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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propylparaben
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Accession:CHEBI:32063 term browser browse the term
Definition:The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.
Synonyms:exact_synonym: propyl 4-hydroxybenzoate
 related_synonym: 4-Hydroxybenzoic acid propyl ester;   Formula=C10H12O3;   InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3;   InChIKey=QELSKZZBTMNZEB-UHFFFAOYSA-N;   Propyl p-hydroxybenzoate;   Propyl parahydroxybenzoate;   SMILES=CCCOC(=O)c1ccc(O)cc1;   n-Propyl 4-hydroxybenzoate;   n-Propyl p-hydroxybenzoate;   n-propyl paraben;   p-Hydroxybenzoic acid propyl ester;   p-Hydroxybenzoic propyl ester;   p-Hydroxypropyl benzoate;   p-Oxybenzoesaeurepropylester;   propyl paraben
 xref: CAS:94-13-3;   Drug_Central:2307;   HMDB:HMDB0032574;   KEGG:D01422
 xref_mesh: MESH:C006068
 xref: PMID:21492176;   PMID:21549034;   PMID:21608130;   PMID:21645663;   PMID:21705745;   PMID:21886901;   PMID:22165009;   PMID:22177019;   PMID:22220814;   PMID:22237600;   PMID:22249112;   PMID:22305363;   PMID:22337803;   Reaxys:1103245;   Wikipedia:Propylparaben


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propylparaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca6 ATP binding cassette subfamily A member 6 decreases expression ISO propylparaben results in decreased expression of ABCA6 mRNA CTD PMID:38568856 NCBI chr10:95,142,805...95,212,087
Ensembl chr10:95,142,966...95,211,530 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO propylparaben results in increased expression of ADIPOQ mRNA CTD PMID:22956630 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO propylparaben results in increased expression of AKT1 mRNA CTD PMID:38568856 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases expression ISO propylparaben results in decreased expression of ALDH3A1 mRNA CTD PMID:38568856 NCBI chr10:46,392,464...46,402,151
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Alyref Aly/REF export factor increases expression ISO propylparaben results in increased expression of ALYREF mRNA CTD PMID:38568856 NCBI chr10:106,369,750...106,373,395
Ensembl chr10:105,871,306...105,875,069 		JBrowse link
G Amh anti-Mullerian hormone increases expression EXP propylparaben results in increased expression of AMH mRNA CTD PMID:22777679 PMID:28208728 NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO propylparaben results in increased expression of APAF1 mRNA CTD PMID:24481588 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 propylparaben binds to AR protein
propylparaben inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]		 CTD PMID:14565775 PMID:20371976 PMID:33049310 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression ISO propylparaben results in increased expression of AREG mRNA CTD PMID:31939680 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO propylparaben results in increased expression of ATF4 mRNA CTD PMID:36277366 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atm ATM serine/threonine kinase affects expression ISO propylparaben affects the expression of ATM mRNA CTD PMID:24481588 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase increases expression ISO propylparaben results in increased expression of ATR mRNA CTD PMID:24481588 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Aven apoptosis and caspase activation inhibitor increases expression ISO propylparaben results in increased expression of AVEN mRNA CTD PMID:38568856 NCBI chr 3:119,753,395...119,886,009
Ensembl chr 3:99,298,930...99,431,634 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
decreases expression		 ISO propylparaben results in increased expression of BAD mRNA
propylparaben results in decreased expression of BAD mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO propylparaben results in increased expression of BAK1 mRNA CTD PMID:24481588 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO propylparaben results in increased expression of BAX mRNA CTD PMID:24481588 PMID:31306770 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO propylparaben results in increased expression of BBC3 mRNA CTD PMID:24481588 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression		 ISO propylparaben results in increased expression of BCL2 mRNA
propylparaben results in decreased expression of BCL2 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO propylparaben results in increased expression of BCL2L1 mRNA; propylparaben results in increased expression of BCL2L1 protein CTD PMID:24481588 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO propylparaben results in increased expression of BCL2L11 mRNA CTD PMID:24481588 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO propylparaben results in increased expression of BCL2L2 mRNA CTD PMID:24481588 NCBI chr15:32,326,686...32,337,834
