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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sodium hydrogencarbonate
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Accession:CHEBI:32139 term browser browse the term
Definition:An one-carbon compound that has formula CHNaO3.
Synonyms:related_synonym: E 500;   E500;   Formula=CHNaO3;   Formula=CHO3.Na;   InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1;   InChIKey=UIIMBOGNXHQVGW-UHFFFAOYSA-M;   NaHCO3;   Natriumhydrogenkarbonat;   SMILES=[Na+].OC([O-])=O;   Sodium bicarbonate;   baking soda;   bicarbonate of soda;   carbonic acid monosodium salt;   sodium acid carbonate;   sodium hydrogen carbonate
 xref: CAS:144-55-8;   DrugBank:DB01390;   KEGG:C12603;   KEGG:D01203
 xref_mesh: MESH:D017693
 xref: PPDB:2873;   Wikipedia:Sodium_Bicarbonate


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sodium hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression ISO Sodium Bicarbonate results in increased expression of ABCC2 mRNA CTD PMID:29126803 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases expression ISO Sodium Bicarbonate results in decreased expression of ABCG2 mRNA CTD PMID:29126803 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Car2 carbonic anhydrase 2 decreases expression ISO Sodium Bicarbonate results in decreased expression of CAR2 mRNA CTD PMID:31569818 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830 		JBrowse link
G Cat catalase multiple interactions EXP [Folic Acid co-treated with Sodium Bicarbonate] results in decreased activity of CAT protein CTD PMID:25559736 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10430982 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Nefh neurofilament, heavy polypeptide affects expression ISO Sodium Bicarbonate affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064 		JBrowse link
G Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 multiple interactions EXP [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA] CTD PMID:25559736 NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA] CTD PMID:25559736 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 decreases expression ISO Sodium Bicarbonate results in decreased expression of SLC15A1 mRNA CTD PMID:29126803 NCBI chr14:121,697,033...121,742,666
Ensembl chr14:121,697,033...121,742,664 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 decreases expression ISO Sodium Bicarbonate results in decreased expression of SLC22A6 mRNA CTD PMID:29126803 NCBI chr19:8,595,360...8,605,663
Ensembl chr19:8,595,403...8,605,663 		JBrowse link
G Slc39a8 solute carrier family 39 (metal ion transporter), member 8 multiple interactions ISO SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]; SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride] CTD PMID:21509381 NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333 		JBrowse link
G Slc4a1 solute carrier family 4 (anion exchanger), member 1 decreases expression ISO Sodium Bicarbonate results in decreased expression of SLC4A1 mRNA CTD PMID:31569818 NCBI chr11:102,239,646...102,256,107
Ensembl chr11:102,239,650...102,257,029 		JBrowse link
G Slc4a4 solute carrier family 4 (anion exchanger), member 4 increases transport
decreases expression		 ISO SLC4A4 protein results in increased transport of Sodium Bicarbonate
Sodium Bicarbonate results in decreased expression of SLC4A4 mRNA		 CTD PMID:18614622 PMID:31569818 NCBI chr 5:88,941,717...89,387,515
Ensembl chr 5:89,034,345...89,387,512 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] CTD PMID:10430982 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA] CTD PMID:25559736 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA] CTD PMID:25559736 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Vim vimentin multiple interactions ISO Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of VIM protein] CTD PMID:10430982 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        pharmacological role 19784
          antacid 196
            sodium hydrogencarbonate 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoanion 54
                                    hydrogencarbonate 31
                                      sodium hydrogencarbonate 17
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