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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trospium chloride
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Accession:CHEBI:32270 term browser browse the term
Definition:An organic chloride salt of trospium. It is an antispasmodic drug used for the treatment of overactive bladder.
Synonyms:exact_synonym: (1S,3R,5R)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8lambda(5)-azaspiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ylium chloride
 related_synonym: Formula=C25H30NO3.Cl;   IP-631;   IP631;   InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23+;;   InChIKey=RVCSYOQWLPPAOA-QKYUOBHYSA-M;   Regurin;   Relaspium;   SMILES=[N+]12([C@]3(C[C@H](OC(C(C4=CC=CC=C4)(C5=CC=CC=C5)O)=O)C[C@@]1(CC3)[H])[H])CCCC2.[Cl-];   Sanctura;   Sanctura XR;   Santura;   Spasmed;   Spasmex;   Spasmo 3;   Spasmo-lyt;   Spasmolyt;   Spasmoplex;   Trofame;   Trosec;   Trospikan;   Uraplex;   chlorure de trospium;   cloruro de trospio;   trospii chloridum;   trospium Cl
 xref: CAS:10405-02-4;   DrugBank:DBSALT000883;   Drug_Central:2776;   KEGG:D01103
 xref_mesh: MESH:C003330
 xref: PMID:15289745;   PMID:15684176;   PMID:15779697;   PMID:17722614;   PMID:19193592;   PMID:22120415;   PMID:23453648;   PMID:25466967;   PMID:27765726;   PMID:28050642;   PMID:28067745;   PMID:28468509;   PMID:28792105;   PMID:30217174;   PMID:30697533;   PMID:31542894;   Wikipedia:Trospium_chloride


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trospium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport		 ISO valspodar inhibits the reaction [ABCB1 protein results in increased transport of trospium chloride] CTD PMID:25466967 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
increases metabolic processing		 ISO trospium chloride results in decreased activity of SLC22A1 protein
SLC22A1 protein results in increased metabolism of trospium chloride		 CTD PMID:25466967 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO trospium chloride results in decreased activity of SLC22A2 protein CTD PMID:25466967 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases metabolic processing
decreases activity		 ISO SLCO1A2 protein results in increased metabolism of trospium chloride
trospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative form		 CTD PMID:25466967 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity ISO trospium chloride results in decreased activity of SLCO1B3 protein CTD PMID:25466967 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    chemical entity 19907
      molecular entity 19906
        ion 17161
          organic ion 11452
            organic cation 8964
              quaternary ammonium ion 5301
                trospium 5
                  trospium chloride 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    main group molecular entity 19846
                      s-block molecular entity 19679
                        hydrogen molecular entity 19661
                          hydrides 19163
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18079
                                  ammonium 8321
                                    ammonium ion derivative 8316
                                      ammonium compound 5204
                                        organoammonium salt 670
                                          quaternary ammonium salt 553
                                            trospium chloride 5
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