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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tibolone
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Accession:CHEBI:32223 term browser browse the term
Definition:Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.
Synonyms:exact_synonym: 17alpha-ethynyl-17beta-hydroxy-7alpha-methylestr-5(10)-en-3-one
 related_synonym: (17R)-17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)en-3-one;   17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one;   Formula=C21H28O2;   InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1;   InChIKey=WZDGZWOAQTVYBX-XOINTXKNSA-N;   SMILES=[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])[C@H](C)CC1=C2CCC(=O)C1;   tibolona;   tibolonum
 xref: CAS:5630-53-5;   Drug_Central:2655;   KEGG:D01639
 xref_mesh: MESH:C027385
 xref: Patent:US3340279;   Patent:US3475465


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tibolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein increases expression ISO tibolone results in increased expression of CRP protein CTD PMID:17882670 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO tibolone metabolite results in increased activity of ESR1 protein; tibolone results in increased activity of ESR1 protein CTD PMID:16720731 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO tibolone metabolite results in increased activity of ESR2 protein; tibolone results in increased activity of ESR2 protein CTD PMID:16720731 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO tibolone metabolite results in increased expression of F3 protein; tibolone results in increased expression of F3 protein CTD PMID:16011840 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of ICAM1 protein CTD PMID:17882670 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK1 protein; tibolone results in decreased phosphorylation of MAPK1 protein CTD PMID:14764805 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK3 protein; tibolone results in decreased phosphorylation of MAPK3 protein CTD PMID:14764805 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pgr progesterone receptor increases activity ISO tibolone metabolite results in increased activity of PGR protein; tibolone results in increased activity of PGR protein CTD PMID:16011840 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Sele selectin E decreases expression ISO tibolone results in decreased expression of SELE protein CTD PMID:17882670 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO tibolone metabolite results in increased expression of SERPINE1 protein; tibolone results in increased expression of SERPINE1 protein CTD PMID:16011840 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of VCAM1 protein CTD PMID:17882670 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            bone density conservation agent 5976
              tibolone 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic polycyclic compound 16393
                                  steroid 12793
                                    hydroxy steroid 12375
                                      17-hydroxy steroid 11859
                                        17beta-hydroxy steroid 10578
                                          tibolone 11
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