The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
ABCG2 protein results in increased transport of tolfenamic acid ABCG2 protein affects the uptake of tolfenamic acid 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of tolfenamic acid]
tolfenamic acid results in decreased activity of AKR1C3 protein [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]]; tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]
[lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA; tolfenamic acid inhibits the reaction [lead acetate results in increased expression of APP protein modified form]
[tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]
[tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of HK2 protein]; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of SLC2A1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
CAV1 protein affects the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; Cycloheximide inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; methyl-beta-cyclodextrin inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]
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