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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:suxibuzone
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Accession:CHEBI:32173 term browser browse the term
Definition:A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.
Synonyms:exact_synonym: 4-[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
 related_synonym: 4-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate;   4-Hydroxymethylbutazolidine hemisuccinate;   Formula=C24H26N2O6;   InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28);   InChIKey=ONWXNHPOAGOMTG-UHFFFAOYSA-N;   SMILES=CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c1ccccc1)c1ccccc1;   suxibuzona;   suxibuzonum
 xref: AGR:IND44395503;   Beilstein:904563;   CAS:27470-51-5;   Drug_Central:2547;   HMDB:HMDB0042019;   KEGG:D01289;   LINCS:LSM-5851
 xref_mesh: MESH:C003371
 xref: PMID:10505957;   PMID:19927590;   PMID:20037965;   PMID:3425858;   PMID:6345427;   PMID:7097505;   PMID:7452452;   PMID:8230399;   Reaxys:904563;   VSDB:1815;   Wikipedia:Suxibuzone



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suxibuzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pklr pyruvate kinase L/R decreases activity EXP suxibuzone results in decreased activity of PKLR protein CTD PMID:3107799 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      application 19675
        pro-agent 11550
          prodrug 11310
            suxibuzone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            heteroorganic entity 19494
                              organochalcogen compound 19257
                                organooxygen compound 19173
                                  carbonyl compound 18897
                                    dicarboxylic acids and O-substituted derivatives 11133
                                      dicarboxylic acid 11127
                                        alpha,omega-dicarboxylic acid 3173
                                          succinic acid 710
                                            succinate ester 125
                                              hemisuccinate 121
                                                suxibuzone 1
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