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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:budesonide
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Accession:CHEBI:3207 term browser browse the term
Definition:A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.
Synonyms:exact_synonym: 11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
 related_synonym: (11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione;   Formula=C25H34O6;   InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1;   InChIKey=VOVIALXJUBGFJZ-KWVAZRHASA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])C[C@H]2OC(CCC)O[C@@]12C(=O)CO
 xref: CAS:51333-22-3;   DrugBank:DB01222;   Drug_Central:419;   KEGG:D00246
 xref_mesh: MESH:D019819
 xref: PMID:21616561;   Patent:DE2323215;   Patent:US3929768;   Wikipedia:Budesonide


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budesonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Budesonide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Budesonide results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Budesonide results in increased expression of ABCB1 protein CTD PMID:22464980 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Budesonide results in increased expression of ADRB2 protein CTD PMID:20061444 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Ar androgen receptor multiple interactions ISO Budesonide binds to and results in decreased activity of AR protein; Budesonide inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785, PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Budesonide results in decreased expression of BCL2 protein CTD PMID:15475437 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO Budesonide results in decreased expression of BGLAP protein CTD PMID:9232087 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Budesonide results in decreased expression of BIRC5 mRNA CTD PMID:17163412 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 decreases expression ISO Budesonide results in decreased expression of CASP3 mRNA CTD PMID:17163412 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO Budesonide results in increased activity of CASP9 protein CTD PMID:11734450 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Budesonide inhibits the reaction [IL13 protein results in increased expression of CCL11 protein] CTD PMID:17988555 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO Budesonide results in decreased expression of CCL17 protein CTD PMID:15679716 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO
EXP
Budesonide results in decreased expression of CCL2 protein
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 mRNA]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein]
CTD PMID:15734790, PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Budesonide results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Budesonide results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Budesonide inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Budesonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:10903220, PMID:14643170 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Budesonide results in decreased expression of CCNB2 mRNA CTD PMID:17163412 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Budesonide results in decreased expression of CCNE1 mRNA CTD PMID:17163412 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Budesonide inhibits the reaction [vinyl carbamate results in decreased expression of CDKN1A protein]
Budesonide results in increased expression of CDKN1A mRNA
CTD PMID:12117777 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Budesonide inhibits the reaction [vinyl carbamate results in decreased expression of CDKN1B protein] CTD PMID:12117777 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases activity
decreases secretion
ISO Budesonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Budesonide results in increased activity of CSF2 protein
Budesonide results in decreased secretion of CSF2 protein
CTD PMID:7621058, PMID:10460758, PMID:10868704, PMID:11730731 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL1 mRNA]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL1 protein] CTD PMID:15734790 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 protein] CTD PMID:15734790 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL3 mRNA]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL3 protein] CTD PMID:15734790 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP Budesonide results in decreased expression of CYP3A2 mRNA CTD PMID:20888898 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions
EXP
ISO
Budesonide results in increased expression of CYP3A9 mRNA
Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Mifepristone inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]
CTD PMID:12538830, PMID:19562681, PMID:20888898, PMID:24555085 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Budesonide inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:75,160,690...75,171,774
Ensembl chr10:75,160,690...75,171,774
JBrowse link
G Gcg glucagon decreases expression
multiple interactions
EXP Budesonide results in decreased expression of GCG mRNA
[Fatty Acids co-treated with Budesonide] results in increased expression of GCG mRNA
CTD PMID:12524409, PMID:14705828 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Ifng interferon gamma decreases secretion
multiple interactions
ISO Budesonide results in decreased secretion of IFNG protein
[zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein]
CTD PMID:7621058, PMID:16160912 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions ISO Budesonide inhibits the reaction [vinyl carbamate results in decreased methylation of IGF2 protein] CTD PMID:15824018 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Il13 interleukin 13 multiple interactions
increases activity
ISO Budesonide inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]; Budesonide inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Budesonide inhibits the reaction [IL13 protein results in increased expression of IL6 protein]
Budesonide results in increased activity of IL13 protein
CTD PMID:17988555 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta decreases secretion
multiple interactions
ISO
EXP
Budesonide results in decreased secretion of IL1B protein
Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4-16 protein]; Budesonide inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Budesonide inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Budesonide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Hydrogen Peroxide inhibits the reaction [Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4-16 protein]]; Theophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Budesonide inhibits the reaction [IL1B protein results in increased acetylation of H4-16 protein]]]
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate]; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Salmeterol Xinafoate]; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 mRNA]
CTD PMID:7621058, PMID:9371735, PMID:10460758, PMID:15337628, PMID:15734790, PMID:18951874, PMID:20061444 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 decreases expression ISO Budesonide results in decreased expression of IL4 protein CTD PMID:7988651, PMID:12406821, PMID:15086961 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor decreases expression ISO Budesonide results in decreased expression of IL4R protein CTD PMID:15679716 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il5 interleukin 5 decreases expression ISO Budesonide results in decreased expression of IL5 protein CTD PMID:7988651, PMID:12406821, PMID:15086961 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
Budesonide inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Budesonide inhibits the reaction [IL13 protein results in increased expression of IL6 protein]
CTD PMID:15734790, PMID:17988555 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Budesonide results in decreased expression of JUN mRNA CTD PMID:12524409 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Ltf lactotransferrin multiple interactions
