4-hydroxynon-2-enal - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4-hydroxynon-2-enal	go back to main search page
Accession:	CHEBI:32585	browse the term
Definition:	An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Synonyms:	related_synonym:	4-HNE; 4-Hydroxy-2,3-nonenal; 4-Hydroxy-2-nonenal; 4-Hydroxynonenal; Formula=C9H16O2; HNE; InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3; InChIKey=JVJFIQYAHPMBBX-UHFFFAOYSA-N; SMILES=[H]C(=CC=O)C(O)CCCCC
	xref:	CAS:29343-52-0; LINCS:LSM-4344
	xref_mesh:	MESH:C027576
	xref:	Wikipedia:4-Hydroxynonenal

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Genes (808)

4-hydroxynon-2-enal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily C member 1

affects binding
increases expression
multiple interactions

4-hydroxy-2-nonenal binds to ABCC1 protein
4-hydroxy-2-nonenal results in increased expression of ABCC1 mRNA
[GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal

PMID:15672542 PMID:19191707 PMID:21925487

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

affects export
multiple interactions

ABCC2 protein affects the export of 4-hydroxy-2-nonenal metabolite
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]

PMID:12623073 PMID:19326901

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

actin, alpha 1, skeletal muscle

affects binding

4-hydroxy-2-nonenal binds to ACTA1 protein

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:51,883,715...51,886,742

G

actin, beta

affects binding

ACTB protein binds to 4-hydroxy-2-nonenal

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877

G

actinin, alpha 1

affects binding

ACTN1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:98,998,556...99,093,251

G

actinin alpha 4

affects binding

ACTN4 protein binds to 4-hydroxy-2-nonenal

NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:84,182,788...84,251,847

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

increases expression

4-hydroxy-2-nonenal results in increased expression of ADH7 mRNA

NCBI chr 2:229,422,125...229,436,584
Ensembl chr 2:226,741,788...226,763,182

G

acireductone dioxygenase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of ADI1 mRNA

NCBI chr 6:51,035,267...51,042,229
Ensembl chr 6:45,306,841...45,313,842

G

adenosine A1 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ADORA1 mRNA

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2B receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ADORA2B mRNA

NCBI chr10:47,439,712...47,456,092
Ensembl chr10:46,940,384...46,956,772

G

adrenoceptor beta 2

increases expression

4-hydroxy-2-nonenal results in increased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512

G

argonaute RISC catalytic component 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AGO2 mRNA

NCBI chr 7:106,907,209...106,994,124
Ensembl chr 7:105,029,120...105,104,974

G

argonaute RISC catalytic component 3

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of AGO3 mRNA
4-hydroxy-2-nonenal results in increased expression of AGO3 mRNA

NCBI chr 5:143,913,957...143,998,746
Ensembl chr 5:138,639,569...138,714,230

G

agrin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AGRN mRNA

NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:166,749,310...166,786,003

G

angiotensinogen

affects binding
multiple interactions

4-hydroxy-2-nonenal binds to AGT protein modified form; AGT protein modified form binds to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in increased lipidation of AGT protein modified form; [AGT protein modified form results in increased chemical synthesis of Lipid Peroxides] which results in increased abundance of 4-hydroxy-2-nonenal; [Ascorbic Acid co-treated with Copper Sulfate] promotes the reaction [AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]

PMID:20977208 PMID:26111765 PMID:31144504

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

activator of HSP90 ATPase homolog 2

increases expression

4-hydroxy-2-nonenal results in increased expression of AHSA2 mRNA

NCBI chr14:97,476,304...97,485,725
Ensembl chr14:97,476,817...97,485,657

G

apoptosis inducing factor, mitochondria associated 1

increases expression

4-hydroxy-2-nonenal results in increased expression of AIFM1 mRNA

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256

G

AT-hook transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AKNA mRNA

NCBI chr 5:81,792,928...81,839,936
Ensembl chr 5:76,777,415...76,816,017

G

aldo-keto reductase family 1 member A1

increases reduction
increases expression

AKR1A1 protein results in increased reduction of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of AKR1A1 mRNA

PMID:10510318 PMID:19191707

NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1 member B1

affects reduction
increases reduction

AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal
AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal; AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite

PMID:9890881 PMID:10510318 PMID:11306073 PMID:21329684

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases reduction
multiple interactions
increases metabolic processing

AKR1B10 protein results in increased reduction of 4-hydroxy-2-nonenal
Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]

PMID:19013440 PMID:21329684 PMID:27417252

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C3

increases expression
increases response to substance
multiple interactions

4-hydroxy-2-nonenal results in increased expression of AKR1C3 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR1C3 protein
AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]

PMID:22964423 PMID:30849339

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 7, member A2

decreases response to substance
affects response to substance
increases response to substance
multiple interactions
increases expression

AKR7A2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
AKR7A2 protein affects the susceptibility to 4-hydroxy-2-nonenal
AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]
4-hydroxy-2-nonenal results in increased expression of AKR7A2 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR7A2 protein

PMID:22001351 PMID:22964423 PMID:30849339

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

affects response to substance
multiple interactions
increases activity
decreases phosphorylation

AKT1 protein affects the susceptibility to 4-hydroxy-2-nonenal
AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]
4-hydroxy-2-nonenal results in increased activity of AKT1 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of AKT1 protein

PMID:18805481 PMID:23845594 PMID:24825450

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein; [ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]; sulforaphane inhibits the reaction [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases metabolic processing
multiple interactions
increases oxidation

ALDH1A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH1A1 protein results in increased oxidation of 4-hydroxy-2-nonenal

PMID:21256123 PMID:21967605 PMID:22339434

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 2 family member

multiple interactions
increases oxidation

[APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein; ALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]

PMID:21967605 PMID:22339434 PMID:25263579

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

decreases response to substance
affects metabolic processing
affects response to substance
increases metabolic processing
multiple interactions
increases oxidation

ALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased oxidation of 4-hydroxy-2-nonenal

PMID:11018474 PMID:11306050 PMID:15905174 PMID:21256123 PMID:21967605 More...

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681

G

aldehyde dehydrogenase 3 family, member B1

affects binding
decreases response to substance

4-hydroxy-2-nonenal binds to ALDH3B1 protein
ALDH3B1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 1:210,574,545...210,605,188
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 6 family, member A1

increases expression

4-hydroxy-2-nonenal results in increased expression of ALDH6A1 mRNA

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 7 family, member A1

increases metabolic processing
decreases response to substance

ALDH7A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
ALDH7A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr18:52,208,035...52,240,293
Ensembl chr18:50,009,934...50,042,193

G

aldolase, fructose-bisphosphate A

affects binding

ALDOA protein binds to 4-hydroxy-2-nonenal

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate C

multiple interactions

Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein]

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066

G

arachidonate 5-lipoxygenase

multiple interactions

ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743

G

arachidonate 5-lipoxygenase activating protein

increases expression

4-hydroxy-2-nonenal results in increased expression of ALOX5AP mRNA

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:5,748,944...5,772,986

G

alpha-kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ALPK1 mRNA

NCBI chr 2:218,801,425...218,924,013
Ensembl chr 2:216,128,825...216,247,157

G

alsin Rho guanine nucleotide exchange factor ALS2

increases expression

4-hydroxy-2-nonenal results in increased expression of ALS2 mRNA

NCBI chr 9:68,107,310...68,180,192
Ensembl chr 9:60,613,167...60,670,737

G

amphiphysin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AMPH mRNA

NCBI chr17:50,435,018...50,678,583
Ensembl chr17:45,739,395...45,983,315

G

anillin, actin binding protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ANLN mRNA

NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:20,858,228...20,921,538

G

acidic nuclear phosphoprotein 32 family member A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ANP32A mRNA

NCBI chr 8:71,724,578...71,760,922
Ensembl chr 8:62,827,456...62,865,443

G

acyloxyacyl hydrolase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AOAH mRNA

NCBI chr17:48,503,812...48,745,161
Ensembl chr17:43,809,638...44,049,148

G

aldehyde oxidase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit sigma 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AP1S3 mRNA

NCBI chr 9:88,399,109...88,458,396
Ensembl chr 9:80,950,715...81,009,798

G

APC regulator of WNT signaling pathway

decreases expression
multiple interactions
affects response to substance
affects oxidation

4-hydroxy-2-nonenal results in decreased expression of APC mRNA
[APC protein affects the oxidation of 4-hydroxy-2-nonenal] which affects the abundance of 4-hydroxynonenoic acid; [APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of GSTA4 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
APC protein affects the susceptibility to 4-hydroxy-2-nonenal

PMID:12419474 PMID:21967605

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

affects binding

4-hydroxy-2-nonenal binds to APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein D

decreases abundance

APOD protein results in decreased abundance of 4-hydroxy-2-nonenal

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:69,431,260...69,452,305

G

amyloid beta precursor protein

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of APP mRNA
[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; [APP protein modified form inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide]] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; Deferoxamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]

PMID:12419474 PMID:17964426

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

Rho GTPase activating protein 11A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGAP11A mRNA

NCBI chr 3:121,045,187...121,071,985
Ensembl chr 3:100,590,865...100,607,559

G

Rho GTPase activating protein 22

increases expression

4-hydroxy-2-nonenal results in increased expression of ARHGAP22 mRNA

NCBI chr16:8,480,222...8,637,823
Ensembl chr16:8,476,306...8,631,548

G

Rho GTPase activating protein 27

increases expression

4-hydroxy-2-nonenal results in increased expression of ARHGAP27 mRNA

NCBI chr10:88,280,470...88,313,225
Ensembl chr10:88,280,455...88,313,185

G

Rho GTPase activating protein 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGAP5 mRNA

NCBI chr 6:75,711,199...75,774,636
Ensembl chr 6:69,976,214...70,037,660

G

Rho GDP dissociation inhibitor alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGDIA mRNA

NCBI chr10:106,352,858...106,356,347
Ensembl chr10:105,854,533...105,858,023

G

Rho guanine nucleotide exchange factor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARHGEF3 mRNA

NCBI chr16:2,308,311...2,588,634
Ensembl chr16:2,300,138...2,581,945

G

AT-rich interaction domain 5A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ARID5A mRNA

NCBI chr 9:46,030,513...46,058,729
Ensembl chr 9:38,534,590...38,547,597

G

arrestin domain containing 3

increases expression

4-hydroxy-2-nonenal results in increased expression of ARRDC3 mRNA

NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:11,137,460...11,149,978

G

anti-silencing function 1B histone chaperone

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of ASF1B mRNA
4-hydroxy-2-nonenal results in increased expression of ASF1B mRNA

NCBI chr19:41,085,786...41,100,352
Ensembl chr19:24,181,028...24,195,549

G

assembly factor for spindle microtubules

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ASPM mRNA

NCBI chr13:53,625,584...53,674,489
Ensembl chr13:51,074,849...51,123,755

G

ATPase family, AAA domain containing 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ATAD5 mRNA

NCBI chr10:65,568,569...65,616,379
Ensembl chr10:65,070,689...65,117,845

G

activating transcription factor 3

increases expression

4-hydroxy-2-nonenal results in increased expression of ATF3 protein

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of ATF4 mRNA; 4-hydroxy-2-nonenal results in increased expression of ATF4 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 5

increases expression

4-hydroxy-2-nonenal results in increased expression of ATG5 mRNA

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

increases expression

4-hydroxy-2-nonenal results in increased expression of ATG7 mRNA

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593

G

ATM serine/threonine kinase

increases expression

4-hydroxy-2-nonenal results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit beta 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ATP1B3 mRNA

NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:96,910,309...96,941,598
Ensembl chr 8:96,910,309...96,941,598

G

ATP synthase F1 subunit alpha

affects binding

4-hydroxy-2-nonenal binds to ATP5F1A protein

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794

G

ATPase H+ transporting V1 subunit A

increases expression

4-hydroxy-2-nonenal results in increased expression of ATP6V1A mRNA

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:56,560,974...56,614,694

G

ATR serine/threonine kinase

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of ATR mRNA
4-hydroxy-2-nonenal results in increased expression of ATR mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136

G

advillin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AVIL mRNA

NCBI chr 7:64,711,294...64,729,436
Ensembl chr 7:62,826,025...62,844,071

G

beta-2 microglobulin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766

G

BRISC and BRCA1 A complex member 2

increases expression

4-hydroxy-2-nonenal results in increased expression of BABAM2 mRNA

NCBI chr 6:30,089,065...30,467,508
Ensembl chr 6:24,369,022...24,833,951

G

BCL2-associated agonist of cell death

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of BAD mRNA
4-hydroxy-2-nonenal results in increased expression of BAD protein

PMID:12419474 PMID:24825450

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

basic leucine zipper ATF-like transcription factor 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BATF2 mRNA

NCBI chr 1:212,897,076...212,905,740
Ensembl chr 1:203,468,097...203,475,889

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of BAX mRNA
4-hydroxy-2-nonenal results in increased expression of BAX protein

PMID:12419474 PMID:15607904 PMID:21187080 PMID:24825450

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions
increases expression

4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509

G

BBX high mobility group box domain containing

increases expression

4-hydroxy-2-nonenal results in increased expression of BBX mRNA

NCBI chr11:63,850,034...64,097,700
Ensembl chr11:50,381,247...50,623,251

G

BCAR3 adaptor protein, NSP family member

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCAR3 mRNA

NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:210,525,260...210,638,798

G

BCL2-related protein A1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCL2A1B mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCL2L1 mRNA

PMID:12419474 PMID:19191707

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

increases expression

4-hydroxy-2-nonenal results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

BCL3, transcription coactivator

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BCL3 mRNA

NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:79,471,369...79,485,607

G

BCL6, transcription repressor

increases expression

4-hydroxy-2-nonenal results in increased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389

G

brain-derived neurotrophic factor

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA
CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

biglycan

multiple interactions

[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal

NCBI chr X:156,348,633...156,360,797
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e40

