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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:zinc pyrithione
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Accession:CHEBI:32076 term browser browse the term
Definition:A zinc coordination entity that has formula C10H8N2O2S2Zn.
Synonyms:exact_synonym: bis[pyridine-2-thiolato-kappaS 1(oxide-kappaO)]zinc
 related_synonym: (T-4)-bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc;   Formula=C10H8N2O2S2Zn;   InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2;   InChIKey=OTPSWLRZXRHDNX-UHFFFAOYSA-L;   Pyrithion-Zink;   SMILES=S1C2=CC=CC=N2=[O][Zn]11SC2=CC=CC=N2=[O]1;   bis(1-hydroxy-2(1H)-pyridinethionato)zinc;   bis(2-pyridinethiol-1-oxide)zinc;   bis(2-pyridylthio)zinc 1,1'-dioxide;   zinc pyridinethione
 xref: CAS:13463-41-7;   Gmelin:470197;   KEGG:C13427;   KEGG:D01938
 xref_mesh: MESH:C010423
 xref: Wikipedia:Pyrithione_Zinc

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zinc pyrithione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 increases expression ISO pyrithione zinc results in increased expression of ANXA5 mRNA CTD PMID:21424779 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO pyrithione zinc results in increased expression of BAX mRNA; pyrithione zinc results in increased expression of BAX protein CTD PMID:20151177 PMID:21424779 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO pyrithione zinc results in increased expression of BBC3 protein CTD PMID:20151177 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO pyrithione zinc results in decreased expression of BCL2L1 mRNA CTD PMID:21424779 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO pyrithione zinc results in increased cleavage of BID protein CTD PMID:20151177 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Casp1 caspase 1 increases expression ISO pyrithione zinc results in increased expression of CASP1 mRNA CTD PMID:21424779 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases activity ISO pyrithione zinc results in increased activity of CASP3 protein CTD PMID:20151177 PMID:21557991 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity ISO pyrithione zinc results in increased activity of CASP7 protein CTD PMID:20151177 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases activity
increases expression		 ISO pyrithione zinc results in increased activity of CASP8 protein
pyrithione zinc results in increased expression of CASP8 mRNA		 CTD PMID:20151177 PMID:21424779 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity ISO pyrithione zinc results in increased activity of CASP9 protein CTD PMID:20151177 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccng1 cyclin G1 decreases expression ISO pyrithione zinc results in decreased expression of CCNG1 mRNA CTD PMID:21424779 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pyrithione zinc results in increased expression of CDKN1A mRNA; pyrithione zinc results in increased expression of CDKN1A protein CTD PMID:21424779 PMID:21557991 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression ISO pyrithione zinc affects the expression of CDKN2A protein CTD PMID:21557991 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO pyrithione zinc results in increased expression of CHEK2 mRNA CTD PMID:21424779 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO pyrithione zinc results in increased expression of CRYAB mRNA; pyrithione zinc results in increased expression of CRYAB protein CTD PMID:19809895 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Ctsd cathepsin D increases expression ISO pyrithione zinc results in increased expression of CTSD protein CTD PMID:20151177 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO pyrithione zinc affects the localization of CYCS protein CTD PMID:21557991 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO pyrithione zinc results in increased expression of CYP1A1 mRNA CTD PMID:21424779 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO pyrithione zinc results in increased expression of CYP7A1 mRNA CTD PMID:21424779 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression ISO pyrithione zinc results in increased expression of DDB1 mRNA CTD PMID:21424779 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO pyrithione zinc results in increased expression of DDIT3 mRNA CTD PMID:21424779 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO pyrithione zinc results in increased expression of DNAJA1 mRNA; pyrithione zinc results in increased expression of DNAJA1 protein CTD PMID:19809895 PMID:21424779 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO pyrithione zinc results in increased expression of DNAJB4 mRNA CTD PMID:21424779 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242 		JBrowse link
G Egr1 early growth response 1 increases expression ISO pyrithione zinc results in increased expression of EGR1 mRNA CTD PMID:19809895 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO pyrithione zinc results in increased expression of EPHX2 mRNA CTD PMID:21424779 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression ISO pyrithione zinc results in increased expression of FMO1 mRNA CTD PMID:21424779 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases expression
increases expression		 ISO pyrithione zinc results in decreased expression of FMO5 mRNA
pyrithione zinc results in increased expression of FMO5 mRNA		 CTD PMID:21424779 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO pyrithione zinc results in increased expression of GADD45A mRNA CTD PMID:21424779 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO pyrithione zinc results in increased expression of GDF15 mRNA CTD PMID:21424779 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO pyrithione zinc results in increased expression of GPX1 mRNA CTD PMID:21424779 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO pyrithione zinc results in increased expression of GSR mRNA CTD PMID:21424779 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gstm3 glutathione S-transferase mu 3 increases expression ISO pyrithione zinc results in increased expression of GSTM3 mRNA CTD PMID:21424779 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO pyrithione zinc results in increased expression of GSTM3 mRNA CTD PMID:21424779 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO pyrithione zinc results in increased expression of HMOX1 mRNA; pyrithione zinc results in increased expression of HMOX1 protein
