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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-methyl-D-aspartic acid
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Accession:CHEBI:31882 term browser browse the term
Definition:An aspartic acid derivative having an N-methyl substituent and D-configuration.
Synonyms:related_synonym: (R)-2-Methylamino-succinic acid;   2-Methylamino-succinic acid;   Formula=C5H9NO4;   InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1;   InChIKey=HOKKHZGPKSLGJE-GSVOUGTGSA-N;   Methyl aspartic acid;   N-Methyl aspartic acid;   N-Methyl-D-aspartate;   N-Methylaspartate;   NMDA;   SMILES=CN[C@H](CC(O)=O)C(O)=O
 alt_id: CHEBI:164776
 xref: Beilstein:1724431;   CAS:6384-92-5;   HMDB:HMDB0002393;   KEGG:C12269
 xref_mesh: MESH:D016202
 xref: MetaCyc:CPD-10705;   PDBeChem:OEM;   PMID:10514280;   PMID:10893301;   PMID:1967316;   PMID:2170646;   PMID:3351864;   PMID:8568805;   PMID:9572889;   Reaxys:1724431;   Wikipedia:N-Methyl-D-aspartic_acid



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N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of AKT1 protein] CTD PMID:26065936 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A1 protein] CTD PMID:34389372 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A2 protein] CTD PMID:34389372 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
JBrowse link
G Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP2B1 protein] CTD PMID:34389372 NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO N-Methylaspartate results in increased expression of BAX protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of BAX protein]
CTD PMID:26065936 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO kukoamine B inhibits the reaction [N-Methylaspartate results in decreased expression of BCL2 protein] CTD PMID:26065936 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1A protein] CTD PMID:34389372 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875
JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1B protein] CTD PMID:34389372 NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164
JBrowse link
G Cacnb1 calcium channel, voltage-dependent, beta 1 subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB1 protein] CTD PMID:34389372 NCBI chr11:97,892,339...97,913,860
Ensembl chr11:97,892,334...97,913,860
JBrowse link
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB4 protein] CTD PMID:34389372 NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843
JBrowse link
G Capn2 calpain 2 increases activity ISO NMDA increases activity of Capn2 in rat hippocampal neuron cultures RGD PMID:19141074 RGD:13792555 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions
increases phosphorylation
ISO CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]
N-Methylaspartate results in increased phosphorylation of CAV1 protein
CTD PMID:35257817 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
JBrowse link
G Cdk5 cyclin dependent kinase 5 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CDK5 protein] CTD PMID:34389372 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation
multiple interactions
ISO N-Methylaspartate results in decreased phosphorylation of CREB1 protein
kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of CREB1 protein]
CTD PMID:26065936 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Ddo D-aspartate oxidase affects abundance EXP DDO protein affects the abundance of N-Methylaspartate CTD PMID:16516413 NCBI chr10:40,505,933...40,557,847
Ensembl chr10:40,506,007...40,557,843
JBrowse link
G Dlgap1 DLG associated protein 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of DLGAP1 protein] CTD PMID:34389372 NCBI chr17:70,276,068...71,128,408
Ensembl chr17:70,276,068...71,128,408
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions
ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]
CTD PMID:31945382 NCBI chr 8:4,334,781...4,375,104
Ensembl chr 8:4,335,382...4,375,413
JBrowse link
G Fyn Fyn proto-oncogene multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of FYN protein] CTD PMID:34389372 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
JBrowse link
G Gphn gephyrin multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GPHN protein] CTD PMID:34389372 NCBI chr12:78,264,099...78,731,546
Ensembl chr12:78,273,153...78,731,546
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) increases expression
multiple interactions
ISO N-Methylaspartate results in increased expression of GRIN2B protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of GRIN2B protein]
CTD PMID:26065936 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GSK3B protein] CTD PMID:34389372 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hcn2 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of HCN2 protein] CTD PMID:34389372 NCBI chr10:79,552,468...79,571,942
Ensembl chr10:79,552,468...79,571,942
JBrowse link
G Lmna lamin A multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of LMNA protein] CTD PMID:34389372 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases expression
decreases phosphorylation
increases phosphorylation
ISO thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]
CTD PMID:22639866 PMID:26065936 PMID:35257817 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases expression
decreases phosphorylation
increases phosphorylation
ISO thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
N-Methylaspartate results in decreased phosphorylation of MAPK3 protein
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]
CTD PMID:22639866 PMID:26065936 PMID:35257817 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of MAPT protein] CTD PMID:34389372 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
multiple interactions
ISO N-Methylaspartate affects the localization of NCF1 protein
acetovanillone inhibits the reaction [N-Methylaspartate affects the localization of NCF1 protein]
CTD PMID:26065936 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions
decreases expression
ISO 3-(2-((phenylamino)carbonyl)ethenyl)-4,6-dichloroindole-2-carboxylic acid inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of NOS1 protein] CTD PMID:34389372 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases ADP-ribosylation ISO N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of PRKCG protein] CTD PMID:34389372 NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615
JBrowse link
G Rab3a RAB3A, member RAS oncogene family multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RAB3A protein] CTD PMID:34389372 NCBI chr 8:71,207,258...71,211,276
Ensembl chr 8:71,207,328...71,211,323
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RIMS1 protein] CTD PMID:34389372 NCBI chr 1:22,356,196...22,845,239
Ensembl chr 1:22,356,475...22,845,203
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO N-Methylaspartate results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SHANK3 protein] CTD PMID:34389372 NCBI chr15:89,376,929...89,444,464
Ensembl chr15:89,383,826...89,444,464
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Stxbp1 syntaxin binding protein 1 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of STXBP1 protein] CTD PMID:34389372 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
JBrowse link
G Syn1 synapsin I multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SYN1 protein] CTD PMID:34389372 NCBI chr  X:20,726,750...20,787,157
Ensembl chr  X:20,726,750...20,787,243
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
ISO CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]
N-Methylaspartate results in decreased expression of TJP1 mRNA; N-Methylaspartate results in decreased expression of TJP1 protein
CTD PMID:35257817 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tuba1b tubulin, alpha 1B multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of TUBA1B protein] CTD PMID:34389372 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446
JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions EXP N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of VDAC2 protein] CTD PMID:34389372 NCBI chr14:21,881,629...21,895,947
Ensembl chr14:21,875,306...21,895,947
JBrowse link

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  CHEBI ontology 22188
    role 22173
      biological role 22172
        pharmacological role 19758
          neurotransmitter agent 17124
            N-methyl-D-aspartic acid 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic group 20283
                              organic divalent group 20165
                                organodiyl group 20165
                                  carbonyl group 20159
                                    carbonyl compound 20159
                                      carboxylic acid 19557
                                        amino acid 16426
                                          alpha-amino acid 14221
                                            non-proteinogenic alpha-amino acid 3838
                                              D-alpha-amino acid 68
                                                D-aspartic acid 60
                                                  D-aspartic acid derivative 41
                                                    N-methyl-D-aspartic acid 41
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