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:141,618,476...141,624,774

G

basic helix-loop-helix family, member e41

increases expression

4-hydroxy-2-nonenal results in increased expression of BHLHE41 mRNA

NCBI chr 4:180,565,003...180,569,415
Ensembl chr 4:178,834,271...178,838,468

G

BH3 interacting domain death agonist

increases expression

4-hydroxy-2-nonenal results in increased expression of BID mRNA

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of BIRC5 mRNA
4-hydroxy-2-nonenal results in decreased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

BLM RecQ like helicase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BLM mRNA

NCBI chr 1:143,819,072...143,905,300
Ensembl chr 1:134,409,857...134,484,312

G

biliverdin reductase B

increases expression

4-hydroxy-2-nonenal results in increased expression of BLVRB mRNA

NCBI chr 1:91,866,258...91,883,921
Ensembl chr 1:82,738,695...82,770,375

G

bone morphogenetic protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BMP1 mRNA

NCBI chr15:51,961,310...52,005,597
Ensembl chr15:45,551,603...45,595,776

G

BCL2 interacting protein 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BRAF mRNA

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of BUB1B mRNA

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547

G

basic leucine zipper and W2 domains 1

increases expression

4-hydroxy-2-nonenal results in increased expression of BZW1 mRNA

NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:59,930,744...59,944,430

G

complement C5a receptor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of C5AR1 mRNA

NCBI chr 1:86,077,309...86,088,001

G

calcium voltage-gated channel subunit alpha1 A

increases expression

4-hydroxy-2-nonenal results in increased expression of CACNA1A mRNA

NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225

G

calcium dependent secretion activator

increases expression

4-hydroxy-2-nonenal results in increased expression of CADPS mRNA

NCBI chr15:14,719,078...15,173,218
Ensembl chr15:12,290,262...12,742,779

G

calcitonin-related polypeptide alpha

increases secretion

4-hydroxy-2-nonenal results in increased secretion of CALCA protein

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105

G

calcium binding and coiled coil domain 1

increases expression

4-hydroxy-2-nonenal results in increased expression of CALCOCO1 mRNA

NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:133,834,707...133,849,422

G

calreticulin 3

increases expression

4-hydroxy-2-nonenal results in increased expression of CALR3 mRNA

NCBI chr16:17,430,105...17,456,777
Ensembl chr16:17,396,247...17,423,015

G

calcium/calmodulin-dependent protein kinase ID

increases expression

4-hydroxy-2-nonenal results in increased expression of CAMK1D mRNA

NCBI chr17:77,491,191...77,892,018
Ensembl chr17:72,581,979...72,980,556

G

cyclase associated actin cytoskeleton regulatory protein 1

affects binding

CAP1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:135,142,112...135,168,769

G

calpain 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CAPN2 mRNA

NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969

G

calpain, small subunit 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CAPNS1 mRNA

NCBI chr 1:94,572,083...94,582,332
Ensembl chr 1:85,444,608...85,454,795

G

capping actin protein of muscle Z-line subunit beta

affects binding

CAPZB protein binds to 4-hydroxy-2-nonenal

NCBI chr 5:156,718,619...156,818,623
Ensembl chr 5:151,434,871...151,535,409

G

carbonic anhydrase 12

increases expression

4-hydroxy-2-nonenal results in increased expression of CAR12 mRNA

NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 2

affects binding

CA2 protein binds to 4-hydroxy-2-nonenal

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818

G

calcium regulated heat stable protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CARHSP1 mRNA

NCBI chr10:7,453,602...7,467,218
Ensembl chr10:6,946,959...7,020,019

G

calcium/calmodulin dependent serine protein kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASK mRNA

NCBI chr X:11,572,328...11,915,831
Ensembl chr X:8,899,833...9,238,694

G

caspase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP1 mRNA

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases activity
increases cleavage

4-hydroxy-2-nonenal results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
4-hydroxy-2-nonenal results in increased cleavage of CASP3 protein

PMID:11488593 PMID:16322078 PMID:16337876 PMID:17263905 PMID:19326901 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP4 mRNA

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
multiple interactions

4-hydroxy-2-nonenal results in increased activity of CASP9 protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]

PMID:16322078 PMID:17263905 PMID:21187080 PMID:24825450

Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression

4-hydroxy-2-nonenal results in increased expression of CAT mRNA

PMID:19191707 PMID:24423726

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CBLB mRNA

NCBI chr11:62,058,829...62,225,904
Ensembl chr11:48,592,703...48,756,839

G

C-C motif chemokine ligand 17

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of CCL17 mRNA
4-hydroxy-2-nonenal results in increased expression of CCL17 mRNA

NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 22

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL22 mRNA

NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

multiple interactions
decreases expression

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]
4-hydroxy-2-nonenal results in decreased expression of CCL5 mRNA

PMID:19191707 PMID:19627980

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL7 mRNA

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine ligand 9

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCL6 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,366,487...68,371,369

G

cyclin A2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNA2 mRNA

PMID:12419474 PMID:19191707

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CCND1]
4-hydroxy-2-nonenal results in increased expression of CCND1; 4-hydroxy-2-nonenal results in increased expression of CCND1 mRNA

PMID:16328008 PMID:19191707

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCND2 protein

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

multiple interactions

[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein]

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371

G

cyclin F

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNF mRNA

NCBI chr10:13,757,884...13,783,669
Ensembl chr10:13,253,380...13,279,101

G

cyclin G1

increases expression

4-hydroxy-2-nonenal results in increased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641

G

cyclin G2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNG2 mRNA

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830

G

cyclin K

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNK mRNA

NCBI chr 6:132,854,428...132,877,604
Ensembl chr 6:127,090,569...127,113,191

G

cyclin T1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCNT1 mRNA

NCBI chr 7:131,566,176...131,596,988
Ensembl chr 7:129,691,209...129,717,871

G

C-C motif chemokine receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:132,433,711...132,439,266

G

CD14 molecule

increases expression

4-hydroxy-2-nonenal results in increased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261

G

Cd300a molecule

increases expression

4-hydroxy-2-nonenal results in increased expression of CD300A mRNA

NCBI chr10:100,428,826...100,441,693
Ensembl chr10:99,929,801...99,942,674

G

CD300 molecule-like family member b

increases expression

4-hydroxy-2-nonenal results in increased expression of CD300LB mRNA

NCBI chr10:100,463,815...100,473,804
Ensembl chr10:99,964,801...99,974,790

G

Cd300 molecule-like family member F

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD300LF mRNA

NCBI chr10:100,858,924...100,875,111
Ensembl chr10:100,359,943...100,376,041

G

CD36 molecule

increases expression

4-hydroxy-2-nonenal results in increased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD40 mRNA

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

Cd47 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD47 mRNA

NCBI chr11:64,374,816...64,438,763
Ensembl chr11:50,906,177...50,969,425

G

CD83 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD83 mRNA

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083

G

CD86 molecule

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 20

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDC20 mRNA

PMID:12419474 PMID:19191707

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDC25A mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle associated 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDCA2 mRNA

NCBI chr15:46,071,360...46,117,524
Ensembl chr15:41,895,901...41,941,611

G

cadherin 1

multiple interactions

[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in decreased expression of CDH1 protein

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDH2 mRNA

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167

G

cadherin 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDH3 mRNA

NCBI chr19:51,303,414...51,353,900
Ensembl chr19:34,393,727...34,444,084

G

cyclin dependent kinase 2

multiple interactions

4-hydroxy-2-nonenal binds to and results in increased alkylation of and results in decreased activity of CDK2 protein

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 6

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of CDK6 mRNA
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]

PMID:19191707 PMID:33007382

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 9

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDK9 mRNA

NCBI chr 3:36,394,168...36,399,016
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

increases expression

4-hydroxy-2-nonenal results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDKN1C mRNA

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:198,655,407...198,658,048

G

cyclin dependent kinase inhibitor 2D

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CDKN2D mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:19,831,866...19,834,674

G

CCAAT/enhancer binding protein alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412

G

centromere protein A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703
Ensembl chr 6:25,700,142...25,711,675

G

centrosomal protein 290

increases expression

4-hydroxy-2-nonenal results in increased expression of CEP290 mRNA

NCBI chr 7:37,196,765...37,285,955
Ensembl chr 7:35,310,199...35,399,392

G

carboxylesterase 1D

decreases activity

4-hydroxy-2-nonenal results in decreased activity of CES1 protein

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

increases activity

4-hydroxy-2-nonenal results in increased activity of CES2 protein

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830

G

complement factor B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CFB mRNA

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505

G

cofilin 1

affects binding

CFL1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 1:212,227,124...212,230,656
Ensembl chr 1:202,786,627...202,817,587

G

checkpoint kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009

G

CHM like Rab escort protein

increases expression

4-hydroxy-2-nonenal results in increased expression of CHML mRNA

NCBI chr13:90,141,880...90,152,097
Ensembl chr13:87,589,298...87,619,862

G

ciliogenesis associated kinase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of CILK1 mRNA

NCBI chr 8:87,868,294...87,922,995
Ensembl chr 8:78,984,258...79,042,691

G

cytokine inducible SH2-containing protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:107,972,306...107,977,250

G

CDC28 protein kinase regulatory subunit 1B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CKS1B mRNA

NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:174,833,050...174,837,636

G

CDC28 protein kinase regulatory subunit 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519

G

claudin 11

increases expression

4-hydroxy-2-nonenal results in increased expression of CLDN11 mRNA

NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:112,207,745...112,221,050

G

C-type lectin domain family 12, member A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CLEC12A mRNA

NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:162,798,125...162,816,753

G

C-type lectin domain family 4, member A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CLEC4N mRNA

NCBI chr 4:158,026,138...158,119,904
Ensembl chr 4:156,414,688...156,432,402

G

C-type lectin domain family 4, member D

increases expression

4-hydroxy-2-nonenal results in increased expression of CLEC4D mRNA

NCBI chr 4:158,275,287...158,286,978
Ensembl chr 4:156,589,792...156,598,848

G

C-type lectin domain containing 5A

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of CLEC5A mRNA
4-hydroxy-2-nonenal results in increased expression of CLEC5A mRNA

NCBI chr 4:70,373,855...70,383,560
Ensembl chr 4:69,407,835...69,416,859

G

CDC-like kinase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CLK3 mRNA

NCBI chr 8:67,048,121...67,063,192
Ensembl chr 8:58,152,155...58,168,181

G

collagen type I alpha 1 chain

increases expression

4-hydroxy-2-nonenal results in increased expression of COL1A1 mRNA; 4-hydroxy-2-nonenal results in increased expression of COL1A1 protein

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

catechol-O-methyltransferase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of COMT mRNA

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

decreases expression
affects abundance

4-hydroxy-2-nonenal results in decreased expression of CP mRNA
CP protein affects the abundance of 4-hydroxy-2-nonenal

PMID:12572680 PMID:19191707

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075

G

carboxypeptidase E

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CPE mRNA

NCBI chr16:29,796,707...29,908,647
Ensembl chr16:25,030,276...25,142,233

G

cAMP responsive element binding protein 1

decreases expression
increases phosphorylation

4-hydroxy-2-nonenal results in decreased expression of CREB1 mRNA
4-hydroxy-2-nonenal results in increased phosphorylation of CREB1 protein

PMID:12419474 PMID:16337876

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

CREB binding protein

multiple interactions

CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888

G

cellular repressor of E1A-stimulated genes 1

increases expression

4-hydroxy-2-nonenal results in increased expression of CREG1 mRNA

NCBI chr13:80,552,779...80,565,272
Ensembl chr13:78,019,843...78,032,308

G

carnitine O-octanoyltransferase

increases expression

4-hydroxy-2-nonenal results in increased expression of CROT mRNA

NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:25,080,587...25,133,109

G

cryptochrome circadian regulator 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CRY1 mRNA

NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:18,529,823...18,594,091

G

cryptochrome circadian regulator 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CRY2 mRNA

NCBI chr 3:98,830,479...98,860,437
Ensembl chr 3:78,374,995...78,404,965

G

crystallin zeta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CRYZ mRNA

NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:243,552,119...243,579,758

G

colony stimulating factor 1 receptor

increases expression

4-hydroxy-2-nonenal results in increased expression of CSF1R mRNA

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of CSF3 mRNA
4-hydroxy-2-nonenal results in increased expression of CSF3 mRNA; 4-hydroxy-2-nonenal results in increased expression of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 1, gamma 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CSNK1G2 mRNA

NCBI chr 7:9,727,430...9,746,341
Ensembl chr 7:9,076,740...9,095,052

G

cysteine and serine rich nuclear protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of AXUD1 mRNA

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:119,704,713...119,718,183

G

catenin beta 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CTNNB1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of CTNNB1 protein

PMID:12419474 PMID:24825450

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin L

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CTSL mRNA

NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548

G

cortactin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CTTN mRNA

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:199,599,710...199,635,164

G

cut-like homeobox 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CUX1 mRNA

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

C-X-C motif chemokine ligand 10

multiple interactions

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 protein]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 14

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CXCL14 mRNA

NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 3

increases expression

4-hydroxy-2-nonenal results in increased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

increases expression

4-hydroxy-2-nonenal results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b-245 beta chain

increases abundance

CYBB protein results in increased abundance of 4-hydroxy-2-nonenal

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

affects localization
multiple interactions

4-hydroxy-2-nonenal affects the localization of CYCS protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]

PMID:16322078 PMID:17263905 PMID:21187080

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[CYP1A2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP1A2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

[CYP2B6 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2B6 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2B6 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

[CYP2C29 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2C29 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2C29 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions

[CYP2J2 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2J2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2J2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal; [CYP3A4 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cysteinyl leukotriene receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CYSLTR1 mRNA

NCBI chr X:75,734,281...75,762,873
Ensembl chr X:71,663,821...71,690,121

G

cytohesin 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of CYTH4 mRNA

NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:110,152,272...110,176,741

G

death-associated protein

increases expression

4-hydroxy-2-nonenal results in increased expression of DAP mRNA

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:82,199,280...82,251,752

G

death associated protein kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,930,213...4,090,991

