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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulpiride
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Accession:CHEBI:32168 term browser browse the term
Definition:A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Synonyms:exact_synonym: N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
 related_synonym: 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide;   Formula=C15H23N3O4S;   InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21);   InChIKey=BGRJTUBHPOOWDU-UHFFFAOYSA-N;   N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide;   N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide;   SMILES=CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O;   Sulpirid;   Sulpyrid;   sulpirida;   sulpiridum
 xref: CAS:15676-16-1;   DrugBank:DB00391;   Drug_Central:2537;   KEGG:D01226;   LINCS:LSM-5080
 xref_mesh: MESH:D013469
 xref: PMID:16327907;   PMID:16924461;   PMID:17912501;   PMID:17942035;   PMID:18757738;   PMID:18985321;   PMID:19370694;   PMID:19546258;   PMID:19672580;   PMID:19864199;   PMID:19941957;   PMID:20061345;   PMID:20091661;   PMID:20177884;   PMID:20304506;   PMID:20305607;   PMID:20538381;   PMID:20599913;   PMID:20875676;   Patent:DE2903891;   Patent:US3342826;   Reaxys:494008;   Wikipedia:Sulpiride

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sulpiride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport		 ISO Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Sulpiride] CTD PMID:28597291 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport		 ISO Elacridar inhibits the reaction [ABCG2 protein results in increased transport of Sulpiride] CTD PMID:28597291 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Sulpiride CTD PMID:12223546 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression		 EXP Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]
Sulpiride results in decreased expression of AHR mRNA		 CTD PMID:26466350 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions EXP Sulpiride promotes the reaction [Benzo(a)pyrene results in increased expression of AHRR mRNA] CTD PMID:26466350 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of AIF1 protein] CTD PMID:30922767 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression EXP Sulpiride results in decreased expression of AKR1C3 mRNA CTD PMID:21427058 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA] CTD PMID:26466350 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of BAX protein] CTD PMID:30922767 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of BCL2 protein] CTD PMID:30922767 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO Sulpiride binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 multiple interactions ISO Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein] CTD PMID:20340177 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Sulpiride binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased cleavage of CASP3 protein] CTD PMID:30922767 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions ISO Sulpiride promotes the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] CTD PMID:14730115 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Sulpiride CTD PMID:11403953 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298 		JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of CD86 mRNA] CTD PMID:30922767 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795 		JBrowse link
G Cish cytokine inducible SH2-containing protein increases expression
multiple interactions		 EXP Sulpiride results in increased expression of CISH mRNA
Estradiol promotes the reaction [Sulpiride results in increased expression of CISH mRNA]		 CTD PMID:18162529 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Sulpiride results in increased expression of CYP11A1 mRNA; Sulpiride results in increased expression of CYP11A1 protein CTD PMID:21427058 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
multiple interactions		 EXP Sulpiride results in decreased expression of CYP1A1 mRNA
Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]		 CTD PMID:26466350 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions		 EXP Sulpiride results in decreased expression of CYP1A2 mRNA
Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]		 CTD PMID:26466350 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Drd2 dopamine receptor D2 affects binding
decreases activity
multiple interactions
increases expression		 ISO
EXP		 Sulpiride binds to DRD2 protein
Sulpiride results in decreased activity of DRD2 protein
[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine
Sulpiride results in increased expression of DRD2
Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
Methamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]; Sulpiride binds to and results in decreased activity of DRD2 protein; Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]		 CTD PMID:1351265, PMID:2891082, PMID:2901473, PMID:7644023, PMID:8032591, PMID:8774428, PMID:15332494, PMID:20340177, PMID:20361897 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR3 mRNA] CTD PMID:30922767 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036 		JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR2B mRNA] CTD PMID:30922767 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815 		JBrowse link
G Foxo1 forkhead box O1 affects localization EXP Sulpiride affects the localization of FOXO1 protein modified form CTD PMID:26466350 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Gad1 glutamate decarboxylase 1 decreases methylation
