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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mithramycin
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Accession:CHEBI:31856 term browser browse the term
Definition:An aureolic acid that has formula C52H76O24.
Synonyms:exact_synonym: (1S)-5-deoxy-1-C-[(2S,3S)-7-{[2,6-dideoxy-3-O-(2,6-dideoxy-beta-D-arabino-hexopyranosyl)-beta-D-arabino-hexopyranosyl]oxy}-3-{[2,6-dideoxy-3-C-methyl-beta-D-ribo-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl]oxy}-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-1-O-methyl-D-xylulose
 related_synonym: Formula=C52H76O24;   InChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45+,49+,50+,51-,52+/m1/s1;   InChIKey=CFCUWKMKBJTWLW-BKHRDMLASA-N;   Mithracin;   Mithramycine;   Mithramycinum;   Plicamycin;   Plicamycine;   Plicamycinum;   SMILES=[H][C@]1(Cc2cc3cc(O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1O[C@H]1C[C@@H](O[C@H]2C[C@@H](O[C@H]3C[C@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](O)[C@@H](C)O2)[C@H](O)[C@@H](C)O1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O;   aureolic acid
 xref: CAS:18378-89-7;   DrugBank:DB06810;   Drug_Central:2223;   KEGG:C12389;   KEGG:D00468
 xref_mesh: MESH:D008926


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mithramycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression EXP Plicamycin results in decreased expression of ANKRD37 mRNA CTD PMID:23814049 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions
decreases expression
EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of ATP7A mRNA]
Plicamycin results in decreased expression of ATP7A mRNA
CTD PMID:23814049 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO Plicamycin results in decreased expression of AXL CTD PMID:18522535 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions
decreases expression
EXP
ISO
Plicamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BNIP3L mRNA]
Plicamycin results in decreased expression of BNIP3L mRNA
CTD PMID:16291751 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter] CTD PMID:24244623 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cybrd1 cytochrome b reductase 1 multiple interactions
decreases expression
EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of CYBRD1 mRNA]
Plicamycin results in decreased expression of CYBRD1 mRNA
CTD PMID:23814049 NCBI chr 3:57,718,496...57,745,749
Ensembl chr 3:57,718,364...57,746,097
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein] CTD PMID:17307335 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression EXP Plicamycin results in decreased expression of EPAS1 mRNA CTD PMID:23814049 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of ERN1 protein] CTD PMID:26784903 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression
ISO Plicamycin inhibits the reaction [Asbestos results in increased expression of F3 mRNA]
Plicamycin results in decreased expression of F3 mRNA
CTD PMID:15636197 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of HSPA5 protein] CTD PMID:26784903 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Plicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA] CTD PMID:15946989 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA] CTD PMID:24244623 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO Plicamycin inhibits the reaction [Chlorpyrifos results in increased expression of PON2 mRNA] CTD PMID:24979751 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
decreases expression
EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC11A2 mRNA]
Plicamycin results in decreased expression of SLC11A2 mRNA
CTD PMID:23814049 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions
EXP Plicamycin results in decreased expression of SLC40A1 mRNA
Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC40A1 mRNA]
CTD PMID:23814049 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Sp1 Sp1 transcription factor decreases activity
decreases expression
multiple interactions
ISO
EXP
Plicamycin results in decreased activity of SP1 protein
Plicamycin results in decreased expression of SP1 mRNA
[Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter]; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]
CTD PMID:15946989, PMID:17307335, PMID:21603612, PMID:23814049, PMID:24244623 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tfrc transferrin receptor increases expression EXP Plicamycin results in increased expression of TFRC mRNA CTD PMID:23814049 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter] CTD PMID:21603612 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 decreases expression ISO Plicamycin results in decreased expression of TNIP1 mRNA CTD PMID:23464785 NCBI chr10:40,255,776...40,303,092
Ensembl chr10:40,255,776...40,296,470
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression ISO Mithramycin A decreases expression of XRCC1 mRNA in lung and liver cancer and liver cancer cell lines RGD PMID:30088263 RGD:15036795 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          carbohydrate-containing antibiotic 2547
            mithramycin 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxyketone 8631
                                          alpha-oxyketone 8631
                                            alpha-hydroxy ketone 8631
                                              secondary alpha-hydroxy ketone 879
                                                mithramycin 30
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.