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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulpiride
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Accession:CHEBI:32168 term browser browse the term
Definition:A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Synonyms:exact_synonym: N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
 related_synonym: 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide;   Formula=C15H23N3O4S;   InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21);   InChIKey=BGRJTUBHPOOWDU-UHFFFAOYSA-N;   N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide;   N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide;   SMILES=CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O;   Sulpirid;   Sulpyrid;   sulpirida;   sulpiridum
 xref: CAS:15676-16-1;   DrugBank:DB00391;   Drug_Central:2537;   KEGG:D01226;   LINCS:LSM-5080
 xref_mesh: MESH:D013469
 xref: PMID:16327907;   PMID:16924461;   PMID:17912501;   PMID:17942035;   PMID:18757738;   PMID:18985321;   PMID:19370694;   PMID:19546258;   PMID:19672580;   PMID:19864199;   PMID:19941957;   PMID:20061345;   PMID:20091661;   PMID:20177884;   PMID:20304506;   PMID:20305607;   PMID:20538381;   PMID:20599913;   PMID:20875676;   Patent:DE2903891;   Patent:US3342826;   Reaxys:494008;   Wikipedia:Sulpiride


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sulpiride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport		 ISO Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Sulpiride] CTD PMID:28597291 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport		 ISO Elacridar inhibits the reaction [ABCG2 protein results in increased transport of Sulpiride] CTD PMID:28597291 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Sulpiride CTD PMID:12223546 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression		 EXP Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]
Sulpiride results in decreased expression of AHR mRNA		 CTD PMID:26466350 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions EXP Sulpiride promotes the reaction [Benzo(a)pyrene results in increased expression of AHRR mRNA] CTD PMID:26466350 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of AIF1 protein] CTD PMID:30922767 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression EXP Sulpiride results in decreased expression of AKR1C3 mRNA CTD PMID:21427058 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA] CTD PMID:26466350 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of BAX protein] CTD PMID:30922767 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of BCL2 protein] CTD PMID:30922767 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 multiple interactions ISO Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein] CTD PMID:20340177 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Sulpiride binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO Sulpiride binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased cleavage of CASP3 protein] CTD PMID:30922767 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO Sulpiride promotes the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] CTD PMID:14730115 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Sulpiride CTD PMID:11403953 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of CD86 mRNA] CTD PMID:30922767 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cish cytokine inducible SH2-containing protein increases expression
multiple interactions		 EXP Sulpiride results in increased expression of CISH mRNA
Estradiol promotes the reaction [Sulpiride results in increased expression of CISH mRNA]		 CTD PMID:18162529 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Sulpiride results in increased expression of CYP11A1 mRNA; Sulpiride results in increased expression of CYP11A1 protein CTD PMID:21427058 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
multiple interactions		 EXP Sulpiride results in decreased expression of CYP1A1 mRNA
Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]		 CTD PMID:26466350 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions		 EXP Sulpiride results in decreased expression of CYP1A2 mRNA
Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]		 CTD PMID:26466350 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Drd2 dopamine receptor D2 affects binding
multiple interactions
increases expression
decreases activity		 ISO
EXP		 Sulpiride binds to DRD2 protein
Methamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]; Sulpiride binds to and results in decreased activity of DRD2 protein; Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]
Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
Sulpiride results in increased expression of DRD2
[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine
Sulpiride results in decreased activity of DRD2 protein		 CTD PMID:1351265 PMID:2891082 PMID:2901473 PMID:7644023 PMID:8032591 More... NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Fcgr2a Fc gamma receptor 2A multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR3 mRNA] CTD PMID:30922767 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fcgr2b Fc gamma receptor 2B multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR2B mRNA] CTD PMID:30922767 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Foxo1 forkhead box O1 affects localization EXP Sulpiride affects the localization of FOXO1 protein modified form CTD PMID:26466350 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gad1 glutamate decarboxylase 1 decreases methylation
multiple interactions		 ISO Sulpiride results in decreased methylation of GAD1 promoter
Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]		 CTD PMID:18757738 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gh1 growth hormone 1 decreases expression
multiple interactions		 EXP Sulpiride results in decreased expression of GH1 protein
Benzo(a)pyrene affects the reaction [Sulpiride results in decreased expression of GH1 protein]		 CTD PMID:26466350 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression		 EXP Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA]
Sulpiride results in increased expression of HSP90AA1 mRNA		 CTD PMID:26466350 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Ins2 insulin 2 increases expression ISO Sulpiride results in increased expression of INS protein CTD PMID:16601995 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases expression		 EXP Sulpiride results in decreased expression of and results in increased phosphorylation of IRS1 protein
Sulpiride results in decreased expression of IRS1 mRNA		 CTD PMID:29551354 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO Sulpiride binds to and results in decreased activity of KCNH1 protein CTD PMID:17982510 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740 		JBrowse link
G Lhb luteinizing hormone subunit beta affects secretion EXP Sulpiride affects the secretion of LHB protein CTD PMID:18162529 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression EXP Sulpiride results in increased expression of NR5A2 mRNA CTD PMID:21427058 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Prl prolactin increases abundance
increases expression
multiple interactions
increases secretion		 ISO
EXP		 Sulpiride results in increased abundance of PRL protein
Sulpiride results in increased expression of PRL protein
Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein]; Verapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein]
Benzo(a)pyrene promotes the reaction [Sulpiride results in increased expression of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Cabergoline results in decreased secretion of PRL protein]
Sulpiride results in increased expression of PRL mRNA; Sulpiride results in increased expression of PRL protein		 CTD PMID:956353 PMID:2948424 PMID:2954994 PMID:3137082 PMID:3891423 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prlr prolactin receptor increases expression EXP Sulpiride results in increased expression of PRLR mRNA alternative form CTD PMID:18162529 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Reln reelin multiple interactions
decreases methylation		 ISO Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of RELN promoter] CTD PMID:18757738 PMID:19110320 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression EXP Sulpiride results in increased expression of SCARB1 mRNA; Sulpiride results in increased expression of SCARB1 protein CTD PMID:21427058 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC18A2 protein] CTD PMID:30922767 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc22a23 solute carrier family 22, member 23 multiple interactions ISO Sulpiride inhibits the reaction [SLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:28597291 NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake ISO SLC22A3 protein results in increased uptake of Sulpiride CTD PMID:28597291 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Sulpiride inhibits the reaction [Dopamine affects the localization of SLC6A3 protein]; Sulpiride inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC6A3 protein]		 CTD PMID:20875051 PMID:30922767 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP Sulpiride results in increased expression of SOCS1 mRNA CTD PMID:18162529 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions		 EXP Sulpiride results in increased expression of SOCS3 mRNA
Estradiol promotes the reaction [Sulpiride results in increased expression of SOCS3 mRNA]		 CTD PMID:18162529 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression EXP Sulpiride results in increased expression of SRD5A1 mRNA CTD PMID:18978642 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression EXP Sulpiride results in increased expression of SRD5A2 mRNA CTD PMID:18978642 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Sulpiride results in increased expression of STAR mRNA; Sulpiride results in increased expression of STAR protein CTD PMID:21427058 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity		 EXP
ISO		 Sulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein]; Sulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein]
Sulpiride results in increased activity of TH protein
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein]		 CTD PMID:2884129 PMID:18289173 PMID:30922767 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        pharmacological role 18974
          antagonist 17005
            dopaminergic antagonist 1595
              sulpiride 47
                (R)-(+)-sulpiride 0
                (S)-(-)-sulpiride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        carboacyl group 17656
                                          univalent carboacyl group 17656
                                            carbamoyl group 17497
                                              carboxamide 17497
                                                monocarboxylic acid amide 15562
                                                  arenecarboxamide 7310
                                                    benzamides 7310
                                                      sulpiride 47
                                                        (R)-(+)-sulpiride 0
                                                        (S)-(-)-sulpiride 0
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