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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:modafinil
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Accession:CHEBI:31859 term browser browse the term
Definition:A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
Synonyms:exact_synonym: rac-2-[(diphenylmethyl)sulfinyl]acetamide
 related_synonym: 2-(benzhydrylsulfinyl)acetamide;   CEP-1538;   CRL 40476;   Provigil;   modafinilo;   modafinilum
 xref: CAS:68693-11-8;   DrugBank:DB00745;   HMDB:HMDB0014883;   KEGG:D01832
 xref_mesh: MESH:C048833
 xref: PMID:17712350;   PMID:22537794;   PMID:23017017;   PMID:23261131;   PMID:24109471;   PMID:24120858;   PMID:24287166;   PMID:24530829;   Patent:DE2809625;   Patent:US4177290;   Reaxys:1978970;   Wikipedia:Modafinil


show annotations for term's descendants           Sort by:
modafinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
increases expression		 EXP Alendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA]
modafinil results in increased expression of ACP5 mRNA; modafinil results in increased expression of ACP5 protein		 CTD PMID:29649498 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Adora2a adenosine A2a receptor increases activity EXP modafinil results in increased activity of ADORA2A protein CTD PMID:29649498 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Adora2b adenosine A2B receptor increases activity EXP modafinil results in increased activity of ADORA2B protein CTD PMID:29649498 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Comt catechol-O-methyltransferase affects response to substance ISO COMT gene polymorphism affects the susceptibility to modafinil; COMT protein affects the susceptibility to modafinil CTD PMID:20815183 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression ISO modafinil affects the expression of FOS protein CTD PMID:19194377 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 EXP modafinil results in increased expression of RUNX2 mRNA
Alendronate promotes the reaction [modafinil results in increased expression of RUNX2 mRNA]		 CTD PMID:29649498 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases response to substance
multiple interactions
affects response to substance		 ISO
EXP		 SLC6A3 gene mutant form results in decreased susceptibility to modafinil
modafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]
SLC6A3 gene polymorphism affects the susceptibility to modafinil		 CTD PMID:11222668 PMID:19197004 PMID:24403155 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A increases expression EXP modafinil results in increased expression of TNFRSF11A mRNA CTD PMID:29649498 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
increases expression		 EXP Alendronate inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; KT 5720 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]
Modafinil results in increased expression of TNFSF11 mRNA; Modafinil results in increased expression of TNFSF11 protein		 CTD PMID:29649498 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      chemical substance 14403
        mixture 13722
          racemate 12097
            modafinil 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17549
                                            carboxamide 17549
                                              monocarboxylic acid amide 15680
                                                2-[(diphenylmethyl)sulfinyl]acetamide 9
                                                  armodafinil 9
                                                    modafinil 9
paths to the root