multiple interactions		 ISO Sulpiride results in decreased methylation of GAD1 promoter
Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]		 CTD PMID:18757738 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157 		JBrowse link
G Gh1 growth hormone 1 decreases expression
multiple interactions		 EXP Sulpiride results in decreased expression of GH1 protein
Benzo(a)pyrene affects the reaction [Sulpiride results in decreased expression of GH1 protein]		 CTD PMID:26466350 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression		 EXP Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA]
Sulpiride results in increased expression of HSP90AA1 mRNA		 CTD PMID:26466350 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Ins2 insulin 2 increases expression ISO Sulpiride results in increased expression of INS protein CTD PMID:16601995 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases expression		 EXP Sulpiride results in decreased expression of and results in increased phosphorylation of IRS1 protein
Sulpiride results in decreased expression of IRS1 mRNA		 CTD PMID:29551354 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO Sulpiride binds to and results in decreased activity of KCNH1 protein CTD PMID:17982510 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269 		JBrowse link
G Lhb luteinizing hormone subunit beta affects secretion EXP Sulpiride affects the secretion of LHB protein CTD PMID:18162529 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression EXP Sulpiride results in increased expression of NR5A2 mRNA CTD PMID:21427058 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428 		JBrowse link
G Prl prolactin increases abundance
increases expression
increases secretion
multiple interactions		 ISO
EXP		 Sulpiride results in increased abundance of PRL protein
Sulpiride results in increased expression of PRL mRNA; Sulpiride results in increased expression of PRL protein
Sulpiride results in increased secretion of PRL protein
Benzo(a)pyrene promotes the reaction [Sulpiride results in increased expression of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Cabergoline results in decreased secretion of PRL protein]
Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein]; Verapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein]		 CTD PMID:956353, PMID:2948424, PMID:2954994, PMID:3137082, PMID:3891423, PMID:4001434, PMID:7106173, PMID:7243090, PMID:7670571, PMID:7851873, PMID:18978642, PMID:21427058, PMID:26466350 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Prlr prolactin receptor increases expression EXP Sulpiride results in increased expression of PRLR mRNA alternative form CTD PMID:18162529 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692 		JBrowse link
G Reln reelin multiple interactions
decreases methylation		 ISO Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of RELN promoter] CTD PMID:18757738, PMID:19110320 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression EXP Sulpiride results in increased expression of SCARB1 mRNA; Sulpiride results in increased expression of SCARB1 protein CTD PMID:21427058 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC18A2 protein] CTD PMID:30922767 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Slc22a23 solute carrier family 22, member 23 multiple interactions ISO Sulpiride inhibits the reaction [SLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:28597291 NCBI chr17:31,236,015...31,403,685
Ensembl chr17:31,236,015...31,403,685 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake ISO SLC22A3 protein results in increased uptake of Sulpiride CTD PMID:28597291 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Sulpiride inhibits the reaction [Dopamine affects the localization of SLC6A3 protein]; Sulpiride inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC6A3 protein]		 CTD PMID:20875051, PMID:30922767 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP Sulpiride results in increased expression of SOCS1 mRNA CTD PMID:18162529 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions		 EXP Sulpiride results in increased expression of SOCS3 mRNA
Estradiol promotes the reaction [Sulpiride results in increased expression of SOCS3 mRNA]		 CTD PMID:18162529 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression EXP Sulpiride results in increased expression of SRD5A1 mRNA CTD PMID:18978642 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression EXP Sulpiride results in increased expression of SRD5A2 mRNA CTD PMID:18978642 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Sulpiride results in increased expression of STAR mRNA; Sulpiride results in increased expression of STAR protein CTD PMID:21427058 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases activity		 EXP
ISO		 Sulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein]; Sulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein]
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein]
Sulpiride results in increased activity of TH protein		 CTD PMID:2884129, PMID:18289173, PMID:30922767 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antiemetic 5125
              sulpiride 47
                (R)-(+)-sulpiride 0
                (S)-(-)-sulpiride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  arenecarboxamide 6508
                                                    benzamides 6508
                                                      sulpiride 47
                                                        (R)-(+)-sulpiride 0
                                                        (S)-(-)-sulpiride 0
paths to the root

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