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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pirfenidone
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Accession:CHEBI:32016 term browser browse the term
Definition:A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Synonyms:exact_synonym: 5-methyl-1-phenylpyridin-2(1H)-one
 related_synonym: AMR-69;   Esbriet;   Formula=C12H11NO;   InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3;   InChIKey=ISWRGOKTTBVCFA-UHFFFAOYSA-N;   SMILES=Cc1ccc(=O)n(c1)-c1ccccc1;   pirfenidona;   pirfenidonum
 xref: Beilstein:1526549;   CAS:53179-13-8;   Drug_Central:4224;   KEGG:D01583;   LINCS:LSM-4190
 xref_mesh: MESH:C093844
 xref: PMID:25432946;   PMID:25459156;   PMID:25542603;   PMID:25593606;   PMID:25596380;   PMID:25604027;   PMID:25624597;   PMID:25639750;   PMID:25678074;   PMID:25691376;   PMID:25726556;   PMID:25727967;   PMID:25738437;   Reaxys:1526549;   Wikipedia:Pirfenidone


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pirfenidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases expression EXP pirfenidone results in decreased expression of ACE protein CTD PMID:28091615 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression EXP pirfenidone results in increased expression of ACE2 protein CTD PMID:28091615 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO
EXP
pirfenidone results in decreased expression of ACTA2 mRNA; pirfenidone results in decreased expression of ACTA2 protein
pirfenidone inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]
CTD PMID:24706986 PMID:28091615 PMID:29273418 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP pirfenidone results in decreased expression of AGTR1 protein CTD PMID:28091615 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO pirfenidone results in decreased expression of BIRC5 mRNA CTD PMID:30481203 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Cat catalase multiple interactions ISO
EXP
pirfenidone inhibits the reaction [Paraquat results in increased activity of CAT protein]
[Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; pirfenidone inhibits the reaction [Paraquat results in decreased activity of CAT protein]
CTD PMID:28696894 PMID:28921394 PMID:29273418 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP
ISO
pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA]
pirfenidone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]
pirfenidone results in decreased expression of COL1A1 mRNA
CTD PMID:15571005 PMID:27235791 PMID:29273418 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA] CTD PMID:29273418 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in increased phosphorylation of EGFR protein; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]; pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]] CTD PMID:28739874 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein] CTD PMID:22399296 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in decreased expression of GPX1 mRNA] CTD PMID:29273418 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression ISO pirfenidone results in decreased expression of HDAC9 mRNA CTD PMID:30481203 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein] CTD PMID:22399296 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in increased phosphorylation of EGFR protein; [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]; pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]; pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]] CTD PMID:22399296 PMID:28739874 NCBI chr 7:130,109,214...130,120,918
Ensembl chr 7:130,109,663...130,120,579
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression EXP pirfenidone results in decreased expression of MAPK14 protein CTD PMID:28091615 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]] CTD PMID:15571005 PMID:28696894 PMID:28921394 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA] CTD PMID:29273418 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA] CTD PMID:29273418 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA] CTD PMID:29273418 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP pirfenidone results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 multiple interactions ISO [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein; lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]]; pirfenidone inhibits the reaction [EGFR protein binds to PTPN3 protein]; pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to PTPN3 protein]] CTD PMID:28739874 NCBI chr 5:74,248,996...74,368,167
Ensembl chr 5:74,248,996...74,368,186
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 mRNA] CTD PMID:12445421 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD7 mRNA] CTD PMID:12445421 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]
pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]
CTD PMID:12445421 PMID:15571005 PMID:21619834 PMID:28696894 PMID:28921394 PMID:29273418 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP pirfenidone inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; pirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]]; pirfenidone promotes the reaction [Tacrolimus results in decreased expression of TIMP1 mRNA] CTD PMID:12445421 PMID:15571005 PMID:15854665 PMID:28696894 PMID:28921394 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of TNF mRNA] CTD PMID:28696894 PMID:28921394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        anti-inflammatory agent 15761
          anti-inflammatory drug 13619
            non-steroidal anti-inflammatory drug 12714
              pirfenidone 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteromonocyclic compound 16987
                                    pyridines 8429
                                      pyridone 124
                                        pirfenidone 26
paths to the root