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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:brinzolamide
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Accession:CHEBI:3176 term browser browse the term
Definition:A thienothiazine that has formula C12H21N3O5S3.
Synonyms:exact_synonym: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
 related_synonym: Azopt;   Formula=C12H21N3O5S3;   InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1;   InChIKey=HCRKCZRJWPKOAR-JTQLQIEISA-N;   SMILES=CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
 alt_id: CHEBI:499968
 xref: Beilstein:9651552;   CAS:138890-62-7;   DrugBank:DB01194;   KEGG:C07760;   KEGG:D00652;   LINCS:LSM-3677
 xref_mesh: MESH:C111827
 xref: PDBeChem:BZ1;   Wikipedia:Brinzolamide

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brinzolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO brinzolamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296 		JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO brinzolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO brinzolamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO brinzolamide affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        pharmaceutical 19338
          drug 19338
            ophthalmology drug 407
              antiglaucoma drug 402
                brinzolamide 4
                  3,4-didehydro-N(4)-deethylbrinzolamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      chalcogen 19425
                        oxygen atom 19387
                          oxygen molecular entity 19387
                            hydroxides 19113
                              oxoacid 18243
                                chalcogen oxoacid 11491
                                  sulfur oxoacid 11095
                                    sulfonic acid 7347
                                      sulfonic acid derivative 7347
                                        sulfonamide 3181
                                          brinzolamide 4
                                            3,4-didehydro-N(4)-deethylbrinzolamide 0
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