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO propylparaben results in increased expression of BID mRNA CTD PMID:24481588 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO propylparaben results in increased expression of BIK mRNA CTD PMID:24481588 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO propylparaben results in increased expression of BIRC5 mRNA CTD PMID:24481588 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO propylparaben results in increased expression of BIRC6 mRNA CTD PMID:24481588 NCBI chr 6:26,474,843...26,668,275
Ensembl chr 6:20,722,922...20,916,434 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK increases expression ISO propylparaben results in increased expression of BOK mRNA CTD PMID:24481588 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp1 caspase 1 increases expression ISO propylparaben results in increased expression of CASP1 mRNA CTD PMID:24481588 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 increases expression ISO propylparaben results in increased expression of CASP2 mRNA CTD PMID:24481588 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases expression ISO propylparaben results in increased expression of CASP3 mRNA CTD PMID:24481588 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression ISO propylparaben results in increased expression of CASP4 mRNA CTD PMID:24481588 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 increases expression ISO propylparaben results in increased expression of CASP6 mRNA CTD PMID:24481588 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases expression ISO propylparaben results in increased expression of CASP7 mRNA CTD PMID:24481588 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases expression ISO propylparaben results in increased expression of CASP8 mRNA; propylparaben results in increased expression of CASP8 protein CTD PMID:24481588 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO propylparaben results in increased expression of CASP8AP2 mRNA CTD PMID:24481588 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275 		JBrowse link
G Casp9 caspase 9 increases expression ISO propylparaben results in increased expression of CASP9 mRNA; propylparaben results in increased expression of CASP9 protein CTD PMID:24481588 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO propylparaben results in increased expression of CCN1 mRNA CTD PMID:38568856 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO propylparaben results in increased expression of CCNA1 mRNA CTD PMID:24481588 NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression		 ISO propylparaben results in increased expression of CCNA2 mRNA
propylparaben results in decreased expression of CCNA2 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO propylparaben results in decreased expression of CCNB1 mRNA CTD PMID:24481588 PMID:33358972 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO propylparaben results in increased expression of CCND1 mRNA CTD PMID:24481588 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression		 ISO propylparaben results in increased expression of CCNE1 mRNA
propylparaben results in decreased expression of CCNE1 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO propylparaben results in increased expression of CDC25A mRNA CTD PMID:24481588 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression
decreases expression		 ISO propylparaben results in increased expression of CDK2 mRNA
propylparaben results in decreased expression of CDK2 mRNA		 CTD PMID:24481588 PMID:33358972 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO propylparaben results in increased expression of CDK4 mRNA CTD PMID:24481588 PMID:31306770 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO propylparaben results in decreased expression of CDK6 mRNA CTD PMID:24481588 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression		 ISO propylparaben results in decreased expression of CDKN1A mRNA; propylparaben results in decreased expression of CDKN1A protein
propylparaben results in increased expression of CDKN1A mRNA		 CTD PMID:24481588 PMID:31306770 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO propylparaben results in increased expression of CEBPA mRNA CTD PMID:22956630 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Clptm1l CLPTM1-like increases expression ISO propylparaben results in increased expression of CLPTM1L mRNA CTD PMID:38568856 NCBI chr 1:31,496,094...31,512,148
Ensembl chr 1:29,667,545...29,683,530 		JBrowse link
G Csf3 colony stimulating factor 3 increases expression ISO propylparaben results in increased expression of CSF3 mRNA CTD PMID:38568856 NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO propylparaben results in increased expression of CXCL1 mRNA CTD PMID:38568856 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO propylparaben results in increased expression of CXCL1 mRNA CTD PMID:38568856 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 affects expression EXP propylparaben affects the expression of CYP11A1 mRNA CTD PMID:22777679 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects expression
