Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfadimethoxine
go back to main search page
Accession:CHEBI:32161 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
Synonyms:exact_synonym: 4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
 related_synonym: 2,4-dimethoxy-6-sulfanilamido-1,3-diazine;   2,6-dimethoxy-4-(p-aminobenzenesulfonamido)pyrimidine;   2,6-dimethoxy-4-sulfanilamidopyrimidine;   4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;   6-sulfanilamido-2,4-dimethoxypyrimidine;   Abcid (TN);   Agribon (TN);   Formula=C12H14N4O4S;   InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16);   InChIKey=ZZORFUFYDOWNEF-UHFFFAOYSA-N;   N(1)-(2,6-dimethoxy-4-pyrimidinyl)sulfanilamide;   SMILES=COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1;   Sulfadimethoxydiazine;   Sulphadimethoxine;   sulfadimethoxinum;   sulfadimetoxina
 xref: Beilstein:306856;   CAS:122-11-2;   DrugBank:DB06150;   Drug_Central:2501;   Gmelin:677830;   HMDB:HMDB0015621;   KEGG:D01142;   LINCS:LSM-5790
 xref_mesh: MESH:D013412
 xref: PMID:11431418;   PMID:12038137;   PMID:13831481;   PMID:13840927;   PMID:14435331;   PMID:14437387;   PMID:16001847;   PMID:16390193;   PMID:18574183;   PMID:19927815;   Reaxys:306856;   VSDB:1833;   Wikipedia:Sulfadimethoxine


show annotations for term's descendants           Sort by:
 
sulfadimethoxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Complex Mixtures co-treated with Sulfadimethoxine] results in increased expression of AKT1 mRNA CTD PMID:22687987 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ca13 carbonic anhydrase 13 increases expression ISO Sulfadimethoxine results in increased expression of CAR13 mRNA CTD PMID:19000923 NCBI chr 2:88,282,961...88,314,254
Ensembl chr 2:88,282,961...88,314,254
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sulfadimethoxine results in increased expression of CCNB1 mRNA CTD PMID:19000923 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Sulfadimethoxine results in increased expression of CDK1 protein CTD PMID:23535288 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Sulfadimethoxine results in increased expression of CDKN1A protein CTD PMID:23535288 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Sulfadimethoxine results in increased expression of FOSL1 mRNA CTD PMID:19000923 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Complex Mixtures co-treated with Sulfadimethoxine] results in increased expression of HIF1A mRNA CTD PMID:22687987 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sulfadimethoxine results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Sulfadimethoxine results in increased expression of JUN mRNA CTD PMID:19000923 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Sulfadimethoxine results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sulfadimethoxine results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression
EXP [Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein; Indomethacin inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein]; Indomethacin inhibits the reaction [Sulfadimethoxine results in increased expression of MKI67 protein]; nimesulide inhibits the reaction [[Sulfadimethoxine co-treated with diisopropanolnitrosamine] results in increased expression of MKI67 protein] CTD PMID:22387750, PMID:23535288 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Sulfadimethoxine results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Ptges2 prostaglandin E synthase 2 increases expression EXP Sulfadimethoxine results in increased expression of PTGES2 protein CTD PMID:22387750 NCBI chr 3:11,424,195...11,431,379
Ensembl chr 3:11,424,099...11,431,402
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sulfadimethoxine results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Sulfadimethoxine results in increased expression of SCARB1 mRNA CTD PMID:19000923 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Sulfadimethoxine results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Sulfadimethoxine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Sulfadimethoxine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Tfrc transferrin receptor increases expression ISO Sulfadimethoxine results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Sulfadimethoxine results in increased expression of VEGFA mRNA CTD PMID:19000923 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B multiple interactions EXP [Complex Mixtures co-treated with Sulfadimethoxine] results in increased expression of VEGFB mRNA CTD PMID:22687987 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          sulfadimethoxine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        aromatic amine 13618
                                          anilines 12329
                                            substituted aniline 11825
                                              sulfanilamide 245
                                                sulfadimethoxine 22
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.