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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tropisetron
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Accession:CHEBI:32269 term browser browse the term
Definition:An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine.
Synonyms:exact_synonym: (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylate
 related_synonym: 1alphaH,5alphaH-Tropan-3alpha-yl indole-3-carboxylate;   Formula=C17H20N2O2;   InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+;   InChIKey=ZNRGQMMCGHDTEI-ITGUQSILSA-N;   SMILES=CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12;   tropisetronum
 xref: CAS:89565-68-4;   Drug_Central:2775;   KEGG:C13666;   KEGG:D02130
 xref_mesh: MESH:C045504
 xref: PDBeChem:TKT;   PMID:22905891;   PMID:23135693;   PMID:23415734;   PMID:23440693;   PMID:23515583;   PMID:23717236;   PMID:23727438;   PMID:23774631;   PMID:23868810;   PMID:23896722;   PMID:23937291;   PMID:24226381;   PMID:24374478;   PMID:24389031;   PMID:24455480;   PMID:24461640;   Reaxys:3619989;   Wikipedia:Tropisetron
 cyclic_relationship: is_conjugate_base_of CHEBI:77571


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tropisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression
multiple interactions		 EXP
ISO		 Tropisetron results in increased expression of CASP3 protein modified form
Paclitaxel inhibits the reaction [Tropisetron results in increased expression of CASP3 protein modified form]
Tropisetron inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]		 CTD PMID:34654991 PMID:36504472 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein] CTD PMID:23285267 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Cst3 cystatin C multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein] CTD PMID:23285267 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of CXCL2 protein]
tropisetron results in decreased expression of CXCL2 protein		 CTD PMID:23285267 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO tropisetron results in increased expression of HMOX1 protein
SB 203580 inhibits the reaction [tropisetron results in increased expression of HMOX1 protein]		 CTD PMID:23285267 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein] CTD PMID:23285267 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Tropisetron inhibits the reaction [Streptozocin results in increased expression of IL1B protein]		 CTD PMID:24374478 PMID:36504472 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] CTD PMID:24374478 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of IL6 protein] CTD PMID:23285267 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] CTD PMID:36504472 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Mir146 microRNA 146 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] CTD PMID:36504472 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA] CTD PMID:33387473 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP9 mRNA] CTD PMID:33387473 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 ISO
EXP		 chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein]
tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]		 CTD PMID:23285267 PMID:25837923 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO
EXP		 [Paclitaxel co-treated with Tropisetron] results in decreased expression of RELA protein
Tropisetron inhibits the reaction [Streptozocin results in increased expression of RELA protein]		 CTD PMID:34654991 PMID:36504472 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:33387473 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:36504472 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of TNF protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
tropisetron results in decreased expression of TNF protein
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]		 CTD PMID:23285267 PMID:24374478 PMID:36504472 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Traf6 TNF receptor-associated factor 6 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] CTD PMID:36504472 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Tropisetron inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:33387473 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        immunomodulator 15681
          tropisetron 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic heterocyclic compound 20352
                                  organic heteropolycyclic compound 19645
                                    organic heterobicyclic compound 18203
                                      benzopyrrole 9696
                                        indoles 9314
                                          indolyl carboxylic acid 3450
                                            indol-3-yl carboxylic acid 3451
                                              indole-3-carboxylic acid 23
                                                tropisetron 22
paths to the root