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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tibolone
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Accession:CHEBI:32223 term browser browse the term
Definition:Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.
Synonyms:exact_synonym: 17alpha-ethynyl-17beta-hydroxy-7alpha-methylestr-5(10)-en-3-one
 related_synonym: (17R)-17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)en-3-one;   17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one;   Formula=C21H28O2;   InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1;   InChIKey=WZDGZWOAQTVYBX-XOINTXKNSA-N;   SMILES=[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])[C@H](C)CC1=C2CCC(=O)C1;   tibolona;   tibolonum
 xref: CAS:5630-53-5;   Drug_Central:2655;   KEGG:D01639
 xref_mesh: MESH:C027385
 xref: Patent:US3340279;   Patent:US3475465


show annotations for term's descendants           Sort by:
tibolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4e C-type lectin domain family 4, member e increases expression ISO tibolone results in increased expression of CLEC4E mRNA CTD PMID:22217510 NCBI chr 6:123,258,748...123,266,830
Ensembl chr 6:123,258,748...123,266,829 		JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO tibolone results in increased expression of CRP protein CTD PMID:17882670 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases activity ISO tibolone metabolite results in increased activity of ESR1 protein; tibolone results in increased activity of ESR1 protein CTD PMID:16720731 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) increases activity ISO tibolone metabolite results in increased activity of ESR2 protein; tibolone results in increased activity of ESR2 protein CTD PMID:16720731 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F3 coagulation factor III increases expression ISO tibolone metabolite results in increased expression of F3 protein; tibolone results in increased expression of F3 protein CTD PMID:16011840 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fkbp5 FK506 binding protein 5 increases expression ISO tibolone results in increased expression of FKBP5 mRNA CTD PMID:22217510 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of ICAM1 protein CTD PMID:17882670 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il13ra1 interleukin 13 receptor, alpha 1 increases expression ISO tibolone results in increased expression of IL13RA1 mRNA CTD PMID:22217510 NCBI chr  X:35,375,761...35,434,915
Ensembl chr  X:35,375,763...35,434,912 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK1 protein; tibolone results in decreased phosphorylation of MAPK1 protein CTD PMID:14764805 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK3 protein; tibolone results in decreased phosphorylation of MAPK3 protein CTD PMID:14764805 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Pgr progesterone receptor increases activity ISO tibolone metabolite results in increased activity of PGR protein; tibolone results in increased activity of PGR protein CTD PMID:16011840 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Ppm1k protein phosphatase 1K (PP2C domain containing) decreases expression ISO tibolone results in decreased expression of PPM1K mRNA CTD PMID:22217510 NCBI chr 6:57,483,487...57,512,537
Ensembl chr 6:57,483,487...57,512,453 		JBrowse link
G Sele selectin, endothelial cell decreases expression ISO tibolone results in decreased expression of SELE protein CTD PMID:17882670 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression ISO tibolone metabolite results in increased expression of SERPINE1 protein; tibolone results in increased expression of SERPINE1 protein CTD PMID:16011840 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Smap2 small ArfGAP 2 increases expression ISO tibolone results in increased expression of SMAP2 mRNA CTD PMID:22217510 NCBI chr 4:120,825,514...120,874,497
Ensembl chr 4:120,825,514...120,874,444 		JBrowse link
G Tcf7 transcription factor 7, T cell specific decreases expression ISO tibolone results in decreased expression of TCF7 mRNA CTD PMID:22217510 NCBI chr11:52,137,347...52,174,211
Ensembl chr11:52,143,198...52,174,158 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO tibolone results in increased expression of TLR2 mRNA CTD PMID:22217510 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tpst1 protein-tyrosine sulfotransferase 1 increases expression ISO tibolone results in increased expression of TPST1 mRNA CTD PMID:22217510 NCBI chr 5:130,102,167...130,164,575
Ensembl chr 5:130,102,167...130,164,570 		JBrowse link
G Trav3-1 T cell receptor alpha variable 3-1 decreases expression ISO tibolone results in decreased expression of TRAV5 mRNA CTD PMID:22217510 NCBI chr14:52,818,219...52,818,670
Ensembl chr14:52,818,122...52,818,670 		JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 decreases expression ISO tibolone results in decreased expression of UXS1 mRNA CTD PMID:22217510 NCBI chr 1:43,786,121...43,866,999
Ensembl chr 1:43,786,126...43,866,960 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of VCAM1 protein CTD PMID:17882670 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pharmaceutical 21187
          drug 21159
            bone density conservation agent 6172
              tibolone 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            organic molecule 21647
                              organic cyclic compound 21252
                                organic polycyclic compound 17940
                                  steroid 14869
                                    hydroxy steroid 14604
                                      17-hydroxy steroid 14185
                                        17beta-hydroxy steroid 13401
                                          tibolone 21
paths to the root