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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolfenamic acid
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Accession:CHEBI:32243 term browser browse the term
Definition:An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
Synonyms:exact_synonym: 2-[(3-chloro-2-methylphenyl)amino]benzoic acid
 related_synonym: Formula=C14H12ClNO2;   InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18);   InChIKey=YEZNLOUZAIOMLT-UHFFFAOYSA-N;   N-(2-Methyl-3-chlorophenyl)anthranilic acid;   N-(3-Chloro-2-methylphenyl)anthranilic acid;   N-(3-Chloro-o-tolyl)-anthranilic acid;   SMILES=Cc1c(Cl)cccc1Nc1ccccc1C(O)=O;   acide tolfenamique;   acido tolfenamico;   acidum tolfenamicum
 xref: CAS:13710-19-5;   Drug_Central:2698;   KEGG:D01183;   LINCS:LSM-5612
 xref_mesh: MESH:C009500
 xref: PMID:20797618;   PMID:21392038;   PMID:21879384;   PMID:22213339;   PMID:22815231;   PMID:22954807;   PMID:23340327;   PMID:23576386;   PMID:23609055;   PMID:23620261;   PMID:23639209;   PMID:23661145;   PMID:23670891;   PMID:23686785;   PMID:23784084;   PMID:23811329;   PMID:23864386;   PMID:23874066;   PMID:23896517;   PMID:24030139;   PMID:24073394;   PMID:24104354;   PMID:24216474;   Patent:US2003060465;   Reaxys:657821;   VSDB:1874;   Wikipedia:Tolfenamic_acid


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tolfenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport
affects uptake
ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of tolfenamic acid]
ABCG2 protein affects the uptake of tolfenamic acid
CTD PMID:34062171 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity
multiple interactions
ISO tolfenamic acid results in decreased activity of AKR1C3 protein
[tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased chemical synthesis of farnesoic acid; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]]; tolfenamic acid inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Cisplatin]
CTD PMID:21187079 PMID:23165153 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Alb albumin multiple interactions ISO ALB protein inhibits the reaction [tolfenamic acid results in decreased activity of CYP1A2 protein] CTD PMID:17618427 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA; tolfenamic acid inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:24462621 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bace1 beta-secretase 1 decreases expression ISO tolfenamic acid results in decreased expression of BACE1 mRNA; tolfenamic acid results in decreased expression of BACE1 protein CTD PMID:24462621 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO CAV1 protein affects the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein] CTD PMID:31381904 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:31381904 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO ALB protein inhibits the reaction [tolfenamic acid results in decreased activity of CYP1A2 protein] CTD PMID:17618427 PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO tolfenamic acid affects the reaction [TGFB1 protein affects the expression of HK2 protein] CTD PMID:31381904 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein] CTD PMID:31381904 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression ISO tolfenamic acid results in increased expression of PSMB10 mRNA CTD PMID:23165153 NCBI chr19:33,830,958...33,833,442 JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression ISO tolfenamic acid results in increased expression of PSMB9 mRNA CTD PMID:23165153 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO tolfenamic acid affects the reaction [TGFB1 protein affects the expression of SLC2A1 protein] CTD PMID:31381904 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31381904 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:31381904 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] CTD PMID:24462621 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [tolfenamic acid co-treated with TGFB1 protein] results in increased expression of CDH1 protein; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of HK2 protein]; tolfenamic acid affects the reaction [TGFB1 protein affects the expression of SLC2A1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; tolfenamic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:31381904 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR1 protein] CTD PMID:31381904 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression
multiple interactions
ISO tolfenamic acid results in decreased expression of TGFBR2 protein
CAV1 protein affects the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; Cycloheximide inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]; methyl-beta-cyclodextrin inhibits the reaction [tolfenamic acid results in decreased expression of TGFBR2 protein]
CTD PMID:31381904 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        anti-inflammatory agent 15831
          anti-inflammatory drug 13623
            non-steroidal anti-inflammatory drug 12712
              tolfenamic acid 19
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        aromatic carboxylic acid 11710
                                          benzoic acids 11683
                                            aminobenzoic acid 1627
                                              anthranilic acid 1498
                                                tolfenamic acid 19
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