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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:verteporfin
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Accession:CHEBI:32293 term browser browse the term
Definition:An equimolar mixture of the 9-methyl ester and 13-methyl ester of trans-(+-)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid. It is used as a photosensitizer in photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when activated by red (693 nm) laser light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Synonyms:related_synonym: Visudyne;   trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester;   trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester
 xref: CAS:129497-78-5;   DrugBank:DB00460;   KEGG:D01162
 xref_mesh: MESH:C098350
 xref: PMID:25494214;   PMID:26361148;   PMID:26443705;   Reaxys:13501128;   Reaxys:13501141


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verteporfin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd1 ankyrin repeat domain 1 multiple interactions
decreases expression
ISO verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]
verteporfin results in decreased expression of ANKRD1 mRNA
CTD PMID:29725256 PMID:29893953 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA] CTD PMID:29893953 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein] CTD PMID:31812773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein] CTD PMID:31812773 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]
Verteporfin results in decreased expression of CCN1 mRNA
CTD PMID:29725256 PMID:29893953 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of CCN2 mRNA
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
CTD PMID:29725256 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA] CTD PMID:29893953 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA] CTD PMID:29893953 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cma1 chymase 1 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein] CTD PMID:31812773 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein] CTD PMID:31812773 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA] CTD PMID:29893953 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA] CTD PMID:29893953 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO verteporfin results in increased expression of HMOX1 protein CTD PMID:16462769 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
CTD PMID:31812773 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases expression
ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein
Verteporfin results in decreased expression of JAK1 protein
CTD PMID:31812773 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of JAK2 protein
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein
CTD PMID:31812773 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA] CTD PMID:29893953 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Verteporfin results in increased cleavage of PARP1 protein CTD PMID:31494105 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein] CTD PMID:31812773 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions
ISO Verteporfin results in decreased expression of STAT1 protein
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD PMID:31812773 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein]
Verteporfin results in decreased expression of STAT3 protein
CTD PMID:31812773 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tead1 TEA domain transcription factor 1 multiple interactions ISO Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein] CTD PMID:29893953 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD PMID:31812773 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
decreases expression
ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin results in decreased expression of YAP1 protein
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
CTD PMID:29725256 PMID:29893953 PMID:31494105 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link

Term paths to the root
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  CHEBI ontology 19812
    chemical entity 19812
      chemical substance 12981
        mixture 12153
          verteporfin 24
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organonitrogen heterocyclic compound 17639
                                    polypyrrole 665
                                      tetrapyrrole 555
                                        cyclic tetrapyrrole 426
                                          porphyrins 352
                                            beta-substituted porphyrin 24
                                              (2R,2(1)S)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid 24
                                                (2R,2(1)S)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid 24
                                                  verteporfin 24
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