CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: lornoxicam
Accession: CHEBI:31783
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Definition: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.
Synonyms: exact_synonym: 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
related_synonym: CCRIS 8589; Chlortenoxicam; Formula=C13H10ClN3O4S2; InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19); InChIKey=WLHQHAUOOXYABV-UHFFFAOYSA-N; Ro 13-9297; SMILES=CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O; lornoxicamum
xref: Beilstein:1039965; CAS:70374-39-9; DrugBank:DB06725; Drug_Central:1609; KEGG:D01866
xref_mesh: MESH:C059451
xref: PMID:21789617; PMID:21968509; PMID:22306394; PMID:22459464; PMID:22502750; PMID:22545424; PMID:22584689; PMID:23215687; PMID:23273940; PMID:23385560; PMID:23411533; PMID:23428763; PMID:23556534; PMID:23567043; PMID:23656309; PMID:23657985; PMID:23713572; PMID:23781487; PMID:23818079; PMID:23827761; PMID:23829186; PMID:23884669; PMID:23931243; PMID:24029201; Patent:US2008014272; Reaxys:1039965; Wikipedia:Lornoxicam
G
Igf1
insulin-like growth factor 1
decreases expression
EXP
lornoxicam results in decreased expression of IGF1 mRNA
CTD
PMID:23142791
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Il6
interleukin 6
multiple interactions
ISO
lornoxicam inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:10450786
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Lamc2
laminin subunit gamma 2
increases expression
EXP
lornoxicam results in increased expression of LAMC2 mRNA
CTD
PMID:23142791
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
lornoxicam inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]
CTD
PMID:10450786
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Ptgs1
prostaglandin-endoperoxide synthase 1
decreases activity
ISO
lornoxicam results in decreased activity of PTGS1 protein
CTD
PMID:10450786
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases activity
ISO
lornoxicam results in decreased activity of PTGS2 protein
CTD
PMID:10450786
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
lornoxicam results in increased expression of TIMP1 mRNA
CTD
PMID:23142791
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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