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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mithramycin
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Accession:CHEBI:31856 term browser browse the term
Definition:An aureolic acid that has formula C52H76O24.
Synonyms:exact_synonym: (1S)-5-deoxy-1-C-[(2S,3S)-7-{[2,6-dideoxy-3-O-(2,6-dideoxy-beta-D-arabino-hexopyranosyl)-beta-D-arabino-hexopyranosyl]oxy}-3-{[2,6-dideoxy-3-C-methyl-beta-D-ribo-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl-(1->3)-2,6-dideoxy-beta-D-arabino-hexopyranosyl]oxy}-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-1-O-methyl-D-xylulose
 related_synonym: Formula=C52H76O24;   InChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45+,49+,50+,51-,52+/m1/s1;   InChIKey=CFCUWKMKBJTWLW-BKHRDMLASA-N;   Mithracin;   Mithramycine;   Mithramycinum;   Plicamycin;   Plicamycine;   Plicamycinum;   SMILES=[H][C@]1(Cc2cc3cc(O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1O[C@H]1C[C@@H](O[C@H]2C[C@@H](O[C@H]3C[C@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](O)[C@@H](C)O2)[C@H](O)[C@@H](C)O1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O;   aureolic acid
 xref: CAS:18378-89-7;   DrugBank:DB06810;   Drug_Central:2223;   KEGG:C12389;   KEGG:D00468
 xref_mesh: MESH:D008926


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mithramycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression EXP Plicamycin results in decreased expression of ANKRD37 mRNA CTD PMID:23814049 NCBI chr16:46,269,025...46,271,971
Ensembl chr16:46,268,443...46,271,963
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions
decreases expression
EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of ATP7A mRNA]
Plicamycin results in decreased expression of ATP7A mRNA
CTD PMID:23814049 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO Plicamycin results in decreased expression of AXL CTD PMID:18522535 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions
decreases expression
EXP
ISO
Plicamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BNIP3L mRNA]
Plicamycin results in decreased expression of BNIP3L mRNA
CTD PMID:16291751 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter] CTD PMID:24244623 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cybrd1 cytochrome b reductase 1 multiple interactions
decreases expression
EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of CYBRD1 mRNA]
Plicamycin results in decreased expression of CYBRD1 mRNA
CTD PMID:23814049 NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein] CTD PMID:17307335 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression EXP Plicamycin results in decreased expression of EPAS1 mRNA CTD PMID:23814049 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of ERN1 protein] CTD PMID:26784903 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression
ISO Plicamycin inhibits the reaction [Asbestos results in increased expression of F3 mRNA]
Plicamycin results in decreased expression of F3 mRNA
CTD PMID:15636197 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of HSPA5 protein] CTD PMID:26784903 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ifng interferon gamma multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Plicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA] CTD PMID:15946989 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA] CTD PMID:24244623 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO Plicamycin inhibits the reaction [Chlorpyrifos results in increased expression of PON2 mRNA] CTD PMID:24979751 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
decreases expression
EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC11A2 mRNA]
Plicamycin results in decreased expression of SLC11A2 mRNA
CTD PMID:23814049 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions
EXP Plicamycin results in decreased expression of SLC40A1 mRNA
Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC40A1 mRNA]
CTD PMID:23814049 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Sp1 Sp1 transcription factor decreases activity
decreases expression
multiple interactions
ISO
EXP
Plicamycin results in decreased activity of SP1 protein
Plicamycin results in decreased expression of SP1 mRNA
[Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter]; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]
CTD PMID:15946989 PMID:17307335 PMID:21603612 PMID:23814049 PMID:24244623 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tfrc transferrin receptor increases expression EXP Plicamycin results in increased expression of TFRC mRNA CTD PMID:23814049 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter] CTD PMID:21603612 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 decreases expression ISO Plicamycin results in decreased expression of TNIP1 mRNA CTD PMID:23464785 NCBI chr10:39,037,048...39,084,328
Ensembl chr10:39,037,058...39,077,625
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression ISO Mithramycin A decreases expression of XRCC1 mRNA in lung and liver cancer and liver cancer cell lines RGD PMID:30088263 RGD:15036795 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          carbohydrate-containing antibiotic 2557
            mithramycin 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        oxyketone 8656
                                          alpha-oxyketone 8656
                                            alpha-hydroxy ketone 8656
                                              secondary alpha-hydroxy ketone 894
                                                mithramycin 30
paths to the root