decreases secretion
ISO Budesonide inhibits the reaction [methylcholine results in increased secretion of LTF protein]
Budesonide results in decreased secretion of LTF protein
CTD PMID:11112886 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Budesonide inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MMP9 mRNA]; Budesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]]; Formoterol Fumarate promotes the reaction [Budesonide inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]] CTD PMID:15734790, PMID:25313925 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MPO protein] CTD PMID:15734790 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt2A metallothionein 2A increases expression
multiple interactions
ISO Budesonide results in increased expression of MT2A mRNA
Terbutaline affects the reaction [Budesonide results in increased expression of MT2A mRNA]
CTD PMID:9973176 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Budesonide inhibits the reaction [Benzo(a)pyrene results in increased expression of MYC mRNA] CTD PMID:15969944 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
Budesonide results in decreased expression of NOS2 mRNA
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]
CTD PMID:15734790, PMID:17163412 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions
increases activity
EXP
ISO
Budesonide results in increased expression of NR1I2 mRNA
[Budesonide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:19562681, PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
increases activity
decreases expression
ISO
EXP
2,2',3,5',6-pentachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,3',4,4',5-pentachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; 2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein]; Budesonide affects the reaction [Terbutaline results in increased expression of NR3C1 mRNA]
[Budesonide binds to NR3C1 protein] which results in increased expression of SLC51A mRNA; [Budesonide binds to NR3C1 protein] which results in increased expression of SLC51B mRNA
Budesonide results in decreased expression of NR3C1 mRNA
CTD PMID:8977508, PMID:9973176, PMID:10335001, PMID:15362971, PMID:16507850, PMID:19562681, PMID:21782008 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Budesonide results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Budesonide results in decreased expression of PCNA protein CTD PMID:12117777 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Budesonide binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases activity ISO Budesonide results in decreased activity of PLA2G4A protein CTD PMID:15337628 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Budesonide co-treated with Glucose] binds to PPARA protein; Budesonide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions EXP Budesonide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGES2 protein] CTD PMID:15734790 NCBI chr 3:11,424,195...11,431,379
Ensembl chr 3:11,424,099...11,431,402
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP Budesonide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS1 mRNA] CTD PMID:15734790 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 mRNA]
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]
CTD PMID:15734790, PMID:20061444 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of RELA protein] CTD PMID:15734790 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnase3 ribonuclease A family member 3 decreases expression ISO Budesonide results in decreased expression of RNASE3 protein CTD PMID:15612964 NCBI chr15:28,216,744...28,217,614
Ensembl chr15:28,216,744...28,217,614
JBrowse link
G Sele selectin E multiple interactions EXP
ISO
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE mRNA]
Budesonide inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]
CTD PMID:9371735, PMID:15734790 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELL mRNA] CTD PMID:15734790 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Selp selectin P multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELP mRNA] CTD PMID:15734790 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Budesonide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Budesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Budesonide results in decreased transport of Formoterol Fumarate] CTD PMID:17920670, PMID:21914487 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc51a solute carrier family 51 subunit alpha increases expression
multiple interactions
ISO
EXP
Budesonide results in increased expression of SLC51A mRNA
[Budesonide binds to NR3C1 protein] which results in increased expression of SLC51A mRNA
CTD PMID:19562681 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression
multiple interactions
ISO
EXP
Budesonide results in increased expression of SLC51B mRNA
[Budesonide binds to NR3C1 protein] which results in increased expression of SLC51B mRNA
CTD PMID:19562681 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:21430235 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine]; Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:21430235 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Budesonide results in increased expression of SPP1 protein CTD PMID:21885873 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Budesonide promotes the reaction [LG 100268 promotes the reaction [TO-901317 results in increased expression of STAR mRNA]]; Budesonide promotes the reaction [LG 100268 promotes the reaction [TO-901317 results in increased expression of STAR protein]]; Budesonide promotes the reaction [TO-901317 promotes the reaction [LG 100268 results in increased expression of STAR protein]] CTD PMID:23362264 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO Budesonide results in increased expression of TGM2 protein CTD PMID:21885873 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TIMP1 mRNA] CTD PMID:15734790 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
decreases secretion
ISO
EXP
Budesonide results in decreased expression of TNF protein
Budesonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Budesonide inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Budesonide inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Budesonide inhibits the reaction [TNF protein results in increased secretion of CXCL8 mRNA]; Budesonide inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate]; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Salmeterol Xinafoate]; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Terbutaline]; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 mRNA]
Budesonide results in decreased secretion of TNF protein
CTD PMID:7621058, PMID:10100995, PMID:10903220, PMID:14643170, PMID:15589479, PMID:15734790, PMID:20061444 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Budesonide results in decreased expression of TP53 protein CTD PMID:15475437 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP
ISO
Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 mRNA]
Budesonide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:10100995, PMID:15734790 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO Budesonide results in decreased expression of VEGFA protein
Budesonide inhibits the reaction [Benzo(a)pyrene results in increased expression of VEGFA mRNA]; Budesonide inhibits the reaction [Benzo(a)pyrene results in increased expression of VEGFA protein]
CTD PMID:15969944, PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        anti-inflammatory agent 14948
          anti-inflammatory drug 13611
            budesonide 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxyketone 8629
                                          alpha-oxyketone 8629
                                            alpha-hydroxy ketone 8629
                                              primary alpha-hydroxy ketone 7514
                                                budesonide 71
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.