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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:brompheniramine
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Accession:CHEBI:3183 term browser browse the term
Definition:Pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Synonyms:exact_synonym: 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
 related_synonym: 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane;   2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine;   3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine;   3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine;   Formula=C16H19BrN2;   InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3;   InChIKey=ZDIGNSYAACHWNL-UHFFFAOYSA-N;   SMILES=CN(C)CCC(c1ccc(Br)cc1)c1ccccn1;   [3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine;   bromfeniramina;   brompheniraminum
 alt_id: CHEBI:154051
 xref: Beilstein:217066;   CAS:86-22-6;   DrugBank:DB00835;   Drug_Central:408;   KEGG:C06857;   KEGG:D07543;   LINCS:LSM-1736
 xref_mesh: MESH:D001977
 xref: PMID:2570152;   PMID:2579237;   PMID:6458703;   PMID:9526560;   Patent:US2567245;   Patent:US2676964;   Wikipedia:Brompheniramine



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brompheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Brompheniramine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Brompheniramine results in decreased activity of KCNH2 protein CTD PMID:17010640 PMID:17516459 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Brompheniramine results in decreased activity of SCN5A protein CTD PMID:17010640 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Brompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
dexbrompheniramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO dexbrompheniramine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO dexbrompheniramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19715
    role 19690
      application 19522
        pharmaceutical 19409
          drug 19409
            anti-allergic agent 3920
              brompheniramine 4
                brompheniramine maleate + 0
                dexbrompheniramine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19606
                        carbon atom 19603
                          organic molecular entity 19603
                            organic molecule 19562
                              organic cyclic compound 19378
                                organic heterocyclic compound 18720
                                  organic heteromonocyclic compound 17501
                                    pyridines 9194
                                      brompheniramine 4
                                        brompheniramine maleate + 0
                                        dexbrompheniramine + 2
paths to the root