G

DBF4-CDC7 kinase regulatory subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DBF4 mRNA

NCBI chr 4:26,631,491...26,656,080
Ensembl chr 4:25,676,634...25,701,066

G

decorin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA; 4-hydroxy-2-nonenal results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105

G

discoidin domain receptor tyrosine kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DDR2 mRNA

NCBI chr13:84,726,412...84,851,032
Ensembl chr13:82,195,463...82,317,363

G

density regulated reinitiation and release factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DENR mRNA

NCBI chr12:38,323,433...38,346,207
Ensembl chr12:32,662,516...32,683,843

G

DNA fragmentation factor subunit alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DFFA mRNA

NCBI chr 5:164,823,807...164,836,729
Ensembl chr 5:159,540,715...159,553,633

G

DNA fragmentation factor subunit beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628

G

diacylglycerol kinase, eta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DGKH mRNA

NCBI chr15:60,390,279...60,559,777
Ensembl chr15:53,991,481...54,150,706

G

DEXH-box helicase 58

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DHX58 mRNA

NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525

G

iodothyronine deiodinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DIO2 mRNA

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809

G

DLG associated protein 5

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of DLGAP5 mRNA
4-hydroxy-2-nonenal results in increased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:20,633,966...20,664,518

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

4-hydroxy-2-nonenal results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member C3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:96,025,624...96,065,181

G

deoxyribonuclease 2, lysosomal

increases expression

4-hydroxy-2-nonenal results in increased expression of DNASE2A mRNA

NCBI chr19:40,149,505...40,152,225
Ensembl chr19:23,244,664...23,247,376

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DNPH1 mRNA

NCBI chr 9:21,978,894...21,981,631
Ensembl chr 9:14,481,066...14,484,022

G

dihydropyrimidinase-like 2

affects binding

4-hydroxy-2-nonenal binds to DPYSL2 protein

NCBI chr15:45,181,041...45,287,065
Ensembl chr15:41,005,551...41,111,829

G

dopamine receptor D2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DRD2 protein

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

dystonin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of DST mRNA

NCBI chr 9:43,631,716...44,025,535
Ensembl chr 9:36,135,284...36,529,615

G

dynein light chain Tctex-type 3

affects binding

DYNLT3 protein binds to 4-hydroxy-2-nonenal

NCBI chr X:16,000,425...16,009,632
Ensembl chr X:13,327,892...13,337,139

G

E2F transcription factor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

increases expression

4-hydroxy-2-nonenal results in increased expression of E2F2 mRNA

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:98,565,717...98,584,098

G

enoyl CoA hydratase domain containing 3

increases expression

4-hydroxy-2-nonenal results in increased expression of ECHDC3 mRNA

NCBI chr17:76,980,112...77,002,934
Ensembl chr17:72,070,668...72,093,516

G

endothelin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EEF2 protein

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183

G

ephrin A4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EFNA4 mRNA

NCBI chr 2:177,046,463...177,050,713
Ensembl chr 2:174,748,724...174,752,979

G

EP300 interacting inhibitor of differentiation 3

increases expression

4-hydroxy-2-nonenal results in increased expression of EID3 mRNA

NCBI chr 7:22,747,645...22,748,967

G

eukaryotic translation initiation factor 2A

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of EIF2A protein

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2-alpha kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EIF2AK2 mRNA

NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E

increases expression

4-hydroxy-2-nonenal results in increased expression of EIF4E mRNA

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E family member 2

increases expression

4-hydroxy-2-nonenal results in increased expression of EIF4E2 mRNA

NCBI chr 9:95,333,439...95,362,366
Ensembl chr 9:87,878,085...87,914,482

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of EIF4EBP1 protein

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 5A

increases expression

4-hydroxy-2-nonenal results in increased expression of EIF5A mRNA

NCBI chr10:55,138,821...55,143,272
Ensembl chr10:54,640,024...54,644,656

G

ETS transcription factor ELK1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ELK1 mRNA

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:1,139,756...1,155,713

G

elongin C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ELOC mRNA

NCBI chr 5:7,444,769...7,461,187
Ensembl chr 5:2,661,724...2,677,890
Ensembl chr20:2,661,724...2,677,890

G

elongator acetyltransferase complex subunit 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ELP1 mRNA

NCBI chr 5:76,248,545...76,300,985
Ensembl chr 5:71,456,310...71,505,762

G

essential meiotic structure-specific endonuclease 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EME1 mRNA

NCBI chr10:80,083,585...80,092,450
Ensembl chr10:79,586,729...79,595,435

G

enolase 1

affects binding

4-hydroxy-2-nonenal binds to ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

epoxide hydrolase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235

G

epidermal growth factor receptor pathway substrate 15

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EPS15 mRNA

NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:124,045,926...124,146,221

G

EGFR pathway substrate 8, signaling adaptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EPS8 mRNA

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:170,388,378...170,486,873

G

epithelial stromal interaction 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EPSTI1 mRNA

NCBI chr15:59,692,712...59,791,376
Ensembl chr15:53,284,216...53,382,191

G

erb-b2 receptor tyrosine kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERBB2 mRNA

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERBB4 mRNA

NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595

G

ERCC excision repair 1, endonuclease non-catalytic subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC1 mRNA

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC2 mRNA

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 5, endonuclease

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC5 mRNA

NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:46,309,389...46,354,472

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERCC6L mRNA

NCBI chr X:71,285,380...71,301,186
Ensembl chr X:67,245,414...67,280,756

G

endoplasmic reticulum to nucleus signaling 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ERN1 mRNA

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029

G

extra spindle pole bodies like 1, separase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ESPL1 mRNA

NCBI chr 7:135,302,460...135,329,570
Ensembl chr 7:133,424,130...133,450,984

G

ETS proto-oncogene 1, transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:31,045,945...31,168,010

G

ETS proto-oncogene 2, transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETS2 mRNA

NCBI chr11:48,491,057...48,507,843
Ensembl chr11:35,021,596...35,038,319

G

ETS variant transcription factor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETV3 mRNA

NCBI chr 2:175,263,389...175,278,217
Ensembl chr 2:172,965,588...172,980,314

G

ETS variant transcription factor 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ETV6 mRNA

NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:166,847,686...167,084,992

G

ezrin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of EZR mRNA

NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor X

increases expression

4-hydroxy-2-nonenal results in increased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor II (thrombin) receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of F2R mRNA

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:26,868,404...26,885,870

G

coagulation factor III, tissue factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of F3 mRNA

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668

G

FA complementation group D2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:146,679,179...146,743,412

G

Fas-activated serine/threonine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FASTK mRNA

NCBI chr 4:11,624,697...11,628,769
Ensembl chr 4:10,732,256...10,737,430

G

F-box and leucine-rich repeat protein 17

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXL17 mRNA

NCBI chr 9:110,227,609...110,666,184
Ensembl chr 9:102,782,440...103,208,950

G

F-box and leucine-rich repeat protein 20

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of FBXL20 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXL20 mRNA

NCBI chr10:83,577,038...83,640,022
Ensembl chr10:83,086,551...83,144,162

G

F-box protein 15

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FBXO15 mRNA

NCBI chr18:80,594,444...80,909,549
Ensembl chr18:78,319,534...78,390,765

G

F-box protein 22

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXO22 mRNA

NCBI chr 8:64,476,034...64,492,063
Ensembl chr 8:55,579,891...55,596,148

G

F-box protein 30

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXO30 mRNA

NCBI chr 1:7,475,636...7,491,719
Ensembl chr 1:5,655,339...5,672,441

G

F-box protein 31

increases expression

4-hydroxy-2-nonenal results in increased expression of FBXO31 mRNA

NCBI chr19:66,533,437...66,564,674
Ensembl chr19:49,627,686...49,656,010

G

F-box protein 39

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FBXO39 mRNA

NCBI chr10:57,428,259...57,433,468
Ensembl chr10:56,932,297...56,934,906

G

F-box protein 5

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of FBXO5 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXO5 mRNA

NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:42,196,068...42,202,437

G

Fc gamma receptor 1A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FCGR1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of FCGR1A mRNA

NCBI chr 2:186,539,941...186,548,941
Ensembl chr 2:183,851,077...183,859,994

G

Fc gamma receptor 2B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FCGR2B mRNA

NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778

G

ferrochelatase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FECH mRNA

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:57,945,122...57,979,348

G

fem-1 homolog C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FEM1C mRNA

NCBI chr18:41,419,511...41,445,300
Ensembl chr18:39,232,900...39,258,692

G

flap structure-specific endonuclease 1

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of FEN1 mRNA
4-hydroxy-2-nonenal results in decreased expression of FEN1 mRNA

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:206,844,884...206,850,003

G

Fibroblast growth factor receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350

G

FGR proto-oncogene, Src family tyrosine kinase

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of FGR mRNA
4-hydroxy-2-nonenal results in decreased expression of FGR mRNA

NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:145,189,841...145,217,326

G

FKBP prolyl isomerase 14

increases expression

4-hydroxy-2-nonenal results in increased expression of FKBP14 mRNA

NCBI chr 4:85,035,840...85,051,917
Ensembl chr 4:83,705,652...83,721,528

G

FKBP prolyl isomerase like

increases expression

4-hydroxy-2-nonenal results in increased expression of FKBPL mRNA

NCBI chr20:4,104,457...4,105,927
Ensembl chr20:4,099,806...4,101,368

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of FOS mRNA
4-hydroxy-2-nonenal results in decreased expression of FOS protein
resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of FOS protein]
4-hydroxy-2-nonenal promotes the reaction [FOS protein binds to GGT1 promoter]

PMID:12419474 PMID:16195535 PMID:16322078

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [FOSB protein binds to GGT1 promoter]

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [FOSL1 protein binds to GGT1 promoter]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]

PMID:9890986 PMID:16195535

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [FOSL2 protein binds to GGT1 promoter]

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box M1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FOXM1 mRNA

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box O3

multiple interactions

FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]]

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FOXP1 mRNA

NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258

G

formyl peptide receptor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FPR3 mRNA

NCBI chr 1:67,557,464...67,566,509
Ensembl chr 1:58,845,118...58,893,467

G

far upstream element binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of FUBP1 mRNA

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602

G

frataxin

multiple interactions

4-hydroxy-2-nonenal affects the reaction [Ethanol affects the expression of FXN protein]

NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:221,872,420...221,897,540

G

glucose-6-phosphate dehydrogenase

increases expression

4-hydroxy-2-nonenal results in increased expression of G6PDX mRNA

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of GABARAPL1 mRNA

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:162,980,249...162,989,450

G

growth arrest and DNA-damage-inducible, alpha

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]

PMID:19191707 PMID:24291486

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115

G

cyclin G associated kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GAK mRNA

NCBI chr14:1,234,272...1,308,492
Ensembl chr14:1,089,866...1,216,398

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

[Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]

PMID:20889679 PMID:23696560

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GATA3 mRNA

PMID:12419474 PMID:19191707

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391

G

GATA zinc finger domain containing 2B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GATAD2B mRNA

NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:175,749,433...175,825,542

G

glutamyl-tRNA amidotransferase subunit B

increases expression

4-hydroxy-2-nonenal results in increased expression of GATB mRNA

NCBI chr 2:173,228,562...173,315,144
Ensembl chr 2:170,930,542...171,016,695

G

guanylate binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GBP1 mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GBP3 mRNA

NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:231,305,244...231,318,879

G

guanylate binding protein 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GBP5 mRNA

NCBI chr 2:233,910,999...233,930,320
Ensembl chr 2:231,237,748...231,257,061

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of GCLC mRNA
4-hydroxy-2-nonenal results in increased expression of GCLC protein
NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]

PMID:19191707 PMID:24291486

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

4-hydroxy-2-nonenal results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

GEN1 Holliday junction 5' flap endonuclease

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GEN1 mRNA

NCBI chr 6:39,666,675...39,697,480
Ensembl chr 6:33,948,206...33,978,401

G

gametogenetin binding protein 1

increases expression

4-hydroxy-2-nonenal results in increased expression of GGNBP1 mRNA

NCBI chr20:5,111,734...5,118,034
Ensembl chr20:5,099,311...5,116,183

G

gamma-glutamyltransferase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GGT1 mRNA]; 4-hydroxy-2-nonenal promotes the reaction [FOS protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [FOSB protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [FOSL1 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [FOSL2 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [JUN protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [JUNB protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [NFE2L1 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal promotes the reaction [NFE2L2 protein binds to GGT1 promoter]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GGT1 mRNA]

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442

G

G protein subunit alpha 13

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNA13 mRNA

NCBI chr10:94,837,271...94,870,290
Ensembl chr10:94,337,725...94,370,774

G

G protein subunit alpha q

increases expression

4-hydroxy-2-nonenal results in increased expression of GNAQ mRNA

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672

G

GNAS complex locus

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNAS mRNA

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit alpha transducin 3

increases expression

4-hydroxy-2-nonenal results in increased expression of GNAT3 mRNA

NCBI chr 4:18,054,551...18,104,332
Ensembl chr 4:17,162,490...17,212,283

G

G protein subunit beta 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNB1 mRNA

NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:166,075,629...166,142,124

G

G protein subunit beta 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GNB2 mRNA

NCBI chr12:24,795,505...24,800,796
Ensembl chr12:19,158,973...19,164,019

G

glutamic-oxaloacetic transaminase 2

multiple interactions

Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein]

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,174,311...9,199,994

G

G protein-coupled receptor 183

increases expression

4-hydroxy-2-nonenal results in increased expression of GPR183 mRNA

NCBI chr15:105,445,129...105,457,192
Ensembl chr15:99,036,367...99,050,559

G

glutathione peroxidase 1

increases abundance

GPX1 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877

G

glycogen synthase kinase 3 beta

decreases expression
decreases phosphorylation

4-hydroxy-2-nonenal results in decreased expression of GSK3B mRNA
4-hydroxy-2-nonenal results in decreased phosphorylation of GSK3B protein

PMID:12419474 PMID:24825450

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

increases expression

4-hydroxy-2-nonenal results in increased expression of GSN mRNA

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

increases expression

4-hydroxy-2-nonenal results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases expression

4-hydroxy-2-nonenal results in increased expression of GSS mRNA

NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

decreases response to substance
increases expression
affects metabolic processing
multiple interactions

GSTA1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA
GSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog

PMID:9799558 PMID:11256969 PMID:15829614

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 3

multiple interactions

[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 4

multiple interactions
affects metabolic processing
increases expression

GSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenal
GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal; GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analog
4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA; 4-hydroxy-2-nonenal results in increased expression of GSTA4 protein

PMID:2619714 PMID:7878679 PMID:8142470 PMID:8203886 PMID:9461507 More...

