CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: brinzolamide
Accession: CHEBI:3176
browse the term
Definition: A thienothiazine that has formula C12H21N3O5S3.
Synonyms: exact_synonym: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
related_synonym: Azopt; Formula=C12H21N3O5S3; InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1; InChIKey=HCRKCZRJWPKOAR-JTQLQIEISA-N; SMILES=CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
alt_id: CHEBI:499968
xref: Beilstein:9651552; CAS:138890-62-7; DrugBank:DB01194; KEGG:C07760; KEGG:D00652; LINCS:LSM-3677
xref_mesh: MESH:C111827
xref: PDBeChem:BZ1; Wikipedia:Brinzolamide
G
Arhgap45
Rho GTPase activating protein 45
affects expression
ISO
brinzolamide affects the expression of ARHGAP45 mRNA
CTD
PMID:25811541
NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
G
Ca3
carbonic anhydrase 3
multiple interactions
ISO
brinzolamide binds to and results in decreased activity of CA3 protein
CTD
PMID:17826101
NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
G
Car2
carbonic anhydrase 2
multiple interactions
ISO
brinzolamide binds to and results in decreased activity of CA2 protein
CTD
PMID:17826101
NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
G
LOC100364500
RT1 class I, locus CE11-like
affects expression
ISO
brinzolamide affects the expression of HLA-A mRNA
CTD
PMID:25811541
NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
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