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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:31912 term browser browse the term
Definition:A nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia.
Synonyms:related_synonym: 1-methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;   1-methylnitrazepam;   Dormalon;   Erimin;   Formula=C16H13N3O3;   InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3;   InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N;   Ro 5-3453;   SMILES=CN1c2ccc(cc2C(=NCC1=O)c1ccccc1)[N+]([O-])=O;   methylnitrazepam;   nimetazepamum
 xref: CAS:2011-67-8;   Drug_Central:1936;   KEGG:D01593;   LINCS:LSM-5785
 xref_mesh: MESH:C002714
 xref: PMID:1154804;   PMID:1274372;   PMID:2241855;   PMID:23085494;   PMID:23245766;   PMID:6151222;   PMID:7452466;   Patent:DE1816046;   Patent:US3109843;   Patent:US3121114;   Patent:US3141890;   Patent:US3144439;   Patent:US3203990;   Patent:US3243427;   Reaxys:759813;   Wikipedia:Nimetazepam

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nimetazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO nimetazepam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biophysical role 12642
          membrane transport modulator 12441
            GABA modulator 4655
              nimetazepam 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organonitrogen heterocyclic compound 17485
                                    benzodiazepine 542
                                      1,4-benzodiazepinone 116
                                        nitrazepam 7
                                          nimetazepam 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.