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase mu 1

multiple interactions
affects metabolic processing

[GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; [GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal
GSTM1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog

PMID:11256969 PMID:21925487

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases response to substance
multiple interactions
affects metabolic processing

GSTM2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
GSTM2 protein affects the metabolism of 4-hydroxy-2-nonenal analog

PMID:11256969 PMID:15829614

NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

multiple interactions
decreases response to substance
increases expression
affects binding
decreases expression

4-hydroxy-2-nonenal binds to and results in decreased activity of GSTP1 protein
GSTP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of GSTP1 protein
4-hydroxy-2-nonenal analog binds to GSTP1
4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein
Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]
4-hydroxy-2-nonenal results in increased expression of GSTP1 mRNA

PMID:9463521 PMID:11600134 PMID:15829614 PMID:18232660 PMID:19191707 More...

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

general transcription factor IIB

decreases expression

4-hydroxy-2-nonenal results in decreased expression of GTF2B mRNA

NCBI chr 2:234,427,734...234,446,043
Ensembl chr 2:231,767,238...231,785,651

G

H2A.X variant histone

multiple interactions
increases expression
increases phosphorylation

POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
4-hydroxy-2-nonenal results in increased expression of H2AX protein
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in increased expression of H2AX protein

PMID:22331492 PMID:34503147

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

decreases activity

4-hydroxy-2-nonenal results in decreased activity of H6PD protein

NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:160,438,697...160,470,171

G

histone H3 associated protein kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HASPIN mRNA

NCBI chr10:58,246,244...58,249,031
Ensembl chr10:57,747,573...57,750,512

G

heparin-binding EGF-like growth factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441

G

HMG-box transcription factor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:48,529,372...48,555,787

G

HCK proto-oncogene, Src family tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HCK mRNA

NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:141,571,587...141,614,693

G

histidine decarboxylase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HDC mRNA

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341

G

helicase, lymphoid specific

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HELLS mRNA

NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:236,701,758...236,746,844

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

increases expression

4-hydroxy-2-nonenal results in increased expression of HERC3 mRNA

NCBI chr 4:89,282,374...89,372,656
Ensembl chr 4:87,952,274...88,042,488

G

HECT and RLD domain containing E3 ubiquitin protein ligase 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HERC5 mRNA

NCBI chr20:25,329,005...25,403,443
Ensembl chr20:25,330,280...25,404,657

G

hepatocyte growth factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409

G

histidine triad nucleotide binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HINT1 mRNA

NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:92,100,973...92,101,568

G

HIVEP zinc finger 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNA

PMID:12419474 PMID:19191707

NCBI chr 1:10,176,880...10,376,089
Ensembl chr 1:8,359,289...8,555,993

G

HIVEP zinc finger 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HIVEP3 mRNA

NCBI chr 5:138,610,592...139,013,058
Ensembl chr 5:133,658,052...133,727,795

G

H2.0-like homeobox

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HLX mRNA

NCBI chr13:98,811,852...98,817,264
Ensembl chr13:96,280,339...96,285,750

G

high mobility group AT-hook 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HMGA1 mRNA

NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,611,694...5,618,752

G

high mobility group AT-hook 2

increases expression

4-hydroxy-2-nonenal results in increased expression of HMGA2 mRNA

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784

G

heme oxygenase 1

increases expression
multiple interactions

4-hydroxy-2-nonenal analog results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA; 4-hydroxy-2-nonenal results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; methyl-beta-cyclodextrin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]

PMID:18232660 PMID:19191707 PMID:20638469 PMID:23845594 PMID:24291486 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HNF4A mRNA

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320

G

hypoxanthine phosphoribosyltransferase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:132,736,096...132,768,154

G

hydroxysteroid (17-beta) dehydrogenase 11

increases expression

4-hydroxy-2-nonenal results in increased expression of HSD17B11 mRNA

NCBI chr14:5,997,893...6,047,816
Ensembl chr14:5,711,964...5,743,161

G

heat shock protein 90 alpha family class A member 1

affects binding

4-hydroxy-2-nonenal binds to HSP90AA1 protein
4-hydroxy-2-nonenal analog binds to HSP90AA1

PMID:18232660 PMID:21749116

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

affects binding

4-hydroxy-2-nonenal binds to HSP90AB1 protein

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

affects binding

4-hydroxy-2-nonenal analog binds to HSPA1A

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

4-hydroxy-2-nonenal results in increased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 1 like

affects binding

4-hydroxy-2-nonenal analog binds to HSPA1L

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4 like

increases expression

4-hydroxy-2-nonenal results in increased expression of HSPA4L mRNA

NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family A (Hsp70) member 5

affects binding
multiple interactions
increases expression

4-hydroxy-2-nonenal analog binds to HSPA5
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]
4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA; 4-hydroxy-2-nonenal results in increased expression of HSPA5 protein

PMID:18232660 PMID:24291486

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

affects binding

4-hydroxy-2-nonenal analog binds to HSPA9

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family D (Hsp60) member 1

affects binding

4-hydroxy-2-nonenal analog binds to HSPD1

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family H (Hsp110) member 1

increases expression

4-hydroxy-2-nonenal results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:5,390,922...5,410,224

G

HIV-1 Tat interactive protein 2

increases expression

4-hydroxy-2-nonenal results in increased expression of HTATIP2 mRNA

NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:99,469,245...99,488,629

G

HUS1 checkpoint clamp component

decreases expression

4-hydroxy-2-nonenal results in decreased expression of HUS1 mRNA

NCBI chr14:87,902,458...87,917,221
Ensembl chr14:83,688,708...83,703,442

G

intercellular adhesion molecule 1

increases expression

4-hydroxy-2-nonenal results in increased expression of ICAM1 mRNA

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ID1 mRNA

PMID:12419474 PMID:19191707

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419

G

isocitrate dehydrogenase (NADP(+)) 1

increases expression

4-hydroxy-2-nonenal results in increased expression of IDH1 mRNA

NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708

G

immediate early response 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IER3 mRNA

PMID:12419474 PMID:19191707

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583

G

interferon-induced protein 44-like

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFIH1 mRNA

NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFIT2 mRNA

NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFIT3 mRNA

NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:232,114,166...232,119,307

G

interferon induced transmembrane protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFITM2 mRNA

NCBI chr 1:205,481,168...205,482,348
Ensembl chr 1:196,051,537...196,052,741

G

interferon beta 1

multiple interactions

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IFNG protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]

PMID:18267128 PMID:33007382

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

increases expression

4-hydroxy-2-nonenal results in increased expression of IKBKE mRNA

NCBI chr13:45,264,404...45,290,737
Ensembl chr13:42,712,159...42,737,143

G

IKAROS family zinc finger 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IKZF1 mRNA

NCBI chr14:90,468,696...90,556,522
Ensembl chr14:86,255,065...86,342,416

G

interleukin 10

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL10 mRNA

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 10 receptor subunit alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of IL10RA mRNA

NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 12 receptor subunit beta 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL12RB1 mRNA

NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,620,770...18,632,769

G

interleukin 13 receptor subunit alpha 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL13RA1 mRNA

NCBI chr X:120,213,670...120,294,777
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 17A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL17A mRNA

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA

PMID:12419474 PMID:19191707

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 receptor accessory protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL18RAP mRNA

NCBI chr 9:50,263,723...50,296,583
Ensembl chr 9:42,768,220...42,800,959

G

interleukin 1 alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1RL1 mRNA

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

multiple interactions

[Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 27

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL27 mRNA

NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:181,173,372...181,178,582

G

interleukin 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL3 mRNA

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066

G

interleukin 36, alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL36A mRNA

NCBI chr 3:27,395,146...27,399,695
Ensembl chr 3:6,996,851...7,001,400

G

interleukin 4 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL4RA mRNA

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of IL6 mRNA
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]

PMID:19191707 PMID:33007382

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536

G

interleukin 6 cytokine family signal transducer

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNA

PMID:12419474 PMID:19191707

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:44,066,130...44,109,936

G

interleukin 7 receptor

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of IL7R mRNA
4-hydroxy-2-nonenal results in increased expression of IL7R mRNA

PMID:12419474 PMID:19191707

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:58,454,217...58,477,757

G

interleukin 9

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IL9 mRNA

NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,111,772...8,114,895

G

impact RWD domain protein

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of IMPACT mRNA
4-hydroxy-2-nonenal results in increased expression of IMPACT mRNA

NCBI chr18:4,383,546...4,422,280
Ensembl chr18:4,108,853...4,147,569

G

inositol polyphosphate phosphatase-like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of INPPL1 mRNA

NCBI chr 1:165,595,047...165,609,503
Ensembl chr 1:156,183,059...156,197,500

G

insulin induced gene 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of INSIG2 mRNA

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:32,473,742...32,494,923

G

interleukin-1 receptor-associated kinase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRAK3 mRNA

NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:55,653,962...55,713,121

G

interferon regulatory factor 3

multiple interactions

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:95,479,821...95,484,935

G

interferon regulatory factor 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832

G

interferon regulatory factor 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRF8 mRNA

NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829

G

immunity-related GTPase M

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IRGM mRNA

NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578

G

ISG15 ubiquitin-like modifier

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ISG15 mRNA

NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ISG20 mRNA

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027

G

integrin subunit alpha 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGA5 mRNA

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit alpha 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGA6 mRNA

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:56,617,268...56,689,428

G

integrin subunit alpha 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGA7 mRNA

NCBI chr 7:1,944,447...1,973,347
Ensembl chr 7:1,359,940...1,388,450

G

integrin subunit alpha L

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGAL mRNA

NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:181,918,183...181,955,732

G

integrin subunit alpha M

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGAM mRNA

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITGB6 mRNA

NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:45,048,044...45,121,671

G

intersectin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ITSN1 mRNA

NCBI chr11:44,464,515...44,646,598
Ensembl chr11:30,978,590...31,160,645

G

Janus kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of JAK2 mRNA

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

Jun dimerization protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of JDP2 mRNA

NCBI chr 6:110,988,927...111,033,392
Ensembl chr 6:105,261,373...105,301,485

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions
increases phosphorylation
affects response to substance

4-hydroxy-2-nonenal results in decreased expression of JUN mRNA
4-hydroxy-2-nonenal promotes the reaction [JUN protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased localization of JUN protein; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]
JUN protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein]

PMID:9890986 PMID:11488593 PMID:12419474 PMID:16195535 PMID:16322078 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

4-hydroxy-2-nonenal promotes the reaction [JUNB protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]

PMID:9890986 PMID:16195535

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of JUND mRNA
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]

PMID:9890986 PMID:12419474

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799

G

lysine acetyltransferase 8

increases expression

4-hydroxy-2-nonenal results in increased expression of KAT8 mRNA

NCBI chr 1:191,954,827...191,967,107
Ensembl chr 1:182,515,327...182,536,633

G

lysine demethylase 6B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KDM6B mRNA

NCBI chr10:54,619,520...54,641,014
Ensembl chr10:54,121,848...54,130,794

G

kinesin family member 11

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 20B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KIF20B mRNA

NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:232,428,371...232,483,787

G

KIT ligand

increases expression

4-hydroxy-2-nonenal results in increased expression of KITL mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 7

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KLF7 mRNA

NCBI chr 9:72,927,485...73,020,167
Ensembl chr 9:65,437,167...65,526,261

G

kelch-like family member 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KLHL6 mRNA

NCBI chr11:94,475,262...94,514,653
Ensembl chr11:80,970,917...81,009,677

G

karyopherin subunit alpha 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of KPNA2 mRNA

NCBI chr10:92,433,678...92,445,841
Ensembl chr10:91,933,951...91,946,150

G

lysosomal-associated membrane protein 1

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of LAMP1 mRNA; 4-hydroxy-2-nonenal results in increased expression of LAMP1 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883

G

linker for activation of T cells

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LAT mRNA

NCBI chr 1:190,367,111...190,372,515
Ensembl chr 1:180,936,534...180,941,578

G

lecithin cholesterol acyltransferase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LCAT mRNA

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231

G

LCK proto-oncogene, Src family tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LCK mRNA

NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794

G

LIF, interleukin 6 family cytokine

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

lipase A, lysosomal acid type

increases expression

4-hydroxy-2-nonenal results in increased expression of LIPA mRNA

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:232,024,356...232,057,633

G

lipase G, endothelial type

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LIPG mRNA

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:68,514,923...68,536,260

G

lysophosphatidic acid receptor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of LPAR1 mRNA

NCBI chr 5:78,024,139...78,147,071
Ensembl chr 5:73,229,625...73,369,895

G

lipin 1

increases expression

4-hydroxy-2-nonenal results in increased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:39,312,748...39,417,097

G

leucine rich repeat containing 59

affects binding

LRRC59 protein binds to 4-hydroxy-2-nonenal

NCBI chr10:80,069,162...80,083,820
Ensembl chr10:79,572,317...79,602,533

G

LRR binding FLII interacting protein 2

increases expression

4-hydroxy-2-nonenal results in increased expression of LRRFIP2 mRNA

NCBI chr 8:119,969,908...120,071,270
Ensembl chr 8:111,091,503...111,193,255

G

lymphotoxin beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LTB mRNA

NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381

G

lymphocyte antigen 6 family member E

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LY6E mRNA

NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:106,935,761...106,939,689

G

lymphocyte antigen 96

increases expression

4-hydroxy-2-nonenal results in increased expression of LY96 mRNA

NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:2,582,254...2,612,386

G

LYN proto-oncogene, Src family tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of LYN mRNA

