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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tiaprofenic acid
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Accession:CHEBI:32221 term browser browse the term
Definition:An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.
Synonyms:exact_synonym: 2-(5-benzoylthiophen-2-yl)propanoic acid
 related_synonym: 2-(5-Benzoyl-thiophen-2-yl)-propionic acid;   2-(5-Benzyl-2-thienyl)propionsaeure;   5-benzoyl-alpha-methyl-2-thiopheneacetic acid;   5-benzoyl-alpha-methylthiophene-2-acetic acid;   Formula=C14H12O3S;   InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17);   InChIKey=GUHPRPJDBZHYCJ-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1ccc(s1)C(=O)c1ccccc1;   Tiaprofensaeure;   acide tiaprofenique;   acido tiaprofenico;   acidum tiaprofenicum;   alpha-methyl-5-benzoyl-2-thienylacetic acid
 alt_id: CHEBI:417367
 xref: Beilstein:1380662;   CAS:33005-95-7;   DrugBank:DB01600;   Drug_Central:2652;   KEGG:D01325;   LINCS:LSM-1769
 xref_mesh: MESH:C021270
 xref: PMID:11169173;   PMID:19753743;   PMID:19821426;   PMID:21116781;   PMID:2248025;   PMID:23231046;   PMID:9799928;   Patent:DE2055264;   Patent:FR2112111;   Reaxys:1380662;   Wikipedia:Tiaprofenic_acid


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tiaprofenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr1 carbonyl reductase 1 increases reduction ISO CBR1 protein results in increased reduction of tiaprofenic acid CTD PMID:28322780 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO tiaprofenic acid results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
ISO tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of tiaprofenic acid; UGT2B7 protein results in increased glucuronidation of tiaprofenic acid
CTD PMID:8423545, PMID:8517101, PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          anti-inflammatory drug 13613
            non-steroidal anti-inflammatory drug 12696
              tiaprofenic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          tiaprofenic acid 3
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