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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:buclizine
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Accession:CHEBI:3205 term browser browse the term
Definition:An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.
Synonyms:exact_synonym: 1-(4-tert-butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
 related_synonym: 1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine;   Formula=C28H33ClN2;   InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3;   InChIKey=MOYGZHXDRJNJEP-UHFFFAOYSA-N;   SMILES=CC(C)(C)c1ccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)cc1;   buclizina;   buclizinum
 xref: Beilstein:349567;   CAS:82-95-1;   DrugBank:DB00354;   Drug_Central:416;   HMDB:HMDB0014498;   KEGG:C07777;   KEGG:D07547
 xref_mesh: MESH:C046894
 xref: PMID:13620483;   PMID:14428806;   PMID:22469258;   PMID:4387177;   PMID:5304814;   Patent:GB1311286;   Patent:US2709169;   Reaxys:349567;   Wikipedia:Buclizine
 cyclic_relationship: is_conjugate_base_of CHEBI:61192



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buclizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO buclizine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Term Annotations click to browse term
  CHEBI ontology 19715
    role 19690
      biological role 19688
        pharmacological role 18940
          antagonist 16617
            histamine antagonist 4865
              buclizine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19511
                        hydrogen molecular entity 19504
                          hydrides 18967
                            inorganic hydride 17790
                              pnictogen hydride 17773
                                nitrogen hydride 17658
                                  azane 17428
                                    ammonia 17427
                                      organic amino compound 17427
                                        tertiary amino compound 9090
                                          N-alkylpiperazine 3360
                                            buclizine 1
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