CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: molsidomine
Accession: CHEBI:31861
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Definition: A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Synonyms: exact_synonym: N-(ethoxycarbonyl)-3-(morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-aminide
related_synonym: 5-[(ethoxycarbonyl)amino]-3-(4-morpholinyl)-1,2,3-oxadiazolium inner salt; CAS 276; Corraton; Coruno; Corvaton; Covarsal; Formula=C9H14N4O4; InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3; InChIKey=XLFWDASMENKTKL-UHFFFAOYSA-N; MolsiCare; Molsicor; Morial; N-(ethoxycarbonyl)-3-morpholinosydnone imine; N-carboxy-3-morpholinosydnone imine ethyl ester; N-ethoxycarbonyl-3-morpholinosydnonimine; SIN-10; SMILES=CCOC(=O)[N-]C1=C[N+](=NO1)N1CCOCC1; Sydnopharm; molsidolat; molsidomin; molsidomina; molsidominum; morsydomine; motazomin
xref: CAS:25717-80-0; Chemspider:4090; DrugBank:DB09282; Drug_Central:1831; HMDB:HMDB0245703; KEGG:D01320
xref_mesh: MESH:D008981
xref: PMID:14718172; PMID:24120390; PMID:24157421; PMID:25032121; PMID:25269886; PMID:26469102; PMID:26833172; PMID:27238492; PMID:27482866; PMID:27721541; PMID:27760216; PMID:27816693; PMID:27897441; PMID:27918857; PMID:28166419; PMID:29323543; PMID:29477039; PMID:30587924; PMID:30898683; PMID:31085310; PMID:32706246; PMID:34330056; PMID:34557650; Reaxys:3999414; Wikipedia:Molsidomine
G
Fxn
frataxin
increases expression
ISO
Molsidomine results in increased expression of FXN mRNA
CTD
PMID:23418481
NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
G
Ptgis
prostaglandin I2 synthase
multiple interactions
EXP
Molsidomine inhibits the reaction [Hypoxia increases expression of Ptgis mRNA in the lung]
RGD
PMID:12062720
RGD:401959327
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
G
Slc22a1
solute carrier family 22 member 1
multiple interactions
ISO
Molsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:21641380
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO
Molsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:21641380
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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