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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:molsidomine
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Accession:CHEBI:31861 term browser browse the term
Definition:A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Synonyms:exact_synonym: N-(ethoxycarbonyl)-3-(morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-aminide
 related_synonym: 5-[(ethoxycarbonyl)amino]-3-(4-morpholinyl)-1,2,3-oxadiazolium inner salt;   CAS 276;   Corraton;   Coruno;   Corvaton;   Covarsal;   Formula=C9H14N4O4;   InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3;   InChIKey=XLFWDASMENKTKL-UHFFFAOYSA-N;   MolsiCare;   Molsicor;   Morial;   N-(ethoxycarbonyl)-3-morpholinosydnone imine;   N-carboxy-3-morpholinosydnone imine ethyl ester;   N-ethoxycarbonyl-3-morpholinosydnonimine;   SIN-10;   SMILES=CCOC(=O)[N-]C1=C[N+](=NO1)N1CCOCC1;   Sydnopharm;   molsidolat;   molsidomin;   molsidomina;   molsidominum;   morsydomine;   motazomin
 xref: CAS:25717-80-0;   Chemspider:4090;   DrugBank:DB09282;   Drug_Central:1831;   HMDB:HMDB0245703;   KEGG:D01320
 xref_mesh: MESH:D008981
 xref: PMID:14718172;   PMID:24120390;   PMID:24157421;   PMID:25032121;   PMID:25269886;   PMID:26469102;   PMID:26833172;   PMID:27238492;   PMID:27482866;   PMID:27721541;   PMID:27760216;   PMID:27816693;   PMID:27897441;   PMID:27918857;   PMID:28166419;   PMID:29323543;   PMID:29477039;   PMID:30587924;   PMID:30898683;   PMID:31085310;   PMID:32706246;   PMID:34330056;   PMID:34557650;   Reaxys:3999414;   Wikipedia:Molsidomine



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molsidomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin increases expression ISO Molsidomine results in increased expression of FXN mRNA CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      chemical role 19582
        antioxidant 15709
          molsidomine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      chalcogen 19727
                        oxygen atom 19696
                          oxygen molecular entity 19696
                            hydroxides 19452
                              organic hydroxy compound 19003
                                alcohol 15208
                                  primary alcohol 14109
                                    ethanols 8287
                                      ethanol 8287
                                        ethyl ester 3333
                                          molsidomine 3
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