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G |
Ace2 |
angiotensin I converting enzyme 2 |
increases expression multiple interactions increases activity |
ISO EXP |
diminazene aceturate results in increased expression of ACE2 mRNA; diminazene aceturate results in increased expression of ACE2 protein [Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 mRNA; [Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 protein; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]] diminazene aceturate results in increased activity of ACE2 protein PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein] |
CTD |
PMID:25301841 PMID:26862037 PMID:27550926 PMID:28688122 PMID:31982938 |
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NCBI chr X:32,050,734...32,095,860
Ensembl chr X:32,049,931...32,096,016
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression |
ISO |
diminazene aceturate results in decreased expression of ACTA2 protein |
CTD |
PMID:29977014 |
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NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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G |
Agt |
angiotensinogen |
increases expression multiple interactions |
ISO |
diminazene aceturate results in increased expression of AGT protein modified form diminazene aceturate results in increased expression of AGT protein alternative form 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]; diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form] |
CTD |
PMID:25301841 PMID:26862037 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA] |
CTD |
PMID:26862037 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
App |
amyloid beta precursor protein |
affects expression |
ISO |
diminazene aceturate affects the expression of APP protein alternative form |
CTD |
PMID:31982938 |
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NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression multiple interactions |
ISO |
diminazene aceturate results in decreased expression of MCP1 protein 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] |
CTD |
PMID:26862037 PMID:29977014 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
diminazene aceturate results in decreased expression of COL1A1 protein |
CTD |
PMID:29977014 |
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NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Cybb |
cytochrome b-245 beta chain |
decreases expression |
ISO |
diminazene aceturate results in decreased expression of NOX2 protein |
CTD |
PMID:29977014 |
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NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
increases phosphorylation |
ISO |
diminazene aceturate results in increased phosphorylation of GRIN2B protein |
CTD |
PMID:31982938 |
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NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
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G |
Il1b |
interleukin 1 beta |
decreases expression |
EXP ISO |
diminazene aceturate results in decreased expression of IL1B mRNA diminazene aceturate results in decreased expression of IL1B protein |
CTD |
PMID:25883526 PMID:31982938 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
decreases expression multiple interactions |
ISO EXP |
diminazene aceturate results in decreased expression of IL6 protein 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:25883526 PMID:26862037 PMID:29977014 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
diminazene aceturate results in increased phosphorylation of MAPK1 protein 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:26862037 PMID:31982938 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk14 |
mitogen activated protein kinase 14 |
decreases phosphorylation |
EXP |
diminazene aceturate results in decreased phosphorylation of MAPK14 protein |
CTD |
PMID:25883526 |
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NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
diminazene aceturate results in increased phosphorylation of MAPK3 protein 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:26862037 PMID:31982938 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
increases expression |
ISO |
diminazene aceturate results in increased expression of MAS1 protein |
CTD |
PMID:31982938 |
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NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
decreases expression |
ISO |
diminazene aceturate results in decreased expression of NCF1 protein |
CTD |
PMID:29977014 |
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NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
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G |
Ncf2 |
neutrophil cytosolic factor 2 |
decreases transport |
ISO |
diminazene aceturate results in decreased transport of NCF2 protein |
CTD |
PMID:29977014 |
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NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:26862037 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nos1 |
nitric oxide synthase 1 |
decreases expression |
EXP |
diminazene aceturate results in decreased expression of NOS1 mRNA |
CTD |
PMID:25883526 |
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NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
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G |
Nox1 |
NADPH oxidase 1 |
decreases expression |
ISO |
diminazene aceturate results in decreased expression of NOX1 protein |
CTD |
PMID:29977014 |
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NCBI chr X:104,909,328...104,932,508
Ensembl chr X:104,909,326...104,932,508
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases activity decreases expression |
EXP |
diminazene aceturate results in decreased activity of RELA protein diminazene aceturate results in decreased expression of RELA mRNA; diminazene aceturate results in decreased expression of RELA protein |
CTD |
PMID:25883526 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Smad2 |
SMAD family member 2 |
decreases phosphorylation |
ISO |
diminazene aceturate results in decreased phosphorylation of SMAD2 protein |
CTD |
PMID:29977014 |
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NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
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G |
Smad3 |
SMAD family member 3 |
decreases phosphorylation |
ISO |
diminazene aceturate results in decreased phosphorylation of SMAD3 protein |
CTD |
PMID:29977014 |
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NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
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G |
Tnf |
tumor necrosis factor |
decreases expression decreases secretion |
EXP ISO |
diminazene aceturate results in decreased expression of TNF mRNA; diminazene aceturate results in decreased expression of TNF protein diminazene aceturate results in decreased secretion of TNF protein |
CTD |
PMID:25883526 PMID:29977014 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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