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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolfenamic acid
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Accession:CHEBI:32243 term browser browse the term
Definition:An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
Synonyms:exact_synonym: 2-[(3-chloro-2-methylphenyl)amino]benzoic acid
 related_synonym: Formula=C14H12ClNO2;   InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18);   InChIKey=YEZNLOUZAIOMLT-UHFFFAOYSA-N;   N-(2-Methyl-3-chlorophenyl)anthranilic acid;   N-(3-Chloro-2-methylphenyl)anthranilic acid;   N-(3-Chloro-o-tolyl)-anthranilic acid;   SMILES=Cc1c(Cl)cccc1Nc1ccccc1C(O)=O;   acide tolfenamique;   acido tolfenamico;   acidum tolfenamicum
 xref: CAS:13710-19-5;   Drug_Central:2698;   KEGG:D01183;   LINCS:LSM-5612
 xref_mesh: MESH:C009500
 xref: PMID:20797618;   PMID:21392038;   PMID:21879384;   PMID:22213339;   PMID:22815231;   PMID:22954807;   PMID:23340327;   PMID:23576386;   PMID:23609055;   PMID:23620261;   PMID:23639209;   PMID:23661145;   PMID:23670891;   PMID:23686785;   PMID:23784084;   PMID:23811329;   PMID:23864386;   PMID:23874066;   PMID:23896517;   PMID:24030139;   PMID:24073394;   PMID:24104354;   PMID:24216474;   Patent:US2003060465;   Reaxys:657821;   VSDB:1874;   Wikipedia:Tolfenamic_acid


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tolfenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
multiple interactions
ISO tolfenamic acid results in decreased activity of AKR1C3 protein
[tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]]; tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]
CTD PMID:21187079, PMID:23165153 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [tolfenamic acid results in decreased activity of CYP1A2 protein] CTD PMID:17618427 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA; tolfenamic acid inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:24462621 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bace1 beta-secretase 1 decreases expression ISO tolfenamic acid results in decreased expression of BACE1 mRNA; tolfenamic acid results in decreased expression of BACE1 protein CTD PMID:24462621 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO CAV1 protein affects the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein] CTD PMID:31381904 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:31381904 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO ALB protein inhibits the reaction [tolfenamic acid results in decreased activity of CYP1A2 protein] CTD PMID:17618427, PMID:18816299 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO tolfenamic acid affects the reaction [TGFB1 protein affects the expression of HK2 protein] CTD PMID:31381904 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein] CTD PMID:31381904 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression ISO tolfenamic acid results in increased expression of PSMB10 mRNA CTD PMID:23165153 NCBI chr19:37,909,543...37,912,027
Ensembl chr19:37,909,546...37,912,027
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression ISO tolfenamic acid results in increased expression of PSMB9 mRNA CTD PMID:23165153 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO tolfenamic acid affects the reaction [TGFB1 protein affects the expression of SLC2A1 protein] CTD PMID:31381904 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31381904 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:31381904 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] CTD PMID:24462621 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of HK2 protein]; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of SLC2A1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31381904 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR1 protein] CTD PMID:31381904 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression
multiple interactions
ISO tolfenamic acid results in decreased expression of TGFBR2 protein
CAV1 protein affects the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; Cycloheximide inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; methyl-beta-cyclodextrin inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]
CTD PMID:31381904 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        anti-inflammatory agent 14948
          anti-inflammatory drug 13611
            non-steroidal anti-inflammatory drug 12694
              tolfenamic acid 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            aminobenzoic acid 1614
                                              anthranilic acid 1488
                                                tolfenamic acid 18
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