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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Pranoprofen
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Accession:CHEBI:32040 term browser browse the term
Synonyms:related_synonym: Formula=C15H13NO3;   InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18);   InChIKey=TVQZAMVBTVNYLA-UHFFFAOYSA-N;   SMILES=CC(C1=CC2=C(C=C1)OC3=C(C2)C=CC=N3)C(=O)O;   dl-Pranoprofen;   niflan;   oftalar
 alt_id: CHEBI:94417
 xref: CAS:52549-17-4;   Drug_Central:2238;   HMDB:HMDB0041996;   KEGG:D01578;   LINCS:LSM-5110
 xref_mesh: MESH:C043940


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Pranoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO pyranoprofen results in increased expression of AIFM1 protein CTD PMID:31765691 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO pyranoprofen results in increased phosphorylation of ATM protein CTD PMID:31765691 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pyranoprofen results in increased expression of BAD protein CTD PMID:31765691 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO pyranoprofen results in increased expression of BAX protein CTD PMID:31765691 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO pyranoprofen results in decreased expression of BCL2 protein CTD PMID:31765691 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO pyranoprofen results in decreased expression of BCL2L1 protein CTD PMID:31765691 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]] CTD PMID:16473424 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Casp2 caspase 2 increases activity ISO pyranoprofen results in increased activity of CASP2 protein CTD PMID:31765691 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity ISO pyranoprofen results in increased activity of CASP3 protein CTD PMID:31765691 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO pyranoprofen results in increased activity of CASP8 protein CTD PMID:31765691 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO pyranoprofen results in increased activity of CASP9 protein CTD PMID:31765691 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO B 4162 inhibits the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium] CTD PMID:16473424 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase increases expression ISO pyranoprofen results in increased expression of MLKL protein CTD PMID:31765691 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO pyranoprofen results in increased activity of PPARG protein CTD PMID:12065695 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO pyranoprofen results in increased expression of PTGS2 mRNA CTD PMID:10594327 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO pyranoprofen results in increased expression of RIPK1 protein CTD PMID:31765691 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO pyranoprofen results in increased expression of RIPK3 protein CTD PMID:31765691 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        polyatomic entity 19697
          molecule 19520
            cyclic compound 19324
              polycyclic compound 18525
                heteropolycyclic compound 17824
                  heterotricyclic compound 14571
                    organic heterotricyclic compound 14571
                      pyridochromene 36
                        Pranoprofen 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotricyclic compound 14571
                                      pyridochromene 36
                                        Pranoprofen 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.