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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:verteporfin
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Accession:CHEBI:32293 term browser browse the term
Definition:An equimolar mixture of the 9-methyl ester and 13-methyl ester of trans-(+-)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid. It is used as a photosensitizer in photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when activated by red (693 nm) laser light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Synonyms:related_synonym: Visudyne;   trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester;   trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester
 xref: CAS:129497-78-5;   DrugBank:DB00460;   KEGG:D01162
 xref_mesh: MESH:C098350
 xref: PMID:25494214;   PMID:26361148;   PMID:26443705;   Reaxys:13501128;   Reaxys:13501141



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verteporfin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]] CTD PMID:35093381 NCBI chr  X:110,739,633...110,803,416 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]] CTD PMID:38992766 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Amotl1 angiomotin-like 1 multiple interactions
decreases response to substance
ISO Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]
Verteporfin results in decreased susceptibility to AMOTL1 protein
CTD PMID:34480788 NCBI chr 8:11,348,651...11,467,564 JBrowse link
G Ankrd1 ankyrin repeat domain 1 multiple interactions
decreases expression
ISO verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]
verteporfin results in decreased expression of ANKRD1 mRNA
[calcipotriene co-treated with Verteporfin] promotes the reaction [Carbon Tetrachloride results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]; Verteporfin promotes the reaction [Carbon Tetrachloride results in increased expression of ANKRD1 mRNA]
CTD PMID:29725256 PMID:29893953 PMID:38992766 NCBI chr 1:233,815,851...233,834,891 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]] CTD PMID:35093381 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]] CTD PMID:35093381 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA] CTD PMID:29893953 NCBI chr10:103,567,369...103,580,069 JBrowse link
G Casp9 caspase 9 multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]] CTD PMID:35093381
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein] CTD PMID:31812773 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein] CTD PMID:31812773 NCBI chr10:68,820,330...68,824,906 JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]
Verteporfin results in decreased expression of CCN1 mRNA
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]
CTD PMID:29725256 PMID:29893953 NCBI chr 2:234,562,410...234,565,370 JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of CCN2 mRNA
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
[calcipotriene co-treated with Verteporfin] promotes the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA]; Verteporfin inhibits the reaction [[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA]; Verteporfin promotes the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA]
CTD PMID:29725256 PMID:35027733 PMID:38992766 NCBI chr 1:22,621,498...22,624,614 JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA] CTD PMID:29893953 NCBI chr 2:121,355,363...121,361,762 JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA] CTD PMID:29893953 NCBI chr 2:33,646,252...33,655,225 JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Verteporfin co-treated with calcipotriene] inhibits the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA] CTD PMID:38992766 NCBI chr 5:137,251,596...137,255,799 JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of CDC6 mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of CDC6 mRNA] CTD PMID:38992766 NCBI chr10:84,360,361...84,374,239 JBrowse link
G Cma1 chymase 1 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein] CTD PMID:31812773 NCBI chr15:33,387,351...33,390,133 JBrowse link
G Cnn2 calponin 2 multiple interactions ISO Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of CNN2 mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of CNN2 mRNA] CTD PMID:38992766 NCBI chr 7:9,712,505...9,719,678 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [calcipotriene co-treated with Verteporfin] inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:38992766 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein] CTD PMID:31812773 NCBI chr10:84,157,485...84,159,860 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA] CTD PMID:29893953 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA] CTD PMID:29893953 NCBI chr 1:236,873,967...236,936,238 JBrowse link
G Fundc1 FUN14 domain containing 1 multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]] CTD PMID:35093381 NCBI chr  X:5,083,635...5,100,293 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Verteporfin results in decreased expression of GCLC protein CTD PMID:37832483 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of GPT protein]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:38992766 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression
EXP
ISO
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]]
Verteporfin results in decreased expression of GPX4 protein
CTD PMID:35093381 PMID:37832483 NCBI chr 7:10,300,833...10,303,629 JBrowse link
