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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:josamycin
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Accession:CHEBI:31739 term browser browse the term
Definition:A macrolide antibiotic produced by certain strains of Streptomyces narbonensis var. josamyceticus.
Synonyms:related_synonym: EN-141;   Formula=C42H69NO15;   InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1;   InChIKey=XJSFLOJWULLJQS-NGVXBBESSA-N;   JM;   SMILES=CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\\C=C\\C=C\\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O;   Yl-704 A3;   antibiotic yl-704 A3;   josamicina;   josamycine;   josamycinum;   kitasamycin A3;   leucomycin A3;   leucomycin V 3-acetate 4(B)-(3-methylbutanoate);   leucomycin V 3-acetate 4(beta)-(3-methylbutanoate);   leucomycin V 3-acetate 4B-(3-methylbutanoate);   turimycin A5
 xref: CAS:16846-24-5;   DrugBank:DB01321;   Drug_Central:1518;   HMDB:HMDB0015418;   KEGG:C12662;   KEGG:D01235;   KNApSAcK:C00018736
 xref_mesh: MESH:D015570
 xref: PDBeChem:JOS;   PMID:18343618;   PMID:22326844;   PMID:6072799;   Wikipedia:Josamycin


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josamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase affects response to substance ISO ACLY protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Arf1 ADP-ribosylation factor 1 affects response to substance ISO ARF1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects response to substance ISO ATP5B protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b affects response to substance ISO ATP5F1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:208,566,385...208,577,147
Ensembl chr 2:208,566,385...208,577,146
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d affects response to substance ISO ATP5H protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP affects response to substance ISO ATP5O protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Atrx ATRX, chromatin remodeler affects response to substance ISO ATRX protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects response to substance ISO CLPP protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 9:10,048,715...10,056,068
Ensembl chr 9:10,048,886...10,054,359
JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X affects response to substance ISO CLPX protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 8:70,789,137...70,843,133
Ensembl chr 8:70,789,256...70,843,123
JBrowse link
G Cs citrate synthase affects response to substance ISO CS protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Dazap1 DAZ associated protein 1 affects response to substance ISO DAZAP1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:12,289,895...12,315,897
Ensembl chr 7:12,290,402...12,311,149
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 affects response to substance ISO EIF2AK1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 affects response to substance ISO EIF4G1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr11:83,907,659...83,927,683
Ensembl chr11:83,908,109...83,926,524
JBrowse link
G Fbxo11 F-box protein 11 affects response to substance ISO FBXO11 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 6:11,662,356...11,737,427
Ensembl chr 6:11,662,356...11,686,682
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Josamycin results in increased expression of FOS mRNA; Josamycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects response to substance ISO GADD45A protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gfm2 GTP dependent ribosome recycling factor mitochondrial 2 affects response to substance ISO GFM2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:27,949,195...27,984,045
Ensembl chr 2:27,949,208...27,984,256
JBrowse link
G Gpi glucose-6-phosphate isomerase decreases response to substance ISO GPI protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
JBrowse link
G Hk2 hexokinase 2 decreases response to substance ISO HK2 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 affects response to substance ISO HNRNPA1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions
decreases expression
ISO Ribomunyl inhibits the reaction [Josamycin results in decreased expression of ITGB2 protein] CTD PMID:8096833 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 affects response to substance ISO MAP2K3 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 decreases response to substance ISO MAP3K4 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:48,625,714...48,711,642
Ensembl chr 1:48,625,743...48,711,642
JBrowse link
G Me2 malic enzyme 2 affects response to substance ISO ME2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr18:69,737,515...69,784,099
Ensembl chr18:69,738,686...69,784,099
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Josamycin results in decreased expression of COX2 protein CTD PMID:31915244 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase decreases response to substance ISO MTFMT protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 8:70,952,209...70,986,393
Ensembl chr 8:70,952,203...70,986,408
JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 decreases response to substance ISO MTIF2 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr14:113,946,084...113,965,574
Ensembl chr14:113,945,843...113,965,745
JBrowse link
G Mtif3 mitochondrial translational initiation factor 3 decreases response to substance ISO MTIF3 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr12:9,846,355...9,857,548
Ensembl chr12:9,846,398...9,857,548
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 affects response to substance ISO NDUFB8 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:264,298,671...264,303,712
Ensembl chr 1:264,298,669...264,303,762
JBrowse link
G Npm1 nucleophosmin 1 affects response to substance ISO NPM1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Pcm1 pericentriolar material 1 affects response to substance ISO PCM1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr16:54,040,721...54,137,675
Ensembl chr16:54,040,721...54,137,660
JBrowse link
G Pfkp phosphofructokinase, platelet decreases response to substance ISO PFKP protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B affects response to substance ISO PPP1R15B protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha affects response to substance ISO PPP2R2A protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit affects response to substance ISO PRKDC protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Rtraf RNA transcription, translation and transport factor affects response to substance ISO RTRAF protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr15:4,882,925...4,893,890
Ensembl chr15:4,882,947...4,893,919
JBrowse link
G Slc16a1 solute carrier family 16 member 1 affects response to substance ISO SLC16A1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase affects response to substance ISO SMG1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:187,781,577...187,882,833
Ensembl chr 1:187,784,270...187,883,157
JBrowse link
G Smg7 SMG7 nonsense mediated mRNA decay factor affects response to substance ISO SMG7 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr13:70,258,919...70,321,886
Ensembl chr13:70,258,915...70,321,752
JBrowse link
G Strap serine/threonine kinase receptor associated protein affects response to substance ISO STRAP protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 4:171,730,629...171,744,877
Ensembl chr 4:171,730,635...171,745,377
JBrowse link
G Taf3 TATA-box binding protein associated factor 3 affects response to substance ISO TAF3 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr17:72,240,785...72,393,448
Ensembl chr17:72,209,373...72,394,271
JBrowse link
G Taf4 TATA-box binding protein associated factor 4 affects response to substance ISO TAF4 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 3:175,300,842...175,364,655
Ensembl chr 3:175,301,879...175,327,689
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor affects response to substance ISO TPX2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 3:148,327,965...148,370,187
Ensembl chr 3:148,327,965...148,370,187
JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 affects response to substance ISO TRIAP1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897
JBrowse link
G Ubap2l ubiquitin associated protein 2-like affects response to substance ISO UBAP2L protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:189,334,341...189,400,334
Ensembl chr 2:189,334,341...189,400,323
JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects response to substance ISO VDAC1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vdac2 voltage-dependent anion channel 2 affects response to substance ISO VDAC2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          macrolide antibiotic 392
            josamycin 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            formyl group 7847
                                              aldehyde 7847
                                                josamycin 47
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.