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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ipriflavone
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Accession:CHEBI:31719 term browser browse the term
Definition:A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women.
Synonyms:exact_synonym: 7-isopropoxy-3-phenyl-4H-chromen-4-one
 related_synonym: 7-(1-methylethoxy)-3-phenyl-4H-1-benzopyran-4-one;   7-isopropoxyisoflavone;   FL-113;   Formula=C18H16O3;   InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3;   InChIKey=SFBODOKJTYAUCM-UHFFFAOYSA-N;   Iprosten;   Osten;   SMILES=CC(C)Oc1ccc2c(c1)occ(-c1ccccc1)c2=O;   Yambolap;   ipriflavona;   ipriflavonum
 xref: CAS:35212-22-7;   Drug_Central:1477;   HMDB:HMDB0032987;   KEGG:D01338;   LINCS:LSM-5981
 xref_mesh: MESH:C018986
 xref: PMID:11255425;   PMID:17297162;   PMID:21594876;   PMID:23265084;   PMID:24084576;   PMID:24389340;   PMID:24404906;   PMID:7196240;   PMID:8148667;   PMID:8461568;   PMID:9263607;   PMID:9263610;   PMID:9263615;   PMID:9517377;   PMID:9988779;   Patent:DE2125245;   Patent:US3833730;   Patent:US3949085;   Reaxys:4754346;   Wikipedia:Ipriflavone


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ipriflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR1 protein CTD PMID:9751507 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ipriflavone binds to and results in increased activity of ESR2 protein CTD PMID:9751507 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ipriflavone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO ipriflavone inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      application 19403
        pharmaceutical 19303
          drug 19303
            bone density conservation agent 5989
              ipriflavone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16832
                                        cyclic ketone 15247
                                          isoflavones 3750
                                            ipriflavone 5
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