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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Lafutidine
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Accession:CHEBI:31759 term browser browse the term
Synonyms:related_synonym: FRG-8813;   Formula=C22H29N3O4S;   InChI=1S/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2-;   InChIKey=KMZQAVXSMUKBPD-DJWKRKHSSA-N;   SMILES=C1CCN(CC1)CC2=CC(=NC=C2)OC/C=C\\CNC(CS(CC3=CC=CO3)=O)=O;   laflutidine;   protecadin
 xref: CAS:118288-08-7;   CAS:206449-93-6;   Drug_Central:1537;   HMDB:HMDB0240216;   KEGG:D01131
 xref_mesh: MESH:C076948



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Lafutidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha increases expression
multiple interactions
ISO
EXP
lafutidine results in increased expression of CALCA protein
CALCA protein modified form affects the susceptibility to [lafutidine co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide]
CTD PMID:12542603 PMID:16416222 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP lafutidine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; lafutidine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:10671773 PMID:15573930 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions EXP lafutidine inhibits the reaction [loxoprofen results in decreased expression of MUC2] CTD PMID:20586851 NCBI chr 1:196,796,257...196,831,740 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP lafutidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; lafutidine inhibits the reaction [loxoprofen results in increased expression of NOS2] CTD PMID:10671773 PMID:20586851 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO lafutidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sst somatostatin increases expression ISO lafutidine results in increased expression of SST protein CTD PMID:16416222 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects activity EXP lafutidine affects the activity of TRPV1 protein CTD PMID:18344609 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          carbon atom 19633
            organic molecular entity 19633
              Lafutidine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            Lafutidine 7
paths to the root