G Gsr glutathione-disulfide reductase decreases expression ISO Verteporfin results in decreased expression of GSR protein CTD PMID:37832483 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Hmmr hyaluronan-mediated motility receptor multiple interactions ISO Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of HMMR mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMMR mRNA] CTD PMID:38992766 NCBI chr10:25,635,249...25,665,389 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO verteporfin results in increased expression of HMOX1 protein CTD PMID:16462769 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Il11 interleukin 11 multiple interactions ISO Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL11 mRNA]; Verteporfin promotes the reaction [calcipotriene inhibits the reaction [Carbon Tetrachloride results in increased expression of IL11 mRNA]] CTD PMID:38992766 NCBI chr 1:69,069,829...69,076,129 JBrowse link
G Il6 interleukin 6 multiple interactions ISO [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
CTD PMID:31812773 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 multiple interactions ISO [Verteporfin co-treated with calcipotriene] inhibits the reaction [Carbon Tetrachloride results in increased expression of IQGAP3 mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of IQGAP3 mRNA] CTD PMID:38992766 NCBI chr 2:173,542,151...173,583,956 JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases expression
ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein
Verteporfin results in decreased expression of JAK1 protein
CTD PMID:31812773 NCBI chr 5:120,895,606...121,004,207 JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of JAK2 protein
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein
CTD PMID:31812773 NCBI chr 1:236,408,905...236,468,769 JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA] CTD PMID:29893953 NCBI chr 4:122,903,679...122,918,205 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of MKI67 mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of MKI67 mRNA]; Verteporfin inhibits the reaction [perfluorooctanoic acid results in increased expression of MKI67 protein] CTD PMID:36152675 PMID:38992766 NCBI chr 1:199,926,150...199,952,847 JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA] CTD PMID:35027733 NCBI chr19:10,831,959...10,832,975 JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA] CTD PMID:35027733 NCBI chr19:10,837,934...10,838,708 JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]] CTD PMID:35093381 NCBI chr 5:163,699,955...163,701,314 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]] CTD PMID:35093381 NCBI chr11:84,612,943...84,690,025 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Verteporfin results in increased cleavage of PARP1 protein CTD PMID:31494105 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Rasal2 RAS protein activator like 2 multiple interactions ISO Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein] CTD PMID:34826200 NCBI chr13:69,279,882...69,569,161 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein] CTD PMID:31812773 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of STAT1 protein
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD PMID:31812773 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein]
Verteporfin results in decreased expression of STAT3 protein
CTD PMID:31812773 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Tead1 TEA domain transcription factor 1 multiple interactions ISO Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein] CTD PMID:29893953 NCBI chr 1:166,791,900...167,010,591 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [Verteporfin co-treated with Carbon Tetrachloride] results in increased expression of TIMP1 mRNA; Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of TIMP1 mRNA] CTD PMID:38992766 NCBI chr  X:3,766,509...3,772,578 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:31812773 PMID:38992766 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO [Verteporfin co-treated with calcipotriene] inhibits the reaction [Carbon Tetrachloride results in increased expression of TOP2A mRNA]; Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of TOP2A mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of TOP2A mRNA] CTD PMID:38992766 NCBI chr10:84,441,954...84,473,093 JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
decreases expression
decreases activity
ISO
EXP
Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
Verteporfin results in decreased expression of YAP1 protein
Verteporfin results in decreased activity of YAP1 protein
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]]
CTD PMID:29725256 PMID:29893953 PMID:31494105 PMID:34351699 PMID:34480788 More... NCBI chr 8:5,095,705...5,166,808 JBrowse link

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  CHEBI ontology 19898
    chemical entity 19896
      chemical substance 14414
        mixture 13729
          verteporfin 50
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  organonitrogen heterocyclic compound 18177
                                    polypyrrole 707
                                      tetrapyrrole 594
                                        cyclic tetrapyrrole 465
                                          porphyrins 383
                                            beta-substituted porphyrin 50
                                              (2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid 50
                                                (2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid 50
                                                  verteporfin 50
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