Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:molsidomine
go back to main search page
Accession:CHEBI:31861 term browser browse the term
Definition:A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Synonyms:exact_synonym: N-(ethoxycarbonyl)-3-(morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-aminide
 related_synonym: 5-[(ethoxycarbonyl)amino]-3-(4-morpholinyl)-1,2,3-oxadiazolium inner salt;   CAS 276;   Corraton;   Coruno;   Corvaton;   Covarsal;   Formula=C9H14N4O4;   InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3;   InChIKey=XLFWDASMENKTKL-UHFFFAOYSA-N;   MolsiCare;   Molsicor;   Morial;   N-(ethoxycarbonyl)-3-morpholinosydnone imine;   N-carboxy-3-morpholinosydnone imine ethyl ester;   N-ethoxycarbonyl-3-morpholinosydnonimine;   SIN-10;   SMILES=CCOC(=O)[N-]C1=C[N+](=NO1)N1CCOCC1;   Sydnopharm;   molsidolat;   molsidomin;   molsidomina;   molsidominum;   morsydomine;   motazomin
 xref: CAS:25717-80-0;   Chemspider:4090;   DrugBank:DB09282;   Drug_Central:1831;   HMDB:HMDB0245703;   KEGG:D01320
 xref_mesh: MESH:D008981
 xref: PMID:14718172;   PMID:24120390;   PMID:24157421;   PMID:25032121;   PMID:25269886;   PMID:26469102;   PMID:26833172;   PMID:27238492;   PMID:27482866;   PMID:27721541;   PMID:27760216;   PMID:27816693;   PMID:27897441;   PMID:27918857;   PMID:28166419;   PMID:29323543;   PMID:29477039;   PMID:30587924;   PMID:30898683;   PMID:31085310;   PMID:32706246;   PMID:34330056;   PMID:34557650;   Reaxys:3999414;   Wikipedia:Molsidomine



show annotations for term's descendants           Sort by:
molsidomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin increases expression ISO Molsidomine results in increased expression of FXN mRNA CTD PMID:23418481 NCBI chr 1:231,300,457...231,323,989 JBrowse link
G Ptgis prostaglandin I2 synthase multiple interactions EXP Molsidomine inhibits the reaction [Hypoxia increases expression of Ptgis mRNA in the lung] RGD PMID:12062720 RGD:401959327 NCBI chr 3:155,928,564...155,964,228 JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:50,624,339...50,651,437 JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:50,783,218...50,872,358 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      chemical role 19500
        antioxidant 16189
          molsidomine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19587
                        oxygen atom 19559
                          oxygen molecular entity 19559
                            hydroxides 19370
                              organic hydroxy compound 18982
                                alcohol 15751
                                  primary alcohol 14704
                                    ethanols 8928
                                      ethanol 8928
                                        ethyl ester 4385
                                          molsidomine 4
paths to the root