increases expression		 ISO propylparaben affects the expression of CYP19A1 mRNA; propylparaben affects the expression of CYP19A1 protein
propylparaben results in increased expression of CYP19A1 mRNA; propylparaben results in increased expression of CYP19A1 protein		 CTD PMID:23744433 PMID:34365652 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP
ISO		 propylparaben results in decreased activity of CYP1A1 protein CTD PMID:27432241 PMID:34181028 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP propylparaben results in decreased activity of CYP1A2 protein CTD PMID:27432241 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP propylparaben results in decreased activity of CYP2B1 protein CTD PMID:27432241 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP propylparaben results in decreased activity of CYP2C11 protein CTD PMID:27432241 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP propylparaben results in decreased activity of CYP2E1 protein CTD PMID:27432241 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP propylparaben results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases expression ISO propylparaben results in decreased expression of CYP4B1 mRNA CTD PMID:38568856 NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO propylparaben results in increased expression of DDIT3 mRNA CTD PMID:36277366 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddx54 DEAD-box helicase 54 increases expression ISO propylparaben results in increased expression of DDX54 mRNA CTD PMID:38568856 NCBI chr12:35,934,713...35,949,956
Ensembl chr12:35,934,716...35,972,523 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO propylparaben results in increased expression of DIABLO mRNA CTD PMID:24481588 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 decreases expression ISO propylparaben results in decreased expression of DLG3 mRNA CTD PMID:38568856 NCBI chr  X:69,899,694...69,951,928
Ensembl chr  X:65,860,172...65,910,322 		JBrowse link
G Dus1l dihydrouridine synthase 1-like increases expression ISO propylparaben results in increased expression of DUS1L mRNA CTD PMID:38568856 NCBI chr10:106,055,519...106,062,656
Ensembl chr10:106,055,519...106,062,781 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO propylparaben results in increased expression of E2F1 mRNA CTD PMID:24481588 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f3 E2F transcription factor 3 affects expression ISO propylparaben affects the expression of E2F3 mRNA CTD PMID:24481588 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G Egr1 early growth response 1 increases expression ISO propylparaben results in increased expression of EGR1 mRNA CTD PMID:38568856 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases expression
increases activity
multiple interactions		 EXP
ISO		 propylparaben binds to ESR1 protein
propylparaben results in increased expression of ESR1 mRNA; propylparaben results in increased expression of ESR1 protein
propylparaben results in increased activity of ESR1 protein
Fulvestrant inhibits the reaction [propylparaben results in increased activity of ESR1 protein]; propylparaben binds to and results in increased activity of ESR1 protein		 CTD PMID:11193391 PMID:19063592 PMID:20132880 PMID:22562034 PMID:23567241 More... NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
increases expression
multiple interactions		 EXP
ISO		 propylparaben binds to ESR2 protein
propylparaben results in increased expression of ESR2 mRNA; propylparaben results in increased expression of ESR2 protein
propylparaben binds to and results in increased activity of ESR2 protein		 CTD PMID:11193391 PMID:20132880 PMID:23567241 PMID:25128701 PMID:33049310 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:101,699,043...102,316,877
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Etnk2 ethanolamine kinase 2 decreases expression ISO propylparaben results in decreased expression of ETNK2 mRNA CTD PMID:38568856 NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037 		JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO propylparaben results in decreased activity of FAAH protein CTD PMID:27659731 NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO propylparaben results in increased expression of FABP4 mRNA CTD PMID:22956630 PMID:24155963 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO propylparaben results in increased expression of FADD mRNA CTD PMID:24481588 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fasn fatty acid synthase increases expression ISO propylparaben results in increased expression of FASN mRNA CTD PMID:22956630 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbxo45 F-box protein 45 increases expression ISO propylparaben results in increased expression of FBXO45 mRNA CTD PMID:38568856 NCBI chr11:68,551,430...68,567,053
