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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methyl salicylate
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Accession:CHEBI:31832 term browser browse the term
Definition:A benzoate ester that is the methyl ester of salicylic acid.
Synonyms:related_synonym: 2-(Methoxycarbonyl)phenol;   2-Carbomethoxyphenol;   2-Hydroxybenzoic acid methyl ester;   Betula oil;   Formula=C8H8O3;   Gaultheria oil;   InChI=1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3;   InChIKey=OSWPMRLSEDHDFF-UHFFFAOYSA-N;   Methyl 2-hydroxybenzoate;   Methyl o-hydroxybenzoate;   Natural wintergreen oil;   Oil of wintergreen;   SMILES=COC(=O)c1ccccc1O;   Spicewood Oil;   Sweet birch oil;   Teaberry oil
 xref: CAS:119-36-8;   Drug_Central:4245;   KEGG:C12305;   KEGG:D01087;   KNApSAcK:C00030767
 xref_mesh: MESH:C033069
 xref: PMID:21249432;   PMID:21287406;   PMID:21327960;   PMID:21404848;   PMID:21609308;   PMID:21790190;   PMID:21936953;   Reaxys:971516;   Wikipedia:Methyl_salicylate


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methyl salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 affects expression ISO methyl salicylate affects the expression of ACOD1 mRNA CTD PMID:22302311 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO methyl salicylate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO methyl salicylate results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO methyl salicylate results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO methyl salicylate affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO methyl salicylate affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:172,791,007...172,802,018 JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO methyl salicylate affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects expression ISO methyl salicylate affects the expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
increases expression
ISO methyl salicylate results in decreased expression of CXCL2 protein
methyl salicylate results in increased expression of CXCL2 protein
CTD PMID:23178550 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Emd emerin affects expression ISO methyl salicylate affects the expression of EMD mRNA CTD PMID:19527780 NCBI chr  X:152,038,990...152,042,190
Ensembl chr  X:152,038,998...152,045,807
JBrowse link
G Esr1 estrogen receptor 1 affects expression ISO methyl salicylate affects the expression of ESR1 mRNA CTD PMID:19527780 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Fech ferrochelatase increases expression ISO methyl salicylate results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO methyl salicylate results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO methyl salicylate results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 affects expression ISO methyl salicylate affects the expression of GAL3ST1 mRNA CTD PMID:19527780 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO methyl salicylate results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO methyl salicylate results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO methyl salicylate results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO methyl salicylate results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il17a interleukin 17A decreases expression ISO methyl salicylate results in decreased expression of IL17A protein CTD PMID:28826779 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO methyl salicylate results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il4 interleukin 4 affects expression ISO methyl salicylate affects the expression of IL4 mRNA CTD PMID:22302311 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 increases secretion ISO methyl salicylate results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgav integrin subunit alpha V affects expression ISO methyl salicylate affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Lgals7 galectin 7 affects expression ISO methyl salicylate affects the expression of LGALS7 mRNA CTD PMID:22302311 NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO methyl salicylate results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
JBrowse link
G Me1 malic enzyme 1 increases expression ISO methyl salicylate results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO methyl salicylate affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO methyl salicylate inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO methyl salicylate results in decreased expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Npr3 natriuretic peptide receptor 3 affects expression ISO methyl salicylate affects the expression of NPR3 mRNA CTD PMID:19527780 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO methyl salicylate results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO methyl salicylate results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO methyl salicylate results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase increases expression ISO methyl salicylate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO methyl salicylate results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO methyl salicylate affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO methyl salicylate affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623
JBrowse link
G Tnf tumor necrosis factor affects expression ISO methyl salicylate affects the expression of TNF mRNA CTD PMID:20385217 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO methyl salicylate results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of methyl salicylate CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases metabolic processing
affects metabolic processing
EXP UGT1A6 protein results in increased metabolism of methyl salicylate
UGT1A6 gene polymorphism affects the metabolism of methyl salicylate
CTD PMID:9429234 NCBI chr 9:88,747,229...88,808,465 JBrowse link

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  CHEBI ontology 19812
    role 19761
      biological role 19761
        insect attractant 61
          methyl salicylate 43
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        aromatic carboxylic acid 11708
                                          benzoic acids 11681
                                            benzoic acid 4157
                                              hydroxybenzoic acid 3562
                                                monohydroxybenzoic acid 1290
                                                  salicylic acid 771
                                                    methyl salicylate 43
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