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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iopamidol
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Accession:CHEBI:31711 term browser browse the term
Definition:A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position.
Synonyms:exact_synonym: N,N'-bis(1,3-dihydroxypropan-2-yl)-5-{[(2S)-2-hydroxypropanoyl]amino}-2,4,6-triiodobenzene-1,3-dicarboxamide
 related_synonym: (S)-N,N'-bis(2-Hydroxy-1-(hydroxymethyl)ethyl)-2,4,6-triiodo-5-lactamidoisophthalamide;   Formula=C17H22I3N3O8;   InChI=1S/C17H22I3N3O8/c1-6(28)15(29)23-14-12(19)9(16(30)21-7(2-24)3-25)11(18)10(13(14)20)17(31)22-8(4-26)5-27/h6-8,24-28H,2-5H2,1H3,(H,21,30)(H,22,31)(H,23,29)/t6-/m0/s1;   InChIKey=XQZXYNRDCRIARQ-LURJTMIESA-N;   L-(+)-N,N'-Bis(2-hydroxy-1-hydroxymethylethyl)-2,4,6-triiodo-5-lactamide isophthalamide;   L-5alpha-Hydroxypropionylamino-2,4,6-triiodoisophthalic acid di(1,3-dihydroxy-2-propylamide);   SMILES=C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I;   iopamidolum
 alt_id: CHEBI:75986
 xref: Beilstein:6250226;   CAS:60166-93-0;   Drug_Central:1464;   KEGG:D01797;   LINCS:LSM-5833
 xref_mesh: MESH:D007479
 xref: PMID:15206581;   PMID:23359781;   PMID:23518934;   PMID:23608563;   PMID:24060817;   PMID:24091357;   PMID:24570337;   Reaxys:6250226;   Wikipedia:Iopamidol


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iopamidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Iopamidol results in increased expression of BAK1 mRNA CTD PMID:29705293 NCBI chr20:5,100,480...5,109,669 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Iopamidol results in increased expression of BAX mRNA CTD PMID:29705293 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Iopamidol results in increased expression of BBC3 mRNA CTD PMID:29705293 NCBI chr 1:77,013,281...77,022,509 JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO Iopamidol results in increased expression of and results in increased cleavage of CASP9 protein
Iopamidol results in increased expression of CASP9 mRNA
CTD PMID:29705293 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cryab crystallin, alpha B increases expression ISO Iopamidol results in increased expression of CRYAB mRNA CTD PMID:29705293 NCBI chr 8:51,093,441...51,099,161 JBrowse link
G Eng endoglin decreases expression ISO Iopamidol results in decreased expression of ENG protein CTD PMID:29705293 NCBI chr 3:15,934,566...15,972,618 JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Iopamidol results in increased expression of FABP3 mRNA CTD PMID:29705293 NCBI chr 5:142,651,962...142,658,707 JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Iopamidol results in increased expression of FABP4 mRNA CTD PMID:29705293 NCBI chr 2:91,580,858...91,585,578 JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Iopamidol results in decreased expression of IFI44 mRNA CTD PMID:29705293 NCBI chr 2:240,626,058...240,643,879 JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Iopamidol results in decreased expression of IFIH1 mRNA CTD PMID:29705293 NCBI chr 3:47,228,980...47,275,403 JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Iopamidol results in increased expression of MAP3K1 mRNA CTD PMID:29705293 NCBI chr 2:43,348,572...43,414,706 JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Iopamidol results in increased expression of MAPK14 mRNA CTD PMID:29705293 NCBI chr20:6,749,646...6,810,590 JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Iopamidol results in decreased expression of MX1 mRNA CTD PMID:29705293 NCBI chr11:36,799,659...36,825,209 JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Iopamidol results in decreased expression of OAS3 mRNA CTD PMID:29705293 NCBI chr12:35,779,028...35,802,781 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Iopamidol results in increased expression of PMAIP1 mRNA CTD PMID:29705293 NCBI chr18:59,986,187...59,990,174 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Iopamidol results in increased expression of RELA mRNA CTD PMID:29705293 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Iopamidol results in decreased expression of RSAD2 mRNA CTD PMID:29705293 NCBI chr 6:43,046,514...43,059,737 JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO Iopamidol results in increased expression of S100A4 mRNA CTD PMID:29705293 NCBI chr 2:176,090,951...176,093,258 JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Iopamidol results in increased expression of SOX9 mRNA CTD PMID:29705293 NCBI chr10:97,806,485...97,811,994 JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Iopamidol results in decreased expression of STAT1 mRNA CTD PMID:29705293 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO Iopamidol results in decreased expression of THY1 protein CTD PMID:29705293 NCBI chr 8:44,389,495...44,394,688 JBrowse link
G Tp53 tumor protein p53 increases expression ISO Iopamidol results in increased expression of TP53 mRNA CTD PMID:29705293 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tubb3 tubulin, beta 3 class III increases expression ISO Iopamidol results in increased expression of TUBB3 mRNA CTD PMID:29705293 NCBI chr19:51,457,187...51,466,243 JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO Iopamidol results in decreased expression of USP18 mRNA CTD PMID:29705293 NCBI chr 4:154,471,634...154,499,154 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          iopamidol 24
Path 2
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  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      carboxylic acid 18195
                                        carboacyl group 17423
                                          univalent carboacyl group 17423
                                            carbamoyl group 17230
                                              carboxamide 17230
                                                dicarboxylic acid amide 3135
                                                  dicarboxylic acid diamide 2684
                                                    benzenedicarboxamide 50
                                                      iopamidol 24
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