MTF1 gene mutant form promotes the reaction [pyrithione zinc results in increased expression of HMOX1 mRNA]		 CTD PMID:19809895 PMID:21424779 PMID:23085594 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases expression ISO pyrithione zinc results in increased expression of HSF1 mRNA CTD PMID:21424779 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO pyrithione zinc results in increased expression of HSP90AA1 mRNA CTD PMID:21424779 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO pyrithione zinc results in increased expression of HSP90AB1 mRNA CTD PMID:21424779 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO pyrithione zinc results in increased expression of HSPA1A mRNA; pyrithione zinc results in increased expression of HSPA1A protein CTD PMID:19809895 PMID:21424779 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO pyrithione zinc results in increased expression of HSPA1L mRNA; pyrithione zinc results in increased expression of HSPA1L protein CTD PMID:19809895 PMID:21424779 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO pyrithione zinc results in increased expression of HSPA4 mRNA CTD PMID:21424779 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO pyrithione zinc results in increased expression of HSPA5 mRNA CTD PMID:21424779 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO pyrithione zinc results in increased expression of HSPA8 mRNA CTD PMID:21424779 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO pyrithione zinc results in increased expression of HSPD1 mRNA CTD PMID:21424779 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression ISO pyrithione zinc results in increased expression of HSPE1 mRNA CTD PMID:21424779 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO pyrithione zinc results in increased expression of HSPH1 mRNA CTD PMID:21424779 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 decreases expression ISO pyrithione zinc results in decreased expression of IGFBP6 mRNA CTD PMID:21424779 NCBI chr 7:143,749,385...143,754,018
Ensembl chr 7:143,749,221...143,754,054 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pyrithione zinc results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO pyrithione zinc results in increased expression of HSPA6 mRNA; pyrithione zinc results in increased expression of HSPA6 protein CTD PMID:19809895 PMID:21424779 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Lta lymphotoxin alpha increases expression ISO pyrithione zinc results in increased expression of LTA mRNA CTD PMID:21424779 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO pyrithione zinc results in increased expression of MDM2 mRNA CTD PMID:21424779 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mt1 metallothionein 1 increases expression ISO pyrithione zinc results in increased expression of MT1 mRNA CTD PMID:23085594 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A increases expression
multiple interactions		 ISO pyrithione zinc results in increased expression of MT2A mRNA; pyrithione zinc results in increased expression of MT2A protein
[zinc chloride co-treated with pyrithione zinc] results in increased expression of MT2A mRNA		 CTD PMID:20151177 PMID:20801194 PMID:21424779 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO MTF1 gene mutant form promotes the reaction [pyrithione zinc results in increased expression of HMOX1 mRNA] CTD PMID:23085594 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO pyrithione zinc results in decreased expression of MTOR protein CTD PMID:21557991 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions		 ISO pyrithione zinc results in increased expression of NFE2L2 protein
SQSTM1 protein affects the reaction [pyrithione zinc results in increased expression of NFE2L2 protein]		 CTD PMID:30261176 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO pyrithione zinc results in increased expression of NFKB1 mRNA CTD PMID:21424779 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO pyrithione zinc results in decreased expression of NFKBIA mRNA CTD PMID:21424779 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
affects response to substance		 ISO Pentetic Acid inhibits the reaction [pyrithione zinc results in increased activity of PARP1 protein]
PARP1 protein affects the susceptibility to pyrithione zinc
PARP1 protein affects the reaction [pyrithione zinc results in decreased abundance of Adenosine Triphosphate]		 CTD PMID:19809895 PMID:21424779 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression ISO pyrithione zinc results in decreased expression of POR mRNA CTD PMID:21424779 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO pyrithione zinc results in increased expression of PRDX1 mRNA CTD PMID:21424779 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO pyrithione zinc results in decreased expression of PTGS1 mRNA CTD PMID:21424779 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression ISO pyrithione zinc results in increased expression of RAD23A mRNA CTD PMID:21424779 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391 		JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO pyrithione zinc results in increased expression of RAD50 mRNA CTD PMID:21424779 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142 		JBrowse link
G Rps6 ribosomal protein S6 affects phosphorylation ISO pyrithione zinc affects the phosphorylation of RPS6 protein CTD PMID:21557991 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO pyrithione zinc results in decreased expression of SERPINE1 mRNA CTD PMID:21424779 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO pyrithione zinc results in increased expression of SOD1 mRNA CTD PMID:21424779 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO pyrithione zinc results in increased expression of SOD2 mRNA CTD PMID:21424779 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO SQSTM1 protein affects the reaction [pyrithione zinc results in increased expression of NFE2L2 protein] CTD PMID:30261176 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO pyrithione zinc results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO pyrithione zinc results in increased expression of TNF mRNA CTD PMID:21424779 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO Pentetic Acid inhibits the reaction [pyrithione zinc results in increased expression of TP53 protein]; Pentetic Acid inhibits the reaction [pyrithione zinc results in increased phosphorylation of TP53 protein]; pyrithione zinc results in increased expression of and results in increased phosphorylation of TP53 protein; pyrithione zinc results in increased phosphorylation of and results in increased activity of TP53 protein
pyrithione zinc results in increased expression of TP53 mRNA; pyrithione zinc results in increased expression of TP53 protein		 CTD PMID:20151177 PMID:21424779 PMID:21557991 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Ung uracil-DNA glycosylase increases expression ISO pyrithione zinc results in increased expression of UNG mRNA CTD PMID:21424779 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      molecular entity 19839
        polyatomic entity 19754
          heteroatomic molecular entity 19681
            coordination entity 13737
              zinc group coordination entity 7807
                zinc coordination entity 246
                  zinc pyrithione 72
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  metal atom 17286
                    transition element atom 16740
                      d-block element atom 16730
                        zinc group element atom 10464
                          zinc atom 2698
                            zinc molecular entity 2698
                              zinc coordination entity 246
                                zinc pyrithione 72
paths to the root