CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sulpiride
Accession: CHEBI:32168
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Definition: A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Synonyms: exact_synonym: N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
related_synonym: 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide; Formula=C15H23N3O4S; InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21); InChIKey=BGRJTUBHPOOWDU-UHFFFAOYSA-N; N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide; N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide; SMILES=CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O; Sulpirid; Sulpyrid; sulpirida; sulpiridum
xref: CAS:15676-16-1; DrugBank:DB00391; Drug_Central:2537; KEGG:D01226; LINCS:LSM-5080
xref_mesh: MESH:D013469
xref: PMID:16327907; PMID:16924461; PMID:17912501; PMID:17942035; PMID:18757738; PMID:18985321; PMID:19370694; PMID:19546258; PMID:19672580; PMID:19864199; PMID:19941957; PMID:20061345; PMID:20091661; PMID:20177884; PMID:20304506; PMID:20305607; PMID:20538381; PMID:20599913; PMID:20875676; Patent:DE2903891; Patent:US3342826; Reaxys:494008; Wikipedia:Sulpiride
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions increases transport
ISO
Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Sulpiride]
CTD
PMID:28597291
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions increases transport
ISO
Elacridar inhibits the reaction [ABCG2 protein results in increased transport of Sulpiride]
CTD
PMID:28597291
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Adcy5
adenylate cyclase 5
increases response to substance
ISO
ADCY5 protein results in increased susceptibility to Sulpiride
CTD
PMID:12223546
NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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Ahr
aryl hydrocarbon receptor
multiple interactions decreases expression
EXP
Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA] Sulpiride results in decreased expression of AHR mRNA
CTD
PMID:26466350
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ahrr
aryl-hydrocarbon receptor repressor
multiple interactions
EXP
Sulpiride promotes the reaction [Benzo(a)pyrene results in increased expression of AHRR mRNA]
CTD
PMID:26466350
NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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Aif1
allograft inflammatory factor 1
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of AIF1 protein]
CTD
PMID:30922767
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Akr1c3
aldo-keto reductase family 1, member C3
decreases expression
EXP
Sulpiride results in decreased expression of AKR1C3 mRNA
CTD
PMID:21427058
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
EXP
Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]
CTD
PMID:26466350
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of BAX protein]
CTD
PMID:30922767
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of BCL2 protein]
CTD
PMID:30922767
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
multiple interactions
ISO
Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]
CTD
PMID:20340177
NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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Car2
carbonic anhydrase 2
multiple interactions
ISO
Sulpiride binds to and results in decreased activity of CA2 protein
CTD
PMID:17826101
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Car3
carbonic anhydrase 3
multiple interactions
ISO
Sulpiride binds to and results in decreased activity of CA3 protein
CTD
PMID:17826101
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Casp3
caspase 3
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased cleavage of CASP3 protein]
CTD
PMID:30922767
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
ISO
Sulpiride promotes the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]]
CTD
PMID:14730115
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cckbr
cholecystokinin B receptor
affects response to substance
ISO
CCKBR protein affects the susceptibility to Sulpiride
CTD
PMID:11403953
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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Cd86
CD86 molecule
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of CD86 mRNA]
CTD
PMID:30922767
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cish
cytokine inducible SH2-containing protein
increases expression multiple interactions
EXP
Sulpiride results in increased expression of CISH mRNA Estradiol promotes the reaction [Sulpiride results in increased expression of CISH mRNA]
CTD
PMID:18162529
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
EXP
Sulpiride results in increased expression of CYP11A1 mRNA; Sulpiride results in increased expression of CYP11A1 protein
CTD
PMID:21427058
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
decreases expression multiple interactions
EXP
Sulpiride results in decreased expression of CYP1A1 mRNA Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD
PMID:26466350
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases expression multiple interactions
EXP
Sulpiride results in decreased expression of CYP1A2 mRNA Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
CTD
PMID:26466350
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Drd2
dopamine receptor D2
affects binding multiple interactions increases expression decreases activity
ISO EXP
Sulpiride binds to DRD2 protein Methamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]; Sulpiride binds to and results in decreased activity of DRD2 protein; Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein] Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]; Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium] Sulpiride results in increased expression of DRD2 [Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine Sulpiride results in decreased activity of DRD2 protein
CTD
PMID:1351265 PMID:2891082 PMID:2901473 PMID:7644023 PMID:8032591 PMID:8774428 PMID:15332494 PMID:20340177 PMID:20361897 More...
