CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Pranoprofen
Accession: CHEBI:32040
browse the term
Synonyms: related_synonym: Formula=C15H13NO3; InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18); InChIKey=TVQZAMVBTVNYLA-UHFFFAOYSA-N; SMILES=CC(C1=CC2=C(C=C1)OC3=C(C2)C=CC=N3)C(=O)O; dl-Pranoprofen; niflan; oftalar
alt_id: CHEBI:94417
xref: CAS:52549-17-4; Drug_Central:2238; HMDB:HMDB0041996; KEGG:D01578; LINCS:LSM-5110
xref_mesh: MESH:C043940
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
pyranoprofen results in increased expression of AIFM1 protein
CTD
PMID:31765691
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Atm
ATM serine/threonine kinase
increases phosphorylation
ISO
pyranoprofen results in increased phosphorylation of ATM protein
CTD
PMID:31765691
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
pyranoprofen results in increased expression of BAD protein
CTD
PMID:31765691
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
pyranoprofen results in increased expression of BAX protein
CTD
PMID:31765691
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
pyranoprofen results in decreased expression of BCL2 protein
CTD
PMID:31765691
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
pyranoprofen results in decreased expression of BCL2L1 protein
CTD
PMID:31765691
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdkrb2
bradykinin receptor B2
multiple interactions
ISO
BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]
CTD
PMID:16473424
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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Casp2
caspase 2
increases activity
ISO
pyranoprofen results in increased activity of CASP2 protein
CTD
PMID:31765691
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
increases activity
ISO
pyranoprofen results in increased activity of CASP3 protein
CTD
PMID:31765691
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases activity
ISO
pyranoprofen results in increased activity of CASP8 protein
CTD
PMID:31765691
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity
ISO
pyranoprofen results in increased activity of CASP9 protein
CTD
PMID:31765691
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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H2ax
H2A.X variant histone
increases expression
ISO
pyranoprofen results in increased expression of H2AX protein
CTD
PMID:31765691
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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Kng1
kininogen 1
multiple interactions
ISO
B 4162 inhibits the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; BDKRB2 protein affects the reaction [pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]]; pyranoprofen inhibits the reaction [KNG1 protein affects the transport of and affects the localization of Calcium]
CTD
PMID:16473424
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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Mlkl
mixed lineage kinase domain like pseudokinase
increases expression
ISO
pyranoprofen results in increased expression of MLKL protein
CTD
PMID:31765691
NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
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Pparg
peroxisome proliferator-activated receptor gamma
increases activity
ISO
pyranoprofen results in increased activity of PPARG protein
CTD
PMID:12065695
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
pyranoprofen results in increased expression of PTGS2 mRNA
CTD
PMID:10594327
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ripk1
receptor interacting serine/threonine kinase 1
increases expression
ISO
pyranoprofen results in increased expression of RIPK1 protein
CTD
PMID:31765691
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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Ripk3
receptor-interacting serine-threonine kinase 3
increases expression
ISO
pyranoprofen results in increased expression of RIPK3 protein
CTD
PMID:31765691
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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