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ONTOLOGY REPORT - ANNOTATIONS


Term:bumetanide
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Accession:CHEBI:3213 term browser browse the term
Definition:A member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.
Synonyms:related_synonym: 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;   3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid;   3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid;   Formula=C17H20N2O5S;   InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23);   InChIKey=MAEIEVLCKWDQJH-UHFFFAOYSA-N;   SMILES=CCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O;   bumetanida;   bumetanidum
 alt_id: CHEBI:239281
 xref: Beilstein:2185351 "Beilstein";   CAS:28395-03-1 "ChemIDplus";   CAS:28395-03-1 "KEGG DRUG";   DrugBank:DB00887;   Drug_Central:427 "DrugCentral";   HMDB:HMDB0015024;   KEGG:D00247;   LINCS:LSM-2848
 xref_mesh: MESH:D002034
 xref: PMID:18374572 "ChEMBL";   PMID:19454284 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:3989818 "ChEMBL";   Patent:DE1964503;   Patent:DE1964504;   Patent:US3806534;   Reaxys:2185351 "Reaxys";   Wikipedia:Bumetanide


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bumetanide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:6480464
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Slc12a2 solute carrier family 12 member 2 JBrowse link 18 52,917,124 52,985,281 RGD:6480464
G Slc12a7 solute carrier family 12 member 7 JBrowse link 1 32,086,755 32,167,950 RGD:6480464
G Slc17a3 solute carrier family 17 member 3 JBrowse link 17 43,518,760 43,545,160 RGD:6480464
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,354,517 RGD:6480464
G Slc22a7 solute carrier family 22 member 7 JBrowse link 9 16,925,321 16,931,119 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            diuretic 1091
              bumetanide 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        aromatic carboxylic acid 10709
                                          benzoic acids 10674
                                            bumetanide 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.