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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxatomide
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Accession:CHEBI:31943 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug.
Synonyms:exact_synonym: 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-1,3-dihydro-2H-benzimidazol-2-one
 related_synonym: 1-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one;   Cenacert;   Cobiona;   Formula=C27H30N4O;   InChI=1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32);   InChIKey=BAINIUMDFURPJM-UHFFFAOYSA-N;   KW-4354;   R 35 443;   R 35443;   SMILES=O=C1NC2=C(C=CC=C2)N1CCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1;   Tinset;   celtect;   celtomide;   oxatomida;   oxatomidum
 xref: CAS:60607-34-3;   Chemspider:4454;   DrugBank:DB12877;   Drug_Central:2014;   HMDB:HMDB0240225;   KEGG:D01773
 xref_mesh: MESH:C015408
 xref: PMID:10513346;   PMID:12095890;   PMID:12635496;   PMID:12804426;   PMID:14685044;   PMID:18348338;   PMID:22464080;   PMID:24134630;   PMID:24474428;   PMID:26463039;   PMID:33896411;   PMID:3447306;   PMID:6130032;   PMID:6130033;   PMID:6131021;   PMID:6138301;   PMID:6475104;   PMID:6986007;   PMID:7465684;   Patent:WO9858924;   Reaxys:4724760;   Wikipedia:Oxatomide



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oxatomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO oxatomide results in decreased activity of CYP2D6 protein CTD PMID:15684493 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
decreases activity
ISO CYP3A4 protein results in increased metabolism of oxatomide
oxatomide results in decreased activity of CYP3A4 protein
CTD PMID:15684493 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Hexb hexosaminidase subunit beta affects secretion EXP oxatomide affects the secretion of HEXB protein CTD PMID:7655991 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO oxatomide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

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  CHEBI ontology 19740
    role 19713
      application 19546
        anti-inflammatory agent 16471
          oxatomide 4
Path 2
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  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    main group molecular entity 19686
                      s-block molecular entity 19541
                        hydrogen molecular entity 19534
                          hydrides 19019
                            inorganic hydride 17950
                              pnictogen hydride 17935
                                nitrogen hydride 17832
                                  azane 17616
                                    ammonia 17615
                                      organic amino compound 17615
                                        tertiary amino compound 9927
                                          N-alkylpiperazine 3362
                                            oxatomide 4
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