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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:butorphanol
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Accession:CHEBI:3242 term browser browse the term
Definition:Levorphanol in which a hydrogen at position 14 of the morphinan skeleton is substituted by hydroxy and one of the hydrogens of the N-methyl group is substituted by cyclopropyl. A semi-synthetic opioid agonist-antagonist analgesic, it is used as its (S,S)-tartaric acid salt for relief or moderate to severe pain.
Synonyms:related_synonym: (-)-17-(cyclobutylmethyl)morphinan-3,14-diol;   (-)-N-cyclobutylmethyl-3,14-dihydroxymorphinan;   Formula=C21H29NO2;   InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1;   InChIKey=IFKLAQQSCNILHL-QHAWAJNXSA-N;   SMILES=Oc1ccc2C[C@H]3N(CC[C@@]4(CCCC[C@@]34O)c2c1)CC1CCC1;   butorfanol;   butorphanolum
 alt_id: CHEBI:145838
 xref: Beilstein:8134188;   CAS:42408-82-2;   DrugBank:DB00611;   Drug_Central:454;   KEGG:C06863;   KEGG:D03197
 xref_mesh: MESH:D002077
 xref: PMID:6114178;   PMID:6166748;   PMID:6767032;   PMID:6796691;   PMID:7192744;   Patent:DE2243961;   Patent:US3775414;   Patent:US3819635;   VSDB:1780;   Wikipedia:Butorphanol


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butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity
increases activity		 ISO
EXP		 Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein		 CTD PMID:17909753 PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        pharmaceutical 19491
          drug 19491
            antitussive 268
              butorphanol 4
                butorphanol D-tartrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organonitrogen compound 18804
                                alkaloid 7816
                                  isoquinoline alkaloid 1194
                                    morphinane alkaloid 697
                                      butorphanol 4
                                        butorphanol D-tartrate 0
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