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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Tegafur
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Accession:CHEBI:32188 term browser browse the term
Definition:A pyrimidine that has formula C8H9FN2O3.
Synonyms:related_synonym: FT-207;   Formula=C8H9FN2O3;   InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13);   InChIKey=WFWLQNSHRPWKFK-UHFFFAOYSA-N;   SMILES=Fc1cn(C2CCCO2)c(=O)[nH]c1=O;   florafur;   ftorafur;   futraful
 xref: CAS:17902-23-7;   Drug_Central:4398;   KEGG:C12673;   KEGG:D01244;   LINCS:LSM-5155
 xref_mesh: MESH:D005641


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Tegafur term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cda cytidine deaminase affects response to substance ISO CDA gene polymorphism affects the susceptibility to Tegafur CTD PMID:18537153 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects response to substance ISO DPYD gene polymorphism affects the susceptibility to Tegafur CTD PMID:18537153 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tegafur inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tp53 tumor protein p53 affects response to substance
multiple interactions
ISO TP53 protein affects the susceptibility to Tegafur
TP53 protein affects the susceptibility to [Uracil co-treated with Tegafur]
CTD PMID:15182437 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS promoter polymorphism affects the susceptibility to Tegafur CTD PMID:16617381 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        polyatomic entity 19695
          heteroatomic molecular entity 19620
            halide 17977
              organohalogen compound 17713
                Tegafur 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    diazines 12138
                                      pyrimidines 11955
                                        Tegafur 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.