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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nimetazepam
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Accession:CHEBI:31912 term browser browse the term
Definition:A nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia.
Synonyms:related_synonym: 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;   1-methylnitrazepam;   Dormalon;   Erimin;   Formula=C16H13N3O3;   InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3;   InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N;   Ro 5-3453;   SMILES=CN1c2ccc(cc2C(=NCC1=O)c1ccccc1)[N+]([O-])=O;   methylnitrazepam;   nimetazepamum
 xref: CAS:2011-67-8;   Drug_Central:1936;   KEGG:D01593;   LINCS:LSM-5785
 xref_mesh: MESH:C002714
 xref: PMID:1154804;   PMID:1274372;   PMID:2241855;   PMID:23085494;   PMID:23245766;   PMID:6151222;   PMID:7452466;   Patent:DE1816046;   Patent:US3109843;   Patent:US3121114;   Patent:US3141890;   Patent:US3144439;   Patent:US3203990;   Patent:US3243427;   Reaxys:759813;   Wikipedia:Nimetazepam


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nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of nimetazepam CTD PMID:19005028 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biophysical role 14056
          membrane transport modulator 13899
            GABA modulator 5103
              nimetazepam 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  organonitrogen heterocyclic compound 18154
                                    benzodiazepine 911
                                      1,4-benzodiazepinone 125
                                        nitrazepam 8
                                          nimetazepam 4
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