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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetaminophen O-beta-D-glucosiduronic acid
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Accession:CHEBI:32636 term browser browse the term
Definition:A beta-D-glucosiduronic acid that is the O-glucuronide of paracetamol (acetaminophen).
Synonyms:exact_synonym: 4-acetamidophenyl beta-D-glucopyranosiduronic acid
 related_synonym: Acetaminophen glucuronide;   Formula=C14H17NO8;   InChI=1S/C14H17NO8/c1-6(16)15-7-2-4-8(5-3-7)22-14-11(19)9(17)10(18)12(23-14)13(20)21/h2-5,9-12,14,17-19H,1H3,(H,15,16)(H,20,21)/t9-,10-,11+,12-,14+/m0/s1;   InChIKey=IPROLSVTVHAQLE-BYNIDDHOSA-N;   Paracetamol glucuronide;   SMILES=CC(=O)Nc1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc1
 xref: CAS:16110-10-4;   HMDB:HMDB0010316
 xref_mesh: MESH:C037386
 xref: PMID:22770225;   Reaxys:46644
 cyclic_relationship: is_conjugate_acid_of CHEBI:132962


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acetaminophen O-beta-D-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 increases activity
affects export
multiple interactions
ISO
EXP
acetaminophen glucuronide results in increased activity of ABCC3 protein
ABCC3 protein affects the export of acetaminophen glucuronide
Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]
CTD PMID:16250050 PMID:16554369 PMID:17569508 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Ins2 insulin II increases abundance ISO INS protein results in increased abundance of acetaminophen glucuronide CTD PMID:26739624 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) multiple interactions EXP OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] CTD PMID:29325178 NCBI chr  X:101,640,011...101,684,351
Ensembl chr  X:101,640,060...101,684,351
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21552
    role 21530
      biological role 21528
        xenobiotic 18958
          paracetamol 10941
            acetaminophen O-beta-D-glucosiduronic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 21552
    subatomic particle 21537
      composite particle 21537
        hadron 21537
          baryon 21537
            nucleon 21537
              atomic nucleus 21537
                atom 21537
                  main group element atom 21442
                    p-block element atom 21442
                      carbon group element atom 21235
                        carbon atom 21133
                          organic molecular entity 21133
                            organic group 19572
                              organic divalent group 19562
                                organodiyl group 19562
                                  carbonyl group 19543
                                    carbonyl compound 19543
                                      carboxylic acid 19118
                                        monocarboxylic acid 18403
                                          uronic acid 14
                                            hexuronic acid 14
                                              glucuronic acids 13
                                                glucuronic acid 11
                                                  D-glucuronic acid 10
                                                    D-glucopyranuronic acid 10
                                                      beta-D-glucuronic acid 4
                                                        acetaminophen O-beta-D-glucosiduronic acid 3
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