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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:suxibuzone
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Accession:CHEBI:32173 term browser browse the term
Definition:A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.
Synonyms:exact_synonym: 4-[(4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
 related_synonym: 4-Butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate;   4-Hydroxymethylbutazolidine hemisuccinate;   Formula=C24H26N2O6;   InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28);   InChIKey=ONWXNHPOAGOMTG-UHFFFAOYSA-N;   SMILES=CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c1ccccc1)c1ccccc1;   suxibuzona;   suxibuzonum
 xref: AGR:IND44395503;   Beilstein:904563;   CAS:27470-51-5;   Drug_Central:2547;   HMDB:HMDB0042019;   KEGG:D01289;   LINCS:LSM-5851
 xref_mesh: MESH:C003371
 xref: PMID:10505957;   PMID:19927590;   PMID:20037965;   PMID:3425858;   PMID:6345427;   PMID:7097505;   PMID:7452452;   PMID:8230399;   Reaxys:904563;   VSDB:1815;   Wikipedia:Suxibuzone


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suxibuzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pklr pyruvate kinase L/R decreases activity EXP suxibuzone results in decreased activity of PKLR protein CTD PMID:3107799 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pro-agent 8830
          prodrug 8610
            suxibuzone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      dicarboxylic acids and O-substituted derivatives 10272
                                        dicarboxylic acid 10265
                                          alpha,omega-dicarboxylic acid 2774
                                            succinic acid 216
                                              succinate ester 110
                                                hemisuccinate 106
                                                  suxibuzone 1
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