO
Triallate results in decreased activity of PARK7 protein
CTD
PMID:36842454
NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
G
Cxcl15
C-X-C motif chemokine ligand 15
increases expression
ISO
triethanolamine results in increased expression of CXCL8 mRNA
CTD
PMID:29594315
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
G
Ifng
interferon gamma
multiple interactions
ISO
[triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
G
Il2
interleukin 2
multiple interactions
ISO
[triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
G
Kcnk18
potassium channel, subfamily K, member 18
multiple interactions
ISO
triethanolamine inhibits the reaction [KCNK18 protein results in increased transport of Potassium]
CTD
PMID:12754259
NCBI chr19:59,208,080...59,225,802
Ensembl chr19:59,207,646...59,225,806
G
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
decreases activity
ISO
Triflupromazine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
G
Fmo3
flavin containing monooxygenase 3
affects metabolic processing increases metabolic processing multiple interactions increases oxidation
ISO
FMO3 gene polymorphism affects the metabolism of trimethylamine FMO3 protein results in increased metabolism of trimethylamine trimethylamine inhibits the reaction [FMO3 protein results in increased oxidation of Methimazole] FMO3 protein results in increased oxidation of trimethylamine FMO3 protein results in increased oxidation of trimethylamine; FMO3 results in increased oxidation of trimethylamine
CTD
PMID:11414682 PMID:12214664 PMID:16601883 PMID:17050781 PMID:17142560
NCBI chr 1:162,781,368...162,812,097
Ensembl chr 1:162,781,369...162,812,097
G
Mtarc1
mitochondrial amidoxime reducing component 1
increases chemical synthesis multiple interactions
ISO
MTARC1 protein results in increased chemical synthesis of trimethylamine [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine
CTD
PMID:29856598
NCBI chr 1:184,518,964...184,543,622
Ensembl chr 1:184,518,964...184,543,394
G
Slco1a1
solute carrier organic anion transporter family, member 1a1
affects abundance
EXP
SLCO1A1 protein affects the abundance of trimethylamine
CTD
PMID:21561886
NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688
G
Slco1a4
solute carrier organic anion transporter family, member 1a4
affects abundance
EXP
SLCO1A4 protein affects the abundance of trimethylamine
CTD
PMID:21561886
NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
G
Taar5
trace amine-associated receptor 5
increases activity
ISO
trimethylamine results in increased activity of TAAR5 protein
CTD
PMID:23393561
NCBI chr10:23,846,604...23,847,617
Ensembl chr10:23,846,604...23,847,617
G
Atf4
activating transcription factor 4
multiple interactions
ISO
trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]
CTD
PMID:25568320
NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
G
Casp3
caspase 3
multiple interactions
ISO
trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein]
CTD
PMID:25568320
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein]
CTD
PMID:25568320
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
G
Mbp
myelin basic protein
multiple interactions
EXP
trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form]
CTD
PMID:12372316
NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
G
Mtarc1
mitochondrial amidoxime reducing component 1
multiple interactions increases reduction
ISO
[MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine]
CTD
PMID:29856598
NCBI chr 1:184,518,964...184,543,622
Ensembl chr 1:184,518,964...184,543,394
G
Slco1a4
solute carrier organic anion transporter family, member 1a4
affects abundance
EXP
SLCO1A4 protein affects the abundance of trimethyloxamine
CTD
PMID:21561886
NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
G
Vamp2
vesicle-associated membrane protein 2
multiple interactions
ISO
trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form]
CTD
PMID:27032463
NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
22194
role
22179
application
21760
NMR chemical shift reference compound
18740
ammonia
18446
organic amino compound
18446
amine
8330
tertiary amine
638
(-)-lobeline
7
(2E)-4-\{[3-(4-bromophenyl)-1-benzofuran-6-yl]oxy\}-N-methyl-N-prop-2-en-1-ylbut-2-en-1-amine
0
(6S)-6-hydroxyhyoscyamine
0
1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine +
9
1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate +
8
1-isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane
0
17-dimethylaminolobohedleolide
0
2-(1-Aziridinyl)ethanol
0
2-[4-(dimethylamino)styryl]-1-methylpyridinium +
0
2-[4-(dimethylamino)styryl]-1-methylpyridinium iodide
0
25-azacoprostane
0
3-quinuclidinol +
1
4-(4-dihexadecylaminostyryl)-N-methylpyridium +
0
4-hydroxyphenyl-1-ONN-azoxyformamide