PMID:12419474 PMID:19191707

NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868

G

MAF1 homolog, negative regulator of RNA polymerase III

increases expression

4-hydroxy-2-nonenal results in increased expression of MAF1 mRNA

NCBI chr 7:109,955,876...109,958,909
Ensembl chr 7:108,075,189...108,078,249

G

MAF bZIP transcription factor B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MAFB mRNA

NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:148,998,122...149,000,031

G

MAF bZIP transcription factor G

increases expression

4-hydroxy-2-nonenal results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159
Ensembl chr10:105,903,237...105,912,026

G

microtubule-associated protein 1 light chain 3 beta

increases expression

4-hydroxy-2-nonenal results in increased expression of MAP1LC3B mRNA

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MAP2K5 mRNA

NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:63,625,221...63,851,983

G

mitogen-activated protein kinase kinase kinase 20

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MAP3K20 mRNA

NCBI chr 3:77,538,146...77,697,540
Ensembl chr 3:57,130,551...57,289,626

G

mitogen activated protein kinase 1

decreases activity
multiple interactions
increases phosphorylation

4-hydroxy-2-nonenal results in decreased activity of MAPK1 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK1 protein
4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK1 protein

PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions
increases expression

4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; Acetylcysteine inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]
4-hydroxy-2-nonenal results in increased expression of MAPK14 mRNA
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]

PMID:12684028 PMID:16322078 PMID:19191707

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

decreases activity
multiple interactions
increases phosphorylation

4-hydroxy-2-nonenal results in decreased activity of MAPK3 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK3 protein
4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK3 protein

PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases activity
increases phosphorylation
affects response to substance
multiple interactions

4-hydroxy-2-nonenal results in increased activity of MAPK8 protein
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; GSTA4 protein inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein]; Resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]

PMID:11488593 PMID:12684028 PMID:15064094 PMID:16322078 PMID:17263905 More...

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178

G

MARCKS-like 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MARCKSL1 mRNA

NCBI chr 5:147,135,827...147,138,150
Ensembl chr 5:141,850,110...141,853,817

G

microtubule affinity regulating kinase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MARK3 mRNA

NCBI chr 6:136,447,327...136,537,409
Ensembl chr 6:130,627,482...130,716,647

G

minichromosome maintenance complex component 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MCM4 mRNA

NCBI chr11:98,762,599...98,776,300
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 6

increases expression

4-hydroxy-2-nonenal results in increased expression of MCM6 mRNA

NCBI chr13:42,379,161...42,404,352
Ensembl chr13:39,826,763...39,851,960

G

methionyl aminopeptidase type 1D (mitochondrial)

increases expression

4-hydroxy-2-nonenal results in increased expression of METAP1D mRNA

NCBI chr 3:56,279,471...56,354,518
Ensembl chr 3:56,279,493...56,351,981

G

methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

multiple interactions

METTL14 protein promotes the reaction [Doxorubicin results in increased abundance of 4-hydroxy-2-nonenal]

NCBI chr 2:214,215,165...214,231,412
Ensembl chr 2:211,530,602...211,546,821

G

melanocyte inducing transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MITF mRNA

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145

G

marker of proliferation Ki-67

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MKNK1 mRNA

NCBI chr 5:134,554,881...134,594,392
Ensembl chr 5:129,318,170...129,357,639

G

mutL homolog 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MLH1 mRNA

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 1

increases activity
increases expression

4-hydroxy-2-nonenal results in increased activity of MMP1 protein
4-hydroxy-2-nonenal results in increased expression of MMP1 mRNA

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

increases activity
increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased activity of MMP2 protein
4-hydroxy-2-nonenal results in increased expression of MMP2 mRNA
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 4-hydroxy-2-nonenal results in increased expression of and results in increased secretion of and results in increased activity of MMP2 protein; AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]

PMID:14672615 PMID:18805481

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
increases activity
multiple interactions
increases expression

4-hydroxy-2-nonenal results in decreased expression of MMP9 mRNA
4-hydroxy-2-nonenal results in increased activity of MMP9 protein
ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; MK-886 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; U 75302 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]
4-hydroxy-2-nonenal results in increased expression of MMP9 mRNA; 4-hydroxy-2-nonenal results in increased expression of MMP9 protein

PMID:19191707 PMID:19837106

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

myeloid cell nuclear differentiation antigen

decreases expression

4-hydroxy-2-nonenal results in decreased expression of IFI16 mRNA; 4-hydroxy-2-nonenal results in decreased expression of IFI204 mRNA
4-hydroxy-2-nonenal results in decreased expression of MNDA mRNA

PMID:12419474 PMID:19191707

NCBI chr13:88,550,224...88,567,892
Ensembl chr13:86,017,892...86,034,201

G

molybdenum cofactor sulfurase

increases expression

4-hydroxy-2-nonenal results in increased expression of MOCOS mRNA

NCBI chr18:16,206,402...16,251,928
Ensembl chr18:15,931,654...15,977,187

G

Mov10 RNA helicase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MOV10 mRNA

NCBI chr 2:194,982,014...195,003,513
Ensembl chr 2:192,293,470...192,315,083

G

membrane spanning 4-domains A6A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MS4A6C mRNA

NCBI chr 1:217,826,261...217,839,606
Ensembl chr 1:208,401,466...208,414,758

G

mutS homolog 5

increases expression

4-hydroxy-2-nonenal results in increased expression of MSH5 mRNA

NCBI chr20:3,779,180...3,797,996
Ensembl chr20:3,776,942...3,793,336

G

metallothionein 1

increases expression

4-hydroxy-2-nonenal results in increased expression of MT1 mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MT2 mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784

G

methenyltetrahydrofolate synthetase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MTHFS mRNA

NCBI chr 8:98,609,410...98,681,901
Ensembl chr 8:89,729,508...89,799,089

G

myotubularin related protein 10

increases expression

4-hydroxy-2-nonenal results in increased expression of MTMR10 mRNA

NCBI chr 1:127,271,139...127,322,621
Ensembl chr 1:117,859,267...117,910,849

G

mechanistic target of rapamycin kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MTOR mRNA

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

MTSS I-BAR domain containing 1

increases expression

4-hydroxy-2-nonenal results in increased expression of MTSS1 mRNA

NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:90,488,754...90,627,968

G

mutY DNA glycosylase

increases expression

4-hydroxy-2-nonenal results in increased expression of MUTYH mRNA

NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:130,274,122...130,286,146

G

MX dynamin like GTPase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MX1 mRNA

NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507

G

MX dynamin like GTPase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MX2 mRNA

NCBI chr11:50,375,101...50,399,373
Ensembl chr11:36,906,111...36,930,342

G

max dimerization protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MXD1 mRNA

NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:119,097,353...119,117,751

G

MYB proto-oncogene like 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MYBL2 mRNA

NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:151,705,288...151,733,708

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of MYLK mRNA

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261

G

Ngfi-A binding protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NAB2 mRNA

NCBI chr 7:65,382,863...65,389,527
Ensembl chr 7:63,497,589...63,503,989

G

NSF attachment protein beta

increases expression

4-hydroxy-2-nonenal results in increased expression of NAPB mRNA

NCBI chr 3:156,585,394...156,632,418
Ensembl chr 3:136,133,428...136,179,345

G

nibrin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NBN mRNA

PMID:12419474 PMID:19191707

NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:29,459,457...29,494,150

G

NCK adaptor protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NCK1 mRNA

NCBI chr 8:109,897,723...109,958,247
Ensembl chr 8:101,018,702...101,079,300

G

NDC80 kinetochore complex component

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NDC80 mRNA

NCBI chr 9:118,853,806...118,887,582
Ensembl chr 9:111,407,191...111,440,924

G

nectin cell adhesion molecule 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NECTIN1 mRNA

NCBI chr 8:52,998,662...53,061,745
Ensembl chr 8:44,101,776...44,189,787

G

nei-like DNA glycosylase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NEIL3 mRNA

NCBI chr16:45,091,401...45,151,419
Ensembl chr16:38,359,371...38,418,527

G

NIMA-related kinase 2

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of NEK2 mRNA
4-hydroxy-2-nonenal results in increased expression of NEK2 mRNA

NCBI chr13:105,936,809...105,950,054
Ensembl chr13:103,405,819...103,419,051

G

NIMA-related kinase 3

increases expression

4-hydroxy-2-nonenal results in increased expression of NEK3 mRNA

NCBI chr16:76,569,465...76,594,921
Ensembl chr16:69,867,047...69,892,508

G

NIMA-related kinase 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NEK6 mRNA

NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:22,284,279...22,395,990

G

neogenin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NEO1 mRNA

NCBI chr 8:68,169,711...68,322,158
Ensembl chr 8:59,275,569...59,430,348

G

neuraminidase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NEU1 mRNA

NCBI chr20:3,902,120...3,906,383
Ensembl chr20:3,897,480...3,901,745

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NF2 mRNA

NCBI chr14:83,850,894...83,934,263
Ensembl chr14:79,627,399...79,710,667

G

NFAT activating protein with ITAM motif 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NFAM1 mRNA

NCBI chr 7:116,019,383...116,055,628
Ensembl chr 7:114,139,345...114,175,442

G

nuclear factor of activated T-cells 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFATC1 mRNA

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 1

decreases expression
multiple interactions
increases expression

4-hydroxy-2-nonenal results in decreased expression of NFE2L1 mRNA
4-hydroxy-2-nonenal promotes the reaction [NFE2L1 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased expression of and results in increased localization of NFE2L1 protein
4-hydroxy-2-nonenal results in increased expression of NFE2L1 protein

PMID:12419474 PMID:16195535

NCBI chr10:82,296,824...82,309,472
Ensembl chr10:81,800,366...81,832,318

G

NFE2 like bZIP transcription factor 2

decreases activity
multiple interactions
affects response to substance
affects localization
increases expression

4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein
AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]
4-hydroxy-2-nonenal affects the localization of NFE2L2 protein
4-hydroxy-2-nonenal affects the localization of and results in increased activity of NFE2L2 protein; [GSTA4 protein mutant form results in decreased glutathionylation of 4-hydroxy-2-nonenal] which results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein]
4-hydroxy-2-nonenal results in increased expression of NFE2L2 protein
4-hydroxy-2-nonenal promotes the reaction [NFE2L2 protein binds to GGT1 promoter]; 4-hydroxy-2-nonenal results in increased expression of and results in increased localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]

PMID:16195535 PMID:16322078 PMID:19880816 PMID:24291486 PMID:24423726 More...

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor I/C

increases expression

4-hydroxy-2-nonenal results in increased expression of NFIC mRNA

NCBI chr 7:8,928,423...8,963,455
Ensembl chr 7:8,253,361...8,309,936

G

nuclear factor I X

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFIX mRNA

NCBI chr19:40,259,873...40,356,966
Ensembl chr19:23,355,498...23,448,265

G

nuclear factor kappa B subunit 1

decreases expression
multiple interactions

4-hydroxy-2-nonenal results in decreased expression of NFKB1 mRNA
4-hydroxy-2-nonenal results in decreased activity of [NFKB1 protein binds to NFKB1 protein]; 4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein]

PMID:11146106 PMID:12419474 PMID:19191707

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
increases expression

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
4-hydroxy-2-nonenal results in increased expression of NFKBIA mRNA

PMID:19191707 PMID:19627980

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor epsilon

increases expression

4-hydroxy-2-nonenal results in increased expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:15,436,941...15,450,437

G

NFKB inhibitor zeta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723

G

nuclear factor related to kappa B binding protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFRKB mRNA

NCBI chr 8:38,089,574...38,121,506
Ensembl chr 8:29,831,812...29,863,359

G

nuclear transcription factor, X-box binding 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NFX1 mRNA

NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:56,105,234...56,162,912

G

nerve growth factor receptor

increases expression

4-hydroxy-2-nonenal results in increased expression of TNFRSF10B mRNA

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518

G

NFKB inhibitor interacting Ras-like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NKIRAS1 mRNA

NCBI chr15:9,924,316...9,934,538
Ensembl chr15:7,493,531...7,503,854

G

NLR family, CARD domain containing 4

increases expression

4-hydroxy-2-nonenal results in increased expression of NLRC4 mRNA

NCBI chr 6:26,743,658...26,771,783
Ensembl chr 6:20,995,266...21,018,248

G

NLR family, pyrin domain containing 10

increases expression

4-hydroxy-2-nonenal results in increased expression of NLRP10 mRNA

NCBI chr 1:172,357,648...172,365,205
Ensembl chr 1:162,922,806...162,930,363

G

NLR family, pyrin domain containing 3

increases expression

4-hydroxy-2-nonenal results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811

G

neuromedin B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NMB mRNA

NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:134,869,446...134,872,190

G

NME/NM23 nucleoside diphosphate kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NME2 mRNA

NCBI chr10:79,394,999...79,400,418
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538

G

nitric oxide synthase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NOTCH1 mRNA

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531

G

NAD(P)H quinone dehydrogenase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA
4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA; 4-hydroxy-2-nonenal results in increased expression of NQO1 protein

PMID:24423726 PMID:29108775 PMID:30849339

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group D, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group D, member 2

increases expression

4-hydroxy-2-nonenal results in increased expression of NR1D2 mRNA

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 1, group I, member 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR1I3 mRNA

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 2, group F, member 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR2F6 mRNA

