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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tiaprofenic acid
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Accession:CHEBI:32221 term browser browse the term
Definition:An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.
Synonyms:exact_synonym: 2-(5-benzoylthiophen-2-yl)propanoic acid
 related_synonym: 2-(5-Benzoyl-thiophen-2-yl)-propionic acid;   2-(5-Benzyl-2-thienyl)propionsaeure;   5-benzoyl-alpha-methyl-2-thiopheneacetic acid;   5-benzoyl-alpha-methylthiophene-2-acetic acid;   Formula=C14H12O3S;   InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17);   InChIKey=GUHPRPJDBZHYCJ-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1ccc(s1)C(=O)c1ccccc1;   Tiaprofensaeure;   acide tiaprofenique;   acido tiaprofenico;   acidum tiaprofenicum;   alpha-methyl-5-benzoyl-2-thienylacetic acid
 alt_id: CHEBI:417367
 xref: Beilstein:1380662;   CAS:33005-95-7;   DrugBank:DB01600;   Drug_Central:2652;   KEGG:D01325;   LINCS:LSM-1769
 xref_mesh: MESH:C021270
 xref: PMID:11169173;   PMID:19753743;   PMID:19821426;   PMID:21116781;   PMID:2248025;   PMID:23231046;   PMID:9799928;   Patent:DE2055264;   Patent:FR2112111;   Reaxys:1380662;   Wikipedia:Tiaprofenic_acid

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tiaprofenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr1 carbonyl reductase 1 increases reduction ISO CBR1 protein results in increased reduction of tiaprofenic acid CTD PMID:28322780 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tiaprofenic acid results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of tiaprofenic acid; UGT2B7 protein results in increased glucuronidation of tiaprofenic acid
CTD PMID:8423545 PMID:8517101 PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        anti-inflammatory agent 15835
          anti-inflammatory drug 13630
            non-steroidal anti-inflammatory drug 12717
              tiaprofenic acid 3
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        monocarboxylic acid 17639
                                          tiaprofenic acid 3
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