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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:molsidomine
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Accession:CHEBI:31861 term browser browse the term
Definition:A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure.
Synonyms:exact_synonym: N-(ethoxycarbonyl)-3-(morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-aminide
 related_synonym: 5-[(ethoxycarbonyl)amino]-3-(4-morpholinyl)-1,2,3-oxadiazolium inner salt;   CAS 276;   Corraton;   Coruno;   Corvaton;   Covarsal;   Formula=C9H14N4O4;   InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3;   InChIKey=XLFWDASMENKTKL-UHFFFAOYSA-N;   MolsiCare;   Molsicor;   Morial;   N-(ethoxycarbonyl)-3-morpholinosydnone imine;   N-carboxy-3-morpholinosydnone imine ethyl ester;   N-ethoxycarbonyl-3-morpholinosydnonimine;   SIN-10;   SMILES=CCOC(=O)[N-]C1=C[N+](=NO1)N1CCOCC1;   Sydnopharm;   molsidolat;   molsidomin;   molsidomina;   molsidominum;   morsydomine;   motazomin
 xref: CAS:25717-80-0;   Chemspider:4090;   DrugBank:DB09282;   Drug_Central:1831;   HMDB:HMDB0245703;   KEGG:D01320
 xref_mesh: MESH:D008981
 xref: PMID:14718172;   PMID:24120390;   PMID:24157421;   PMID:25032121;   PMID:25269886;   PMID:26469102;   PMID:26833172;   PMID:27238492;   PMID:27482866;   PMID:27721541;   PMID:27760216;   PMID:27816693;   PMID:27897441;   PMID:27918857;   PMID:28166419;   PMID:29323543;   PMID:29477039;   PMID:30587924;   PMID:30898683;   PMID:31085310;   PMID:32706246;   PMID:34330056;   PMID:34557650;   Reaxys:3999414;   Wikipedia:Molsidomine



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molsidomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin increases expression ISO Molsidomine results in increased expression of FXN mRNA CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Ptgis prostaglandin I2 synthase multiple interactions EXP Molsidomine inhibits the reaction [Hypoxia increases expression of Ptgis mRNA in the lung] RGD PMID:12062720 RGD:401959327 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Molsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link

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  CHEBI ontology 19904
    role 19880
      chemical role 19500
        antioxidant 16060
          molsidomine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19852
                    p-block element atom 19852
                      chalcogen 19597
                        oxygen atom 19571
                          oxygen molecular entity 19571
                            hydroxides 19375
                              organic hydroxy compound 18992
                                alcohol 15550
                                  primary alcohol 14460
                                    ethanols 8802
                                      ethanol 8802
                                        ethyl ester 4108
                                          molsidomine 4
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