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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trospium chloride
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Accession:CHEBI:32270 term browser browse the term
Definition:An organic chloride salt of trospium. It is an antispasmodic drug used for the treatment of overactive bladder.
Synonyms:exact_synonym: (1S,3R,5R)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8lambda(5)-azaspiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ylium chloride
 related_synonym: Formula=C25H30NO3.Cl;   IP-631;   IP631;   InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23+;;   InChIKey=RVCSYOQWLPPAOA-QKYUOBHYSA-M;   Regurin;   Relaspium;   SMILES=[N+]12([C@]3(C[C@H](OC(C(C4=CC=CC=C4)(C5=CC=CC=C5)O)=O)C[C@@]1(CC3)[H])[H])CCCC2.[Cl-];   Sanctura;   Sanctura XR;   Santura;   Spasmed;   Spasmex;   Spasmo 3;   Spasmo-lyt;   Spasmolyt;   Spasmoplex;   Trofame;   Trosec;   Trospikan;   Uraplex;   chlorure de trospium;   cloruro de trospio;   trospii chloridum;   trospium Cl
 xref: CAS:10405-02-4;   DrugBank:DBSALT000883;   Drug_Central:2776;   KEGG:D01103
 xref_mesh: MESH:C003330
 xref: PMID:15289745;   PMID:15684176;   PMID:15779697;   PMID:17722614;   PMID:19193592;   PMID:22120415;   PMID:23453648;   PMID:25466967;   PMID:27765726;   PMID:28050642;   PMID:28067745;   PMID:28468509;   PMID:28792105;   PMID:30217174;   PMID:30697533;   PMID:31542894;   Wikipedia:Trospium_chloride


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trospium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride] CTD PMID:25466967 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
increases metabolic processing
ISO trospium chloride results in decreased activity of SLC22A1 protein
SLC22A1 protein results in increased metabolism of trospium chloride
CTD PMID:25466967 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO trospium chloride results in decreased activity of SLC22A2 protein CTD PMID:25466967 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases metabolic processing
decreases activity
ISO SLCO1A2 protein results in increased metabolism of trospium chloride
trospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative form
CTD PMID:25466967 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO trospium chloride results in decreased activity of SLCO1B3 protein CTD PMID:25466967 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      molecular entity 19814
        ion 15935
          organic ion 8327
            organic cation 7147
              quaternary ammonium ion 5086
                trospium 5
                  trospium chloride 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    main group molecular entity 19702
                      s-block molecular entity 19461
                        hydrogen molecular entity 19452
                          hydrides 18707
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17243
                                  ammonium 8224
                                    ammonium ion derivative 8220
                                      ammonium compound 5091
                                        organoammonium salt 421
                                          quaternary ammonium salt 307
                                            trospium chloride 5
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