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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ipriflavone
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Accession:CHEBI:31719 term browser browse the term
Definition:A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.
Synonyms:exact_synonym: 7-isopropoxy-3-phenyl-4H-chromen-4-one
 related_synonym: 7-(1-methylethoxy)-3-phenyl-4H-1-benzopyran-4-one;   7-isopropoxyisoflavone;   FL-113;   Formula=C18H16O3;   InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3;   InChIKey=SFBODOKJTYAUCM-UHFFFAOYSA-N;   Iprosten;   Osten;   SMILES=CC(C)Oc1ccc2c(c1)occ(-c1ccccc1)c2=O;   Yambolap;   ipriflavona;   ipriflavonum
 xref: CAS:35212-22-7;   Drug_Central:1477;   HMDB:HMDB0032987;   KEGG:D01338;   LINCS:LSM-5981
 xref_mesh: MESH:C018986
 xref: PMID:11255425;   PMID:17297162;   PMID:21594876;   PMID:23265084;   PMID:24084576;   PMID:24389340;   PMID:24404906;   PMID:7196240;   PMID:8148667;   PMID:8461568;   PMID:9263607;   PMID:9263610;   PMID:9263615;   PMID:9517377;   PMID:9988779;   Patent:DE2125245;   Patent:US3833730;   Patent:US3949085;   Reaxys:4754346;   Wikipedia:Ipriflavone



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ipriflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR1 protein CTD PMID:9751507 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR2 protein CTD PMID:9751507 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ipriflavone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            bone density conservation agent 5996
              ipriflavone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      ketone 17115
                                        cyclic ketone 15670
                                          isoflavones 3762
                                            ipriflavone 5
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