Ensembl chr11:68,551,122...68,566,800 		JBrowse link
G Flg filaggrin multiple interactions ISO FLG gene mutant form affects the abundance of and affects the susceptibility to propylparaben CTD PMID:28525834 NCBI chr 2:181,583,801...181,596,464 JBrowse link
G Foxl2 forkhead box L2 increases expression EXP propylparaben results in increased expression of FOXL2 mRNA CTD PMID:22777679 NCBI chr 8:108,392,466...108,395,553
Ensembl chr 8:99,513,303...99,514,427 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases secretion		 ISO
EXP		 [Parabens results in increased abundance of propylparaben] which results in decreased secretion of FSHB protein
propylparaben results in increased secretion of FSHB protein		 CTD PMID:28208728 PMID:32122340 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gnas GNAS complex locus increases expression ISO propylparaben results in increased expression of GNAS mRNA CTD PMID:38568856 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression ISO propylparaben results in increased expression of GPER1 mRNA; propylparaben results in increased expression of GPER1 protein CTD PMID:26253279 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression ISO propylparaben results in increased expression of GSK3A mRNA CTD PMID:38568856 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO propylparaben results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [propylparaben results in increased expression of H2AX protein modified form]		 CTD PMID:31939680 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 increases expression ISO propylparaben results in increased expression of HNRNPA0 mRNA CTD PMID:38568856 NCBI chr17:6,513,129...6,515,786
Ensembl chr17:6,507,275...6,509,375 		JBrowse link
G Hoxa10 homeobox A10 decreases expression ISO propylparaben results in decreased expression of HOXA10 protein CTD PMID:34101200 NCBI chr 4:82,662,204...82,671,490
Ensembl chr 4:81,331,591...81,340,919 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO propylparaben results in increased expression of HSPA5 mRNA CTD PMID:36277366 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression ISO propylparaben results in increased expression of IRAK1 mRNA CTD PMID:38568856 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Kctd2 potassium channel tetramerization domain containing 2 increases expression ISO propylparaben results in increased expression of KCTD2 mRNA CTD PMID:38568856 NCBI chr10:101,162,091...101,173,721
Ensembl chr10:100,662,884...100,674,336 		JBrowse link
G Krt17 keratin 17 decreases expression ISO propylparaben results in decreased expression of KRT17 mRNA CTD PMID:38568856 NCBI chr10:85,679,068...85,683,792
Ensembl chr10:85,178,675...85,183,392 		JBrowse link
G Lep leptin decreases expression
increases expression		 ISO propylparaben results in decreased expression of LEP mRNA
propylparaben results in increased expression of LEP mRNA		 CTD PMID:22956630 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO propylparaben results in increased expression of LIF mRNA CTD PMID:38568856 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation ISO propylparaben affects the phosphorylation of MAPK1 protein CTD PMID:26253279 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation ISO propylparaben affects the phosphorylation of MAPK3 protein CTD PMID:26253279 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mark4 microtubule affinity regulating kinase 4 increases expression ISO propylparaben results in increased expression of MARK4 mRNA CTD PMID:38568856 NCBI chr 1:88,203,352...88,239,858
Ensembl chr 1:79,068,904...79,108,556 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO propylparaben results in increased expression of MCL1 mRNA CTD PMID:24481588 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO propylparaben results in decreased expression of MMP9 protein CTD PMID:34101200 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mprip myosin phosphatase Rho interacting protein increases expression ISO propylparaben results in increased expression of MPRIP mRNA CTD PMID:38568856 NCBI chr10:44,953,472...45,073,388
Ensembl chr10:44,453,929...44,569,118 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 ISO NRG1 protein promotes the reaction [propylparaben results in increased expression of MYC mRNA]; propylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA] CTD PMID:26502914 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nacc1 nucleus accumbens associated 1 increases expression ISO propylparaben results in increased expression of NACC1 mRNA CTD PMID:38568856 NCBI chr19:40,373,436...40,391,351
Ensembl chr19:23,468,419...23,486,528 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist increases expression ISO propylparaben results in increased expression of NBL1 mRNA CTD PMID:38568856 NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncs1 neuronal calcium sensor 1 increases expression ISO propylparaben results in increased expression of NCS1 mRNA CTD PMID:38568856 NCBI chr 3:34,920,949...34,966,554