0
6-[4-(6-bromo-1,2-benzothiazol-3-yl)phenoxy]-N-methyl-N-prop-2-en-1-ylhexan-1-amine
0
6-\{[3-(4-bromophenyl)-1,2-benzothiazol-6-yl]oxy\}-N-methyl-N-prop-2-en-1-ylhexan-1-amine
0
6-\{[3-(4-bromophenyl)-1-benzofuran-6-yl]oxy\}-N-methyl-N-prop-2-en-1-ylhexan-1-amine
0
7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane
0
8-acetoxyheterophyllisine
0
Azoxymycin A
0
Azoxymycin B
0
Azoxymycin C
0
Butylate
0
Diallat
0
Disperse Blue 124
0
EPTC
7
Esmareldine A
0
Ethiolate
0
FM 1-43 dye
0
FM 1-43(2+) +
0
FM 4-64(2+) +
0
LDS 751(1+) +
0
LSM-6269
0
N(6),N(6)-dimethyladenine
9
N,N,2,2-tetramethyl-3-hexyn-1-amine
0
N,N-dimethyl-1-(5-pyridin-3-ylfuran-2-yl)methanamine
0
N,N-dimethylaniline +
4
N,N-dimethylbutylamine
0
N,N-dimethylcyclohexylamine
0
N,N-dimethylethanolamine +
1
N-(trans-4'-nitro-4-stilbenyl)-N-methyl-5-aminopentanoic acid
0
N-methyl-1,2,3,4-tetrahydroquinoline
0
NK154183B
0
Otonecine
0
Pebulate
0
PicoGreen
0
S-propyl dipropylcarbamothioate
0
SYBR Green I
0
Tri-allate
1
aceprometazine +
0
almotriptan +
8
alverine
2
amitriptyline +
184
azatadine +
1
benzphetamine +
1
bepridil +
8
bufotenin +
0
butenafine +
8
celesticetin
0
ceratamine A
0
chlorpromazine +
277
clomiphene +
53
cyproheptadine +
14
dicyclomine +
1
diethyl(propyl)amine
0
diethylpropion +
0
difenoxin +
1
dimethylthiambutene
0
diphenoxylate +
1
diphenylpyraline +
2
doxylamine
2
eschscholtzidine
0
exciton(1+) +
0
fexofenadine
0
gallamine
0
lumefantrine
2
lupanine +
0
malachite green isothiocyanate cation +
0
methotrimeprazine
0
naftifine
1
promazine +
4
promethazine
61
prostaglandin F2alpha dimethylamine
0
ravidomycin
0
rolicyclidine
0
ropinirole
13
selegiline +
35
terbinafine
29
tolterodine +
9
toremifene
8
tributylamine +
0
tridodecylamine
0
triethylamine +
102
triflupromazine +
1
trimethylamine +
10
tripropylamine +
0
yanuthone M
0
Path 2
CHEBI ontology
22194
subatomic particle
22186
composite particle
22186
hadron
22186
baryon
22186
nucleon
22186
atomic nucleus
22186
atom
22186
main group element atom
22120
main group molecular entity
22120
s-block molecular entity
21717
hydrogen molecular entity
21634
hydrides
20777
inorganic hydride
18692
pnictogen hydride
18672
nitrogen hydride
18540
azane
18447
ammonia
18446
organic amino compound
18446
tertiary amino compound
10307
tertiary amine
638
(-)-lobeline
7
(2E)-4-\{[3-(4-bromophenyl)-1-benzofuran-6-yl]oxy\}-N-methyl-N-prop-2-en-1-ylbut-2-en-1-amine
0
(6S)-6-hydroxyhyoscyamine
0
1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine +
9
1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate +
8
1-isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane
0
17-dimethylaminolobohedleolide
0
2-(1-Aziridinyl)ethanol
0
2-[4-(dimethylamino)styryl]-1-methylpyridinium +
0
2-[4-(dimethylamino)styryl]-1-methylpyridinium iodide
0
25-azacoprostane
0
3-quinuclidinol +
1
4-(4-dihexadecylaminostyryl)-N-methylpyridium +
0
4-hydroxyphenyl-1-ONN-azoxyformamide
0
6-[4-(6-bromo-1,2-benzothiazol-3-yl)phenoxy]-N-methyl-N-prop-2-en-1-ylhexan-1-amine
0
6-\{[3-(4-bromophenyl)-1,2-benzothiazol-6-yl]oxy\}-N-methyl-N-prop-2-en-1-ylhexan-1-amine
0
6-\{[3-(4-bromophenyl)-1-benzofuran-6-yl]oxy\}-N-methyl-N-prop-2-en-1-ylhexan-1-amine
0
7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane
0
8-acetoxyheterophyllisine
0
Azoxymycin A
0
Azoxymycin B
0
Azoxymycin C
0
Butylate
0
Diallat
0
Disperse Blue 124
0
EPTC
7
Esmareldine A
0
Ethiolate
0
FM 1-43 dye
0
FM 1-43(2+) +
0
FM 4-64(2+) +
0
LDS 751(1+) +
0
LSM-6269
0
N(6),N(6)-dimethyladenine
9
N,N,2,2-tetramethyl-3-hexyn-1-amine
0
N,N-dimethyl-1-(5-pyridin-3-ylfuran-2-yl)methanamine
0
N,N-dimethylaniline +
4
N,N-dimethylbutylamine
0
N,N-dimethylcyclohexylamine
0
N,N-dimethylethanolamine +
1
N-(trans-4'-nitro-4-stilbenyl)-N-methyl-5-aminopentanoic acid
0
N-methyl-1,2,3,4-tetrahydroquinoline
0
NK154183B
0
Otonecine
0
Pebulate
0
PicoGreen
0
S-propyl dipropylcarbamothioate
0
SYBR Green I
0
Tri-allate
1
aceprometazine +
0
almotriptan +
8
alverine
2
amitriptyline +
184
azatadine +
1
benzphetamine +
1
bepridil +
8
bufotenin +
0
butenafine +
8
celesticetin
0
ceratamine A
0
chlorpromazine +
277
clomiphene +
53
cyproheptadine +
14
dicyclomine +
1
diethyl(propyl)amine
0
diethylpropion +
0
difenoxin +
1
dimethylthiambutene
0
diphenoxylate +
1
diphenylpyraline +
2
doxylamine
2
eschscholtzidine
0
exciton(1+) +
0
fexofenadine
0
gallamine
0
lumefantrine
2
lupanine +
0
malachite green isothiocyanate cation +
0
methotrimeprazine
0
naftifine
1
promazine +
4
promethazine
61
prostaglandin F2alpha dimethylamine
0
ravidomycin
0
rolicyclidine
0
ropinirole
13
selegiline +
35
terbinafine
29
tolterodine +
9
toremifene
8
tributylamine +
0
tridodecylamine
0
triethylamine +
102
triflupromazine +
1
trimethylamine +
10
tripropylamine +
0
yanuthone M
0