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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lornoxicam
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Accession:CHEBI:31783 term browser browse the term
Definition:A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.
Synonyms:exact_synonym: 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
 related_synonym: CCRIS 8589;   Chlortenoxicam;   Formula=C13H10ClN3O4S2;   InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19);   InChIKey=WLHQHAUOOXYABV-UHFFFAOYSA-N;   Ro 13-9297;   SMILES=CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O;   lornoxicamum
 xref: Beilstein:1039965;   CAS:70374-39-9;   DrugBank:DB06725;   Drug_Central:1609;   KEGG:D01866
 xref_mesh: MESH:C059451
 xref: PMID:21789617;   PMID:21968509;   PMID:22306394;   PMID:22459464;   PMID:22502750;   PMID:22545424;   PMID:22584689;   PMID:23215687;   PMID:23273940;   PMID:23385560;   PMID:23411533;   PMID:23428763;   PMID:23556534;   PMID:23567043;   PMID:23656309;   PMID:23657985;   PMID:23713572;   PMID:23781487;   PMID:23818079;   PMID:23827761;   PMID:23829186;   PMID:23884669;   PMID:23931243;   PMID:24029201;   Patent:US2008014272;   Reaxys:1039965;   Wikipedia:Lornoxicam


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lornoxicam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 decreases expression EXP lornoxicam results in decreased expression of IGF1 mRNA CTD PMID:23142791 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lornoxicam inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:10450786 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP lornoxicam results in increased expression of LAMC2 mRNA CTD PMID:23142791 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lornoxicam inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:10450786 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO lornoxicam results in decreased activity of PTGS1 protein CTD PMID:10450786 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO lornoxicam results in decreased activity of PTGS2 protein CTD PMID:10450786 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP lornoxicam results in increased expression of TIMP1 mRNA CTD PMID:23142791 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        anti-inflammatory agent 14959
          anti-inflammatory drug 13619
            non-steroidal anti-inflammatory drug 12703
              lornoxicam 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  lornoxicam 7
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