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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:TEMPO
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Accession:CHEBI:32849 term browser browse the term
Definition:An aminoxyl that has formula C9H18NO.
Synonyms:exact_synonym: (2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 1,1,5,5-tetramethylpentamethylene nitroxide;   2,2,6,6-tetramethyl-1-piperidinyloxy;   2,2,6,6-tetramethylpiperidinooxy radical;   Formula=C9H18NO;   InChI=1S/C9H18NO/c1-8(2)6-5-7-9(3,4)10(8)11/h5-7H2,1-4H3;   InChIKey=QYTDEUPAUMOIOP-UHFFFAOYSA-N;   SMILES=CC1(C)CCCC(C)(C)N1[O]
 xref: Beilstein:1422418;   CAS:2564-83-2
 xref_mesh: MESH:C003959


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TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein] CTD PMID:28296042 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO TEMPO results in decreased expression of BCL2 protein CTD PMID:25882087 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
EXP
ISO
TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]
TEMPO results in decreased expression of BCL2L1 protein
CTD PMID:22001173 PMID:25882087 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp12 caspase 12 multiple interactions EXP TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein] CTD PMID:28296042 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]
TEMPO results in increased activity of CASP3 protein
pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP3 protein]
CTD PMID:22001173 PMID:25882087 PMID:28296042 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO TEMPO results in increased activity of CASP7 protein
pyrazolanthrone inhibits the reaction [TEMPO results in increased activity of CASP7 protein]
CTD PMID:25882087 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions EXP TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein] CTD PMID:22001173 PMID:28296042 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP TEMPO inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA] CTD PMID:28296042 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein] CTD PMID:28296042 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G H2ax H2A.X variant histone increases expression ISO TEMPO results in increased expression of H2AX protein CTD PMID:25882087 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO TEMPO inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA] CTD PMID:20888885 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein] CTD PMID:28296042 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO TEMPO results in decreased expression of MCL1 protein CTD PMID:25882087 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO TEMPO inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; TEMPO inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO TEMPO inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein] CTD PMID:16024921 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP TEMPO inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; TEMPO inhibits the reaction [nickel sulfate results in decreased expression of STAR protein] CTD PMID:29567110 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      molecular entity 19880
        radical 393
          organic radical 22
            aminoxyls 16
              TEMPO 16
                4-(\{5-[(2-aminoethyl)amino]-2,4-dinitrophenyl\}amino)-TEMPO 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic heterocyclic compound 18517
                                  organic heteromonocyclic compound 16622
                                    piperidines 7569
                                      TEMPO 16
                                        4-(\{5-[(2-aminoethyl)amino]-2,4-dinitrophenyl\}amino)-TEMPO 0
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