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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:suxibuzone
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Accession:CHEBI:32173 term browser browse the term
Definition:A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.
Synonyms:exact_synonym: 4-[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
 related_synonym: 4-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate;   4-Hydroxymethylbutazolidine hemisuccinate;   Formula=C24H26N2O6;   InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28);   InChIKey=ONWXNHPOAGOMTG-UHFFFAOYSA-N;   SMILES=CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c1ccccc1)c1ccccc1;   suxibuzona;   suxibuzonum
 xref: AGR:IND44395503;   Beilstein:904563;   CAS:27470-51-5;   Drug_Central:2547;   HMDB:HMDB0042019;   KEGG:D01289;   LINCS:LSM-5851
 xref_mesh: MESH:C003371
 xref: PMID:10505957;   PMID:19927590;   PMID:20037965;   PMID:3425858;   PMID:6345427;   PMID:7097505;   PMID:7452452;   PMID:8230399;   Reaxys:904563;   VSDB:1815;   Wikipedia:Suxibuzone



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suxibuzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pklr pyruvate kinase L/R decreases activity EXP suxibuzone results in decreased activity of PKLR protein CTD PMID:3107799 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      application 19546
        pro-agent 10105
          prodrug 9905
            suxibuzone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      dicarboxylic acids and O-substituted derivatives 10394
                                        dicarboxylic acid 10387
                                          alpha,omega-dicarboxylic acid 2811
                                            succinic acid 234
                                              succinate ester 125
                                                hemisuccinate 121
                                                  suxibuzone 1
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