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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methyl salicylate
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Accession:CHEBI:31832 term browser browse the term
Definition:A benzoate ester that is the methyl ester of salicylic acid.
Synonyms:related_synonym: 2-(Methoxycarbonyl)phenol;   2-Carbomethoxyphenol;   2-Hydroxybenzoic acid methyl ester;   Betula oil;   Formula=C8H8O3;   Gaultheria oil;   InChI=1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3;   InChIKey=OSWPMRLSEDHDFF-UHFFFAOYSA-N;   Methyl 2-hydroxybenzoate;   Methyl o-hydroxybenzoate;   Natural wintergreen oil;   Oil of wintergreen;   SMILES=COC(=O)c1ccccc1O;   Spicewood Oil;   Sweet birch oil;   Teaberry oil
 xref: CAS:119-36-8;   Drug_Central:4245;   KEGG:C12305;   KEGG:D01087;   KNApSAcK:C00030767
 xref_mesh: MESH:C033069
 xref: PMID:21249432;   PMID:21287406;   PMID:21327960;   PMID:21404848;   PMID:21609308;   PMID:21790190;   PMID:21936953;   Reaxys:971516;   Wikipedia:Methyl_salicylate


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methyl salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 affects expression ISO methyl salicylate affects the expression of ACOD1 mRNA CTD PMID:22302311 NCBI chr15:93,612,968...93,622,322
Ensembl chr15:93,612,971...93,622,358
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO methyl salicylate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO methyl salicylate results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO methyl salicylate results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO methyl salicylate affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO methyl salicylate affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO methyl salicylate affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects expression ISO methyl salicylate affects the expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
increases expression
ISO methyl salicylate results in decreased expression of CXCL2 protein
methyl salicylate results in increased expression of CXCL2 protein
CTD PMID:23178550 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Emd emerin affects expression ISO methyl salicylate affects the expression of EMD mRNA CTD PMID:19527780 NCBI chr  X:156,452,847...156,455,858
Ensembl chr  X:156,452,818...156,456,035
JBrowse link
G Esr1 estrogen receptor 1 affects expression ISO methyl salicylate affects the expression of ESR1 mRNA CTD PMID:19527780 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fech ferrochelatase increases expression ISO methyl salicylate results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO methyl salicylate results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO methyl salicylate results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 affects expression ISO methyl salicylate affects the expression of GAL3ST1 mRNA CTD PMID:19527780 NCBI chr14:84,231,473...84,247,371
Ensembl chr14:84,231,639...84,247,369
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO methyl salicylate results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO methyl salicylate results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO methyl salicylate results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO methyl salicylate results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il17a interleukin 17A decreases expression ISO methyl salicylate results in decreased expression of IL17A protein CTD PMID:28826779 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO methyl salicylate results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il4 interleukin 4 affects expression ISO methyl salicylate affects the expression of IL4 mRNA CTD PMID:22302311 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases secretion ISO methyl salicylate results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgav integrin subunit alpha V affects expression ISO methyl salicylate affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Lgals7 galectin 7 affects expression ISO methyl salicylate affects the expression of LGALS7 mRNA CTD PMID:22302311 NCBI chr 1:87,044,823...87,047,223
Ensembl chr 1:87,045,335...87,047,223
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO methyl salicylate results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Me1 malic enzyme 1 increases expression ISO methyl salicylate results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO methyl salicylate affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO methyl salicylate results in decreased expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Npr3 natriuretic peptide receptor 3 affects expression ISO methyl salicylate affects the expression of NPR3 mRNA CTD PMID:19527780 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO methyl salicylate results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO methyl salicylate results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO methyl salicylate results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO methyl salicylate results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO methyl salicylate affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO methyl salicylate affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,755,473...31,796,423
Ensembl chr10:31,755,510...31,790,263
JBrowse link
G Tnf tumor necrosis factor affects expression ISO methyl salicylate affects the expression of TNF mRNA CTD PMID:20385217 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO methyl salicylate results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of methyl salicylate CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing
affects metabolic processing
EXP UGT1A6 protein results in increased metabolism of methyl salicylate
UGT1A6 gene polymorphism affects the metabolism of methyl salicylate
CTD PMID:9429234 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of methyl salicylate CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19785
    role 19732
      biological role 19732
        insect attractant 47
          methyl salicylate 43
Path 2
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  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            benzoic acid 3839
                                              hydroxybenzoic acid 3227
                                                monohydroxybenzoic acid 1264
                                                  salicylic acid 740
                                                    methyl salicylate 43
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