Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:buclizine
go back to main search page
Accession:CHEBI:3205 term browser browse the term
Definition:An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.
Synonyms:exact_synonym: 1-(4-tert-butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
 related_synonym: 1-(p-tert-Butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine;   Formula=C28H33ClN2;   InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3;   InChIKey=MOYGZHXDRJNJEP-UHFFFAOYSA-N;   SMILES=CC(C)(C)c1ccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)cc1;   buclizina;   buclizinum
 xref: Beilstein:349567;   CAS:82-95-1;   DrugBank:DB00354;   Drug_Central:416;   HMDB:HMDB0014498;   KEGG:C07777;   KEGG:D07547
 xref_mesh: MESH:C046894
 xref: PMID:13620483;   PMID:14428806;   PMID:22469258;   PMID:4387177;   PMID:5304814;   Patent:GB1311286;   Patent:US2709169;   Reaxys:349567;   Wikipedia:Buclizine
 cyclic_relationship: is_conjugate_base_of CHEBI:61192


show annotations for term's descendants           Sort by:
 
buclizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO buclizine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          antagonist 16277
            histamine antagonist 4616
              buclizine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8679
                                          N-alkylpiperazine 3104
                                            buclizine 1
paths to the root