Ensembl chr 3:14,523,220...14,568,829 		JBrowse link
G Niban2 niban apoptosis regulator 2 increases expression ISO propylparaben results in increased expression of NIBAN2 mRNA CTD PMID:38568856 NCBI chr 3:36,572,356...36,621,968
Ensembl chr 3:16,174,659...16,224,293 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions		 EXP
ISO		 propylparaben results in increased expression of NR1I2 mRNA
propylparaben binds to and results in increased activity of NR1I2 protein		 CTD PMID:31472229 PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO propylparaben results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity		 ISO [butylparaben co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with propylparaben] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein
propylparaben results in increased activity of NR3C1 protein		 CTD PMID:25448277 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO NRG1 protein promotes the reaction [propylparaben results in increased expression of MYC mRNA]; propylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA] CTD PMID:26502914 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Osbp oxysterol binding protein increases expression ISO propylparaben results in increased expression of OSBP mRNA CTD PMID:38568856 NCBI chr 1:218,313,455...218,343,263
Ensembl chr 1:208,887,895...208,918,506 		JBrowse link
G Pgr progesterone receptor increases expression
decreases expression		 ISO propylparaben results in increased expression of PGR mRNA
propylparaben results in decreased expression of PGR mRNA		 CTD PMID:25128701 PMID:31939680 PMID:34101200 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pitpna phosphatidylinositol transfer protein, alpha increases expression ISO propylparaben results in increased expression of PITPNA mRNA CTD PMID:38568856 NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 increases expression ISO propylparaben results in increased expression of PMEPA1 mRNA CTD PMID:38568856 NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:162,012,751...162,060,454 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP propylparaben affects the expression of PPARA mRNA CTD PMID:31472229 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO propylparaben results in increased expression of PPARG mRNA
PPARG protein promotes the reaction [propylparaben binds to and results in increased activity of PPARG protein]; propylparaben binds to and results in increased activity of PPARG protein		 CTD PMID:22956630 PMID:24155963 PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO propylparaben results in increased expression of RIPK1 mRNA CTD PMID:24481588 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 increases expression ISO propylparaben results in increased expression of RIPK2 mRNA CTD PMID:24481588 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 increases expression ISO propylparaben results in increased expression of RPS6KA4 mRNA CTD PMID:38568856 NCBI chr 1:213,451,026...213,461,982
Ensembl chr 1:204,021,806...204,032,761 		JBrowse link
G S100g S100 calcium binding protein G increases expression EXP propylparaben results in increased expression of S100G mRNA; propylparaben results in increased expression of S100G protein CTD PMID:19654335 PMID:22777679 NCBI chr  X:35,337,636...35,340,205
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G Sbno2 strawberry notch homolog 2 increases expression ISO propylparaben results in increased expression of SBNO2 mRNA CTD PMID:38568856 NCBI chr 7:10,256,221...10,300,175
Ensembl chr 7:9,605,627...9,649,527 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta decreases expression ISO propylparaben results in decreased expression of SCNN1B mRNA CTD PMID:38568856 NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Septin9 septin 9 increases expression ISO propylparaben results in increased expression of SEPTIN9 mRNA CTD PMID:38568856 NCBI chr10:102,409,798...102,579,056
Ensembl chr10:102,409,711...102,579,055 		JBrowse link
G Sf3a2 splicing factor 3A subunit 2 increases expression ISO propylparaben results in increased expression of SF3A2 mRNA CTD PMID:38568856 NCBI chr 7:8,909,507...8,916,104
Ensembl chr 7:8,909,507...8,915,530 		JBrowse link
G Shbg sex hormone binding globulin affects binding
decreases secretion		 ISO propylparaben binds to SHBG protein
propylparaben results in decreased secretion of SHBG protein		 CTD PMID:25349334 PMID:30940137 NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Slc17a9 solute carrier family 17 member 9 increases methylation ISO propylparaben results in increased methylation of SLC17A9 gene CTD PMID:34523531 NCBI chr 3:188,211,106...188,233,553
Ensembl chr 3:167,839,385...167,855,985 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO
