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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolfenamic acid
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Accession:CHEBI:32243 term browser browse the term
Definition:An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
Synonyms:exact_synonym: 2-[(3-chloro-2-methylphenyl)amino]benzoic acid
 related_synonym: Formula=C14H12ClNO2;   InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18);   InChIKey=YEZNLOUZAIOMLT-UHFFFAOYSA-N;   N-(2-Methyl-3-chlorophenyl)anthranilic acid;   N-(3-Chloro-2-methylphenyl)anthranilic acid;   N-(3-Chloro-o-tolyl)-anthranilic acid;   SMILES=Cc1c(Cl)cccc1Nc1ccccc1C(O)=O;   acide tolfenamique;   acido tolfenamico;   acidum tolfenamicum
 xref: CAS:13710-19-5;   Drug_Central:2698;   KEGG:D01183;   LINCS:LSM-5612
 xref_mesh: MESH:C009500
 xref: PMID:20797618;   PMID:21392038;   PMID:21879384;   PMID:22213339;   PMID:22815231;   PMID:22954807;   PMID:23340327;   PMID:23576386;   PMID:23609055;   PMID:23620261;   PMID:23639209;   PMID:23661145;   PMID:23670891;   PMID:23686785;   PMID:23784084;   PMID:23811329;   PMID:23864386;   PMID:23874066;   PMID:23896517;   PMID:24030139;   PMID:24073394;   PMID:24104354;   PMID:24216474;   Patent:US2003060465;   Reaxys:657821;   VSDB:1874;   Wikipedia:Tolfenamic_acid



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tolfenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
affects uptake
increases transport
ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of tolfenamic acid]
ABCG2 protein affects the uptake of tolfenamic acid
CTD PMID:34062171 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
multiple interactions
ISO tolfenamic acid results in decreased activity of AKR1C3 protein
[tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]]; tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]
CTD PMID:21187079 PMID:23165153 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438
JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [tolfenamic acid results in decreased activity of CYP1A2 protein] CTD PMID:17618427 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA; tolfenamic acid inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:24462621 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Bace1 beta-secretase 1 decreases expression ISO tolfenamic acid results in decreased expression of BACE1 mRNA; tolfenamic acid results in decreased expression of BACE1 protein CTD PMID:24462621 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO CAV1 protein affects the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein] CTD PMID:31381904 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:31381904 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO ALB protein inhibits the reaction [tolfenamic acid results in decreased activity of CYP1A2 protein] CTD PMID:17618427 PMID:18816299 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO tolfenamic acid affects the reaction [TGFB1 protein affects the expression of HK2 protein] CTD PMID:31381904 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein] CTD PMID:31381904 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression ISO tolfenamic acid results in increased expression of PSMB10 mRNA CTD PMID:23165153 NCBI chr19:50,740,808...50,743,292
Ensembl chr19:50,740,811...50,743,210
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression ISO tolfenamic acid results in increased expression of PSMB9 mRNA CTD PMID:23165153 NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO tolfenamic acid affects the reaction [TGFB1 protein affects the expression of SLC2A1 protein] CTD PMID:31381904 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31381904 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:31381904 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] CTD PMID:24462621 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of HK2 protein]; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of SLC2A1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31381904 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR1 protein] CTD PMID:31381904 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression
multiple interactions
ISO tolfenamic acid results in decreased expression of TGFBR2 protein
CAV1 protein affects the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; Cycloheximide inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; methyl-beta-cyclodextrin inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]
CTD PMID:31381904 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469
JBrowse link

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  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          anti-inflammatory drug 15100
            non-steroidal anti-inflammatory drug 14404
              tolfenamic acid 19
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  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino acid 16340
                                          aromatic amino acid 4034
                                            aminobenzoic acid 1690
                                              anthranilic acid 1532
                                                tolfenamic acid 19
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