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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Fcgr2a
Fc gamma receptor 2A
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR3 mRNA]
CTD
PMID:30922767
NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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Fcgr2b
Fc gamma receptor 2B
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR2B mRNA]
CTD
PMID:30922767
NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
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Foxo1
forkhead box O1
affects localization
EXP
Sulpiride affects the localization of FOXO1 protein modified form
CTD
PMID:26466350
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Gad1
glutamate decarboxylase 1
decreases methylation multiple interactions
ISO
Sulpiride results in decreased methylation of GAD1 promoter Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]
CTD
PMID:18757738
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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Gh1
growth hormone 1
decreases expression multiple interactions
EXP
Sulpiride results in decreased expression of GH1 protein Benzo(a)pyrene affects the reaction [Sulpiride results in decreased expression of GH1 protein]
CTD
PMID:26466350
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
multiple interactions increases expression
EXP
Sulpiride inhibits the reaction [Benzo(a)pyrene results in increased expression of HSP90AA1 mRNA] Sulpiride results in increased expression of HSP90AA1 mRNA
CTD
PMID:26466350
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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Ins2
insulin 2
increases expression
ISO
Sulpiride results in increased expression of INS protein
CTD
PMID:16601995
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Irs1
insulin receptor substrate 1
multiple interactions decreases expression
EXP
Sulpiride results in decreased expression of and results in increased phosphorylation of IRS1 protein Sulpiride results in decreased expression of IRS1 mRNA
CTD
PMID:29551354
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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Kcnh1
potassium voltage-gated channel subfamily H member 1
multiple interactions
ISO
Sulpiride binds to and results in decreased activity of KCNH1 protein
CTD
PMID:17982510
NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
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Lhb
luteinizing hormone subunit beta
affects secretion
EXP
Sulpiride affects the secretion of LHB protein
CTD
PMID:18162529
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Nr5a2
nuclear receptor subfamily 5, group A, member 2
increases expression
EXP
Sulpiride results in increased expression of NR5A2 mRNA
CTD
PMID:21427058
NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
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Prl
prolactin
increases abundance increases expression multiple interactions increases secretion
ISO EXP
Sulpiride results in increased abundance of PRL protein Sulpiride results in increased expression of PRL protein Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein]; Verapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein] Benzo(a)pyrene promotes the reaction [Sulpiride results in increased expression of PRL protein]; Sulpiride inhibits the reaction [Bromocriptine results in decreased secretion of PRL protein]; Sulpiride inhibits the reaction [Cabergoline results in decreased secretion of PRL protein] Sulpiride results in increased expression of PRL mRNA; Sulpiride results in increased expression of PRL protein
CTD
PMID:956353 PMID:2948424 PMID:2954994 PMID:3137082 PMID:3891423 PMID:4001434 PMID:7106173 PMID:7243090 PMID:7670571 PMID:7851873 PMID:18978642 PMID:21427058 PMID:26466350 More...
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prlr
prolactin receptor
increases expression
EXP
Sulpiride results in increased expression of PRLR mRNA alternative form
CTD
PMID:18162529
NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
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Reln
reelin
multiple interactions decreases methylation
ISO
Valproic Acid promotes the reaction [Sulpiride results in decreased methylation of RELN promoter]
CTD
PMID:18757738 PMID:19110320
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Scarb1
scavenger receptor class B, member 1
increases expression
EXP
Sulpiride results in increased expression of SCARB1 mRNA; Sulpiride results in increased expression of SCARB1 protein
CTD
PMID:21427058
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Slc18a2
solute carrier family 18 member A2
multiple interactions
ISO
Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC18A2 protein]
CTD
PMID:30922767
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc22a23
solute carrier family 22, member 23
multiple interactions
ISO
Sulpiride inhibits the reaction [SLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
CTD
PMID:28597291
NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790
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Slc22a3
solute carrier family 22 member 3
increases uptake
ISO
SLC22A3 protein results in increased uptake of Sulpiride
CTD
PMID:28597291
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc6a3
solute carrier family 6 member 3
multiple interactions
ISO
Sulpiride inhibits the reaction [Dopamine affects the localization of SLC6A3 protein]; Sulpiride inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine] Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC6A3 protein]
CTD
PMID:20875051 PMID:30922767
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Socs1
suppressor of cytokine signaling 1
increases expression
EXP
Sulpiride results in increased expression of SOCS1 mRNA
CTD
PMID:18162529
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
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Socs3
suppressor of cytokine signaling 3
increases expression multiple interactions
EXP
Sulpiride results in increased expression of SOCS3 mRNA Estradiol promotes the reaction [Sulpiride results in increased expression of SOCS3 mRNA]
CTD
PMID:18162529
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Srd5a1
steroid 5 alpha-reductase 1
increases expression
EXP
Sulpiride results in increased expression of SRD5A1 mRNA
CTD
PMID:18978642
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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Srd5a2
steroid 5 alpha-reductase 2
increases expression
EXP
Sulpiride results in increased expression of SRD5A2 mRNA
CTD
PMID:18978642
NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
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Star
steroidogenic acute regulatory protein
increases expression
EXP
Sulpiride results in increased expression of STAR mRNA; Sulpiride results in increased expression of STAR protein
CTD
PMID:21427058
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Th
tyrosine hydroxylase
multiple interactions increases activity
EXP ISO
Sulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein]; Sulpiride inhibits the reaction [Rotenone results in decreased expression of TH protein] Sulpiride results in increased activity of TH protein Sulpiride inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein]
CTD
PMID:2884129 PMID:18289173 PMID:30922767
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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