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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ipriflavone
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Accession:CHEBI:31719 term browser browse the term
Definition:A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.
Synonyms:exact_synonym: 7-isopropoxy-3-phenyl-4H-chromen-4-one
 related_synonym: 7-(1-methylethoxy)-3-phenyl-4H-1-benzopyran-4-one;   7-isopropoxyisoflavone;   FL-113;   Formula=C18H16O3;   InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3;   InChIKey=SFBODOKJTYAUCM-UHFFFAOYSA-N;   Iprosten;   Osten;   SMILES=CC(C)Oc1ccc2c(c1)occ(-c1ccccc1)c2=O;   Yambolap;   ipriflavona;   ipriflavonum
 xref: CAS:35212-22-7;   Drug_Central:1477;   HMDB:HMDB0032987;   KEGG:D01338;   LINCS:LSM-5981
 xref_mesh: MESH:C018986
 xref: PMID:11255425;   PMID:17297162;   PMID:21594876;   PMID:23265084;   PMID:24084576;   PMID:24389340;   PMID:24404906;   PMID:7196240;   PMID:8148667;   PMID:8461568;   PMID:9263607;   PMID:9263610;   PMID:9263615;   PMID:9517377;   PMID:9988779;   Patent:DE2125245;   Patent:US3833730;   Patent:US3949085;   Reaxys:4754346;   Wikipedia:Ipriflavone


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ipriflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR1 protein CTD PMID:9751507 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR2 protein CTD PMID:9751507 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ipriflavone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19825
      application 19667
        pharmaceutical 19507
          drug 19507
            bone density conservation agent 6055
              ipriflavone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19797
                    p-block element atom 19797
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19685
                              organic cyclic compound 19496
                                organic heterocyclic compound 18871
                                  oxacycle 17889
                                    benzopyran 11973
                                      1-benzopyran 11726
                                        isoflavonoid 3834
                                          isoflavones 3815
                                            ipriflavone 5
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