NCBI chr16:18,080,003...18,087,449
Ensembl chr16:18,046,013...18,053,459

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297

G

neuropilin 1

increases expression

4-hydroxy-2-nonenal results in increased expression of NRP1 mRNA

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:56,359,455...56,513,633

G

NSL1 component of MIS12 kinetochore complex

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NSL1 mRNA

NCBI chr13:105,176,163...105,205,179
Ensembl chr13:102,649,058...102,674,054

G

NUF2 component of NDC80 kinetochore complex

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NUF2 mRNA

NCBI chr13:84,226,448...84,290,957
Ensembl chr13:81,693,598...81,722,766

G

nuclear FMR1 interacting protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NUFIP1 mRNA

NCBI chr15:57,838,864...57,869,597
Ensembl chr15:51,429,549...51,460,310

G

nucleoporin 210

increases expression

4-hydroxy-2-nonenal results in increased expression of NUP210 mRNA

NCBI chr 4:125,068,736...125,167,238
Ensembl chr 4:123,511,559...123,609,874

G

nucleoporin 85

increases expression

4-hydroxy-2-nonenal results in increased expression of NUP85 mRNA

NCBI chr10:101,305,241...101,323,980
Ensembl chr10:100,806,437...100,825,043

G

nucleolar and spindle associated protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624

G

2'-5'-oligoadenylate synthetase 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of OAS3 mRNA

NCBI chr12:41,439,645...41,463,392
Ensembl chr12:35,779,022...35,802,781

G

olfactory receptor 1271

increases expression

4-hydroxy-2-nonenal results in increased expression of OR8D1 mRNA; 4-hydroxy-2-nonenal results in increased expression of OR8D1B mRNA

NCBI chr 8:48,024,543...48,029,052
Ensembl chr 8:39,127,352...39,131,900

G

oncostatin M

decreases expression

4-hydroxy-2-nonenal results in decreased expression of OSM mRNA

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:79,104,344...79,108,313

G

OTU deubiquitinase, ubiquitin aldehyde binding 1

multiple interactions

[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal

NCBI chr 1:213,816,400...213,824,679
Ensembl chr 1:204,387,215...204,395,483

G

purinergic receptor P2X 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of P2RX5 mRNA

NCBI chr10:58,276,329...58,291,108
Ensembl chr10:57,777,819...57,789,423

G

purinergic receptor P2Y2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of P2RY2 mRNA

NCBI chr 1:164,764,119...164,779,578
Ensembl chr 1:155,351,165...155,367,632

G

prolyl 4-hydroxylase subunit beta

affects metabolic processing

4-hydroxy-2-nonenal affects the metabolism of P4HB protein

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:105,836,982...105,848,500

G

proliferation-associated 2G4

increases expression

4-hydroxy-2-nonenal results in increased expression of PA2G4 mRNA

NCBI chr 7:1,569,326...1,576,794
Ensembl chr 7:983,971...992,331

G

poly(A) binding protein interacting protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PAIP1 mRNA

NCBI chr 2:53,255,916...53,282,965
Ensembl chr 2:51,522,921...51,550,241

G

poly (ADP-ribose) polymerase 1

increases degradation

4-hydroxy-2-nonenal results in increased degradation of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

poly (ADP-ribose) polymerase family, member 12

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PARP12 mRNA

NCBI chr 4:68,793,411...68,851,214
Ensembl chr 4:67,839,237...67,883,685

G

PDZ binding kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:40,023,002...40,034,014

G

polycomb group ring finger 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PCGF5 mRNA

NCBI chr 1:243,476,450...243,592,603
Ensembl chr 1:234,063,892...234,175,315

G

proliferating cell nuclear antigen

increases expression

4-hydroxy-2-nonenal results in increased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

proprotein convertase subtilisin/kexin type 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PCSK2 mRNA

NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:130,880,422...131,183,127

G

prenylcysteine oxidase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of PCYOX1 mRNA

NCBI chr 4:120,389,545...120,400,382
Ensembl chr 4:118,830,638...118,842,951

G

programmed cell death 4

increases expression

4-hydroxy-2-nonenal results in increased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275

G

platelet derived growth factor subunit B

increases expression

4-hydroxy-2-nonenal results in increased expression of PDGFB mRNA

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984

G

protein disulfide isomerase family A, member 3

affects binding

4-hydroxy-2-nonenal analog binds to PDIA3

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:108,388,245...108,413,236

G

decaprenyl diphosphate synthase subunit 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PDSS1 mRNA

NCBI chr17:89,964,768...90,006,819
Ensembl chr17:85,060,106...85,098,730

G

prodynorphin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PDYN mRNA

NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:116,900,992...116,913,334

G

proenkephalin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PENK mRNA

NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129

G

period circadian regulator 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PER1 mRNA

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:53,805,535...53,814,431

G

peroxisomal biogenesis factor 7

increases expression

4-hydroxy-2-nonenal results in increased expression of PEX7 mRNA

NCBI chr 1:16,402,319...16,466,304
Ensembl chr 1:14,582,699...14,646,748

G

phosphogluconate dehydrogenase

increases expression

4-hydroxy-2-nonenal results in increased expression of PGD mRNA

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:159,561,271...159,742,778

G

peptidoglycan recognition protein 3

increases expression

4-hydroxy-2-nonenal results in increased expression of PGLYRP3 mRNA

NCBI chr 2:180,174,931...180,186,007
Ensembl chr 2:177,477,407...177,490,736
Ensembl chr 2:177,477,407...177,490,736

G

phosphoglucomutase 2-like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of PGM2L1 mRNA

NCBI chr 1:163,983,917...164,033,027
Ensembl chr 1:154,571,766...154,620,902

G

phosphatidylglycerophosphate synthase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PGS1 mRNA

NCBI chr10:103,713,306...103,748,924
Ensembl chr10:103,214,646...103,250,254

G

prohibitin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PHB1 mRNA

NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042

G

PHD finger protein 11

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PHF11 mRNA

NCBI chr15:37,568,090...37,592,490
Ensembl chr15:33,390,292...33,413,009

G

PHD finger protein 21A

increases expression

4-hydroxy-2-nonenal results in increased expression of PHF21A mRNA

NCBI chr 3:98,600,933...98,791,132
Ensembl chr 3:78,194,549...78,331,865

G

phosphoglycerate dehydrogenase

affects binding

PHGDH protein binds to 4-hydroxy-2-nonenal

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944

G

pleckstrin homology-like domain, family A, member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:46,967,409...46,969,861

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

increases expression

4-hydroxy-2-nonenal results in increased expression of PIK3CB mRNA

NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PIK3CD mRNA

NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930

G

phosphoinositide-3-kinase regulatory subunit 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PIK3R2 mRNA

NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065

G

paired immunoglobin-like type 2 receptor alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of PILRA mRNA

NCBI chr12:23,452,626...23,464,772
Ensembl chr12:17,787,127...17,798,094

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

affects binding
increases response to substance

4-hydroxy-2-nonenal binds to PIN1 protein
PIN1 protein results in increased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785

G

pyruvate kinase M1/2

affects binding
multiple interactions

4-hydroxy-2-nonenal analog binds to PKM protein
4-hydroxy-2-nonenal binds to and results in decreased activity of PKM protein; 4-hydroxy-2-nonenal promotes the reaction [PKM protein binds to PKM protein]

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599

G

phospholipase A2 group VII

increases expression

4-hydroxy-2-nonenal results in increased expression of PLA2G7 mRNA

NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:17,362,225...17,404,476

G

PLAG1 like zinc finger 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PLAGL2 mRNA

NCBI chr 3:162,155,554...162,168,748
Ensembl chr 3:141,695,322...141,708,503

G

phospholipase D2

increases expression

4-hydroxy-2-nonenal results in increased expression of PLD2 mRNA

NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,256,359...55,272,808

G

pleckstrin homology and RUN domain containing M1

increases expression

4-hydroxy-2-nonenal results in increased expression of PLEKHM1 mRNA

NCBI chr10:88,814,699...88,876,570
Ensembl chr10:88,314,651...88,362,412

G

pleckstrin homology domain containing O1

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of PLEKHO1 mRNA
4-hydroxy-2-nonenal results in increased expression of PLEKHO1 mRNA

NCBI chr 2:186,233,435...186,242,114
Ensembl chr 2:183,544,499...183,552,785

G

polo-like kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 2

increases expression

4-hydroxy-2-nonenal results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947

G

DNA polymerase beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POLB mRNA

NCBI chr16:76,081,903...76,105,174
Ensembl chr16:69,379,400...69,404,812

G

DNA polymerase delta 1, catalytic subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POLD1 mRNA

NCBI chr 1:104,161,984...104,178,074
Ensembl chr 1:95,025,499...95,036,465

G

DNA polymerase epsilon, catalytic subunit

increases expression

4-hydroxy-2-nonenal results in increased expression of POLE mRNA

NCBI chr12:52,005,155...52,053,761
Ensembl chr12:46,345,420...46,393,939

G

DNA polymerase eta

multiple interactions
affects response to substance

POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
POLH protein affects the susceptibility to 4-hydroxy-2-nonenal

NCBI chr 9:22,275,929...22,310,576
Ensembl chr 9:14,777,888...14,812,723

G

DNA polymerase kappa

multiple interactions

POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]

NCBI chr 2:29,556,831...29,616,960
Ensembl chr 2:27,822,679...27,882,313

G

DNA polymerase lambda

affects response to substance
multiple interactions

POLL protein affects the susceptibility to 4-hydroxy-2-nonenal
POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]

NCBI chr 1:254,349,229...254,357,689
Ensembl chr 1:244,400,204...244,408,662

G

DNA polymerase theta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POLQ mRNA

NCBI chr11:77,179,190...77,281,270
Ensembl chr11:63,673,816...63,775,878

G

paraoxonase 1

multiple interactions
decreases activity

4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
4-hydroxy-2-nonenal results in decreased activity of PON1 protein

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360

G

POU class 2 homeobox 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of POU2F2 mRNA

NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:80,685,741...80,724,261

G

peroxisome proliferator-activated receptor gamma

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

peptidylprolyl isomerase D

increases expression

4-hydroxy-2-nonenal results in increased expression of PPID mRNA

NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:164,727,779...164,740,221

G

peptidylprolyl isomerase like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of PPIL1 mRNA

NCBI chr20:7,303,919...7,323,962
Ensembl chr20:7,302,621...7,322,354

G

protein phosphatase 1 catalytic subunit alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPP1CA mRNA

NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327

G

protein phosphatase 1, regulatory subunit 15A

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA]

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 15B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPP1R15B mRNA

NCBI chr13:47,130,000...47,137,805
Ensembl chr13:44,577,932...44,585,737

G

protein phosphatase 3 catalytic subunit alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974

G

PR/SET domain 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:47,959,858...47,981,488

G

peroxiredoxin 1

affects binding
increases expression

4-hydroxy-2-nonenal analog binds to PRDX1
4-hydroxy-2-nonenal results in increased expression of PRDX1 mRNA

PMID:18232660 PMID:19191707

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952

G

protein C receptor

increases expression

4-hydroxy-2-nonenal results in increased expression of PROCR mRNA

NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:144,254,380...144,258,903

G

proteasome 20S subunit beta 10

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PSMB10 mRNA

NCBI chr19:50,740,808...50,743,292
Ensembl chr19:33,827,229...33,833,626

G

PSMC3 interacting protein

increases expression

4-hydroxy-2-nonenal results in increased expression of PSMC3IP mRNA

NCBI chr10:86,524,546...86,527,764
Ensembl chr10:86,023,950...86,027,423

G

proteasome 26S subunit, non-ATPase 12

increases expression

4-hydroxy-2-nonenal results in increased expression of PSMD12 mRNA

NCBI chr10:92,937,957...92,956,601
Ensembl chr10:92,438,298...92,457,287

G

prostaglandin E receptor 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PTGER4 mRNA

NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

increases expression

4-hydroxy-2-nonenal results in increased expression of PTGES mRNA

NCBI chr 3:34,575,643...34,586,987

G

prostaglandin reductase 1

multiple interactions
decreases response to substance

[PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenal
PTGR1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:73,784,009...73,802,666

G

protein tyrosine kinase 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PTK2 mRNA

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PTPN1 mRNA

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504

G

protein tyrosine phosphatase, receptor type, A

increases expression

4-hydroxy-2-nonenal results in increased expression of PTPRA mRNA

NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:117,650,183...117,759,728

G

PX domain containing serine/threonine kinase like

decreases expression

4-hydroxy-2-nonenal results in decreased expression of PXK mRNA

NCBI chr15:19,190,085...19,258,711
Ensembl chr15:16,759,862...16,828,444

G

RAB11a, member RAS oncogene family

increases expression

4-hydroxy-2-nonenal results in increased expression of RAB11A mRNA

NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:65,222,949...65,246,525

G

RAB guanine nucleotide exchange factor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RABGEF1 mRNA

NCBI chr12:32,096,338...32,139,949
Ensembl chr12:26,460,175...26,503,744

G

RAD23 homolog A, nucleotide excision repair protein

increases expression

4-hydroxy-2-nonenal results in increased expression of RAD23A mRNA

NCBI chr19:40,219,235...40,225,543
Ensembl chr19:23,314,797...23,320,695

G

RAD51 recombinase

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of RAD51 mRNA
4-hydroxy-2-nonenal results in increased expression of RAD51 mRNA

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

RAD54 like

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RAD54L mRNA

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:129,575,378...129,605,070

G

retinoic acid early transcript 1E

increases expression

4-hydroxy-2-nonenal results in increased expression of RAET1E mRNA

NCBI chr 1:3,474,487...3,476,431
Ensembl chr 1:1,807,644...1,812,755

G

Raf-1 proto-oncogene, serine/threonine kinase

increases expression

4-hydroxy-2-nonenal results in increased expression of RAF1 mRNA

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317

G

ralA binding protein 1

decreases response to substance

RALBP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal

NCBI chr 9:112,903,289...112,940,093
Ensembl chr 9:105,456,425...105,492,707

G

ral guanine nucleotide dissociation stimulator

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RALGDS mRNA

NCBI chr 3:32,237,644...32,278,045
Ensembl chr 3:11,839,416...11,880,059

G

Ral GEF with PH domain and SH3 binding motif 1

increases expression

4-hydroxy-2-nonenal results in increased expression of RALGPS1 mRNA

NCBI chr 3:36,831,029...37,067,659
Ensembl chr 3:16,433,742...16,669,972

G

retinoic acid receptor, alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RARB mRNA

