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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bumetanide
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Accession:CHEBI:3213 term browser browse the term
Definition:A member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.
Synonyms:related_synonym: 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;   3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid;   3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid;   Formula=C17H20N2O5S;   InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23);   InChIKey=MAEIEVLCKWDQJH-UHFFFAOYSA-N;   SMILES=CCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O;   bumetanida;   bumetanidum
 alt_id: CHEBI:239281
 xref: Beilstein:2185351;   CAS:28395-03-1;   DrugBank:DB00887;   Drug_Central:427;   HMDB:HMDB0015024;   KEGG:D00247;   LINCS:LSM-2848
 xref_mesh: MESH:D002034
 xref: PMID:18374572;   PMID:19454284;   PMID:28166217;   PMID:3989818;   Patent:DE1964503;   Patent:DE1964504;   Patent:US3806534;   Reaxys:2185351;   Wikipedia:Bumetanide



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bumetanide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Bumetanide CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Bumetanide results in decreased activity of CFTR protein CTD PMID:15131065 PMID:15802612 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO Bumetanide inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] CTD PMID:11804840 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Bumetanide results in increased expression of PTGS1 mRNA CTD PMID:14504926 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
ISO [Bumetanide co-treated with trandolapril] results in increased expression of REN protein; Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]; Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]
Bumetanide results in increased expression of REN protein
Bumetanide results in increased expression of REN mRNA
CTD PMID:6756707 PMID:7040495 PMID:14504926 PMID:16635047 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Bumetanide affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Slc12a2 solute carrier family 12 member 2 increases response to substance
decreases activity
multiple interactions
ISO
EXP
SLC12A2 results in increased susceptibility to Bumetanide
Bumetanide results in decreased activity of SLC12A2 protein; Bumetanide results in decreased activity of SLC12A2 protein mutant form
Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]]
[calyculin A results in increased phosphorylation of SLC12A2 protein] inhibits the reaction [Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:12556450 PMID:14630635 PMID:16709721 PMID:17259435 PMID:22872759 More... NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO Bumetanide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:29,472,692...29,554,246
Ensembl chr 1:29,472,692...29,554,302
JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of Bumetanide CTD PMID:21282933 NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP Bumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Bumetanide results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP Bumetanide inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate] CTD PMID:16079298 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
increases transport
ISO Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
SLC22A7 protein results in increased transport of Bumetanide
CTD PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP
ISO
Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
CTD PMID:10224140 PMID:11306713 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      application 19546
        pharmaceutical 19425
          drug 19425
            diuretic 4079
              bumetanide 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        aromatic carboxylic acid 11801
                                          benzoic acids 11775
                                            bumetanide 13
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