Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:9-cis,11-trans-octadecadienoic acid
go back to main search page
Accession:CHEBI:32798 term browser browse the term
Definition:An octadeca-9,11-dienoic acid having 9-cis,11-trans-stereochemistry.
Synonyms:related_synonym: (9Z,11E)-octadeca-9,11-dienoic acid;   (Z,E)-octadeca-9,11-dienoic acid;   9(Z),11(E)-octadecadienoic acid;   9,11-cis,trans-octadecanoic acid;   9-cis-11-trans-linoleic acid;   9Z,11E-Octadecadienoic acid;   C18:2, n-7,9 trans,cis;   Formula=C18H32O2;   InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-10H,2-6,11-17H2,1H3,(H,19,20)/b8-7+,10-9-;   InChIKey=JBYXPOFIGCOSSB-GOJKSUSPSA-N;   SMILES=CCCCCC\\C=C\\C=C/CCCCCCCC(O)=O;   cis-9,trans-11 conjugated linoleic acid;   cis-9,trans-11-CLA;   rumenic acid
 alt_id: CHEBI:20825;   CHEBI:2339;   MESH:C503589
 xref: Beilstein:1726545;   KEGG:C04056;   LIPID_MAPS_instance:LMFA01030118
 xref_mesh: MESH:C503589
 xref: PMID:15829653;   PMID:16303327;   PMID:16890934;   PMID:18567757;   PMID:19083449;   PMID:9727617;   Reaxys:1726546
 cyclic_relationship: is_conjugate_acid_of CHEBI:17539


show annotations for term's descendants           Sort by:
9-cis,11-trans-octadecadienoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOR1 adiponectin receptor 1 multiple interactions ISO [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of ADIPOR1 mRNA CTD PMID:17408517 NCBI chr 1:202,940,825...202,958,572
Ensembl chr 1:202,940,826...202,958,572 		JBrowse link
G ADIPOR2 adiponectin receptor 2 multiple interactions ISO [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of ADIPOR2 mRNA CTD PMID:17408517 NCBI chr12:1,691,070...1,788,674
Ensembl chr12:1,688,574...1,788,674 		JBrowse link
G CD68 CD68 molecule affects expression ISO cis-9, trans-11-conjugated linoleic acid affects the expression of CD68 mRNA CTD PMID:17327424 NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased activity of CYCS protein CTD PMID:17408517 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 decreases expression ISO cis-9, trans-11-conjugated linoleic acid results in decreased expression of FMO3 mRNA CTD PMID:17217560 NCBI chr 1:171,090,905...171,117,819
Ensembl chr 1:171,090,901...171,117,819 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased activity of GSR protein CTD PMID:17408517 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO cis-9, trans-11-conjugated linoleic acid promotes the reaction [INS1 protein affects the transport of Glucose] CTD PMID:17327424 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G INSR insulin receptor affects expression ISO cis-9, trans-11-conjugated linoleic acid affects the expression of INSR protein CTD PMID:17327424 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IRS1 insulin receptor substrate 1 multiple interactions ISO [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in decreased phosphorylation of IRS1 protein
cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of IRS1 mRNA]		 CTD PMID:17327424 PMID:17408517 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions ISO [cis-9, trans-11-conjugated linoleic acid co-treated with trans-10,cis-12-conjugated linoleic acid] results in increased phosphorylation of and results in increased activity of MAP2K1 protein; cis-9, trans-11-conjugated linoleic acid results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:17869086 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K3 mitogen-activated protein kinase kinase 3 multiple interactions ISO [cis-9, trans-11-conjugated linoleic acid co-treated with trans-10,cis-12-conjugated linoleic acid] results in increased phosphorylation of and results in increased activity of MAP2K3 protein; cis-9, trans-11-conjugated linoleic acid results in increased phosphorylation of and results in increased activity of MAP2K3 protein CTD PMID:17869086 NCBI chr17:21,284,711...21,315,240
Ensembl chr17:21,284,672...21,315,232 		JBrowse link
G ME1 malic enzyme 1 increases expression ISO cis-9, trans-11-conjugated linoleic acid results in increased expression of ME1 mRNA CTD PMID:17217560 NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 affects activity ISO cis-9, trans-11-conjugated linoleic acid affects the activity of NFKB1 protein CTD PMID:17327424 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 affects activity ISO cis-9, trans-11-conjugated linoleic acid affects the activity of NFKB2 protein CTD PMID:17327424 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 affects expression ISO cis-9, trans-11-conjugated linoleic acid affects the expression of NR1H3 mRNA CTD PMID:17327424 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G POR cytochrome p450 oxidoreductase decreases expression ISO cis-9, trans-11-conjugated linoleic acid results in decreased expression of POR mRNA CTD PMID:17217560 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of PPARA mRNA; [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased expression of PPARA protein CTD PMID:17408517 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[cis-9, trans-11-conjugated linoleic acid co-treated with trans-10,cis-12-conjugated linoleic acid] results in increased expression of PPARG protein]; [cis-9, trans-11-conjugated linoleic acid co-treated with trans-10,cis-12-conjugated linoleic acid] results in increased expression of PPARG protein CTD PMID:36875279 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit affects activity ISO cis-9, trans-11-conjugated linoleic acid affects the activity of REL protein CTD PMID:17327424 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO cis-9, trans-11-conjugated linoleic acid affects the expression of and affects the activity of RELA protein CTD PMID:17327424 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit affects activity ISO cis-9, trans-11-conjugated linoleic acid affects the activity of RELB protein CTD PMID:17327424 NCBI chr19:45,001,464...45,038,192
Ensembl chr19:45,001,461...45,038,192 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 increases expression
multiple interactions		 ISO cis-9, trans-11-conjugated linoleic acid results in increased expression of SLC2A4 protein
cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of SLC2A4 mRNA]		 CTD PMID:17327424 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO [trans-10,cis-12-conjugated linoleic acid co-treated with cis-9, trans-11-conjugated linoleic acid] results in increased activity of SOD2 protein CTD PMID:17408517 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 affects expression ISO cis-9, trans-11-conjugated linoleic acid affects the expression of SREBF1 mRNA CTD PMID:17327424 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TNF tumor necrosis factor multiple interactions
affects expression		 ISO cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of IRS1 mRNA]; cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of SLC2A4 mRNA]
cis-9, trans-11-conjugated linoleic acid affects the expression of TNF mRNA		 CTD PMID:17327424 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      atom 26016
        nonmetal atom 25505
          carbon atom 25399
            organic molecular entity 25399
              olefinic compound 18231
                olefinic fatty acid 802
                  octadecadienoic acid 307
                    conjugated linoleic acid 54
                      octadeca-9,11-dienoic acid 29
                        9-cis,11-trans-octadecadienoic acid 25
                          (9Z,11E)-octadecadienoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbon oxoacid 22757
                                    carboxylic acid 22737
                                      monocarboxylic acid 21735
                                        fatty acid 19000
                                          unsaturated fatty acid 1114
                                            polyunsaturated fatty acid 848
                                              octadecadienoic acid 307
                                                conjugated linoleic acid 54
                                                  octadeca-9,11-dienoic acid 29
                                                    9-cis,11-trans-octadecadienoic acid 25
                                                      (9Z,11E)-octadecadienoyl-CoA 0
paths to the root