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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:brinzolamide
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Accession:CHEBI:3176 term browser browse the term
Definition:A thienothiazine that has formula C12H21N3O5S3.
Synonyms:exact_synonym: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
 related_synonym: Azopt;   Formula=C12H21N3O5S3;   InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1;   InChIKey=HCRKCZRJWPKOAR-JTQLQIEISA-N;   SMILES=CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
 alt_id: CHEBI:499968
 xref: Beilstein:9651552;   CAS:138890-62-7;   DrugBank:DB01194;   KEGG:C07760;   KEGG:D00652;   LINCS:LSM-3677
 xref_mesh: MESH:C111827
 xref: PDBeChem:BZ1;   Wikipedia:Brinzolamide


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brinzolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO brinzolamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268 		JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO brinzolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO brinzolamide binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            ophthalmology drug 418
              antiglaucoma drug 404
                brinzolamide 3
                  3,4-didehydro-N(4)-deethylbrinzolamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      chalcogen 19445
                        oxygen atom 19418
                          oxygen molecular entity 19418
                            hydroxides 19152
                              oxoacid 18466
                                chalcogen oxoacid 11497
                                  sulfur oxoacid 11105
                                    sulfonic acid 7370
                                      sulfonic acid derivative 7370
                                        sulfonamide 3195
                                          brinzolamide 3
                                            3,4-didehydro-N(4)-deethylbrinzolamide 0
paths to the root