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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:loteprednol etabonate
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Accession:CHEBI:31784 term browser browse the term
Definition:An etabonate ester that has formula C24H31ClO7.
Synonyms:exact_synonym: chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate
 related_synonym: Formula=C24H31ClO7;   InChI=1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1;   InChIKey=DMKSVUSAATWOCU-HROMYWEYSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(OC(=O)OCC)C(=O)OCCl
 xref: Beilstein:5461012;   CAS:82034-46-6;   DrugBank:DB00873;   Drug_Central:1611;   KEGG:D01689
 xref_mesh: MESH:C063378


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loteprednol etabonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Loteprednol Etabonate binds to and results in decreased activity of AR protein; Loteprednol Etabonate binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
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G Pgr progesterone receptor multiple interactions ISO Loteprednol Etabonate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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  CHEBI ontology 19808
    role 19757
      application 19467
        anti-inflammatory agent 15834
          anti-inflammatory drug 13623
            loteprednol etabonate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      ketone 16925
                                        oxo steroid 9719
                                          3-oxo steroid 9282
                                            3-oxo-Delta(1) steroid 5139
                                              3-oxo-Delta(1),Delta(4)-steroid 5139
                                                loteprednol 2
                                                  loteprednol etabonate 2
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