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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lornoxicam
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Accession:CHEBI:31783 term browser browse the term
Definition:A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.
Synonyms:exact_synonym: 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
 related_synonym: CCRIS 8589;   Chlortenoxicam;   Formula=C13H10ClN3O4S2;   InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19);   InChIKey=WLHQHAUOOXYABV-UHFFFAOYSA-N;   Ro 13-9297;   SMILES=CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O;   lornoxicamum
 xref: Beilstein:1039965;   CAS:70374-39-9;   DrugBank:DB06725;   Drug_Central:1609;   KEGG:D01866
 xref_mesh: MESH:C059451
 xref: PMID:21789617;   PMID:21968509;   PMID:22306394;   PMID:22459464;   PMID:22502750;   PMID:22545424;   PMID:22584689;   PMID:23215687;   PMID:23273940;   PMID:23385560;   PMID:23411533;   PMID:23428763;   PMID:23556534;   PMID:23567043;   PMID:23656309;   PMID:23657985;   PMID:23713572;   PMID:23781487;   PMID:23818079;   PMID:23827761;   PMID:23829186;   PMID:23884669;   PMID:23931243;   PMID:24029201;   Patent:US2008014272;   Reaxys:1039965;   Wikipedia:Lornoxicam



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lornoxicam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 decreases expression EXP lornoxicam results in decreased expression of IGF1 mRNA CTD PMID:23142791 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lornoxicam inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10450786 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP lornoxicam results in increased expression of LAMC2 mRNA CTD PMID:23142791 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lornoxicam inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:10450786 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO lornoxicam results in decreased activity of PTGS1 protein CTD PMID:10450786 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO lornoxicam results in decreased activity of PTGS2 protein CTD PMID:10450786 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP lornoxicam results in increased expression of TIMP1 mRNA CTD PMID:23142791 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        anti-inflammatory agent 16331
          anti-inflammatory drug 14850
            non-steroidal anti-inflammatory drug 14232
              lornoxicam 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      carboxylic acid 18556
                                        carboacyl group 17655
                                          univalent carboacyl group 17655
                                            carbamoyl group 17490
                                              carboxamide 17490
                                                monocarboxylic acid amide 15058
                                                  lornoxicam 7
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