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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lornoxicam
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Accession:CHEBI:31783 term browser browse the term
Definition:A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.
Synonyms:exact_synonym: 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
 related_synonym: CCRIS 8589;   Chlortenoxicam;   Formula=C13H10ClN3O4S2;   InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19);   InChIKey=WLHQHAUOOXYABV-UHFFFAOYSA-N;   Ro 13-9297;   SMILES=CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O;   lornoxicamum
 xref: Beilstein:1039965;   CAS:70374-39-9;   DrugBank:DB06725;   Drug_Central:1609;   KEGG:D01866
 xref_mesh: MESH:C059451
 xref: PMID:21789617;   PMID:21968509;   PMID:22306394;   PMID:22459464;   PMID:22502750;   PMID:22545424;   PMID:22584689;   PMID:23215687;   PMID:23273940;   PMID:23385560;   PMID:23411533;   PMID:23428763;   PMID:23556534;   PMID:23567043;   PMID:23656309;   PMID:23657985;   PMID:23713572;   PMID:23781487;   PMID:23818079;   PMID:23827761;   PMID:23829186;   PMID:23884669;   PMID:23931243;   PMID:24029201;   Patent:US2008014272;   Reaxys:1039965;   Wikipedia:Lornoxicam



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lornoxicam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 decreases expression EXP lornoxicam results in decreased expression of IGF1 mRNA CTD PMID:23142791 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lornoxicam inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10450786 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP lornoxicam results in increased expression of LAMC2 mRNA CTD PMID:23142791 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lornoxicam inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:10450786 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO lornoxicam results in decreased activity of PTGS1 protein CTD PMID:10450786 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO lornoxicam results in decreased activity of PTGS2 protein CTD PMID:10450786 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP lornoxicam results in increased expression of TIMP1 mRNA CTD PMID:23142791 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        anti-inflammatory agent 16531
          anti-inflammatory drug 14962
            non-steroidal anti-inflammatory drug 14276
              lornoxicam 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                monocarboxylic acid amide 15699
                                                  lornoxicam 7
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