EXP		 propylparaben results in increased expression of STAR mRNA; propylparaben results in increased expression of STAR protein CTD PMID:22777679 PMID:31306770 PMID:34365652 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO propylparaben results in decreased expression of SYNE2 mRNA CTD PMID:38568856 NCBI chr 6:100,272,729...100,586,364
Ensembl chr 6:94,537,088...94,848,064 		JBrowse link
G Syt8 synaptotagmin 8 decreases expression ISO propylparaben results in decreased expression of SYT8 mRNA CTD PMID:38568856 NCBI chr 1:197,588,126...197,593,598
Ensembl chr 1:197,590,149...197,593,504 		JBrowse link
G Telo2 telomere maintenance 2 increases expression ISO propylparaben results in increased expression of TELO2 mRNA CTD PMID:38568856 NCBI chr10:14,624,998...14,640,235
Ensembl chr10:14,120,818...14,135,698 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [propylparaben results in increased expression of TFF1 mRNA] CTD PMID:16797915 PMID:22562034 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO propylparaben binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO propylparaben binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tigd5 tigger transposable element derived 5 increases expression ISO propylparaben results in increased expression of TIGD5 mRNA CTD PMID:38568856 NCBI chr 7:109,477,438...109,479,957
Ensembl chr 7:107,596,724...107,599,243 		JBrowse link
G Tmem132a transmembrane protein 132A increases expression ISO propylparaben results in increased expression of TMEM132A mRNA CTD PMID:38568856 NCBI chr 1:216,931,962...216,943,644
Ensembl chr 1:207,507,077...207,518,758 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO propylparaben results in increased expression of TNF mRNA CTD PMID:24481588 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO propylparaben results in increased expression of TNFRSF10A mRNA CTD PMID:24481588 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO propylparaben results in increased expression of TNFRSF1A mRNA CTD PMID:24481588 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO propylparaben results in increased expression of TNFRSF25 mRNA CTD PMID:24481588 NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO propylparaben results in increased expression of TNFSF10 mRNA CTD PMID:24481588 NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tor4a torsin family 4, member A increases expression ISO propylparaben results in increased expression of TOR4A mRNA CTD PMID:38568856 NCBI chr 3:8,004,292...8,007,979
Ensembl chr 3:8,002,023...8,008,042 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO propylparaben results in increased expression of TP53 mRNA; propylparaben results in increased expression of TP53 protein CTD PMID:24481588 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO propylparaben results in increased expression of TP53BP1 protein CTD PMID:31939680 NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO propylparaben results in increased expression of TRADD mRNA CTD PMID:24481588 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression ISO propylparaben results in decreased expression of TSC22D3 mRNA CTD PMID:38568856 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:104,217,925...104,276,861 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO propylparaben results in decreased expression of TXNIP mRNA CTD PMID:38568856 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO propylparaben results in increased expression of XBP1 mRNA; propylparaben results in increased expression of XBP1 mRNA alternative form CTD PMID:36277366 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zfp598 zinc finger protein 598 increases expression ISO propylparaben results in increased expression of ZNF598 mRNA CTD PMID:38568856 NCBI chr10:13,694,224...13,706,235
Ensembl chr10:13,694,286...13,706,233 		JBrowse link
G Zfp787 zinc finger protein 787 increases expression ISO propylparaben results in increased expression of ZNF787 mRNA CTD PMID:38568856 NCBI chr 1:76,778,733...76,804,204
Ensembl chr 1:67,758,757...67,771,132 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        antimicrobial agent 18273
          propylparaben 147
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19537
                              organochalcogen compound 19297
                                organooxygen compound 19215
                                  carbon oxoacid 18693
                                    carboxylic acid 18690
                                      aromatic carboxylic acid 13669
                                        benzoic acids 13651
                                          benzoic acid 5520
                                            hydroxybenzoic acid 4996
                                              monohydroxybenzoic acid 2822
                                                4-hydroxybenzoic acid 1461
                                                  4-hydroxybenzoate ester 1450
                                                    paraben 1450
                                                      propylparaben 147
paths to the root