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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:soblidotin
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Accession:CHEBI:32135 term browser browse the term
Definition:A tetrapeptide derivative of dolastatin 10. It is an inhibitor of tubulin polymerization which exhibits potent antitumor activity.
Synonyms:exact_synonym: N,N-dimethyl-L-valyl-N-{(3R,4S,5S)-3-methoxy-1-[(2S)-2-{(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl}pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl}-N-methyl-L-valinamide
 related_synonym: Formula=C39H67N5O6;   InChI=1S/C39H67N5O6/c1-13-27(6)35(43(10)39(48)33(25(2)3)41-38(47)34(26(4)5)42(8)9)31(49-11)24-32(45)44-23-17-20-30(44)36(50-12)28(7)37(46)40-22-21-29-18-15-14-16-19-29/h14-16,18-19,25-28,30-31,33-36H,13,17,20-24H2,1-12H3,(H,40,46)(H,41,47)/t27-,28+,30-,31+,33-,34-,35+,36+/m0/s1;   InChIKey=DZMVCVHATYROOS-ZBFGKEHZSA-N;   SMILES=[H][C@]([C@@H](C)CC)([C@@H](CC(=O)N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(=O)NCCC1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C;   TZT 1027;   soblidotina;   soblidotine;   soblidotinum
 xref: CAS:149606-27-9;   DrugBank:DB12677;   KEGG:D01919;   PMID:10629886;   PMID:10920282;   PMID:10965026;   PMID:11227216;   PMID:11678375;   PMID:12967483;   PMID:15330161;   PMID:15897580;   PMID:16141595;   PMID:16550209;   PMID:16619516;   PMID:16827132;   PMID:16999818;   PMID:17092603;   PMID:17109446;   PMID:17136542;   PMID:17284247;   PMID:17436580;   PMID:17473826;   PMID:17667596;   PMID:18214483;   PMID:18225550;   PMID:19068085;   PMID:20145173;   PMID:27136567;   PMID:30901820;   PMID:33251248;   PMID:9140117;   Patent:US7008928


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          apoptosis inducer 11019
            soblidotin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                peptide 9416
                                                  oligopeptide 1245
                                                    tetrapeptide 25
                                                      soblidotin 0
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