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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:josamycin
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Accession:CHEBI:31739 term browser browse the term
Definition:A macrolide antibiotic produced by certain strains of Streptomyces narbonensis var. josamyceticus.
Synonyms:related_synonym: EN-141;   Formula=C42H69NO15;   InChI=1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1;   InChIKey=XJSFLOJWULLJQS-NGVXBBESSA-N;   JM;   SMILES=CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\\C=C\\C=C\\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O;   Yl-704 A3;   antibiotic yl-704 A3;   josamicina;   josamycine;   josamycinum;   kitasamycin A3;   leucomycin A3;   leucomycin V 3-acetate 4(B)-(3-methylbutanoate);   leucomycin V 3-acetate 4(beta)-(3-methylbutanoate);   leucomycin V 3-acetate 4B-(3-methylbutanoate);   turimycin A5
 xref: CAS:16846-24-5;   DrugBank:DB01321;   Drug_Central:1518;   HMDB:HMDB0015418;   KEGG:C12662;   KEGG:D01235;   KNApSAcK:C00018736
 xref_mesh: MESH:D015570
 xref: PDBeChem:JOS;   PMID:18343618;   PMID:22326844;   PMID:6072799;   Wikipedia:Josamycin


show annotations for term's descendants           Sort by:
josamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase affects response to substance ISO ACLY protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Arf1 ADP-ribosylation factor 1 affects response to substance ISO ARF1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:43,997,983...44,014,543
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects response to substance ISO ATP5B protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b affects response to substance ISO ATP5F1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d affects response to substance ISO ATP5H protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP affects response to substance ISO ATP5O protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592 		JBrowse link
G Atrx ATRX, chromatin remodeler affects response to substance ISO ATRX protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330 		JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects response to substance ISO CLPP protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693 		JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X affects response to substance ISO CLPX protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082 		JBrowse link
G Cs citrate synthase affects response to substance ISO CS protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Dazap1 DAZ associated protein 1 affects response to substance ISO DAZAP1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:9,423,673...9,448,116
Ensembl chr 7:9,424,178...9,538,818 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 affects response to substance ISO EIF2AK1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 affects response to substance ISO EIF4G1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G Fbxo11 F-box protein 11 affects response to substance ISO FBXO11 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Josamycin results in increased expression of FOS mRNA; Josamycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects response to substance ISO GADD45A protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gfm2 GTP dependent ribosome recycling factor mitochondrial 2 affects response to substance ISO GFM2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:28,449,452...28,488,200
Ensembl chr 2:28,449,517...28,488,197 		JBrowse link
G Gpi glucose-6-phosphate isomerase decreases response to substance ISO GPI protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086 		JBrowse link
G Hk2 hexokinase 2 decreases response to substance ISO HK2 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 affects response to substance ISO HNRNPA1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions
decreases expression		 ISO Ribomunyl inhibits the reaction [Josamycin results in decreased expression of ITGB2 protein] CTD PMID:8096833 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 affects response to substance ISO MAP2K3 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 decreases response to substance ISO MAP3K4 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358 		JBrowse link
G Me2 malic enzyme 2 affects response to substance ISO ME2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Josamycin results in decreased expression of COX2 protein CTD PMID:31915244 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase decreases response to substance ISO MTFMT protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841 		JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 decreases response to substance ISO MTIF2 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr14:103,265,808...103,285,733
Ensembl chr14:103,270,039...103,285,728 		JBrowse link
G Mtif3 mitochondrial translational initiation factor 3 decreases response to substance ISO MTIF3 protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr12:8,126,193...8,140,706
Ensembl chr12:8,126,276...8,140,470 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 affects response to substance ISO NDUFB8 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:243,408,659...243,413,701
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Npm1 nucleophosmin 1 affects response to substance ISO NPM1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Pcm1 pericentriolar material 1 affects response to substance ISO PCM1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases response to substance ISO PFKP protein results in decreased susceptibility to Josamycin CTD PMID:31915244 NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B affects response to substance ISO PPP1R15B protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha affects response to substance ISO PPP2R2A protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit affects response to substance ISO PRKDC protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rtraf RNA transcription, translation and transport factor affects response to substance ISO RTRAF protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr15:4,447,243...4,457,973
Ensembl chr15:4,442,573...4,457,972 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 affects response to substance ISO SLC16A1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase affects response to substance ISO SMG1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 1:172,441,892...172,543,667
Ensembl chr 1:172,444,936...172,543,698 		JBrowse link
G Smg7 SMG7 nonsense mediated mRNA decay factor affects response to substance ISO SMG7 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr13:64,986,145...65,050,698
Ensembl chr13:64,987,434...65,050,582 		JBrowse link
G Strap serine/threonine kinase receptor associated protein affects response to substance ISO STRAP protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828 		JBrowse link
G Taf3 TATA-box binding protein associated factor 3 affects response to substance ISO TAF3 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr17:68,455,389...68,608,367
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
G Taf4 TATA-box binding protein associated factor 4 affects response to substance ISO TAF4 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 3:167,017,992...167,083,413
Ensembl chr 3:167,017,993...167,083,356 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor affects response to substance ISO TPX2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 affects response to substance ISO TRIAP1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
G Ubap2l ubiquitin associated protein 2-like affects response to substance ISO UBAP2L protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr 2:175,438,703...175,494,085
Ensembl chr 2:175,438,703...175,493,998 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects response to substance ISO VDAC1 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 affects response to substance ISO VDAC2 protein affects the susceptibility to Josamycin CTD PMID:31915244 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        antimicrobial agent 17941
          macrolide antibiotic 428
            josamycin 47
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic acid 18564
                                        carboacyl group 17681
                                          univalent carboacyl group 17681
                                            formyl group 8836
                                              aldehyde 8836
                                                josamycin 47
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