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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolvaptan
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Accession:CHEBI:32246 term browser browse the term
Definition:A racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency.
Synonyms:related_synonym: (+-)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide;   Jynarque;   N-(4-{[(5RS)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide;   OPC 41061;   RS-tolvaptan;   jinarc;   rac-N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide;   samsca;   tolvaptanum
 xref: CAS:150683-30-0;   DrugBank:DB06212
 xref_mesh: MESH:C116664
 xref: drugcentral:4110;   kegg.drug:D01213;   pubmed:12742979;   pubmed:16211205;   pubmed:33078835;   pubmed:34070416;   pubmed:34386666;   pubmed:34476570;   pubmed:34514204;   pubmed:34526469;   pubmed:34554640;   pubmed:37214762;   pubmed:37466863;   pubmed:37516894;   pubmed:37587049;   pubmed:37845144;   pubmed:37845430;   pubmed:37916285;   pubmed:37982946;   pubmed:38097698;   pubmed:38288467;   pubmed:38337413;   pubmed:38344178;   pubmed:38396765;   pubmed:38414126;   pubmed:38423003;   pubmed:38468548;   pubmed:38494546;   pubmed:38509003;   pubmed:38512373;   pubmed:38562967;   pubmed:38577748;   pubmed:38606040;   pubmed:38608748;   pubmed:38616432;   pubmed:38652561;   pubmed:38710808;   pubmed:38717378;   wikipedia.en:Tolvaptan
 chemrof_formula: C26H25ClN2O3


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tolvaptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCB11 protein; tolvaptan results in decreased activity of ABCB11 protein CTD PMID:23956101 PMID:26507107 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC2 protein CTD PMID:26507107 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC3 protein CTD PMID:26507107 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO tolvaptan metabolite results in decreased activity of ABCC4 protein CTD PMID:26507107 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Alb albumin decreases expression ISO Tolvaptan results in decreased expression of ALB protein CTD PMID:33022361 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Tolvaptan results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Mir122 microRNA 122 increases export ISO tolvaptan results in increased export of MIR122 CTD PMID:29029277 NCBI chr18:61,028,817...61,028,901 JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases activity ISO tolvaptan metabolite results in decreased activity of SLC10A1 protein CTD PMID:26507107 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO tolvaptan results in increased expression of SLPI mRNA; tolvaptan results in increased expression of SLPI protein CTD PMID:28115652 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 multiple interactions ISO Cyclosporine promotes the reaction [SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan]; SULT1C3 protein results in increased sulfation of and results in increased activity of and results in increased susceptibility to tolvaptan CTD PMID:26660633 NCBI chr 9:7,548,839...7,594,299
Ensembl chr 9:7,548,622...7,594,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      chemical substance 14602
        mixture 13915
          racemate 12303
            tolvaptan 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carboxamide 17697
                                    monocarboxylic acid amide 14860
                                      arenecarboxamide 8280
                                        benzamides 8283
                                          N-\{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl\}-2-methylbenzamide 11
                                            (S)-tolvaptan 11
                                              tolvaptan 11
paths to the root