Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tibolone
go back to main search page
Accession:CHEBI:32223 term browser browse the term
Definition:Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.
Synonyms:exact_synonym: 17alpha-ethynyl-17beta-hydroxy-7alpha-methylestr-5(10)-en-3-one
 related_synonym: (17R)-17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one;   (7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)en-3-one;   17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one;   Formula=C21H28O2;   InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1;   InChIKey=WZDGZWOAQTVYBX-XOINTXKNSA-N;   SMILES=[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])[C@H](C)CC1=C2CCC(=O)C1;   tibolona;   tibolonum
 xref: CAS:5630-53-5;   Drug_Central:2655;   KEGG:D01639
 xref_mesh: MESH:C027385
 xref: Patent:US3340279;   Patent:US3475465



show annotations for term's descendants           Sort by:
 
tibolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein increases expression ISO tibolone results in increased expression of CRP protein CTD PMID:17882670 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO tibolone metabolite results in increased activity of ESR1 protein; tibolone results in increased activity of ESR1 protein CTD PMID:16720731 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO tibolone metabolite results in increased activity of ESR2 protein; tibolone results in increased activity of ESR2 protein CTD PMID:16720731 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO tibolone metabolite results in increased expression of F3 protein; tibolone results in increased expression of F3 protein CTD PMID:16011840 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of ICAM1 protein CTD PMID:17882670 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK1 protein; tibolone results in decreased phosphorylation of MAPK1 protein CTD PMID:14764805 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tibolone metabolite results in decreased phosphorylation of MAPK3 protein; tibolone results in decreased phosphorylation of MAPK3 protein CTD PMID:14764805 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Pgr progesterone receptor increases activity ISO tibolone metabolite results in increased activity of PGR protein; tibolone results in increased activity of PGR protein CTD PMID:16011840 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Sele selectin E decreases expression ISO tibolone results in decreased expression of SELE protein CTD PMID:17882670 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO tibolone metabolite results in increased expression of SERPINE1 protein; tibolone results in increased expression of SERPINE1 protein CTD PMID:16011840 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO tibolone results in decreased expression of VCAM1 protein CTD PMID:17882670 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            bone density conservation agent 5995
              tibolone 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic polycyclic compound 16539
                                  steroid 13056
                                    hydroxy steroid 12658
                                      17-hydroxy steroid 12170
                                        17beta-hydroxy steroid 10927
                                          tibolone 11
paths to the root