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288

G

RasGEF domain family, member 1B

increases expression

4-hydroxy-2-nonenal results in increased expression of RASGEF1B mRNA

NCBI chr14:10,164,366...10,684,184
Ensembl chr14:9,860,247...10,379,741

G

RAS guanyl releasing protein 3

increases expression

4-hydroxy-2-nonenal results in increased expression of RASGRP3 mRNA

NCBI chr 6:25,647,386...25,745,952
Ensembl chr 6:19,895,390...19,958,578

G

Ras association domain family member 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RASSF2 mRNA

NCBI chr 3:139,697,187...139,733,402
Ensembl chr 3:119,245,821...119,280,431

G

Ras association domain family member 8

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RASSF8 mRNA

NCBI chr 4:180,447,050...180,528,792
Ensembl chr 4:178,719,992...178,796,690

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

4-hydroxy-2-nonenal results in decreased phosphorylation of RB1 protein
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form

PMID:15607904 PMID:33007382

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RB transcriptional corepressor like 1

increases expression

4-hydroxy-2-nonenal results in increased expression of RBL1 mRNA

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330

G

RB transcriptional corepressor like 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RBL2 mRNA

NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572

G

REL proto-oncogene, NF-kB subunit

decreases expression

4-hydroxy-2-nonenal results in decreased expression of REL mRNA

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

REV1, DNA directed polymerase

multiple interactions
affects response to substance

REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
REV1 protein affects the susceptibility to 4-hydroxy-2-nonenal

NCBI chr 9:47,773,907...47,847,554
Ensembl chr 9:40,278,101...40,351,576

G

REV3 like, DNA directed polymerase zeta catalytic subunit

multiple interactions
affects response to substance

REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
REV3L protein affects the susceptibility to 4-hydroxy-2-nonenal

NCBI chr20:44,686,482...44,844,668
Ensembl chr20:43,132,363...43,290,099

G

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RFFL mRNA

NCBI chr10:68,238,273...68,301,225
Ensembl chr10:67,740,712...67,824,434

G

regulator of G-protein signaling 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RGS1 mRNA

NCBI chr13:58,568,844...58,573,187
Ensembl chr13:56,018,554...56,022,984

G

RNA sensor RIG-1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RIGI mRNA

NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819

G

RIO kinase 3

increases expression

4-hydroxy-2-nonenal results in increased expression of RIOK3 mRNA

NCBI chr18:3,602,535...3,628,108
Ensembl chr18:3,327,776...3,353,343

G

Ras-like without CAAX 1

increases expression

4-hydroxy-2-nonenal results in increased expression of RIT1 mRNA

NCBI chr 2:176,478,616...176,493,269
Ensembl chr 2:174,180,848...174,195,455

G

Rho family GTPase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:129,821,311...129,828,399

G

ring finger protein 128

increases expression

4-hydroxy-2-nonenal results in increased expression of RNF128 mRNA

NCBI chr X:107,968,973...108,087,037
Ensembl chr X:103,183,831...103,298,423

G

ring finger protein 167

increases expression

4-hydroxy-2-nonenal results in increased expression of RNF167 mRNA

NCBI chr10:55,859,254...55,863,546
Ensembl chr10:55,360,543...55,364,927

G

ring finger protein 19B

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RNF19B mRNA

NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:141,406,118...141,431,380

G

ribonuclease P/MRP subunit p38

increases expression

4-hydroxy-2-nonenal results in increased expression of RPP38 mRNA

NCBI chr17:79,823,237...79,826,908
Ensembl chr17:74,908,932...74,927,431

G

ribosomal protein S6 kinase A2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RPS6KA2 mRNA

NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:52,631,736...52,906,739

G

ribosomal protein S6 kinase B1

increases phosphorylation

4-hydroxy-2-nonenal results in increased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

radical S-adenosyl methionine domain containing 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class Ia, locus A2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of H2-T23 mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class I, locus CE16

decreases expression

4-hydroxy-2-nonenal results in decreased expression of H2-Q1 mRNA

NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563

G

retinoid X receptor alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of RXRA mRNA

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of RXRB mRNA

NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,816,815...4,828,773

G

sphingosine-1-phosphate receptor 2

increases expression

4-hydroxy-2-nonenal results in increased expression of S1PR2 mRNA

NCBI chr 8:27,779,452...27,790,344
Ensembl chr 8:19,502,627...19,523,574

G

SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1

affects binding

SAMHD1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:145,761,558...145,794,386

G

SAM domain, SH3 domain and nuclear localization signals, 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SAMSN1 mRNA

NCBI chr11:27,971,565...28,021,944
Ensembl chr11:14,483,893...14,534,900

G

SAS-6 centriolar assembly protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SASS6 mRNA

NCBI chr 2:207,231,896...207,263,840
Ensembl chr 2:204,546,660...204,578,927

G

SATB homeobox 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SATB1 mRNA

NCBI chr 9:4,916,958...5,010,359
Ensembl chr 9:4,680,920...4,753,251

G

strawberry notch homolog 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SBNO2 mRNA

NCBI chr 7:10,256,221...10,300,175
Ensembl chr 7:9,605,627...9,649,527

G

scavenger receptor class B, member 1

multiple interactions
affects binding

Tobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein]

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647

G

selenium binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SELENBP1 mRNA

NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:182,493,978...182,504,594

G

Serpine1 mRNA binding protein 1

affects binding

SERBP1 protein binds to 4-hydroxy-2-nonenal

NCBI chr 4:97,731,200...97,748,438
Ensembl chr 4:96,401,477...96,421,813

G

serpin family B member 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SERPINB5 mRNA

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:22,985,557...23,005,756

G

serpin family B member 9

increases expression

4-hydroxy-2-nonenal results in increased expression of SERPINB9 mRNA

NCBI chr17:31,628,887...31,652,003
Ensembl chr17:31,420,125...31,443,230

G

serpin family I member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SERPINI1 mRNA

NCBI chr 2:162,645,209...162,731,737
Ensembl chr 2:160,346,758...160,433,135

G

sestrin 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260

G

serum/glucocorticoid regulated kinase 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283

G

shugoshin 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SGO1 mRNA

NCBI chr 9:6,908,661...6,943,483
Ensembl chr 9:6,672,123...6,687,805

G

shugoshin 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SGO2 mRNA

NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:59,548,683...59,573,229

G

sphingosine-1-phosphate lyase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of SGPL1 mRNA

NCBI chr20:29,590,652...29,637,064
Ensembl chr20:29,047,796...29,094,084

G

SHOC2 leucine-rich repeat scaffold protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SHOC2 mRNA

NCBI chr 1:262,964,345...263,052,898
Ensembl chr 1:252,959,723...253,047,337

G

sirtuin 1

multiple interactions

SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 3

multiple interactions

4-hydroxy-2-nonenal binds to and results in decreased activity of SIRT3 protein

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 25, member 27

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SLC25A27 mRNA

NCBI chr 9:24,804,183...24,831,219
Ensembl chr 9:17,307,023...17,332,731

G

solute carrier family 7 member 11

multiple interactions

[APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal

PMID:21967605 PMID:35234341

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7 member 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SLC7A2 mRNA

NCBI chr16:58,115,991...58,174,256
Ensembl chr16:51,417,493...51,470,784

G

SMAD family member 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SMAD1 mRNA

NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651

G

structural maintenance of chromosomes 4

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:153,240,283...153,271,571

G

small nuclear RNA activating complex, polypeptide 5

increases expression

4-hydroxy-2-nonenal results in increased expression of SNAPC5 mRNA

NCBI chr 8:73,572,503...73,576,068
Ensembl chr 8:64,677,205...64,681,964

G

suppressor of cytokine signaling 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SOCS3 mRNA

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 2

affects binding
increases abundance
multiple interactions
decreases abundance
increases expression

4-hydroxy-2-nonenal binds to SOD2 protein
SOD2 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal
SOD2 protein inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased abundance of 4-hydroxy-2-nonenal]
SOD2 protein results in decreased abundance of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of SOD2 mRNA

PMID:11507057 PMID:19191707 PMID:19374891 PMID:23199288

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

SP100 nuclear antigen

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SP100 mRNA

NCBI chr 9:93,758,975...93,825,068
Ensembl chr 9:86,311,032...86,377,034

G

SP110 nuclear body protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SP110 mRNA

NCBI chr 9:93,648,574...93,673,476
Ensembl chr 9:86,200,503...86,222,670

G

Sp2 transcription factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SP2 mRNA

NCBI chr10:82,437,024...82,467,583
Ensembl chr10:81,940,587...81,970,548

G

sperm autoantigenic protein 17

increases expression

4-hydroxy-2-nonenal results in increased expression of SPA17 mRNA

NCBI chr 8:45,496,175...45,507,262
Ensembl chr 8:37,307,557...37,318,639

G

sperm associated antigen 5

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SPAG5 mRNA

NCBI chr10:63,693,300...63,714,813
Ensembl chr10:63,198,768...63,216,745

G

sprouty RTK signaling antagonist 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SPRY1 mRNA

NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:120,556,706...120,566,189

G

sprouty RTK signaling antagonist 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SPRY2 mRNA

NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009

G

sequestosome 1

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]

PMID:19191707 PMID:35550146

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SRC mRNA

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

signal recognition particle 9

affects binding

SRP9 protein binds to 4-hydroxy-2-nonenal

NCBI chr13:96,364,253...96,372,393
Ensembl chr13:93,832,580...93,840,720

G

SRSF protein kinase 2

increases expression

4-hydroxy-2-nonenal results in increased expression of SRPK2 mRNA

NCBI chr 4:12,356,983...12,548,345
Ensembl chr 4:11,464,674...11,655,990

G

sulfiredoxin 1

increases expression

4-hydroxy-2-nonenal results in increased expression of SRXN1 mRNA

PMID:19191707 PMID:22003191

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448

G

single stranded DNA binding protein 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SSBP3 mRNA

NCBI chr 5:126,920,145...127,057,968
Ensembl chr 5:121,691,393...121,827,992

G

signal transducer and activator of transcription 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of STAT5A mRNA

NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866

G

signal transducer and activator of transcription 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of STAT6 mRNA

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495

G

serine/threonine kinase 11

decreases activity
decreases expression
multiple interactions
affects binding

4-hydroxy-2-nonenal results in decreased activity of STK11 protein
4-hydroxy-2-nonenal results in decreased expression of STK11 protein; 4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form
resveratrol inhibits the reaction [4-hydroxy-2-nonenal binds to STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form]

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315

G

serine/threonine kinase 17b

decreases expression

4-hydroxy-2-nonenal results in decreased expression of STK17B mRNA

NCBI chr 9:62,801,912...62,832,511
Ensembl chr 9:55,307,668...55,338,031

G

serine/threonine kinase 3

increases expression

4-hydroxy-2-nonenal results in increased expression of STK3 mRNA

NCBI chr 7:67,938,341...68,208,472
Ensembl chr 7:66,052,345...66,323,233

G

stathmin 1

increases expression

4-hydroxy-2-nonenal results in increased expression of STMN1 mRNA

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154

G

STE20 related adaptor beta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of STRADB mRNA

NCBI chr 9:67,908,277...67,927,224
Ensembl chr 9:60,414,182...60,433,084

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

increases expression

4-hydroxy-2-nonenal results in increased expression of SUCLG1 mRNA

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:105,308,039...105,337,600

G

small ubiquitin-like modifier 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SUMO3 mRNA

NCBI chr20:11,009,730...11,020,502
Ensembl chr20:11,007,148...11,020,877
Ensembl chr20:11,007,148...11,020,877

G

SUV39H1 histone lysine methyltransferase

increases expression

4-hydroxy-2-nonenal results in increased expression of SUV39H1 mRNA

NCBI chr X:17,093,059...17,105,942
Ensembl chr X:14,421,109...14,433,982

G

SUV39H1 histone lysine methyltransferase, pseudogene 1

increases expression

4-hydroxy-2-nonenal results in increased expression of SUV39H1 mRNA

NCBI chr X:146,828,818...146,831,485

G

synaptophysin

decreases expression

4-hydroxy-2-nonenal results in decreased expression of SYP mRNA

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745

G

tachykinin, precursor 1

increases secretion

4-hydroxy-2-nonenal results in increased secretion of TAC1 protein

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178

G

transforming, acidic coiled-coil containing protein 3

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of TACC3 mRNA
4-hydroxy-2-nonenal results in increased expression of TACC3 mRNA

NCBI chr14:81,275,755...81,289,894
Ensembl chr14:77,051,215...77,065,219

G

transcriptional adaptor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TADA3 mRNA

NCBI chr 4:148,065,859...148,077,347
Ensembl chr 4:146,510,246...146,521,590

G

TRAF family member-associated NFKB activator

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TANK mRNA

NCBI chr 3:66,522,834...66,598,864
Ensembl chr 3:46,114,274...46,190,264

G

TBC1 domain family, member 12

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TBC1D12 mRNA

NCBI chr 1:236,603,597...236,685,859
Ensembl chr 1:236,603,607...236,685,859

G

TBC1 domain family, member 31

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TBC1D31 mRNA

NCBI chr 7:91,316,905...91,396,434
Ensembl chr 7:89,426,780...89,506,894

G

TBC1 domain family member 8B

increases expression

4-hydroxy-2-nonenal results in increased expression of TBC1D8B mRNA

NCBI chr X:108,107,796...108,195,744
Ensembl chr X:103,319,340...103,407,133

G

TBL1X/Y related 1

increases expression

4-hydroxy-2-nonenal results in increased expression of TBL1XR1 mRNA

NCBI chr 2:106,718,811...106,857,989
Ensembl chr 2:104,801,721...104,929,055

G

transcription factor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TCF3 mRNA

NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,280,571...9,302,314

G

telomeric repeat binding factor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TERF1 mRNA

NCBI chr 5:8,226,345...8,255,614
Ensembl chr 5:3,443,106...3,472,340

G

transcription factor Dp-2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TFDP2 mRNA

NCBI chr 8:105,640,018...105,781,026
Ensembl chr 8:96,760,504...96,896,682

G

transcription factor EB

multiple interactions
affects response to substance
affects localization

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-hydroxy-2-nonenal affects the localization of TFEB protein]; 4-hydroxy-2-nonenal results in decreased phosphorylation of and affects the localization of TFEB protein; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal affects the localization of TFEB protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]
TFEB protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal affects the localization of TFEB protein; 4-hydroxy-2-nonenal affects the localization of TFEB protein mutant form

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:13,198,891...13,254,714

G

transforming growth factor, beta 1

increases expression

4-hydroxy-2-nonenal results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

increases expression

4-hydroxy-2-nonenal results in increased expression of TGFBR1 mRNA

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777

G

thyroid hormone receptor alpha

decreases expression

4-hydroxy-2-nonenal results in decreased expression of THRA mRNA

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936

G

TIMP metallopeptidase inhibitor 1

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of TIMP1 mRNA
4-hydroxy-2-nonenal results in decreased expression of TIMP1 mRNA

PMID:14672615 PMID:19191707

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

TCDD-inducible poly(ADP-ribose) polymerase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TIPARP mRNA

NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:149,753,682...149,780,327

G

tight junction protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TJP1 mRNA

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 4

multiple interactions
decreases activity

4-hydroxy-2-nonenal inhibits the reaction [TLR4 protein binds to TLR4 protein]
4-hydroxy-2-nonenal results in decreased activity of TLR4 protein
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
increases expression

4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein
4-hydroxy-2-nonenal results in increased expression of TNF mRNA

PMID:19191707 PMID:19627980 PMID:33007382

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TNFAIP2 mRNA

NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:130,476,889...130,489,914

G

TNF alpha induced protein 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 8

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of TNFAIP8 mRNA
4-hydroxy-2-nonenal results in increased expression of TNFAIP8 mRNA

NCBI chr18:45,370,334...45,486,036
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 1A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

DNA topoisomerase I

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TOP1 mRNA

NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:149,293,403...149,376,623

G

DNA topoisomerase II alpha

decreases expression
increases expression

4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA
4-hydroxy-2-nonenal results in increased expression of TOP2A mRNA

PMID:12419474 PMID:19191707

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

increases expression
increases mutagenesis
affects abundance

4-hydroxy-2-nonenal results in increased expression of TP53 mRNA; 4-hydroxy-2-nonenal results in increased expression of TP53 protein
4-hydroxy-2-nonenal results in increased mutagenesis of TP53 gene
TRP53 protein affects the abundance of 4-hydroxy-2-nonenal

PMID:11050162 PMID:15607904 PMID:22229939

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein 1

multiple interactions

[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] affects the expression of TP53BP1 protein

NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:108,169,980...108,269,822

G

tumor protein p53 inducible nuclear protein 1

increases expression

4-hydroxy-2-nonenal results in increased expression of TRP53INP1 mRNA

NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:24,260,568...24,267,968

G

tumor protein p63

increases expression

4-hydroxy-2-nonenal results in increased expression of TP63 protein

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:74,838,859...75,049,398

G

tumor protein p73

increases expression

4-hydroxy-2-nonenal results in increased expression of TP73 protein

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128

G

triosephosphate isomerase 1

affects binding

4-hydroxy-2-nonenal binds to TPI1 protein

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:157,615,386...157,619,541

G

Tnf receptor-associated factor 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TRAF3 mRNA

NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:130,206,484...130,305,481

G

Traf3 interacting protein 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TRAF3IP2 mRNA

NCBI chr20:44,565,992...44,609,240
Ensembl chr20:43,011,450...43,054,667

G

tribbles pseudokinase 3

increases expression
multiple interactions

4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA
4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 24

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TRIM24 mRNA

NCBI chr 4:67,534,240...67,659,014
Ensembl chr 4:66,566,686...66,717,241

G

thyroid hormone receptor interactor 13

increases expression
decreases expression

4-hydroxy-2-nonenal results in increased expression of TRIP13 mRNA
4-hydroxy-2-nonenal results in decreased expression of TRIP13 mRNA

NCBI chr 1:31,185,700...31,230,638
Ensembl chr 1:29,357,130...29,402,074

G

transient receptor potential cation channel, subfamily A, member 1

multiple interactions
increases activity

Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]

PMID:17684094 PMID:21689654

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily V, member 4

increases expression

4-hydroxy-2-nonenal results in increased expression of TRPV4 mRNA

NCBI chr12:47,599,161...47,638,143
Ensembl chr12:41,938,560...41,977,517

G

TSC complex subunit 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TSC1 mRNA

NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:11,979,729...12,015,674

G

TSC complex subunit 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TSC2 mRNA

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951

G

TSC22 domain family, member 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:104,217,925...104,276,861

G

tumor susceptibility 101

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TSG101 mRNA

NCBI chr 1:106,549,035...106,578,859
Ensembl chr 1:97,410,848...97,442,554

G

tetraspanin 31

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TSPAN31 mRNA

NCBI chr 7:64,774,881...64,783,534
Ensembl chr 7:62,889,552...62,898,388

G

TSPY-like 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TSPYL2 mRNA

NCBI chr X:24,918,851...24,924,462
Ensembl chr X:21,439,478...21,445,089

G

tubulin, alpha 1B

affects binding

TUBA1B protein binds to 4-hydroxy-2-nonenal

NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, alpha 4A

increases expression

4-hydroxy-2-nonenal results in increased expression of TUBA4A mRNA

NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:76,709,614...76,713,918

G

thioredoxin 1

decreases activity
affects metabolic processing

4-hydroxy-2-nonenal results in decreased activity of TXN protein
4-hydroxy-2-nonenal affects the metabolism of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin reductase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

tyrosinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of TYR mRNA

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

G

ubiquitin-like modifier activating enzyme 1

multiple interactions

4-hydroxy-2-nonenal results in increased activity of and results in increased ubiquitination of UBA1 protein

NCBI chr X:4,062,216...4,084,192
Ensembl chr X:1,508,666...1,530,636

G

ubiquitin-conjugating enzyme E2A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of UBE2A mRNA

NCBI chr X:120,979,993...120,990,773
Ensembl chr X:116,113,875...116,125,070

G

ubiquitin-conjugating enzyme E2C

decreases expression

4-hydroxy-2-nonenal results in decreased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2D 3

increases expression

4-hydroxy-2-nonenal results in increased expression of UBE2D3 mRNA

NCBI chr 2:226,543,194...226,571,001
Ensembl chr 2:223,868,730...223,898,081

G

ubiquitin-conjugating enzyme E2I

increases expression

4-hydroxy-2-nonenal results in increased expression of UBE2I mRNA

NCBI chr10:14,782,245...14,802,911
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

ubiquitin-conjugating enzyme E2L 6

decreases expression

4-hydroxy-2-nonenal results in decreased expression of UBE2L6 mRNA

NCBI chr 3:90,279,705...90,294,721
Ensembl chr 3:69,873,424...69,888,048

G

ubiquitin-conjugating enzyme E2T

increases expression

4-hydroxy-2-nonenal results in increased expression of UBE2T mRNA

NCBI chr13:48,955,166...48,965,668
Ensembl chr13:46,403,375...46,414,835

G

ubiquitination factor E4B

increases expression

4-hydroxy-2-nonenal results in increased expression of UBE4B mRNA

NCBI chr 5:165,049,897...165,153,572
Ensembl chr 5:159,766,829...159,870,509

G

ubiquitin C-terminal hydrolase L1

increases expression

4-hydroxy-2-nonenal results in increased expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590

G

ubiquitin-like with PHD and ring finger domains 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of UHRF1 mRNA

NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,134,909...1,154,631

G

unc-51 like autophagy activating kinase 1

increases expression

4-hydroxy-2-nonenal results in increased expression of ULK1 mRNA

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966

G

upstream transcription factor 2, c-fos interacting

decreases expression

4-hydroxy-2-nonenal results in decreased expression of USF2 mRNA

NCBI chr 1:95,302,109...95,321,334
Ensembl chr 1:86,174,703...86,185,617

G

ubiquitin specific peptidase 18

decreases expression

4-hydroxy-2-nonenal results in decreased expression of USP18 mRNA

NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144

G

ubiquitin specific peptidase 37

decreases expression

4-hydroxy-2-nonenal results in decreased expression of USP37 mRNA

NCBI chr 9:83,467,966...83,567,848
Ensembl chr 9:76,018,991...76,084,044

G

UV radiation resistance associated

decreases expression

4-hydroxy-2-nonenal results in decreased expression of UVRAG mRNA

NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:153,185,395...153,442,136

G

voltage-dependent anion channel 2

affects binding

VDAC2 protein binds to 4-hydroxy-2-nonenal

NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,463,056...2,476,553

G

vascular endothelial growth factor A

decreases expression

4-hydroxy-2-nonenal results in decreased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

affects binding

VIM protein binds to 4-hydroxy-2-nonenal

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

Wnt family member 6

increases expression

4-hydroxy-2-nonenal results in increased expression of WNT6 mRNA

NCBI chr 9:83,778,552...83,792,186
Ensembl chr 9:76,329,882...76,343,523

G

WD repeat and SOCS box-containing 2

decreases expression

4-hydroxy-2-nonenal results in decreased expression of WSB2 mRNA

NCBI chr12:44,878,483...44,899,474
Ensembl chr12:39,217,648...39,238,640

G

XIAP associated factor 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of XAF1 mRNA

NCBI chr10:57,415,935...57,428,348
Ensembl chr10:56,917,121...56,929,770

G

X-box binding protein 1

increases splicing

4-hydroxy-2-nonenal results in increased splicing of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

G

xanthine dehydrogenase

increases expression

4-hydroxy-2-nonenal results in increased expression of XDH mRNA

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

4-hydroxy-2-nonenal results in decreased expression of XPC mRNA

NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:123,993,666...124,021,010

G

Y box binding protein 3

decreases expression

4-hydroxy-2-nonenal results in decreased expression of YBX3 mRNA

NCBI chr 4:166,861,180...166,884,532
Ensembl chr 4:165,129,758...165,153,161

G

YES proto-oncogene 1, Src family tyrosine kinase

decreases expression

4-hydroxy-2-nonenal results in decreased expression of YES1 mRNA

NCBI chr 9:120,646,657...120,753,880
Ensembl chr 9:113,200,256...113,299,837

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

decreases expression

4-hydroxy-2-nonenal results in decreased expression of YWHAH mRNA

NCBI chr14:81,920,819...81,930,202
Ensembl chr14:77,696,333...77,705,741

G

Z-DNA binding protein 1

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ZBP1 mRNA

NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:161,993,351...162,003,870

G

zinc finger and BTB domain containing 20

increases expression

4-hydroxy-2-nonenal results in increased expression of ZBTB20 mRNA

NCBI chr11:70,558,010...71,297,039
Ensembl chr11:57,072,880...57,510,210

G

zinc finger and BTB domain containing 7C

increases expression

4-hydroxy-2-nonenal results in increased expression of ZBTB7C mRNA

NCBI chr18:71,716,586...72,045,831
Ensembl chr18:69,441,616...69,765,297

G

zinc finger DHHC-type palmitoyltransferase 18

increases expression

4-hydroxy-2-nonenal results in increased expression of ZDHHC18 mRNA

NCBI chr 5:151,105,303...151,143,843
Ensembl chr 5:145,831,446...145,859,993

G

zinc finger protein 36

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ZFP36 mRNA

PMID:12419474 PMID:19191707

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 367

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ZFP367 mRNA

NCBI chr17:970,896...990,025
Ensembl chr17:965,161...984,287

G

zinc finger, matrin type 3

increases expression

4-hydroxy-2-nonenal results in increased expression of ZMAT3 mRNA

NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863

G

zinc finger and SCAN domain containing 29, pseudogene 1

increases expression

4-hydroxy-2-nonenal results in increased expression of ZSCAN29 mRNA

NCBI chr 3:128,589,900...128,594,043

G

zwilch kinetochore protein

decreases expression

4-hydroxy-2-nonenal results in decreased expression of ZWILCH mRNA

NCBI chr 8:73,532,968...73,566,214
Ensembl chr 8:64,637,672...64,675,916

(E)-4-hydroxynon-2-enal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 4

affects binding

(E)-4-hydroxynon-2-enal binds to Gsta4 protein

RGD

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase pi 1

affects binding

(E)-4-hydroxynon-2-enal binds to Gstp1 protein

RGD

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
role	19880
application	19720
solvent	17277
formic acid	9420
formyl group	9381
aldehyde	9381
hydroxyaldehyde	810
4-hydroxynon-2-enal	808
(E)-4-hydroxynon-2-enal +	2
Path 2
Term	Annotations
CHEBI ontology	19909
subatomic particle	19907
composite particle	19907
hadron	19907
baryon	19907
nucleon	19907
atomic nucleus	19907
atom	19907
main group element atom	19846
p-block element atom	19846
carbon group element atom	19784
carbon atom	19781
organic molecular entity	19781
heteroorganic entity	19540
organochalcogen compound	19301
organooxygen compound	19216
carbon oxoacid	18696
carboxylic acid	18693
carboacyl group	17718
univalent carboacyl group	17718
formyl group	9381
aldehyde	9381
aliphatic aldehyde	2423
fatty aldehyde	2152
unsaturated fatty aldehyde	820
monounsaturated fatty aldehyde	815
4-hydroxynonenal	808
4-hydroxynon-2-enal	808
(E)-4-hydroxynon-2-enal +	2

paths to the root