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ONTOLOGY REPORT - ANNOTATIONS
Term:butenafine
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Accession:CHEBI:3238 term browser browse the term
Definition:Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
Synonyms:exact_synonym: 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
 related_synonym: (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine;   (4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;   4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine;   Formula=C23H27N;   InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3;   InChIKey=ABJKWBDEJIDSJZ-UHFFFAOYSA-N;   N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine;   SMILES=CN(Cc1ccc(cc1)C(C)(C)C)Cc1cccc2ccccc12;   butenafina;   butenafinum
 alt_id: CHEBI:205442
 xref: Beilstein:6334654 "Beilstein";   CAS:101828-21-1 "KEGG COMPOUND";   DrugBank:DB01091;   Drug_Central:444 "DrugCentral";   KEGG:C08067;   KEGG:D07596;   LINCS:LSM-5956
 xref_mesh: MESH:C067594
 xref: PMID:17371821 "ChEMBL";   PMID:8340915 "ChEMBL";   Patent:EP164697;   Patent:US5021458;   Wikipedia:Butenafine

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butenafine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        pharmaceutical 19089
          drug 19089
            antifungal drug 5101
              butenafine 7
                butenafine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    main group molecular entity 19534
                      s-block molecular entity 19319
                        hydrogen molecular entity 19310
                          hydrides 18237
                            inorganic hydride 17105
                              pnictogen hydride 17063
                                nitrogen hydride 16886
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        tertiary amino compound 8522
                                          tertiary amine 599
                                            butenafine 7
                                              butenafine hydrochloride 0
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