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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bumetanide
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Accession:CHEBI:3213 term browser browse the term
Definition:A member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.
Synonyms:related_synonym: 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;   3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid;   3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid;   Formula=C17H20N2O5S;   InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23);   InChIKey=MAEIEVLCKWDQJH-UHFFFAOYSA-N;   SMILES=CCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O;   bumetanida;   bumetanidum
 alt_id: CHEBI:239281
 xref: Beilstein:2185351;   CAS:28395-03-1;   DrugBank:DB00887;   Drug_Central:427;   HMDB:HMDB0015024;   KEGG:D00247;   LINCS:LSM-2848
 xref_mesh: MESH:D002034
 xref: PMID:18374572;   PMID:19454284;   PMID:28166217;   PMID:3989818;   Patent:DE1964503;   Patent:DE1964504;   Patent:US3806534;   Reaxys:2185351;   Wikipedia:Bumetanide


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bumetanide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Bumetanide CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Bumetanide results in decreased activity of CFTR protein CTD PMID:15131065, PMID:15802612 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO Bumetanide inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] CTD PMID:11804840 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Bumetanide results in increased expression of PTGS1 mRNA CTD PMID:14504926 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
ISO [Bumetanide co-treated with trandolapril] results in increased expression of REN protein; Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]; Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]
Bumetanide results in increased expression of REN mRNA
Bumetanide results in increased expression of REN protein
CTD PMID:6756707, PMID:7040495, PMID:14504926, PMID:16635047 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases response to substance
multiple interactions
decreases activity
ISO
EXP
SLC12A2 results in increased susceptibility to Bumetanide
Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Bumetanide results in decreased activity of SLC12A2 protein
[calyculin A results in increased phosphorylation of SLC12A2 protein] inhibits the reaction [Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]]
Bumetanide results in decreased activity of SLC12A2 protein; Bumetanide results in decreased activity of SLC12A2 protein mutant form
CTD PMID:12556450, PMID:14630635, PMID:16709721, PMID:17259435, PMID:22872759, PMID:25817889, PMID:29959396 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO Bumetanide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:32,086,755...32,167,950
Ensembl chr 1:32,086,755...32,141,036
JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of Bumetanide CTD PMID:21282933 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP Bumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Bumetanide results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases transport
ISO Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
SLC22A7 protein results in increased transport of Bumetanide
CTD PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP
ISO
Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
CTD PMID:10224140, PMID:11306713 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            diuretic 1121
              bumetanide 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            bumetanide 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.